Project Title

Evaluation of Treatment Response, Drug Resistance and HIV-1 Variability among Adolescents on First- and Second-Line Antiretroviral Therapy in Cameroon: The READY-Study

EDCTP Project Call

Career Development Fellowship (CDF)

Project Objectives

General Objectives: Among Cameroonian adolescents (10-19 years old) receiving ART, we shall monitor the therapeutic response to first- and second-line regimens, drug resistance profiling and HIV-1 genetic variability during one-year follow-up. Specific objectives: In this population of adolescents receiving ART in Cameroon, we shall: 1) Evaluate the rate of immunovirologic failure in the entire population at enrolment, month-6 and month-12 follow-up points; 2) Evaluate acquired DRMs and HIV-1 subtype distribution among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 3) Evaluate the genetic variability in circulating (plasma) versus archived (cellular) viral strains among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 4) Evaluate HIVDR early warning indicators (EWIs), including survival analysis, in the entire study population through out the one-year monitoring period.

Study Design

Prospective, open, observational study

Project Summary

As adolescents living with HIV constitute the most vulnerable target population, the goal of this study is to contribute in the successful transition for pediatric to adult care based on a strategy that consider the treatment experience, circulating and archived viral strains.

Host Organisation

Sites

Current Organisation

CIRCB: Chantal BIYA International Reference Centre for research on HIV/AIDS prevention and management

Current Job Title

Head of Virology Laboratory (Chief or Service)

Biography