Dr
Bourema Kouriba
Project Title
Role of functionally distinct monocyte subpopulations in protection against clinical Plasmodium falciparum malaria in people living in endemic area of Mali
Project Objectives
To assess the role of monocytes activation by infected red blood cell in the protection against clinical falciparum malaria in endemic area and determine the frequency of monocytes subpopulations according to the clinical outcome (asymptomatic, mild and severe) of malaria infection
Results & Outcomes
Antibody titres to all antigens, except MSP-119, and the number of
antigens recognized increased with age. After malaria exposure,
antibody titres increased in children that had low titres at baseline, but
decreased in those with high baseline responses. No significant
differences were found between antibody titers for individual antigens
between children
remaining symptomatic or asymptomatic after exposure, after
adjustment for age. Instead, children remaining asymptomatic following
parasite exposure had a broader repertoire of
antigen recognition. The present study provides immuneepidemiological
evidence from a limited cohort of Malian children that
strong recognition of multiple antigens, rather than antibody titres for
individual antigens, is associated with protection from clinical malaria.
Host Organisation
| Department | Institution | Country |
|---|---|---|
| University of Bamako | Mali |
EDCTP Project
TA.2010.40200.007
EDCTP Program
EDCTP1
EDCTP Project Call
Senior Fellowship (SF)
Study Design
Immunological cohort studies