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Dr
Francis Ndungu

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Current Organisation

KEMRI - Wellcome Trust Research Prgramme

Current Job Title

Group Leader

Biography

Publications

Authors:
Muema, D.K.M. Ndungu, F.M. Kinyanjui, S.M. Berkley, J.A.

Journal:
Malaria Journal

Content:

Date:
2011-01-01

Authors:
Bull, P.C. Pain, A. Ndungu, F.M.

Journal:
Journal of Infectious Diseases

Content:

Date:
2005-01-01

Authors:
Urban, B.C. Ndungu, F.M.

Journal:
Handbook of Dendritic Cells

Content:

Date:
2008-01-01

Authors:
Huttner A Agnandji ST Combescure C Fernandes JF Bache EB Kabwende L Ndungu FM Brosnahan J Monath TP Lemaître B Grillet S Botto M VSV-EBOPLUS Consortia

Journal:
The Lancet. Infectious diseases

Content:

Date:
2018-04-01

Authors:
Langhorne, J. Ndungu, F.M. Sponaas, A.-M. Marsh, K.

Journal:
Nature Immunology

Content:

Date:
2008-01-01

Authors:
John Joseph Valletta John W.G. Addy Adam J. Reid Francis M. Ndungu Yaw Bediako Jedida Mwacharo Khadija Said Mohammed Jennifer Musyoki Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Matt Berriman Philip Bejon Kevin Marsh Jean Langhorne Chris I. Newbold Mario Recker Addy John W.G. Addy John W.G. Addy John W.G. Addy John W.G. Bediako Yaw Bejon Philip Bejon Philip Berriman Matt Berriman Matt Langhorne Jean Langhorne Jean Marsh Kevin Marsh Kevin Mohammed Khadija Said Musyoki Jennifer Mwacharo Jedida Ndungu Francis M. Ndungu Francis M. Newbold Chris I. Newbold Chris I. Ngoi Joyce Mwongeli Otieno Edward Recker Mario Recker Mario Recker Mario Recker Mario Recker Mario Reid Adam J. Reid Adam J. Valletta John Joseph Valletta John Joseph Valletta John Joseph Valletta John Joseph Valletta John Joseph Wambua Joshua

Journal:

Content:

Date:
2022-02-25

Authors:
Ndungu, F.M. Mwacharo, J. Kimani, D. Kai, O. Moris, P. Jongert, E. Vekemans, J. Olotu, A. Bejon, P.

Journal:
PLoS ONE

Content:

Date:
2012-01-01

Authors:
Ndungu, F.M. Sanni, L. Urban, B. Stephens, R. Newbold, C.I. Marsh, K. Langhorne, J.

Journal:
Journal of Immunology

Content:

Date:
2006-01-01

Authors:
John Muthii Muriuki Alexander J. Mentzer Ruth Mitchell Emily L. Webb Anthony O. Etyang Catherine Kyobutungi Alireza Morovat Wandia Kimita Francis M. Ndungu Alex W. Macharia Caroline J. Ngetsa Johnstone Makale Swaib A. Lule Solomon K. Musani Laura M. Raffield Clare L. Cutland Sodiomon B. Sirima Amidou Diarra Alfred B. Tiono Michal Fried Moses Gwamaka Seth Adu-Afarwuah James P. Wirth Rita Wegmüller Shabir A. Madhi Robert W. Snow Adrian V. S. Hill Kirk A. Rockett Manjinder S. Sandhu Dominic P. Kwiatkowski Andrew M. Prentice Kendra A. Byrd Alex Ndjebayi Christine P. Stewart Reina Engle-Stone Tim J. Green Crystal D. Karakochuk Parminder S. Suchdev Philip Bejon Patrick E. Duffy George Davey Smith Alison M. Elliott Thomas N. Williams Sarah H. Atkinson

Journal:
Nature Medicine

Content:

Date:
2021-04-22

Authors:
Lamb, T.J. Ndung'u, F.M.

Journal:
Immunity to Parasitic Infection

Content:

Date:
2012-01-01

Authors:
Ndungu, F.M. Lundblom, K. Rono, J. Illingworth, J. Eriksson, S. Färnert, A.

Journal:
European Journal of Immunology

Content:

Date:
2013-01-01

Authors:
John W.G. Addy Yaw Bediako Francis M. Ndungu John Joseph Valetta Adam J. Reid Jedida Mwacharo Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Jennifer Musyoki Khadija Said Matthew Berriman Kevin Marsh Philip Bejon Mario Recker Jean Langhorne Addy John W.G. Addy John W.G. Addy John W.G. Addy John W.G. Addy John W.G. Addy John W.G. Addy John W.G. Addy John W.G. Bediako Yaw Bediako Yaw Bediako Yaw Bejon Philip Bejon Philip Bejon Philip Berriman Matthew Berriman Matthew Langhorne Jean Langhorne Jean Langhorne Jean Langhorne Jean Marsh Kevin Marsh Kevin Marsh Kevin Musyoki Jennifer Musyoki Jennifer Mwacharo Jedida Mwacharo Jedida Ndungu Francis M. Ndungu Francis M. Ndungu Francis M. Ndungu Francis M. Ndungu Francis M. Ndungu Francis M. Ndungu Francis M. Ndungu Francis M. Ngoi Joyce Mwongeli Ngoi Joyce Mwongeli Otieno Edward Otieno Edward Recker Mario Recker Mario Recker Mario Reid Adam J. Said Khadija Said Khadija Valetta John Joseph Wambua Joshua Wambua Joshua

Journal:

Content:

Date:
2022-02-04

Authors:
Bryan D Silva N Rigsby P Dougall T Corran P Bowyer PW Ho MM Collaborative study group

Journal:
Malaria journal

Content:

Date:
2017-08-01

Authors:
Weiss, G.E. Ndungu, F.M. McKittrick, N. Li, S. Kimani, D. Crompton, P.D. Marsh, K. Pierce, S.K.

Journal:
Journal of Immunological Methods

Content:

Date:
2012-01-01

Authors:
Osii RS Otto TD Garside P Ndungu FM Brewer JM

Journal:
Frontiers in immunology

Content:

Date:
2020-07-01

Authors:
Bull, P.C. Pain, A. Ndungu, F.M. Kinyanjui, S.M. Roberts, D.J. Newbold, C.J. Marsh, K.

Journal:
Journal of Infectious Diseases

Content:

Date:
2005-01-01

Authors:
John W.G. Addy Yaw Bediako Francis M. Ndungu John Joseph Valetta Adam J. Reid Jedida Mwacharo Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Jennifer Musyoki Khadija Said Matthew Berriman Kevin Marsh Philip Bejon Mario Recker Jean Langhorne

Journal:
Wellcome Open Research

Content:

Date:
2021-04-09

Authors:
Illingworth, J. Butler, N.S. Roetynck, S. Mwacharo, J. Pierce, S.K. Bejon, P. Crompton, P.D. Marsh, K. Ndungu, F.M.

Journal:
Journal of Immunology

Content:

Date:
2013-01-01

Authors:
Tan, J. Pieper, K. Piccoli, L. Abdi, A. Foglierini, M. Geiger, R. Maria Tully, C. Jarrossay, D. Maina Ndungu, F. Wambua, J. Bejon, P. Silacci Fregni, C. Fernandez-Rodriguez, B. Barbieri, S. Bianchi, S. Marsh, K. Thathy, V. Corti, D. Sallusto, F. Bull, P. Lanzavecchia, A.

Journal:
Nature

Content:

Date:
2016-01-01

Authors:
Ndungu, F.M. Olotu, A. Mwacharo, J. Nyonda, M. Apfeld, J. Mramba, L.K. Fegan, G.W. Bejon, P. Marsh, K.

Journal:
Proceedings of the National Academy of Sciences of the United States of America

Content:

Date:
2012-01-01

Authors:

Journal:
Science advances

Content:
Iron acquisition is critical for life. Ferroportin (FPN) exports iron from mature erythrocytes, and deletion of the Fpn gene results in hemolytic anemia and increased fatality in malaria-infected mice. The FPN Q248H mutation (glutamine to histidine at position 248) renders FPN partially resistant to hepcidin-induced degradation and was associated with protection from malaria in human studies of limited size. Using data from cohorts including over 18,000 African children, we show that the Q248H mutation is associated with modest protection against anemia, hemolysis, and iron deficiency, but we found little evidence of protection against severe malaria or bacteremia. We additionally observed no excess Plasmodium growth in Q248H erythrocytes ex vivo, nor evidence of selection driven by malaria exposure, suggesting that the Q248H mutation does not protect from malaria and is unlikely to deprive malaria parasites of iron essential for their growth.

Date:
2019-09-04

Authors:
Beeson, J.G. Ndungu, F. Persson, K.E.M. Chesson, J.M. Kelly, G.L. Uyoga, S. Hallamore, S.L. Williams, T.N. Reeder, J.C. Brown, G.V. Marsh, K.

Journal:
American Journal of Tropical Medicine and Hygiene

Content:

Date:
2007-01-01

Authors:
Ndungu, F.M. Urban, B.C. Marsh, K. Langhorne, J.

Journal:
Parasite Immunology

Content:

Date:
2005-01-01

Authors:
Cadman, E.T. Abdallah, A.Y. Voisine, C. Sponaas, A.-M. Corran, P. Lamb, T. Brown, D. Ndungu, F. Langhorne, J.

Journal:
Infection and Immunity

Content:

Date:
2008-01-01

Authors:
Bull, P.C. Kortok, M. Kai, O. Ndungu, F. Ross, A. Lowe, B.S. Newbold, C.I. Marsh, K.

Journal:
Journal of Infectious Diseases

Content:

Date:
2000-01-01

Authors:
Bediako, Y. Ngoi, J.M. Nyangweso, G. Wambua, J. Opiyo, M. Nduati, E.W. Bejon, P. Marsh, K. Ndungu, F.M.

Journal:
BMC Medicine

Content:

Date:
2016-01-01

Authors:
Ibison, F. Olotu, A. Muema, D.M. Mwacharo, J. Ohuma, E. Kimani, D. Marsh, K. Bejon, P. Ndungu, F.M.

Journal:
PLoS ONE

Content:

Date:
2012-01-01

Authors:
Nduati, E.W. Ng, D.H.L. Ndungu, F.M. Gardner, P. Urban, B.C. Langhorne, J.

Journal:
PLoS ONE

Content:

Date:
2010-01-01

Authors:
Sutton HJ Aye R Idris AH Vistein R Nduati E Kai O Mwacharo J Li X Gao X Andrews TD Koutsakos M Nguyen THO Nekrasov M Milburn P Cockburn IA

Journal:
Cell reports

Content:

Date:
2021-02-01

Authors:
Muriuki JM Mentzer AJ Kimita W Ndungu FM Macharia AW Webb EL Lule SA Morovat A Hill AVS Bejon P Elliott AM Williams TN Atkinson SH

Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Content:

Date:
2018-09-01

Authors:
Mandal RK Crane RJ Berkley JA Gumbi W Wambua J Ngoi JM Ndungu FM Schmidt NW

Journal:
The Journal of infectious diseases

Content:

Date:
2018-12-01

Authors:
Pejoski D de Rham C Martinez-Murillo P Santoro F Auderset F Medaglini D Pozzi G Vono M Lambert PH Huttner A Haks MC Ottenhoff THM VSV-EBOPLUS Consortium

Journal:
NPJ vaccines

Content:

Date:
2020-10-01

Authors:
John Joseph Valletta John W.G. Addy Adam J. Reid Francis M. Ndungu Yaw Bediako Jedida Mwacharo Khadija Said Jennifer Musyoki Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Matt Berriman Philip Bejon Kevin Marsh Jean Langhorne Chris I. Newbold Mario Recker

Journal:
Wellcome Open Research

Content:

Date:
2021-02-02

Authors:
Griffiths, M.J. Ndungu, F. Baird, K.L. Muller, D.P.R. Marsh, K. Newton, C.R.J.C.

Journal:
British Journal of Haematology

Content:

Date:
2001-01-01

Authors:
Olotu, A. Clement, F. Jongert, E. Vekemans, J. Njuguna, P. Ndungu, F.M. Marsh, K. Leroux-Roels, G. Bejon, P.

Journal:
PLoS ONE

Content:

Date:
2014-01-01

Authors:
Shaban J. Mwangi Agnes Gwela Kioko Mwikali Joel L. Bargul Eunice W. Nduati Francis M. Ndungu Philip Bejon Julian C. Rayner Abdirahman I. Abdi

Journal:

Content:

Date:
2021-04-13

Authors:
Francis M. Ndungu Jedida Mwacharo Juliana Wambua Patricia Njuguna Kevin Marsh Chris Drakeley Philip Bejon

Journal:

Content:

Date:
2019-03-05

Authors:
Allsopp, C.E.M. Sanni, L.A. Reubsaet, L. Ndungu, F. Newbold, C. Mwangi, T. Marsh, K. Langhorne, J.

Journal:
Journal of Infectious Diseases

Content:

Date:
2002-01-01

Authors:

Journal:
npj Vaccines

Content:

Date:
2020-12-01

Authors:

Journal:
The Journal of Infectious Diseases

Content:

Date:
2019-02-23

Authors:
Dorfman, J.R. Bejon, P. Ndungu, F.M. Langhorne, J. Kortok, M.M. Lowe, B.S. Mwangi, T.W. Williams, T.N. Marsh, K.

Journal:
Journal of Infectious Diseases

Content:

Date:
2005-01-01

Authors:
Emma Nelima Khaemba Caroline Ogwang Sam Kinyanjui John Mutiso Muindi Joseph Kipsigei Koske Domtila Kimani Joyce Ngoi Jedidah Mwacharo Jimmy Shangala Patricia Njuguna Dennis Mutinda Emily Nyatichi Judy Peshu Brian Mutinda Francis Ndungu Anna Farnert Mahfudh M. Bashraheil Philip Bejon Melissa C. Kapulu

Journal:

Content:

Date:
2020-02-20

Authors:
Shaban J. Mwangi Agnes Gwela Kioko Mwikali Joel L. Bargul Eunice W. Nduati Francis M. Ndungu Philip Bejon Julian C. Rayner Abdirahman I. Abdi

Journal:
Wellcome Open Research

Content:

Date:
2020-08-21

Authors:
Beeson JG Ndungu F Persson KE Chesson JM Kelly GL Uyoga S Hallamore SL Williams TN Reeder JC Brown GV Marsh K

Journal:
The American journal of tropical medicine and hygiene

Content:

Date:
2007-07-01

Authors:
John Joseph Valletta John W.G. Addy Adam J. Reid Francis M. Ndungu Yaw Bediako Jedida Mwacharo Khadija Said Jennifer Musyoki Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Matt Berriman Philip Bejon Kevin Marsh Jean Langhorne Chris I. Newbold Mario Recker

Journal:
Wellcome Open Research

Content:

Date:
2021-09-13

Authors:
Ndungu, F.M. Cadman, E.T. Coulcher, J. Nduati, E. Couper, E. MacDonald, D.W. Ng, D. Langhorne, J.

Journal:
PLoS Pathogens

Content:

Date:
2009-01-01

Authors:
Ndungu, F.M. Marsh, K. Fegan, G. Wambua, J. Nyangweso, G. Ogada, E. Mwangi, T. Nyundo, C. Macharia, A. Uyoga, S. Williams, T.N. Bejon, P.

Journal:
BMC Medicine

Content:

Date:
2015-01-01

Authors:
Poetsch JH Dahlke C Zinser ME Kasonta R Lunemann S Rechtien A Ly ML Stubbe HC Krähling V Biedenkopf N Eickmann M Fehling SK Olearo F Addo MM

Journal:
The Journal of infectious diseases

Content:

Date:
2019-01-01

Authors:
Bundi CK Nalwoga A Lubyayi L Muriuki JM Mogire RM Opi H Mentzer AJ Mugyenyi CK Mwacharo J Webb EL Bejon P Williams TN Gikunju JK Atkinson SH

Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Content:

Date:
2020-06-01

Authors:
Stephens, R. Ndungu, F.M. Langhorne, J.

Journal:
Parasite Immunology

Content:

Date:
2009-01-01

Authors:

Journal:
BMC Medicine

Content:

Date:
2020-12-01

Authors:

Journal:
Immunological reviews

Content:
B-cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are critical for control of parasitemia and associated immunopathology. Antibodies also provide protection to reinfection. Long-lasting B-cell memory has been shown to occur in response to Plasmodium spp. in experimental model infections, and in human malaria. However, there are reports that antibody responses to several malaria antigens in young children living with malaria are not similarly long-lived, suggesting a dysfunction in the maintenance of circulating antibodies. Some studies attribute this to the expansion of atypical memory B cells (AMB), which express multiple inhibitory receptors and activation markers, and are hyporesponsive to B-cell receptor (BCR) restimulation in vitro. AMB are also expanded in other chronic infections such as tuberculosis, hepatitis B and C, and HIV, as well as in autoimmunity and old age, highlighting the importance of understanding their role in immunity. Whether AMB are dysfunctional remains controversial, as there are also studies in other infections showing that AMB can produce isotype-switched antibodies and in mouse can contribute to protection against infection. In light of these controversies, we review the most recent literature on either side of the debate and challenge some of the currently held views regarding B-cell responses to Plasmodium infections.

Date:
2019-11-16

Authors:
Pieper, K. Tan, J. Piccoli, L. Foglierini, M. Barbieri, S. Chen, Y. Silacci-Fregni, C. Wolf, T. Jarrossay, D. Anderle, M. Abdi, A. Ndungu, F.M. Doumbo, O.K. Traore, B. Tran, T.M. Jongo, S. Zenklusen, I. Crompton, P.D. Daubenberger, C. Bull, P.C. Sallusto, F. Lanzavecchia, A.

Journal:
Nature

Content:

Date:
2017-01-01

Authors:
John W.G. Addy Yaw Bediako Francis M. Ndungu John Joseph Valetta Adam J. Reid Jedida Mwacharo Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Jennifer Musyoki Khadija Said Matthew Berriman Kevin Marsh Philip Bejon Mario Recker Jean Langhorne

Journal:
Wellcome Open Research

Content:

Date:
2022-02-04

Authors:
Sutton HJ Aye R Idris AH Vistein R Nduati E Kai O Mwacharo J Li X Gao X Andrews TD Koutsakos M Nguyen THO Nekrasov M Milburn P Cockburn IA

Journal:

Content:

Date:
2020-05-01

Authors:
John W.G. Addy Yaw Bediako Francis M. Ndungu John Joseph Valetta Adam J. Reid Jedida Mwacharo Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Jennifer Musyoki Khadija Said Matthew Berriman Kevin Marsh Philip Bejon Mario Recker Jean Langhorne

Journal:
Wellcome Open Research

Content:

Date:
2021-12-03

Authors:
Bediako Y Adams R Reid AJ Valletta JJ Ndungu FM Sodenkamp J Mwacharo J Ngoi JM Kimani D Kai O Wambua J Nyangweso G de Villiers EP Langhorne J

Journal:
BMC medicine

Content:

Date:
2019-03-01

Authors:
Bull, P.C. Lowe, B.S. Kaleli, N. Njuga, F. Kortok, M. Ross, A. Ndungu, F. Snow, R.W. Marsh, K.

Journal:
Journal of Infectious Diseases

Content:

Date:
2002-01-01

Authors:
John Joseph Valletta John W.G. Addy Adam J. Reid Francis M. Ndungu Yaw Bediako Jedida Mwacharo Khadija Said Jennifer Musyoki Joyce Mwongeli Ngoi Joshua Wambua Edward Otieno Matt Berriman Philip Bejon Kevin Marsh Jean Langhorne Chris I. Newbold Mario Recker

Journal:
Wellcome Open Research

Content:

Date:
2022-02-25

Authors:
Illingworth J Butler NS Roetynck S Mwacharo J Pierce SK Bejon P Crompton PD Marsh K Ndungu FM

Journal:
Journal of immunology (Baltimore, Md. : 1950)

Content:

Date:
2012-12-01

Authors:
Medaglini, D. Harandi, A.M. Ottenhof, T.H.M. Siegrist, C.-A. Agnandji, S.T. Ahmed, R. Anderson, J. Auderset, F. Borgianni, L. Brosnahan, J. Ciabattini, A. Engler, O. Haks, M.C. Heppner, G. Gerlini, A. Kremsner, P.G. Leib, S. Monath, T. Ndungu, F. Njuguna, P. Page, M. Pozzi, G. Rappuoli, R. Santoro, F. Strasser, M.

Journal:
Science Translational Medicine

Content:

Date:
2015-01-01

Authors:
Ndungu, F.M. Bull, P.C. Ross, A. Lowe, B.S. Kabiru, E. Marsh, K.

Journal:
Parasite Immunology

Content:

Date:
2002-01-01

Authors:

Journal:
European Journal of Immunology

Content:

Date:
2020-05-04