Project Title

Improving RETention and viral load outcomes for people taking Antiretroviral therapy through early IdentificatioN of missed doses [The RETAIn study].

EDCTP Project Call

Senior Fellowship Plus (SFP)

Host Organisation

Project Title

 A randomised controlled trial of real-time electronic adherence monitoring with text message dosing reminders in people starting first-line antiretroviral therapy

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

This study will use a locally developed real time adherence monitoring tool to explore and improve adherence in ART-naïve individuals commencing treatment in an established ART cohort. The study will use adherence, virological and pharmacokinetic data to examine adherence failure discordance. The questions to be answered by the study are: 1. Does a real-time electronic adherence monitoring tool with text message feedback improve adherence, retention in care and virological outcomes among ART-naïve individuals receiving first-line therapy? 2. Does population pharmacokinetic data explain discordance between adherence and virological response?

Study Design

A randomised controlled trial with two arms, as follows: Control arm: Standard of care at ART clinic with use of an electronic adherence monitoring device (EAMD or Wisepill) to monitor adherence only (i.e., without any feedback). Experimental group: Control arm with the addition of the use of the EAMD text message service when dosing late, and EAMD dosing feedback at 4-monthly visits.

Project Summary

Testing - to be updated?

Host Organisation

Sites

Results & Outcomes

Current Organisation

 Desmond Tutu Health Foundation and University of Cape Town

Current Job Title

Centre for Adherence and Therapeutics, Clinical Research Site Leader

Biography

Publications