The EDCTP Alumni Network

Department	Institution	Country
	University of Dschang	Cameroon

Authors:

Journal:

BMC Infectious Diseases

Content:

Abstract Background Many studies have reported high efficacy and safety of artesunate-amodiaquine (AS-AQ) and artemether-lumefantrine (AL) when administered under direct observation in Cameroon. There is paucity of data to support their continuous use in home-based treatment of uncomplicated Plasmodium falciparum malaria in Cameroon. Hence, this study aimed to assess the effectiveness and safety of AS-AQ versus AL for home-based treatment of uncomplicated P. falciparum malaria among children 6–120 months in Yaoundé, Cameroon. Methods A two-arm, open-label, randomized, controlled trial comparing the equivalence of AS-AQ (experimental group) and AL (control group) was carried out from May 2019 to April 2020 at two secondary hospitals in Yaoundé. Participants were randomized to receive either AS-AQ or AL. After the first dose, antimalarial drugs were given at home, rather than under direct observation by a study staff. The conventional on-treatment and post-treatment laboratory and clinical evaluations were not done until day 3 of the full antimalarial treatment course. The evaluation of effectiveness was mainly based on per protocol polymerase chain reaction adjusted adequate clinical and parasitological response (PP PCR adjusted ACPR) on day 28 post-treatment. Safety was based on assessment of adverse events (AEs) and severe adverse events (SAEs) from day 1 to day 28. Results A total of 242 children were randomized to receive AS-AQ (n = 114) and AL (n = 128). The PP PCR adjusted day 28 cure rates were [AS-AQ = 96.9% (95% CI, 91.2–99.4) versus AL = 95.5% (95% CI, 89.9–98.5), P = 0.797]. Expected mild to moderate adverse events were reported in both arms [AS-AQ = 83 (84.7%) versus AL = 99 (86.1%), P = 0.774]. The most common adverse events included: transient changes of hematologic indices and fever. Conclusions This study demonstrated that AS-AQ and AL are effective and safe for home management of malaria in Yaoundé. The evidence from this study supports the parallel use of the two drugs in routine practice. However, the findings from this study do not describe the likely duration of antimalarial effectiveness in holoendemic areas where multiple courses of treatment might be required. Trial registration: This study is a randomized controlled trial and it was retrospectively registered on 23/09/2020 at ClinicalTrials.gov with registration number NCT04565184.

Date:

2022-12-01

Authors:

Journal:

Pharmacy & Pharmacology International Journal

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Date:

2019-07-02

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Journal:

Heliyon, Volume 8, Issue 11, November 2022, e11861

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Date:

2023-02-27

Authors:

Ali, I.M. Netongo, P.M. Atogho-Tiedeu, B. Ngongang, E.-O. Ajua, A. Achidi, E.A. Mbacham, W.F.

Journal:

Malaria Research and Treatment

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Date:

2013-01-01

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Journal:

Journal of Agriculture and Food Research

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Date:

2021-08-01

Authors:

Mbacham, W.F. Evehe, M.-S.B. Netongo, P.M. Ali, I.M. Nfor, E.N. Akaragwe, A.I. Mimche, P.N. Nji, A. Djoko, C.F. Tawe, B. Gawa, B. Asongna, T. Toh, G.B. Atogho-Tieudeu, B. Nge, N. Ebeng, R. Mokube, J.A. Kuaban, C. Bickii, J. Penlap, V. Titanji, V.P. Njikam, N.

Journal:

African Journal of Biotechnology

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Date:

2009-01-01

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Journal:

AIDS (London, England)

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: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.

Date:

2020-05-20

Authors:

Journal:

PLos Neglected Tropical Diseases

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Date:

2022-11-12

Authors:

Marcel Nyuylam Moyeh Sandra Noukimi Fankem Innocent Mbulli Ali Denis Sofeu Sorelle Mekachie Sandie Dieudonne Lemuh Njimoh Stephen Mbigha Ghogomu Helen Kuokuo Kimbi Wilfred Fon Mbacham

Journal:

Pathogens and Global Health

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Date:

2022-03-31

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Journal:

Pathogens and Global Health Volume 116, 2022 - Issue 8

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Date:

2023-02-27

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Journal:

Malaria Journal

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Date:

2022-03-09

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Journal:

Content:

Date:

Authors:

Akindeh M. Nji Innocent Mbulli Ali Peter Thelma Ngwa Niba Evehe Marie-Solange Christian Heumann Guenter Froeschl Wilfred F. Mbacham

Journal:

Pathogens

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Date:

2021-08-01

Authors:

Journal:

Journal of Clinical Microbiology

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Remote areas of many low and middle income (LMI) countries have poor access to HIV viral load (HIV VL) testing. The SAMBA-II (Simple Amplification-based Assay) Semi-Q Whole Blood Test (Diagnostics for the Real World (DRW), Cambridge, UK) is a point of care assay which uses leucodepletion technology to allow whole blood testing in remote settings. 1540 consecutive HIV-positive clinic patients in Cameroon (250), UK (633), Ukraine (412) and Zimbabwe (245) donated venous blood (all countries) and finger-prick blood (all except UK) for testing on SAMBA-II. SAMBA II results were compared with simultaneous plasma results on the Abbott RealTime HIV-1 (Abbott Molecular, Des Plaines, IL) viral load assay and interpreted as either <1000 RNA copies/ml or ≥1000 RNA copies/ml. For 1528 venous whole-blood samples tested on SAMBA II, overall percent agreement with the reference test at a cut-off of HIV VL ≥1000 cps/ml was 96.9% (1480/1528 95% CI 95.9-97.7), negative percent agreement 97.7% (1259/1289 95% CI 96.7-98.4), positive percent agreement 92.5% (221/239 95% CI 88.4-95.5). For 854 finger-prick samples there was 95.0% (811/854 95% CI 93.3-96.3) overall percent agreement; negative percent agreement 98.0% (625/638, 95% CI 96.5-98.9); positive percent agreement 86.1% (186/216 95% CI 80.8-90.4). These rose to 93.5% (82.1, 98.6), 97.6% (95.6, 98.8) and 95.6% (93.3, 97.3) after exclusion of aberrant results from the Ukraine centre. These results show a high level of agreement between SAMBA-II and a laboratory-based assay. SAMBA-II has a performance that is suitable to use as a VL point of care assay in remote settings

Date:

2020-12-21

Authors:

Journal:

Journal of Agriculture and Food Research

Content:

Date:

2022-03-01

Authors:

Marcel N. Moyeh Dieudonne L. Njimoh Marie Solange Evehe Innocent M. Ali Akindeh M. Nji Dominique N. Nkafu Palmer N. Masumbe Atogho-Tiedeu Barbara Valentine N. Ndikum Wilfred F. Mbacham

Journal:

Malaria Research and Treatment

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Date:

2018-05-02

Authors:

Ali IM Evehe MS Netongo PM Atogho-Tiedeu B Akindeh-Nji M Ngora H Domkam IK Diakite M Baldip K Ranford-Cartwright L Mimche PN Lamb T Mbacham WF

Journal:

Pathogens and global health

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Date:

2014-10-01

Authors:

Atem Bethel Ajong Frank T. Spradley Bruno Kenfack Innocent Mbulli Ali Martin Ndinakie Yakum Ukaogo Prince Onydinma Fulbert Nkwele Mangala Loai Aljerf Phelix Bruno Telefo

Journal:

PLOS ONE

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Date:

2022-05-18

Authors:

Adamu Ndongho Ndifontiayong Innocent Mbulli Ali Jean Baptiste Sokoudjou Jerimiah Mbogwe Ndimumeh Christopher Bonglavnyuy Tume

Journal:

Tropical Medicine and Infectious Disease

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Date:

2021-08-10

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Journal:

African Journal of Biotechnology

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Date:

2016-06-22

Authors:

Karimo Ousenu Leonard Fonkeng Sama Innocent Mbulli Ali Jude Leinyuy Fonbah Ongbayokolak Sylvie Nadine Solange Dabou Christopher Tume

Journal:

BMJ Open

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Date:

2021-09-01

Authors:

Wam EC Sama LF Ali IM Ebile WA Aghangu LA Tume CB

Journal:

BMC research notes

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Date:

2016-08-01

Authors:

Marcel N. Moyeh Innocent M. Ali Dieudonné L. Njimoh Akindeh M. Nji Palmer M. Netongo Marie S. Evehe Barbara Atogho-Tiedeu Stephen M. Ghogomu Wilfred F. Mbacham

Journal:

Journal of Parasitology Research

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Date:

2019-03-10

Authors:

Atem Bethel Ajong Bruno Kenfack Innocent Mbulli Ali Martin Ndinakie Yakum Phelix Bruno Telefo Frank T. Spradley

Journal:

PLOS ONE

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Date:

2019-11-07

Authors:

Journal:

Heliyon

Content:

Date:

2022-11-23

Authors:

Ali IM Bigoga JD Forsah DA Cho-Ngwa F Tchinda V Moor VA Fogako J Nyongalema P Nkoa T Same-Ekobo A Mbede J Fondjo E Mbacham WF Leke RG

Journal:

Malaria journal

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Date:

2016-01-01

Authors:

Nji AM Ali IM Moyeh MN Ngongang EO Ekollo AM Chedjou JP Ndikum VN Evehe MS Froeschl G Heumann C Mansmann U Ogundahunsi O Mbacham WF

Journal:

Malaria journal

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Date:

2015-01-01

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Journal:

Content:

Date:

Authors:

Takah NF Awungafac G Aminde LN Ali I Ndasi J Njukeng P

Journal:

BMC public health

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Date:

2016-07-01

Authors:

Journal:

Children

Content:

Malaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis is considered to be an important strategy in the control of the disease especially in children, who are the most vulnerable group. This study assessed the prevalence of asymptomatic malaria in children at the Nkolbisson health area in Yaoundé, Cameroon. A cross-sectional study design and a convenience sampling plan were used. A total of 127 participants were recruited after informed and signed consent from parents and/or guardians. Blood samples were collected by finger-pricking and venipuncture from children aged 6 months to 10 years and then screened for asymptomatic parasitemia by a rapid diagnostic test (RDT), light microscopy (LM) staining with Giemsa and 18S rRNA polymerase chain reaction (PCR) for speciation. The data were analyzed using SPSS version 20 software. The study identified 85 children who were positive from the PCR, 95 positive from the RDT and 71 from the LM, revealing a malaria prevalence of 66.9%, 74.8% and 55.9%, respectively. The prevalence was not observed to be dependent on the sex and age group of the participants. Plasmodium falciparum was the predominant species followed by Plasmodium malariae and then Plasmodium ovale. The RDT and LM had the same sensitivity (90.6%) with a slight difference in their specificity (RDT: 57.1%; LM: 54.8%). The RDT also demonstrated higher positive and negative predictive values compared with those of the LM.

Date:

2021-10-24

Authors:

Journal:

Journal of Infectious Diseases and Epidemiology

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Date:

2017-06-30

Authors:

Journal:

Diagnostics

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Background: There was an increase in the number of malaria cases in Cameroon in 2018 that could reflect changes in provider practice, despite effective interventions. In this study, we assessed the diagnostic performance of two malaria rapid diagnostic tests (mRDTs) for diagnostic confirmation of suspected cases of malaria in public and private health facilities in two malaria transmission settings in Cameroon. Methods: We evaluated the diagnostic performance of CareStart pf and SD Bioline Pf/PAN mRDT and compared these parameters by RDT type and transmission setting. Nested PCR and blood film microscopy were used as references. The chi square test was used for independent sample comparisons, while the McNemar’s test was used to test for the dependence of categorical data in paired sample testing. A p < 0.05 was considered significant in all comparisons. The R (v.4.0.2) software was used for analyses. Results: A total of 1126 participants consented for the study in the four sites. The diagnostic accuracy of the CareStart Pf mRDT was 0.93.6% (0.911–0.961) in Yaoundé, 0.930% (0.90–0.960) in Ngounso, 0.84% (0.794–0.891) in St Vincent Catholic Hospital Dschang and 0.407 (0.345–0.468) in Dschang district hospital. For SD Bioline Pf/PAN the accuracy was 0.759 (0.738–0.846) for St Vincent Catholic Hospital Dschang and 0.426 (0.372–0.496) for the Dschang district hospital. The accuracy was slightly lower in each case but not statistically different when PCR was considered as the reference. The likelihood ratios of the positive and negative tests were high in the high transmission settings of Yaoundé (10.99 (6.24–19.35)) and Ngounso (14.40 (7.89–26.28)) compared to the low transmission settings of Dschang (0.71 (0.37–1.37)) and St Vincent Catholic hospital (7.37 (4.32−12.59)). There was a high degree of agreement between the tests in Yaoundé (Cohen’s Kappa: 0.85 ± 0.05 (0.7–0.95)) and Ngounso (Cohen’s Kappa: 0.86 ± 0.05 (0.74, 0.97)) and moderate agreement in St Vincent hospital Dschang (k: 0.58 ± 0.06 (0.44–0.71)) and poor agreement in the District Hospital Dschang (Cohen’s Kappa: −0.11 ± 0.05 (−0.21–0.01)). The diagnostic indicators of the SD Bioline Pf/PAN were slightly better than for CareStart Pf mRDT in St Vincent Catholic hospital Dschang, irrespective of the reference test. Conclusions: Publicly procured malaria rapid diagnostic tests in Cameroon have maintained high accuracy (91–94%) in the clinical diagnosis of malaria in high malaria transmission regions of Cameroon, although they failed to reach WHO standards. We observed an exception in the low transmission region of Dschang, West region, where the accuracy tended to be lower and variable between facilities located in this town. These results underscore the importance of the routine monitoring of the quality and performance of malaria RDTs in diverse settings in malaria endemic areas.

Date:

2021-08-27

Authors:

Cliford Ebontane Ebong Innocent Mbulli Ali Hortence Jeanne Fouedjio Estelle Essangui Dorothy Fosah Achu Ayong Lawrence Dohbit Sama

Journal:

Malaria Journal

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Date:

2022-12-01

Authors:

Journal:

Journal of Life Sciences

Content:

Date:

2013-06-28

Authors:

Karimo Ousenu Innocent Mbulli Ali Leonard Fonkeng Sama Marcel Nsangou Ndam Thibau Florant Tchouangueu Christopher Bonglavnyuy Tume Maria De Francesco

Journal:

Canadian Journal of Infectious Diseases and Medical Microbiology

Content:

Date:

2021-08-07

Authors:

Atem Bethel Ajong Frank T. Spradley Bruno Kenfack Innocent Mbulli Ali Martin Ndinakie Yakum Loai Aljerf Phelix Bruno Telefo

Journal:

PLOS ONE

Content:

Date:

2020-11-05

Authors:

Journal:

Global Journal of Infectious Diseases and Clinical Research

Content:

Date:

2017-05-13

Dr
Innocent Ali

Related fellows

Mr Nneka Onyejepu

Professor Pauline Byakika-Kibwika

Dr Clifford Banda

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Current Organisation

Current Job Title

Biography

Publications

Dr Innocent Ali

Related fellows

Mr Nneka Onyejepu

Professor Pauline Byakika-Kibwika

Dr Clifford Banda

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Current Organisation

Current Job Title

Biography

Publications

Dr
Innocent Ali