Project Title

Management of Lower Respiratory Tract Infections in Sub-Saharan Africa, a Pragmatic Approach (LoRTISA study)

EDCTP Project Call

Senior Fellowship (SF)

Host Organisation

Project Title

Short- and long-term clinical and immunological outcomes of patients with HIV/TB coinfections on ART

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

To study short-term effects of TB and ART treatment (the incidence, predictors and clinical characteristics of TB-IRIS, side effects of the therapy, causes of early mortality) and long term effects of ART after completing TB treatment (clinical events such as infections, late-onset IRIS, adverse effects of therapy or immunological and virological events such as changes in CD4 counts, CD4 %; viral load, viral resistance). Also to study possible factors influencing these outcomes such as adherence and factors affecting them, TB relapse and mycobacteriological factors, immunological defects and social factors that are associated with a recurrent TB episode and causes of mortality

Study Design

A cohort study to compare the effectiveness of early versus delayed antiretroviral therapy on prevention of mortality HIV-TB co-infected patients in a programmatic setting

Host Organisation

Sites

Results & Outcomes

Current Organisation

Mulago Hospital, Kampala, Uganda

Current Job Title

Senior Consultant (Internal Medicine) & Head, Division of Respiratory Medicine

Biography