Current Organisation

Bill & Melinda Gates Foundation

Current Job Title

Deputy Director Tuberculosis

Biography

Publications

Project Title

The BCG-induced immune correlates of protection against tuberculosis

EDCTP Project Call

Senior Fellowship (SF)

Host Organisation

Project Objectives

To identify BCG immune correlates of protection against TB in children whose understanding is critical for TB vaccine development. 1. To determine whether the post-vaccination number, function and/or antigenic repertoire of specific conventional CD4+ and CD8+ T cells correlate with protection against TB 2. To determine whether the post-vaccination number and/or function of specific regulatory CD4+ T cells correlate with protection against TB 3. To determine whether the post-vaccination gene expression and cytokine secretion profiles of whole blood, and of PBMC, correlate with protection against TB.

Study Design

Prospective cohort analyses

Results & Outcomes