The EDCTP Alumni Network

Dr
Rose Nabatanzi

Related fellows

Dr Mercy Karoney

Assistant Lecturer

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Dr Olaposi Olatoregun

Deputy Project Director

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Dr Aida Sivro

Scientist

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Profile EDCTP Fellowship 1

Project Title

Characterisation of the latent reservoir among HIV infected individuals on long term antiretroviral therapy (LIIT)

EDCTP Project

TMA2020CDF-3162

EDCTP Program

EDCTP2

EDCTP Project Call

Career Development Fellowship (CDF)

Host Organisation

Department	Institution	Country
	Makerere University - Biomedical Research Centre	Uganda

Current Organisation

Makerere University College of Health Sciences

Current Job Title

Research Scientist

Biography

Publications

Authors:

Journal:

Human Microbiome Journal

Content:

Date:

2020-01-01

Authors:

Journal:

Vaccine

Content:

Date:

2011-01-01

Authors:

Nabatanzi R Bayigga L Cose S Canderan G Rowland Jones S Joloba M Nakanjako D

Journal:

BMC immunology

Content:

Background

Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, as gatekeepers against invading infectious agents through rapid secretion of immune regulatory cytokines. HIV associated destruction of mucosal lymphoid tissue depletes ILCs, among other immune dysfunctions. Studies have described limited restoration of ILCs during the first three years of combined antiretroviral therapy (cART). Little is known about restoration of ILCs during long-term cART, particularly in sub-Saharan Africa which hosts increasing numbers of adults with at least a decade of cART.

Results

We examined phenotypes and function of ILCs from peripheral blood mononuclear cells after 12 years of suppressive cART. We report that ILC1 frequencies (T-BET + CD127 + and CD161 +) were higher in cART-treated HIV-infected relative to age-matched health HIV-negative adults; P = 0.04 whereas ILC precursors (ILCP) were comparable in the two groups (P = 0.56). Interferon gamma (IFN-γ) secretion by ILC1 was higher among cART-treated HIV-infected relative to HIV-negative adults (P = 0.03).

Conclusion

HIV associated alteration of ILC persisted during cART and may likely affect the quality of host innate and adaptive immune responses during long-term cART.

Date:

2021-08-26

Authors:

Journal:

Journal of Hepatology

Content:

Date:

2019-01-01

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Journal:

Highlights on Medicine and Medical Science Vol. 4

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Date:

2021-01-01

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The Journal of infectious diseases

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Date:

2019-01-01

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Journal:

Vaccine

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Date:

2021-01-01

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Journal:

Tropical medicine & international health

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2015-01-01

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PLoS One

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2012-01-01

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Retrovirology

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2020-01-01

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Clinical Immunology

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2019-01-01

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2020-01-01

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Journal:

BMC immunology

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2013-01-01

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Journal:

BMC immunology

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2014-01-01

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Journal:

Immunology letters

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2014-01-01

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Open Journal of Immunology

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2017-01-01

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2021-01-01

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AAS Open Res

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Date:

2019-01-01

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Journal:

Journal of translational medicine

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Date:

2021-01-01

Authors:

Journal:

BMC infectious diseases

Content:

Date:

2011-01-01

Authors:

Journal:

Immunology letters

Content:

Date:

2014-01-01

Authors:

Journal:

Journal of Fungi

Content:

Date:

2019-01-01

Dr Rose Nabatanzi

Related fellows

Dr Mercy Karoney

Dr Olaposi Olatoregun

Dr Aida Sivro

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Current Organisation

Current Job Title

Biography

Publications

Background

Results

Conclusion

Dr
Rose Nabatanzi