Project Title

Frequency and determinants of dual infection with different strains of HIV-1 in low- and high-risk populations in Uganda

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

To evaluate the frequency and determinants of dual infection with different strains of HIV-1 in low- and high- risk populations in Uganda. This study had four major objectives and 1 minor: • Implement and validate novel sequence analysis methods developed at the Rega Institute (Belgium) for the detection of instances of co-infection and superinfection in longitudinally collected samples • Determine the clinical consequences of dual infection by comparing disease progression (viral loads and CD4+ counts) between those with and without dual infection • Determine the course of virologic recombination that occurs after dual infection • Determine the immunologic correlates of dual infection • Determine the prevalence of HIV-1 drug resistance among recently infected commercial sex workers.

Study Design

Prospective cohort study on determinants of dual infection with HIV strains

Host Organisation

Sites

Results & Outcomes

Current Organisation

Medical Research Council Programme on AIDS - Uganda Virus Research Institute (MRC/UVRI)

Current Job Title

Biography