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Mr
Badara Cisse

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Profile EDCTP Fellowship 1

Project Title

A pilot study of the Implementation of Seasonal Intermittent Preventive Treatment with Community Participation in Senegal

EDCTP Project

TA.2005.40200.004

EDCTP Program

EDCTP1

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

The purpose of this trial was to compare the acceptability, efficacy and safety of three alternative drug regimens for use for seasonal Intermittent Preventive Treatment to prevent malaria in children. Children aged 2 months to 5 years were randomized to receive IPT with one of three regimens during the transmission season: sulfadoxinepyrimethamine (SP) plus amodiaquine, show to be highly effective for IPT in a recent trial; SP plus piperaquine, used for malaria prophylaxis in China for many years; or Duocotexcin (a combination of piperaquine with an artemisinin).

Study Design

Phase III Clinical Trial

Host Organisation

Department Institution Country
University Cheikh Anta Diop Senegal

Results & Outcomes

This study provided evidence that seasonal IPTc with SP+PQ among children is highly effective and well tolerated. The combination of two long-acting drugs is optimal for malaria prevention and is most effective in the face of an emergence of resistant parasite genotypes. It was also demonstrated that amendments to age-based dosing of SPamodiaquine had the potential of increasing dosing accuracy and improve tolerability of the IPTc. The work has been an important reference for the WHO scientific advisory group. One junior physician, two nurses and 45 community volunteers were trained. The grantee also recruited an MSc student in parasitology and he was also a recipient of second Senior Fellowship grant from Malaria Capacity Development Consortium. Two more EDCTP-funded projects followed on from the ground work of this project. These were a Senior Fellowship to Jean Louis Ndiaye and the Malaria Vectored Vaccines Consortium (IP.2008.31100.001), both awarded in 2010.