Head of Virology Laboratory (Chief or Service) at CIRCB: Chantal BIYA International Reference Centre for research on HIV/AIDS prevention and management
Evaluation of Treatment Response, Drug Resistance and HIV-1 Variability among Adolescents on First- and Second-Line Antiretroviral Therapy in Cameroon: The READY-Study
Career Development Fellowship (CDF)
General Objectives: Among Cameroonian adolescents (10-19 years old) receiving ART, we shall monitor the therapeutic response to first- and second-line regimens, drug resistance profiling and HIV-1 genetic variability during one-year follow-up. Specific objectives: In this population of adolescents receiving ART in Cameroon, we shall: 1) Evaluate the rate of immunovirologic failure in the entire population at enrolment, month-6 and month-12 follow-up points; 2) Evaluate acquired DRMs and HIV-1 subtype distribution among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 3) Evaluate the genetic variability in circulating (plasma) versus archived (cellular) viral strains among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 4) Evaluate HIVDR early warning indicators (EWIs), including survival analysis, in the entire study population through out the one-year monitoring period.
Prospective, open, observational study
As adolescents living with HIV constitute the most vulnerable target population, the goal of this study is to contribute in the successful transition for pediatric to adult care based on a strategy that consider the treatment experience, circulating and archived viral strains.
|Centre for research on HIV/AIDS prevention and management
|International Reference Centre Chantal Biya (CIRCB)
|Prof. Alexis Ndjolo
|Prof. Vittorio Colizzi
|Prof. Carlo-Federico Perno
|University of Rome Tor Vergata
CIRCB: Chantal BIYA International Reference Centre for research on HIV/AIDS prevention and management
Head of Virology Laboratory (Chief or Service)