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Associate Professor
Emboumbou Moukoko

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Profile EDCTP Fellowship 1

Project Title

Identification of Plasmodium falciparum parasite virulence markers for the evaluation of the impact of malaria control intervention according to the local parasite populations

EDCTP Project

TA.2005.40203.006

EDCTP Program

EDCTP1

EDCTP Project Call

Career Development Fellowship (CDF)

Project Objectives

To perform the combined epidemiological, clinical and genetic analysis (gene mapping of several loci of P. falciparum whole-genome and genotyping human haemoglobin) to identify parasite and human genetic markers associated with higher risk of severe disease (including cerebral malaria, severe malaria related anaemia, convulsion and hyperparasitaemia) compared to uncomplicated malaria (UCM)

Study Design

Cohort study

Host Organisation

Department Institution Country
University of Buea Cameroon

Sites

Results & Outcomes

956 malaria patients were recruited from September 2007 to January 2009. Most of the data concerning the age, the sex, the clinical phenotype, the biological data and the clinical outcome was collected. The verification of the data bases was completed in the participating countries of Cameroon, Gabon and Mali. The project enabled the grantee to set up molecular epidemiology expertise in the institution’s laboratory and he consequently got a lecturer position at the University of Douala in Cameroon.