Project Title

Optimising linezolid use for drug-resistant tuberculosis in South Africa: the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance.

EDCTP Project Call

Career Development Fellowship (CDF)

Project Objectives

1. Develop a population PK model of linezolid in South African patients with DR-TB. 2. Determine the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance in South African patients with MDR and XDR- or pre-XDR-TB. 3. Define the relationships between linezolid PK parameters, functional mitochondrial activity, and clinical toxicity, and explore the association of SNPs in mtDNA with the risk of linezolid toxicity in this population

Study Design

Prospective observational cohort study

Host Organisation

Sites

Current Organisation

University of Cape Town (UCT)

Current Job Title

Senior Lecturer

Biography