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Dr
Sean Wasserman

South Africa

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Profile EDCTP Fellowship 1

Project Title

Optimising linezolid use for drug-resistant tuberculosis in South Africa: the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance.

Project Objectives

1. Develop a population PK model of linezolid in South African patients with DR-TB. 2. Determine the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance in South African patients with MDR and XDR- or pre-XDR-TB. 3. Define the relationships between linezolid PK parameters, functional mitochondrial activity, and clinical toxicity, and explore the association of SNPs in mtDNA with the risk of linezolid toxicity in this population

Host Organisation

Department Institution Country
Wellcome Centre for Infectious Diseases Research in Africa University of Cape Town (UCT) ZA

EDCTP Project

TMA2015CDF1018

EDCTP Program

EDCTP2

EDCTP Project Call

Career Development Fellowship (CDF)

Study Design

Prospective observational cohort study

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