The EDCTP Alumni Network

Dr
Willliam Worodria

Related fellows

Dr Martha Zewdie Gebeyehu

Postdoctoral Scientist

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Dr Sylvie Kwedi

Epidemiologist

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Dr Bugwesa Zablon Katale

Director of Research

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Profile EDCTP Fellowship 1 EDCTP Fellowship 2

Project Title

Management of Lower Respiratory Tract Infections in Sub-Saharan Africa, a Pragmatic Approach (LoRTISA study)

Host Organisation

Department	Institution	Country
	Infectious Diseases Institute Limited (IDI)	Uganda

EDCTP Project

TMA2018SF-2465

EDCTP Program

EDCTP2

EDCTP Project Call

Senior Fellowship (SF)

Project Title

Short- and long-term clinical and immunological outcomes of patients with HIV/TB coinfections on ART

Project Objectives

To study short-term effects of TB and ART treatment (the incidence, predictors and clinical characteristics of TB-IRIS, side effects of the therapy, causes of early mortality) and long term effects of ART after completing TB treatment (clinical events such as infections, late-onset IRIS, adverse effects of therapy or immunological and virological events such as changes in CD4 counts, CD4 %; viral load, viral resistance). Also to study possible factors influencing these outcomes such as adherence and factors affecting them, TB relapse and mycobacteriological factors, immunological defects and social factors that are associated with a recurrent TB episode and causes of mortality

Results & Outcomes

Targeted recruitment: 189 out of 280 patients were enrolled for the study. Capacity Building: 1) Dr Jabo Christian who enrolled for a Masters of Medicine in Radiology at Makerere University successfully defended his thesis in May 2014. 2) Ms Justine Nakiwala, the PhD student at the Institute of Tropical Medicine, Antwerp who was studying the role of neutrophils in the pathogenesis of TB-IRIS completed the initial stage of her data collection at this site and continued with her PhD work in South Africa.

Host Organisation

Department	Institution	Country
Infectious Disease Institute	Makerere University	Uganda

EDCTP Project

TA.2010.40200.0019

EDCTP Program

EDCTP1

EDCTP Project Call

Senior Fellowship (SF)

Study Design

A cohort study to compare the effectiveness of early versus delayed antiretroviral therapy on prevention of mortality HIV-TB co-infected patients in a programmatic setting

Sites

The HIV-TB Clinic of the Infectious Disease Institute, Kampala, Uganda

Current Organisation

Mulago Hospital, Kampala, Uganda

Current Job Title

Senior Consultant (Internal Medicine) & Head, Division of Respiratory Medicine

Biography

Publications

Authors:

Worodria W, Massinga-Loembe M, Mazakpwe D, Luzinda K, Menten J, Van Leth F, Mayanja-Kizza H, Kestens L, Mugerwa R, Reiss P, Colebunders R for the TB-IRIS Study Group.

Journal:

Journal of Acquired Immune Deficiency Syndrome

Content:

Date:

2011-09-01

Authors:

Lusiba JK, Nakiyingi L, Kirenga BJ, Kiragga A, Lukande R, Nsereko M, Ssengooba W, Katamba A, Worodria W, Joloba ML, Mayanja-Kizza H.

Journal:

PLoS One.

Content:

Date:

2014-07-22

Authors:

Worodria W, Massinga-Loembe M, Mayanja-Kizza H, Jane Namaganda, Kambugu A, Manabe C, Kestens L, and Colebunders R.

Journal:

Clinical and Developmental Immunology.

Content:

Date:

2010-12-08

Authors:

Tran HT, Van den Bergh R, Vu TN, Laukens K, Worodria W, Loembé MM, Colebunders R, Kestens L, De Baetselier P, Raes G; for the TB-IRIS Study Group.

Journal:

Immunobiology

Content:

Date:

2015-07-25

Authors:

Yoon C, Cattamanchi A, Davis JL, Worodria W, den Boon S, Kalema N, Katagira W, Kaswabuli S, Miller C, Andama A, Albert H, Nabeta P, Gray C, Ayakaka I, Huang L.

Journal:

PLoS One.

Content:

Date:

2012-11-06

Authors:

Cattamanchi A, Ssewenyana I, Nabatanzi R, Miller CR, Den Boon S, Davis JL, Andama A, Worodria W, Yoo SD, Cao H, Huang L.

Journal:

PLoS One

Content:

Date:

2012-06-26

Authors:

Taylor SM, Meshnick SR, Worodria W, Andama A, Davis JL, Cattamanchi A, den Boon S, Yoo SD, Goodman CD, Huang L;

Journal:

Diagnostic Microbiology and Infectious Disease

Content:

Date:

2012-02-01

Authors:

Shete PB, Ravindran R, Chang E, Worodria W, Chaisson LH, Andama A, Davis JL, Luciw PA, Huang L, Khan IH, Cattamanchi A

Journal:

PLoS One

Content:

Date:

2017-08-02

Authors:

Namiiro S, Wobudeya E, Colebunders R, Worodria W.

Journal:

International Journal of Tuberculosis And Lung Disease

Content:

Date:

2018-03-01

Authors:

Koss CA, Jarlsberg LG, den Boon S, Cattamanchi A, Davis JL, Worodria W, Ayakaka I, Sanyu I, Huang L; International HIV-associated Opportunistic Pneumonias (IHOP) Study.

Journal:

PLoS One.

Content:

Date:

2015-05-11

Authors:

Kruh-Garcia NA, Wolfe LM, Chaisson LH, Worodria WO, Nahid P, Schorey JS, Davis JL, Dobos KM.

Journal:

PLoS One.

Content:

Date:

2014-07-31

Authors:

Dirix V, Schepers K, Massinga-Loembe M, Worodria W, Colebunders R, Singh M, Locht C, Kestens L, Mascart F

Journal:

Journal of Acquired Immune Deficiency Syndrome

Content:

Date:

2016-07-01

Authors:

Andama AO, Boon SD, Meya D, Cattamanchi A, Worodria W, Davis JL, Walter ND, Yoo SD, Kalema N, Haller B, Huang L

Journal:

Journal of Acquired Immune Deficiciency Syndrome.

Content:

Date:

2013-06-01

Authors:

Kalema N, Boon SD, Cattamanchi A, Davis JL, Andama A, Katagira W, Everett C, Walter N, Byanyima P, Kaswabuli S, Worodria W, Huang L.

Journal:

PLoS One

Content:

Date:

2012-06-12

Authors:

Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L, Caceres T, Mehdiyev R, Raymond L, Whitelaw A, Sagadevan K, Alexander H, Albert H, Cobelens F, Cox H, Alland D, Perkins MD.

Journal:

Lancet.

Content:

Date:

2011-04-30

Authors:

Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL.

Journal:

Journal of Infectious Diseases

Content:

Date:

2015-09-15

Authors:

Worodria W, Emily C, Andama A, Sanyu I, Byanyima P, Musisi Bblt E, Kaswabuli S, Zawedde J, Ayakaka I, Sessolo A, Lalitha R, Davis JL, Huang L.

Journal:

J Acquir Immune Defic Syndr.

Content:

Date:

2018-09-14

Authors:

Kirenga BJ, Levin J, Ayakaka I, Worodria W, Reilly N, Mumbowa F, Nabanjja H, Nyakoojo G, Fennelly K, Nakubulwa S, Joloba M, Okwera A, Eisenach KD, McNerney R, Elliott AM, Mugerwa RD, Smith PG, Ellner JJ, Jones-López EC

Journal:

PLoS One

Content:

Date:

2014-03-07

Authors:

Auld E, Lin J, Chang E, Byanyima P, Ayakaka I, Musisi E, Worodria W, Davis JL, Segal M, Blackburn E, Huang L.

Journal:

PLoS One.

Content:

Date:

2016-09-21

Authors:

Nakiwala JK, Walker NF, Diedrich CR, Worodria W, Meintjes G, Wilkinson RJ, Mayanja-Kizza H, Colebunders R, Kestens L, Wilkinson KA, Lowe DM.

Journal:

J Acquir Immune Defic Syndr.

Content:

Date:

2018-02-01

Authors:

Nakiwala JK Walker NF Diedrich CR Worodria W Meintjes G Wilkinson RJ Mayanja-Kizza H Colebunders R Kestens L Wilkinson KA Lowe DM.

Journal:

Content:

Date:

2018-01-01

Authors:

Kalema N, Lindan C, Glidden D, Yoo SD, Katamba A, Alfred A, Katagira W, Byanyima P, Musisi E, Kaswabuli S, Ingvar S, Zawedde J, Yoon C, Ayakaka I, Davis JL, Huang L, Worodria W, Cattamanchi A.

Journal:

South African Respiratory Journal

Content:

Date:

2018-01-22

Authors:

Kibirige D, Mutebi E, Ssekitoleko R, Worodria W, Mayanja-Kizza H.

Journal:

BMC Res Notes

Content:

Date:

2013-07-25

Authors:

Acen EL, Worodria W, Mulamba P, Kambugu A, Erume J.

Journal:

F1000Research

Content:

Date:

2016-07-29

Authors:

Nakiyingi L, Kateete DP, Ocama P, Worodria W, Sempa JB, Asiimwe BB, Katabazi FA, Katamba A, Huang L, Joloba ML, Mayanja-Kizza H.

Journal:

. BMC Research Notes

Content:

Date:

2012-09-05

Authors:

Miremba P, Kalyango JN, Worodria W, Mugerwa H, Nakakawa E, Asiimwe BB.

Journal:

PLoS One

Content:

Date:

2012-10-29

Authors:

Kibirige D, Kampiire L, Atuhe D, Mwebaze R, Katagira W, Muttamba W, Nantanda R, Worodria W, Kirenga B.

Journal:

BMC Pulmonary Medicine

Content:

Date:

2018-12-08

Authors:

Worodria W Ssempijja V Hanrahan C Ssegonja R Muhofwa A Mazapkwe D Mayanja-Kizza H Reynolds SJ Colebunders R Manabe YC.

Journal:

Content:

Date:

2018-01-01

Authors:

Kirenga BJ, Worodria W, Massinga-Loembe M, Nalwoga T, Manabe YC, Kestens L, Colebunders R, Mayanja-Kizza H.

Journal:

International Journal Against Tuberculosis And Lung Disease

Content:

Date:

2013-03-01

Authors:

Tran HT, Van den Bergh R, Loembé MM, Worodria W, Mayanja-Kizza H, Colebunders R, Mascart F, Stordeur P, Kestens L, De Baetselier P, Raes G; for the TB-IRIS study group

Journal:

AIDS.

Content:

Date:

2013-07-17

Authors:

Blount RJ, Jarlsberg LG, Daly KR, Worodria W, Davis JL, Cattamanchi A, Djawe K, Andama A, Koch J, Walzer PD, Huang L

Journal:

PLoS One

Content:

Date:

2012-12-21

Authors:

Walter ND, Moore CM, Kayigire XA, Dide-Agossou C, Worodria W, Huang L, Everett CK, Schoolnik GS, Nahid P, Lucian Davis J.

Journal:

BMC Infectious Diseases

Content:

Date:

2018-07-03

Authors:

Manabe YC, Worodria W, van Leth F, Mayanja-Kizza H, Traore AN, Ferro J, Pakker N, Frank M, Grobusch MP, Colebunders R, Cobelens F.

Journal:

American Journal of Tropical Medicine and Hygiene

Content:

Date:

2016-12-07

Authors:

Taylor SM, Meshnick SR, Worodria W, Andama A, Cattamanchi A, Davis JL, Yoo SD, Byanyima P, Kaswabuli S, Goodman CD, Huang L;

Journal:

PLoS One. 2012 Nov 16;7(11):e49991.

Content:

Date:

2018-10-16

Authors:

Serugendo AN, Kirenga BJ, Hawkes M, Nakiyingi L, Worodria W, Okot-Nwang M.

Journal:

International Journal of Tuberculosis And Lung Disease.

Content:

Date:

2014-03-01

Authors:

Iwai S, Huang D, Fong S, Jarlsberg LG, Worodria W, Yoo S, Cattamanchi A, Davis JL, Kaswabuli S, Segal M, Huang L, Lynch SV.

Journal:

PLoS One.

Content:

Date:

2014-04-21

Authors:

Goovaerts O, Jennes W, Massinga-Loembé M, Ondoa P, Ceulemans A, Vereecken C, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group.

Journal:

PLoS One.

Content:

Date:

2014-07-24

Authors:

Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L, the TB-IRIS Study Group.

Journal:

PLoS One.

Content:

Date:

2013-11-28

Authors:

Conesa-Botella A, Loembé MM, Manabe YC, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Miri M, Mbabazi O, Koole O, Kestens L, Colebunders R.

Journal:

Journal of Acquired Immune Deficiency Syndrome

Content:

Date:

2011-12-15

Authors:

Huang L, Cattamanchi A, Davis JL, Boon SD, Kovacs J, Meshnick S, Miller RF, Walzer PD, Worodria W, Masur H; on behalf of the International HIV-associated Opportunistic Pneumonias (IHOP) Study and the Lung HIV Study.

Journal:

Proceedings of American Thoracic Society.

Content:

Date:

2011-09-01

Authors:

Kisembo, HN, den Boon, S, Davis, JL, Okello, R, Worodria, W, Cattamanchi, A, Huang, L, and Kawooya, MG.

Journal:

British Journal of Radiology

Content:

Date:

2012-06-01

Authors:

Kibirige D, Ssekitoleko R, Mutebi E, Worodria W.

Journal:

BMC Infectious Diseases..

Content:

Date:

2013-03-01

Authors:

Nakiyingi L, Bwanika JM, Lukande R, Kirenga B, Mwambu TP, Worodria W, Okot-Nwang M.

Journal:

Tropical Doctor

Content:

Date:

2012-10-01

Authors:

Tokman S, Barnett CF, Jarlsberg LG, Taub PR, den Boon S, Davis JL, Cattamanchi A, Worodria W, Maisel A, Huang L; the International HIV-Associated Opportunistic Pneumonias (IHOP) Study.

Journal:

Respirology..

Content:

Date:

2014-01-26

Authors:

Sanya RE, Kirenga BJ, Worodria W, Okot-Nwang M.

Journal:

Africa Health Sciences.

Content:

Date:

2014-09-04

Authors:

Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, Worodria W, Huang L, Fletcher DA, Cattamanchi A.

Journal:

Journal of Clinical Microbiology

Content:

Date:

2013-04-03

Authors:

Yoo SD, Cattamanchi A, den Boon S, Worodria W, Kisembo H, Huang L, Davis JL.

Journal:

Respirology

Content:

Date:

2011-07-01

Authors:

Parobek CM, Jiang LY, Patel JC, Alvarez-Martínez MJ, Miro JM, Worodria W, Andama A, Fong S, Huang L, Meshnick SR, Taylor SM, Juliano JJ.

Journal:

Journal of Clinical Microbiology

Content:

Date:

2014-02-12

Authors:

Manabe YC, Worodria W, Cobelens F; PROMPT Study Group.

Journal:

International Journal of Tuberculosis and Lung Disease

Content:

Date:

2012-02-01

Authors:

Acuña-Villaorduña C, Ayakaka I, Dryden-Peterson S, Nakubulwa S, Worodria W, Reilly N, Hosford J, Fennelly KP, Okwera A, Jones-López EC.

Journal:

American Journal of Tropical Medicine and Hygiene

Content:

Date:

2015-05-04

Authors:

Meyer AJ, Atuheire C, Worodria W, Kizito S, Katamba A, Sanyu I, Andama A, Ayakaka I, Cattamanchi A, Bwanga F, Huang L, Davis JL.

Journal:

PLoS One

Content:

Date:

2017-07-20

Authors:

Worodria W, Ssempijja V, Hanrahan C, Ssegonja R, Muhofwa A, Mazapkwe D, Mayanja-Kizza H, Reynolds SJ, Colebunders R, Manabe YC.

Journal:

AIDS

Content:

Date:

2018-09-24

Authors:

Katagira W, Walter ND, den Boon S, Kalema N, Ayakaka I, Vittinghoff E, Worodria W, Cattamanchi A, Huang L, Davis JL

Journal:

Journal of Acquired Immune Deficiency Syndrome

Content:

Date:

2016-02-24

Authors:

Worodria, W, Cattamanchi, A, Davis, JL, den Boon, S, Yoo, S, Joloba, M, Huang, L, and Kato-Maeda, M.

Journal:

PLoS One

Content:

Date:

2011-11-04

Authors:

Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, Strong M, Voskuil MI, Davis JL, Schoolnik GK.

Journal:

Journal of Infectious Diseases. .

Content:

Date:

2016-10-15

Authors:

Shenoy MK, Iwai S, Lin DL, Worodria W, Ayakaka I, Byanyima P, Kaswabuli S, Fong S, Stone S, Chang E, Davis JL, Faruqi AA, Segal MR, Huang L, Lynch SV.

Journal:

American Journal of Respiratory and Critical Care Medicine

Content:

Date:

2016-07-22

Authors:

Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L

Journal:

PLoS One.

Content:

Date:

2014-11-21

Authors:

Worodria W, Menten J, Massinga-Loembe M, Mazakpwe D, Bagenda D, Koole O, Mayanja-Kizza H, Kestens L, Mugerwa R, Reiss P, Colebunders R; the TB-IRIS Study Group.

Journal:

Antiviral Therapy

Content:

Date:

2012-04-27

Authors:

Conesa-Botella A, Goovaerts O, Massinga-Loembé M, Worodria W, Mazakpwe D, Luzinda K, Mayanja-Kizza H, Colebunders R, Kestens L; TB IRIS Study Group.

Journal:

International Journal of Tuberculosis and Lung Disease

Content:

Date:

2012-11-01

Dr Willliam Worodria

Related fellows

Dr Martha Zewdie Gebeyehu

Dr Sylvie Kwedi

Dr Bugwesa Zablon Katale

Project Title

Host Organisation

EDCTP Project

EDCTP Program

EDCTP Project Call

Project Title

Project Objectives

Results & Outcomes

Host Organisation

EDCTP Project

EDCTP Program

EDCTP Project Call

Study Design

Sites

Current Organisation

Current Job Title

Biography

Publications

Dr
Willliam Worodria