The EDCTP Alumni Network

Dr
Barbara Castelnuovo

Related fellows

Dr Mercy Karoney

Assistant Lecturer

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Dr Olaposi Olatoregun

Deputy Project Director

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Dr Aida Sivro

Scientist

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Profile EDCTP Fellowship 1

Project Title

EDCTP-GSK fellowship: Diagnosis and treatment of non-communicable diseases and geriatric syndromes in the HIV aging population in sub-Saharan Africa (Geriatric HIV cohort Africa)

EDCTP Project

TMA2017GSF-1936

EDCTP Program

EDCTP2

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

Specific Aim 1. To establish a cohort of aging patients ≥60 years (Geriatric cohort) in order to capture NCD endpoints and their risk factors: hypertension, cardio vascular disease (annual ECG screening), respiratory disease (peak flow meter screening and spirometry), renal disease (proteinuria and creatinine clearance), cancers (complete skin evaluation, pap smear, faecal occult blood, breast exam) will all be added to other standard of care procedures in place. Specific Aim 2. In the Geriatric cohort we propose to measure physical function using the Short Performance Physical Battery, muscle strength, (Gait speed and assessment of grip strength with handheld dynamometry), frailty phenotype, and history of falls. The tools that were developed and submitted in Year one (paper based), were developed as e-forms using RedCap and are currently used to assess the participants. Specific Aim 3. To form a group of established clinicians and researchers in the area of HIV and various NDCs with interest in HIV and NCDs and HIV and geriatric medicine. This group will be initially advised by international mentors. Aim 3 will also support 2 master and 1 PhD students in the areas of HIV, NCDs and aging.

Study Design

Observational prospective cohort

Project Summary

The study proposal aims to build capacity for the detection and care of non-communicable diseases and geriatric syndromes the geriatric HIV positive population in sub-Saharan Africa. HIV infected individuals are at higher risk of “non AIDS” complications such as multiple non-communicable diseases; non-communicable diseases also often increase with age. Additionally, HIV infection itself seems to be associated to an accelerated aging process, due to multiple factors such as chronic inflammation and long term drug exposure. Within this proposal a cohort of HIV positive aging patients ≥60 years (Geriatric cohort) will be established in order to capture non communicable diseases, and their risk factors. Participants of the geriatric cohort will be screened for hypertension, cardio vascular disease (annual ECG screening), respiratory disease (peak flow meter screening and spirometry), renal disease (proteinuria and creatinine clearance), and cancers (complete skin evaluation, pap smear, faecal occult blood, breast exam) (Aim 1). Additionally, the participants of the cohort will be evaluated for geriatric syndromes through the measurement of physical function using the Short Performance Physical Battery, muscle strength, (Gait speed and assessment of grip strength with handheld dynamometry), frailty phenotype, and history of falls (Aim 3). The third aim of this proposal is to establish a wider capacity for the detection and care of non-communicable diseases and geriatric syndromes. We intend to form a group of established clinicians and researchers in the area of HIV and various NDCs with interest in HIV and NCDs and HIV and geriatric medicine. This group will meet monthly to provide peer to peer mentorship in the format of case presentations, journal clubs, research results presentations. This group will also be linked to a network of international experts in the field through quarterly teleconferences, and will foster and support the translation and exchange of new knowledge on HIV and aging to multiple stakeholders including community, academia and policy makers. Aim 3 will also support 2 master and 1 PhD students in the areas of HIV, NCDs and aging. To ensure sustainability of the work proposed in this application, this group will also start working on 2 grants proposals to be submitted in year 3 and 4, when the fellow and the group are expected to have acquired more skills in research on HIV and non-communicable diseases. The description of geriatric syndromes will constitute the foundation to generate ideas and research questions for future grants in Geriatric medicine.

Host Organisation

Department	Institution	Country
Reserach	Infectious Diseases Institute	Uganda

Sites

Infectious Diseases Institute

Current Organisation

Infectious Diseases Institute

Current Job Title

Head of Department

Biography

Publications

Authors:

Journal:

AIDS care

Content:

We conducted a cross-sectional study to describe routine physical function assessment for HIV-infected adults aged ≥60 years attending a large urban HIV clinic in Kampala, Uganda. Assessed demographic and clinical factors associated with low physical function in the population, generalized linear regression model was used to estimate factors associated with low physical function. Of the 93 elderly patients that underwent the Short Physical Performance Battery (SPPB) assessment, 43/93 (44.1%) scored 1-8 points at the SPPB evaluation and were categorized as low function, 45/93 (48.4%) scored 9-11 points and were categorized as moderate function and 7/93 (7.5%) scored 12 points and were categorized as high (normal) function. Women (adjusted risk ratio (ARR) 2.57; 95% confidence interval (CI): 1.54-4.29, p = 0.000) had increased risk of low physical function compared to men. A one-year increase in age (ARR = 1.09; CI: 1.03-1.15, p = 0.004) and being overweight (BMI > 25.0, ARR = 1.96; CI: 1.89-3.24, p = 0.008) also carried an increased risk of low physical function status. A higher number 13/41(32%) of falls was recorded in female than among male 3/53(5.8%) patients (p = 0.001). The SPPB assessment is a starting point for clinicians to comprehensively evaluate and consider the management of physical function limitation among older HIV-positive patients.

Date:

2019-12-17

Authors:

Buzibye A Musaazi J von Braun A Nanzigu S Sekaggya-Wiltshire C Kambugu A Fehr J Lamorde M Gutteck U Muller D Sowinski S Reynolds SJ Castelnuovo B

Journal:

AIDS research and therapy

Content:

Date:

2019-12-01

Authors:

Masereka EM Ngabirano TD Osingada CP Wiltshire CS Castelnuovo B Kiragga AN

Journal:

BMC public health

Content:

Date:

2019-07-01

Authors:

Twimukye A

Journal:

BMC Infect Dis

Content:

Date:

2022-11-01

Authors:

Mbabazi L

Journal:

BMC Womens Health.

Content:

Date:

2022-06-27

Authors:

Yotebieng M Brazier E Addison D Kimmel AD Cornell M Keiser O Parcesepe AM Onovo A Lancaster KE Castelnuovo B Murnane PM Cohen CR IeDEA Treat All in sub-Saharan Africa Consensus Statement Working Group

Journal:

Journal of the International AIDS Society

Content:

Date:

2019-01-01

Authors:

Kiwanuka G Kiwanuka N Muneza F Nabirye J Oporia F Odikro MA Castelnuovo B Wanyenze RK

Journal:

BMC infectious diseases

Content:

Date:

2018-10-01

Authors:

Calcagno A Cusato J Sekaggya-Wiltshire C von Braun A Motta I Turyasingura G Castelnuovo B Fehr J Di Perri G Lamorde M

Journal:

Clinical pharmacology and therapeutics

Content:

Date:

2019-03-01

Authors:

Sekaggya-Wiltshire C von Braun A Lamorde M Ledergerber B Buzibye A Henning L Musaazi J Gutteck U Denti P de Kock M Jetter A Fehr JS

Journal:

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Content:

Date:

2018-08-01

Authors:

Kiragga AN Mubiru F Kambugu AD Kamya MR Castelnuovo B

Journal:

BMC infectious diseases

Content:

Date:

2019-01-01

Authors:

Muhindo R Castelnuovo B Mujugira A Parkes-Ratanshi R Sewankambo NK Kiguli J Tumwesigye NM Nakku-Joloba E

Journal:

AIDS research and therapy

Content:

Date:

2019-09-01

Authors:

Sarfo FS Castelnuovo B Fanti I Feldt T Incardona F Kaiser R Lwanga I Marrone G Sonnerborg A Tufa TB Zazzi M De Luca A

Journal:

The Journal of infection

Content:

Date:

2019-03-01

Authors:

Lofgren SM

Journal:

Lancet HIV.

Content:

Date:

2022-07-22

Authors:

Okoboi S Castelnuovo B Moore DM Musaazi J Kambugu A Birungi J Nanfuka M Van Rie A

Journal:

BMC public health

Content:

Date:

2019-01-01

Authors:

Baumann A Musaazi J Kambugu A Kälin M Weissberg D Ssemwanga D Fehr J Castelnuovo B Sekaggya-Wiltshire C von Braun A

Journal:

Journal of acquired immune deficiency syndromes (1999)

Content:

Date:

2019-04-01

Authors:

von Braun A Castelnuovo B Ledergerber B Cusato J Buzibye A Kambugu A Fehr J Calcagno A Lamorde M Sekaggya-Wiltshire C

Journal:

The Journal of antimicrobial chemotherapy

Content:

Date:

2019-01-01

Authors:

Bisaso KR Karungi SA Kiragga A Mukonzo JK Castelnuovo B

Journal:

BMC medical informatics and decision making

Content:

Date:

2018-09-01

Authors:

Castelnuovo B Mubiru F Kalule I Kiragga A

Journal:

AIDS research and therapy

Content:

Date:

2019-10-01

Authors:

Twimukye A

Journal:

BMC Infect Dis

Content:

Date:

2022-11-01

Authors:

Bachmann N von Braun A Labhardt ND Kadelka C Günthard HF Sekaggya-Wiltshire C Castelnuovo B Kambugu A Lejone TI Böni J Yerly S Perreau M Swiss HIV Cohort Study

Journal:

The Journal of antimicrobial chemotherapy

Content:

Date:

2019-02-01

Authors:

Brazier E Maruri F Duda SN Tymejczyk O Wester CW Somi G Ross J Freeman A Cornell M Poda A Musick BS Zhang F Althoff KN Mugglin C IeDEA Consortium

Journal:

Journal of the International AIDS Society

Content:

Date:

2019-07-01

Authors:

Okoboi S Castelnuovo B Moore DM Musaazi J Kambugu A Birungi J Kaleebu P Nanfuka M Kamya MR Van Rie A

Journal:

AIDS research and therapy

Content:

Date:

2018-10-01

Authors:

von Braun A Sekaggya-Wiltshire C Bachmann N Ssemwanga D Scherrer AU Nanyonjo M Kapaata A Kaleebu P Günthard HF Castelnuovo B Fehr J Kambugu A

Journal:

Journal of acquired immune deficiency syndromes (1999)

Content:

Date:

2018-08-01

Authors:

Martin NA Kalbarczyk A Nagourney E Reich A Hansoti B Kambugu A Quinn TC Manabe YC Castelnuovo B

Journal:

Annals of global health

Content:

Date:

2019-11-01

Authors:

Laker EAO Nabaggala MS Kaimal A Nalwanga D Castelnuovo B Musubire A Kiragga A Lamorde M Ratanshi RP

Journal:

BMC infectious diseases

Content:

Date:

2019-03-01

Authors:

Okoboi S Twimukye A Lazarus O Castelnuovo B Agaba C Immaculate M Nanfuka M Kambugu A King R

Journal:

Journal of the International AIDS Society

Content:

Date:

2019-03-01

Authors:

Nabukenya S

Journal:

JAMIA Open. 2022 Jul 14;5(3):ooac059. doi: 10.1093/jamiaopen/ooac059. eCollection 2022 Oct.

Content:

Date:

2022-07-09

Authors:

Weissberg D Mubiru F Kambugu A Fehr J Kiragga A von Braun A Baumann A Kaelin M Sekaggya-Wiltshire C Kamya M Castelnuovo B

Journal:

PloS one

Content:

Date:

2018-11-01

Authors:

Sekaggya-Wiltshire C Chirehwa M Musaazi J von Braun A Buzibye A Muller D Gutteck U Motta I Calcagno A Fehr JS Kambugu A Castelnuovo B Denti P

Journal:

Antimicrobial agents and chemotherapy

Content:

Date:

2019-05-01

Authors:

Izudi J

Journal:

Medicine (Baltimore)

Content:

Date:

2022-09-01

Authors:

Musaazi J Sekaggya-Wiltshire C Kiragga AN Kalule I Reynolds SJ Manabe YC Castelnuovo B

Journal:

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Content:

Date:

2019-04-01

Dr Barbara Castelnuovo

Related fellows

Dr Mercy Karoney

Dr Olaposi Olatoregun

Dr Aida Sivro

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Project Objectives

Study Design

Project Summary

Host Organisation

Sites

Current Organisation

Current Job Title

Biography

Publications

Dr
Barbara Castelnuovo