The EDCTP Alumni Network

Professor
Abdoulaye Djimde

Related fellows

Professor Daniel Dodoo

Associate Professor

View

Dr Ndong Ignatius Cheng

EDCTP Career Development Fellow

View

Dr Clifford Banda

Specialist Clinical Pharmacologist

View

Profile EDCTP Fellowship 1

Project Title

Assessment of the Public Health Benefit of artemisinin based combination therapies for uncomplicated malaria treatment in Mali

EDCTP Project

TA.2004.40200.003

EDCTP Program

EDCTP1

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

1. To test the hypothesis that repeated administration of artesunate+amodiaquine (AS+AQ (Arsucam)), artesunate plus sulphadoxine-pyrimethamine (AS/SP) and artemether-lumefantrine (AR-L (Coartem)) for treatment of consecutive episodes of uncomplicated malaria reduces the incidence of uncomplicated malaria 2. To measure the impact of repeated administration of the drugs on malarial immunity and malaria transmission

Study Design

Phase IV Randomised Control Trial

Host Organisation

Department	Institution	Country
	Malaria Research & Training Center	Mali

Results & Outcomes

Study results showed that in this setting of perennial transmission with seasonal peaks, the incidence density of malaria in the AS + SP and Arsucam® arms were reduced as compared to the ARL arm. Using crude efficacy, ARL was also significantly less efficacious during the peak season of malaria while all arms had similar and above 98% efficacy after adjusting for re-infections by PCR. All ACTs maintained acceptable clinical and laboratory safety profiles despite their repetitive usage. Combined therapy of Arsucam or Arsumax reduced malaria incidence more than Coartem.

Current Organisation

Current Job Title

Biography

Publications

Authors:

Djimdé AA Fofana B Sagara I Sidibe B Toure S Dembele D Dama S Ouologuem D Dicko A Doumbo OK.

Journal:

Content:

Date:

0000-00-00

Authors:

Tekete M Djimde AA Beavogui AH Maiga H Sagara I Fofana B Ouologuem D Dama S Kone A Dembele D Wele M Dicko A Doumbo OK.

Journal:

Content:

Date:

0000-00-00

Authors:

Barger B Maiga H Traore OB Tekete M Timbine A Dara A Traore ZI Gantt S Doumbo OK Djimde AA.

Journal:

Content:

Date:

0000-00-00

Authors:

Kaddouri H Djimdé AA Dama S Kodio A Tekete M Hubert V Koné A Maiga H Yattara O Fofana B Sidibe B Sangaré CPO Doumbo OK Le Bras J.

Journal:

Content:

Date:

0000-00-00

Professor Abdoulaye Djimde

Related fellows

Professor Daniel Dodoo

Dr Ndong Ignatius Cheng

Dr Clifford Banda

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Project Objectives

Study Design

Host Organisation

Results & Outcomes

Current Organisation

Current Job Title

Biography

Publications

Professor
Abdoulaye Djimde