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Profile Background
profile

Professor
Collen Masimirembwa

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Dr Moses Egesa

Ms Emily Awuor Abuonji

RESEARCH ASSISTANT

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Dr Moses Egesa

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Senior Lecturer

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Dr Moses Egesa

Dr Zivai Nenguke

Project Director

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Current Organisation

African Institute of Biomedical Science and Technology (AIBST)

Current Job Title

Chief Scientific Officer

Biography

Publications

Authors:
L Afzelius, I Zamora, M Ridderström, TB Andersson, A Karlén, CM Masimirembwa

Journal:
Molecular pharmacology 59 (4)

Content:

Date:
2009-05-05

Authors:
Maimbo M, Kiyotani K, Mushiroda T, Masimirembwa C, Nakamura Y.

Journal:
Eur J Clin Pharmacol. 2012 Mar;68(3):267-71.

Content:

Date:
2012-03-06

Authors:
CM Masimirembwa, R Thompson, TB Andersson

Journal:
Combinatorial chemistry & high throughput screening 4 (3)

Content:

Date:
2001-05-05

Authors:
CM Masimirembwa C Otter M Berg M Jönsson B Leidvik E Jonsson TB Andersson.

Journal:

Content:

Date:
1999-01-01

Authors:
Hayeshi R, Masimirembwa C, Mukanganyama S, Ungell AL

Journal:
Biopharm Drug Dispos. 2008 Sep;29(6):324-34.

Content:

Date:
2008-09-29

Authors:
Kjellander B, Masimirembwa CM, Zamora I.

Journal:
J Chem Inf Model. 2007 May-Jun;47(3):1234-47

Content:

Date:
2007-05-31

Authors:
Adzu B, Mustapha KB, Masimirembwa C, Obodozie O, Kirim RA, Gamaniel KS. Avicenna J Phytomed

Journal:
2013 Summer;3(3):201-

Content:

Date:
2013-03-03

Authors:
XQ Li, A Björkman, TB Andersson, LL Gustafsson, CM Masimirembwa

Journal:
European journal of clinical pharmacology 59 (5-6

Content:

Date:
1996-05-05

Authors:
Dandara C, Huzair F, Borda-Rodriguez A, Chirikure S, Okpechi I, Warnich L, Masimirembwa C

Journal:
OMICS. 2014 Dec;18(12):733-9

Content:

Date:
2014-12-18

Authors:
Gutierrez MM, Pillai G, Felix S, Romero F, Onyango KO, Owusu-Agyei S, Asante KP, Barnes KI, Sinxadi P, Allen E, Abdulla S, Masimirembwa C, Munyoro M, Yimer G, Gebre-Mariam T, Spector J, Ogutu B

Journal:
Clin Pharmacol Ther; 10.1002/cpt.695. [Epub ahead of print]

Content:

Date:
2017-04-05

Authors:
TE Bapiro, AC Egnell, JA Hasler, CM Masimirembwa

Journal:
Drug Metabolism and disposition 29 (1),

Content:

Date:
2001-05-05

Authors:
C Nyakutira D Röshammar E Chigutsa P Chonzi M Ashton C Nhachi CM Masimirembwa

Journal:

Content:

Date:
2008-01-01

Authors:
Chimukangara B, Gwanzura L, Mitchell R, Katzenstein D, Masimirembwa C

Journal:
Curr HIV Res. 2014;12(5):309-16

Content:

Date:
2014-12-05

Authors:
Thelingwani RS, Zvada SP, Dolgos H, Ungell AL, Masimirembwa CM

Journal:
Drug Metab Dispos. 2009 Jun;37(6):1286-94

Content:

Date:
2009-06-03

Authors:
Matimba A, Tybring G, Chitereka J, Zinyama-Gutsire R, Dandara C, Bürén E, Dhoro M, Masimirembwa C

Journal:
Biopreserv Biobank. 2016 Apr 15. [Epub ahead of print] PMID: 27082894

Content:

Date:
2016-04-15

Authors:
Grobler L, Grobler A, Haynes R, Masimirembwa C. Thelingwani R, Steenkamp P, Steyn HS

Journal:
Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):313-25

Content:

Date:
2014-03-24

Authors:
CM Masimirembwa C Otter M Berg M Jönsson B Leidvik E Jonsson

Journal:

Content:

Date:
1999-01-01

Authors:
Adzu B, Masimirembwa C, Mustapha KB, Thelingwani R, Kirim RA, Gamaniel KS

Journal:
Eur J Drug Metab Pharmacokinet. 2015 Mar;40(1):115-8.

Content:

Date:
2015-03-04

Authors:
Bonn B, Masimirembwa CM, Castagnoli N Jr

Journal:
Drug Metab Dispos. 2010 Jan;38(1):187-99.

Content:

Date:
2010-01-04

Authors:
CM Masimirembwa, C Otter, M Berg, M Jönsson, B Leidvik, E Jonsson, ...

Journal:
Drug Metabolism and Disposition 27 (10),

Content:

Date:
1999-05-05

Authors:
Manasa J, Musabaike H, Masimirembwa C, Burke E, Luthy R, Mudzori J

Journal:
Clin Vaccine Immunol. 2007 Mar;14(3):293-8.

Content:

Date:
2007-03-14

Authors:
Simms V, Dauya E, Dakshina S, Bandason T, McHugh G, Munyati S, Chonzi P, Kranzer K, Ncube G, Masimirembwa C, Thelingwani R, Apollo T, Hayes R, Weiss HA, Ferrand RA. PLoS Med

Journal:
e1002360. doi: 10.1371/journal.pmed.1002360. eCollection

Content:

Date:
2018-07-25

Authors:
Adigun RA, Martincigh B, Nyamori VO, Omondi B, Masimirembwa C, Simoyi RH.

Journal:
Dalton Trans. 2014 Sep 14;43(34):12943-51

Content:

Date:
2014-09-14

Authors:
Johansson T, Jurva U, Grönberg G, Weidolf L, Masimirembwa C

Journal:
Drug Metab Dispos. 2009 Mar;37(3):571-9.

Content:

Date:
2009-03-03

Authors:
Jurva U, Holmén A, Grönberg G, Masimirembwa C, Weidolf L

Journal:
Chem Res Toxicol. 2008 Apr;21(4):928-35.

Content:

Date:
2008-04-21

Authors:
Dhoro M, Ngara B, Kadzirange G, Nhachi C, Masimirembwa C

Journal:
Curr HIV Res. 2013 Sep;11(6):481-90.

Content:

Date:
2013-09-11

Authors:
Thelingwani R, Masimirembwa C.

Journal:
Curr Drug Metab. 2014;15(10):942-52

Content:

Date:
2014-10-10

Authors:
Zawaira A, Matimba A, Masimirembwa C

Journal:
Pharmacogenet Genomics. 2008 Jun;18(6):467-76

Content:

Date:
2008-06-18

Authors:
CM Masimirembwa, C Otter, M Berg, M Jönsson, B Leidvik, E Jonsson, TB Andersson

Journal:
Drug Metabolism and Disposition 27 (10)

Content:

Date:
1999-05-05

Authors:
Ongarora DS, Strydom N, Wicht K, Njoroge M, Wiesner L, Egan TJ, Wittlin S, Jurva U, Masimirembwa CM, Chibale K.

Journal:
Bioorg Med Chem. 2015 Sep 1;23(17):5419-32.

Content:

Date:
2015-09-01

Authors:
XQ Li A Björkman TB Andersson LL Gustafsson CM Masimirembwa

Journal:

Content:

Date:
2003-01-01

Authors:
7. Rhead R, Masimirembwa C, Cooke G, Takaruza A, Nyamukapa C, Mutsimhi C, Gregson S

Journal:
PLoS One. 2016 Dec 14;11(12):e0167852. doi: 10.1371/journal.pone.0167852. eCollection 2016.

Content:

Date:
2016-12-14

Authors:
Dhoro M, Zvada S, Ngara B, Nhachi C, Kadzirange G, Chonzi P, Masimirembwa C.

Journal:
BMC Pharmacol Toxicol. 2015 Mar 27;16:4.

Content:

Date:
2015-03-27

Authors:
XQ Li, A Björkman, TB Andersson, M Ridderström, CM Masimirembwa

Journal:
Pharmacology and Experimental Therapeutics 300 (2)

Content:

Amodiaquine (AQ) metabolism to N-desethylamodiaquine (DEAQ) is the principal route of disposition in humans. Using human liver microsomes and two sets of recombinant human cytochrome P450 isoforms (from lymphoblastoids and yeast) we performed studies to identify the CYP isoform(s) involved in the metabolism of AQ. CYP2C8 was the main hepatic isoform that cleared AQ and catalyzed the formation of DEAQ. The extrahepatic P450s, 1A1 and 1B1, also cleared AQ and catalyzed the formation of an unknown metabolite M2. TheKm and Vmaxvalues for AQ N-desethylation were 1.2 μM and 2.6 pmol/min/pmol of CYP2C8 for recombinant CYP2C8, and 2.4 μM and 1462 pmol/min/mg of protein for human liver microsomes (HLMs), respectively. Relative contribution of CYP2C8 in the formation of DEAQ was estimated at 100% using the relative activity factor method. Correlation analyses between AQ metabolism and the activities of eight hepatic P450s were made on 10 different HLM samples. Both the formation of DEAQ and the clearance of AQ showed excellent correlations (r2 = 0.98 and 0.95) with 6α-hydroxylation of paclitaxel, a marker substrate for CYP2C8. The inhibition of DEAQ formation by quercetin was competitive withKi values of 1.96 for CYP2C8 and 1.56 μM for HLMs. Docking of AQ into the active site homology models of the CYP2C isoforms showed favorable interactions with CYP2C8, which supported the likelihood of an N-desethylation reaction. These data show that CYP2C8 is the main hepatic isoform responsible for the metabolism of AQ. The specificity, high affinity, and high turnover make AQ desethylation an excellent marker reaction for CYP2C8 activity.

Date:
2002-01-02

Authors:
Matimba A, Oluka MN, Ebeshi BU, Sayi J, Bolaji OO, Guantai AN, Masimirembwa CM

Journal:
Eur J Hum Genet. 2008 Jul;16(7):780-3.

Content:

Date:
2008-07-08

Authors:
Ericsson T, Masimirembwa C, Abelo A, Ashton M

Journal:
Drug Metab Lett. 2012;6(4):247-57

Content:

Date:
2012-04-02

Authors:
Afzelius L, Raubacher F, Karlén A, Jørgensen FS, Andersson TB, Masimirembwa CM, Zamora I

Journal:
Drug Metab Dispos. 2004 Nov;32(11):1218-29.

Content:

Date:
2004-11-11

Authors:
Thelingwani R, Bonn B, Chibale K, Masimirembwa C

Journal:
Expert Opin Drug Metab Toxicol. 2014 Oct;10(10):1313-24.

Content:

Date:
2014-10-10

Authors:
Makadzange AT, Higgins-Biddle M, Chimukangara B, Birri R, Gordon M, Mahlanza T, McHugh G, van Dijk JH, Bwakura-Dangarembizi M, Ndung'u T, Masimirembwa C, Phelps B, Amzel A, Ojikutu BO, Walker BD, Ndhlovu CE

Journal:
PLoS One. 2015 Dec 14;10(12):

Content:

Date:
2015-12-14

Authors:
Njuguna NM, Masimirembwa C, Chibale K

Journal:
J Nat Prod. 2012 Mar 23;75(3):507-13.

Content:

Date:
2012-03-23

Authors:
L Afzelius I Zamora M Ridderström TB Andersson A Karlén CM Masimirembwa

Journal:

Content:

Date:
2001-01-01

Authors:
CM Masimirembwa, U Bredberg, TB Andersson

Journal:
Clinical pharmacokinetics 42 (6),

Content:

Date:
2003-05-05

Authors:
4. Makadzange AT, Boyd FK, Chimukangara B, Masimirembwa C, Katzenstein D, Ndhlovu CE

Journal:
J Clin Microbiol. 2017 Jul;55(7):2172-2179. doi: 10.1128/JCM.00176-17

Content:

Date:
2017-05-03

Authors:
Chimukangara B, Manasa J, Mitchell R, Nyabadza G, Katzenstein D, Masimirembwa C

Journal:
AIDS Res Hum Retroviruses

Content:

Date:
2016-10-26

Authors:
CM Masimirembwa U Bredberg TB Andersson

Journal:

Content:

Date:
2003-01-01

Authors:
Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K

Journal:
Bioorg Med Chem Lett. 2012 Aug 1;22(15):5046-5010.

Content:

Date:
2012-08-01

Authors:
Bonn B, Masimirembwa CM, Aristei Y, Zamora I

Journal:
Drug Metab Dispos. 2008 Nov;36(11):2199-210

Content:

Date:
1998-11-02

Authors:
Cotton RG; 2006 Human Variome Project, Appelbe W, Auerbach AD, Becker K, Bodmer W, Boone DJ, Boulyjenkov V, Brahmachari S, Brody L, Brookes A, Brown AF, Byers P, Cantu JM, Cassiman JJ, Claustres M, Concannon P, Cotton RG, den Dunnen JT, Flicek P, Gibbs R, Hall J, Hasler J, Katz M, Kwok PY, Laradi S, Lindblom A, Maglott D, Marsh S, Masimirembwa CM, Minoshima S, de Ramirez AM, Pagon R, Ramesar R, Ravine D, Richards S, Rimoin D, Ring HZ, Scriver CR, Sherry S, Shimizu N, Stein L, Tadmouri GO, Taylor G, Watson M

Journal:
Nat Genet. 2007 Apr;39(4):433-6.

Content:

Date:
2007-04-03

Authors:
Thelingwani RS, Dhansay K, Smith P, Chibale K, Masimirembwa CM

Journal:
Xenobiotica. 2012 Oct;42(10):989-1000.

Content:

Date:
2012-10-12

Authors:
Soko ND, Masimirembwa C, Dandara C. OMICS.

Journal:
2016 Sep;20(9):498-509. doi: 10.1089/omi.2016.0114.PMID: 27631189

Content:

Date:
2016-09-20

Authors:
Matimba A, Del-Favero J, Van Broeckhoven C, Masimirembwa C

Journal:
Hum Genomics. 2009 Jan;3(2):169-90.

Content:

Date:
2009-01-05

Authors:
Afzelius L, Zamora I, Masimirembwa CM, Karlén A, Andersson TB, Mecucci S, Baroni M, Cruciani G.

Journal:
J Med Chem. 2004 Feb 12;47(4):907-14.

Content:

Date:
2004-02-12

Authors:
Thelingwani R, Leandersson C, Bonn B, Smith P, Chibale K, Masimirembwa C

Journal:
Xenobiotica. 2015 Sep 4:1-7. [Epub ahead of print] PMID: 26338168

Content:

Date:
2015-09-04

Authors:
1. Soko ND, Masimirembwa C, Dandara C

Journal:
BMC Res Notes.

Content:

Date:
2019-06-14

Authors:
Jurva U, Holmén A, Grönberg G, Masimirembwa C, Weidolf L

Journal:
Chem Res Toxicol. 2008 Apr;21(4):928-35.

Content:

Date:
2008-04-21

Authors:
Bapiro TE, Sayi J, Hasler JA, Jande M, Rimoy G, Masselle A, Masimirembwa CM

Journal:
Eur J Clin Pharmacol. 2005 Nov;61(10):755-61.

Content:

Date:
2005-11-07

Authors:
Adeagbo BA, Bolaji OO, Olugbade TA, Durosinmi MA, Bolarinwa RA, Masimirembwa C. J Clin

Journal:
Pharm Ther. 2016 Oct;41(5):546-51. doi: 10.1111/jcpt.12424. PMID: 27426203

Content:

Date:
2016-10-14

Authors:
Chigorimbo-Murefu NT, Njoroge M, Nzila A, Louw S, Masimirembwa C, Chibale K

Journal:
Future Med Chem. 2012 Dec;4(18):2325-36.

Content:

Date:
2012-12-04

Authors:
Chibale K, Guantai EM, Masimirembwa C.

Journal:
Future Med Chem. 2011 Mar;3(3):257-61

Content:

Date:
2011-03-03

Authors:
XQ Li A Björkman TB Andersson M Ridderström CM Masimirembwa.

Journal:

Content:

Date:
2002-01-01

Authors:
Hayeshi R, Masimirembwa C, Mukanganyama S, Ungell AL

Journal:
Eur J Pharm Sci. 2006 Sep;29(1):70-81.

Content:

Date:
2006-09-29

Authors:
Masimirembwa C, Dandara C, Leutscher PD

Journal:
OMICS. 2016 Oct;20(10):575-580. PMID: 27627692

Content:

Date:
2016-10-20

Authors:
Dandara C, Swart M, Mpeta B, Wonkam A, Masimirembwa C

Journal:
Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):769-85.

Content:

Date:
2014-06-10

Authors:
Nyakutira C, Röshammar D, Chigutsa E, Chonzi P, Ashton M, Nhachi C, Masimirembwa C. Eur J

Journal:
Clin Pharmacol. 2008 Apr;64(4):357-65.

Content:

Date:
2008-04-07

Authors:
Persson KP, Ekehed S, Otter C, Lutz ES, McPheat J, Masimirembwa CM, Andersson TB

Journal:
Pharm Res. 2006 Jan;23(1):56-69

Content:

Date:
2006-01-23

Authors:
Dhoro M, Nhachi C , Masimirembwa C.

Journal:
African Journal of Biotechnology

Content:

Date:
2013-01-01

Authors:
C MASIMIREMBWA I PERSSON L BERTILSSON J HASLER

Journal:

Content:

Date:
1996-01-01

Authors:
TE Bapiro AC Egnell JA Hasler CM Masimirembwa

Journal:

Content:

Date:
2001-01-01

Authors:
Awortwe C, Bouic PJ, Masimirembwa CM, Rosenkranz B

Journal:
Drug Metab Lett. 2014 Jul;7(2):83-95.

Content:

Date:
2014-07-07

Authors:
C Nyakutira, D Röshammar, E Chigutsa, P Chonzi, M Ashton, C Nhachi, CM Masimirembwa

Journal:
European journal of clinical pharmacology 64 (4)

Content:

Date:
2008-05-05

Authors:
C MASIMIREMBWA, I PERSSON, L BERTILSSON, J HASLER

Journal:
British journal of clinical pharmacology 42 (6)

Content:

Date:
2009-05-05

Authors:
CM Masimirembwa R Thompson TB Andersson

Journal:

Content:

Date:
2001-01-01

Authors:
Mao M, Matimba A, Scordo MG, Gunes A, Zengil H, Yasui-Furukori N, Masimirembwa C, Dahl ML

Journal:
Pharmacogenomics. 2009 Sep;10(9):1447-55.

Content:

Date:
2009-09-10