The EDCTP Alumni Network

Mr
Francis Mungathia Kobia

Related fellows

Dr Adebanjo Adegbola

Senior Lecturer

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Mr Nneka Onyejepu

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Professor Pauline Byakika-Kibwika

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Profile EDCTP Fellowship 1

Project Title

Targeting fetal-maternal innate response conflict for better placental malaria outcomes (IRMiP)

EDCTP Project

TMA2019CDF-2736

EDCTP Program

EDCTP2

EDCTP Project Call

Career Development Fellowship (CDF)

Host Organisation

Department	Institution	Country
	Mount Kenya University Trust (MKU)	Kenya

Current Organisation

Mount Kenya University

Current Job Title

Research Fellow

Biography

Publications

Authors:

Kobia F Duchi S Deflorian G Vaccari T

Journal:

Molecular oncology

Content:

Date:

2014-03-01

Authors:

Tognon E Kobia F Busi I Fumagalli A De Masi F Vaccari T

Journal:

Autophagy

Content:

Date:

2016-01-01

Authors:

Francis Kobia Jesse Gitaka Francis Makokha Moses Kamita Joshua Kibera Cynthia Mwenda Gladys Mucee Bactrin Kilingo

Journal:

Content:

Date:

2019-12-03

Authors:

Francis Kobia Jesse Gitaka

Journal:

Content:

Date:

2020-04-17

Authors:

Journal:

[]

Content:

AbstractCooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for cooperative binding to sequence paired sites (SPS) located near many Notch-regulated genes. While most known Notch-dependent phenotypes were unaffected in Notch1/2 dimer-deficient mice, a subset of tissues proved highly sensitive to loss of cooperativity. These phenotypes include heart development, compromising viability in combination with low gene dose, and the gut, developing ulcerative colitis in response to 1% DSS. The most striking phenotypes – gender imbalance and splenic marginal zone B cell lymphoma – emerged in combination with dose reduction or when challenged by chronic fur mite infestation. This study highlights the role of the environment in malignancy and colitis, and is consistent with Notch-dependent anti-parasite immune responses being compromised in the dimer deficient animals.Highlights

Notch dimerization has an in vivo role in contributing to intestinal homeostasis

Loss of cooperativity can manifest as Notch gain or loss of function phenotypes

Mite infestation exacerbates all phenotypes, triggers MZB hyperproliferation in mutant animals

Mite-infested mutant mice develop SMZL with age

Date:

2020-03-06

Authors:

Francis M. Kobia Kaushik Maiti Moses M. Obimbo Roger Smith Jesse Gitaka

Journal:

Trends in Parasitology

Content:

Date:

2022-05-01

Authors:

Journal:

PLOS Biology

Content:

Date:

2020-10-05

Mr Francis Mungathia Kobia

Related fellows

Dr Adebanjo Adegbola

Mr Nneka Onyejepu

Professor Pauline Byakika-Kibwika

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Current Organisation

Current Job Title

Biography

Publications

Mr
Francis Mungathia Kobia