Professor
Abdoulaye Djimde
Project Title
Assessment of the Public Health Benefit of artemisinin based combination therapies for uncomplicated malaria treatment in Mali
Project Objectives
1. To test the hypothesis that repeated administration of artesunate+amodiaquine (AS+AQ (Arsucam)), artesunate plus sulphadoxine-pyrimethamine (AS/SP) and artemether-lumefantrine (AR-L (Coartem)) for treatment of consecutive episodes of uncomplicated malaria reduces the incidence of uncomplicated malaria 2. To measure the impact of repeated administration of the drugs on malarial immunity and malaria transmission
Results & Outcomes
Study results showed that in this setting of perennial transmission with
seasonal peaks, the incidence density of malaria in the AS + SP and
Arsucam® arms were reduced as compared to the ARL arm. Using crude
efficacy, ARL was also significantly less efficacious during the peak
season of malaria while all arms had similar and above 98% efficacy after
adjusting for re-infections by PCR. All ACTs maintained acceptable
clinical and laboratory safety profiles despite their repetitive usage.
Combined therapy of Arsucam or Arsumax reduced malaria incidence
more than Coartem.
Host Organisation
| Department | Institution | Country |
|---|---|---|
| Malaria Research & Training Center | Mali |
EDCTP Project
TA.2004.40200.003
EDCTP Program
EDCTP1
EDCTP Project Call
Senior Fellowship (SF)
Study Design
Phase IV Randomised Control Trial