Project Title

Pre-clinical evaluation of dendritic cell targeted consensus B, C, CRFO2_AG and MOSAIC HIV gag protein vaccines in PBMC from chronically infected patients in Central Africa

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

To examine if a DC targeted consensus B HIV gag p24 protein vaccine could recall in vitro pre-existing gag specific T cells in PBMCs of subjects chronically infected with unrelated HIV-1 strains prevalent in Africa To compare in terms of magnitude, breadth, and depth T cell responses recalled in vitro in PBMCs of subjects chronically infected with HIV-1 in central Africa by 4 four different DC targeted HIV gag p24 protein vaccines based on CRFO2_AG, C, B and MOSAIC HIV gag sequences, which are designed to address the problems associated with HIV-1 diversity.

Study Design

Laboratory pre-clinical evaluation of dendritic cell antigens and HIV gag protein vaccines

Host Organisation

Results & Outcomes

Current Organisation

The chantal Biya international reference center for HIV

Current Job Title

Deputy Director General

Biography