The EDCTP Alumni Network

Dr
Michel Luhembwe

Related fellows

Dr Justin Nono Komguep

Senior Research Officer

View

Associate Professor Richard Phillips

Scientific Director (KCCR), Associate Professor of Medicine

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Dr ADOUAKA Gaetan Robert

Etudiant en Master

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Profile EDCTP Fellowship 1

Project Title

MSc in Epidemiology and Biostatistics

EDCTP Project

CSA2020E-3123

EDCTP Program

EDCTP2

EDCTP Project Call

Disease Outbreak and Epidemic Response (EPI Fellows)

Project Objectives

Décrire les caractéristiques sociodémographiques, comportementales, cliniques/biologique et ceux liées au système de santé ; Identifier les facteurs associés à la non-suppression de la charge virale auprès des PvVIH sous TAR Formuler les recommandations pour améliorer la situation

Study Design

Une étude cas-témoins non appariée a été menée pour la période allant de janvier 2022 à juin 2023, incluant 22 établissements de soins disposant de données sur la charge virale. Les données ont été collectées à partir des dossiers des patients. Pour chaque dossier examiné, le patient a été invité à un entretien après avoir donné son consentement éclairé. Les données ont été analysées à l'aide de SPSS version 27. Dans un modèle de régression logistique binaire multivariée, les variables ayant une valeur p < 0,05 et un intervalle de confiance de 95 % pour le rapport de cotes ajusté ont été considérées comme significativement associées à la CV non supprimée.

Host Organisation

Department	Institution	Country

Current Organisation

Coordination Provinciale du Programme de Lutte contre le Sida (PNLS) Tanganyika

Current Job Title

Médecin Coordonnateur Provincial

Biography

Coordonateur du programme Sida depuis 2016. Ancienneté de 15 ans et plus dans le secteur santé avec expérience professionnelle dans le domaine des soins de santé primaires et de santé publique dans la riposte aux épidémies (polio, rougeole, choléra)

Publications

Authors:

Michel Luhembwe Richard Ingwe Aimée Lulebo Dalau Nkamba John Ditekemena

Journal:

BioMed

Content:

Date:

2024-09-18

Authors:

Michel LUHEMBWE

Journal:

BioMed

Content:

Abstract: Antiretroviral treatment (ART) has revolutionized the management of the human immunodeficiency

virus (HIV) and acquired immunodeficiency syndrome (AIDS), enabling long-term viral

load (VL) suppression in patients. Despite the proven effectiveness of ART, a significant proportion

of patients with HIV receiving ART fail to achieve viral load suppression (VLS). This study aimed to

identify factors associated with low VLS in the Tanganyika province. An unmatched case–control

study was conducted from January 2022 to June 2023, including 22 care facilities with viral load

data. Data were collected from patient records. For each reviewed record, the patient was invited

for an interview upon providing informed consent. Data were analyzed using SPSS version 27. In a

multivariable binary logistic regression model, variables with a p-value < 0.05 and a 95% confidence

interval for the adjusted odds ratio were considered significantly associated with unsuppressed VL.

A total of 462 individuals, including 156 cases and 306 controls, were included in the study. The

mean age (standard deviation) of participants was 42.12 (±11.6) years. The following covariates were

significantly associated with unsuppressed VL: poor HIV status disclosure to a confidant [adjusted

OR = 2.10, 95% CI (1.33–3.31), p = 0.001], poor ART adherence [adjusted OR = 2.01, 95% CI (1.25–3.23),

p = 0.004], ART interruption [adjusted OR = 3.43, 95% CI (2.00–5.88), p < 0.001], no participation in

support groups [adjusted OR = 2.16, 95% CI (1.25–3.71), p = 0.005], baseline WHO clinical stage 3

and 4 [adjusted OR = 2.24, 95% CI (1.32–3.79), p = 0.003], opportunistic infections (OIs) [adjusted

OR = 2.30, 95% CI (1.27–4.16), p = 0.006], and non-communicable chronic diseases (NCDs) [adjusted

OR = 2.30, 95% CI (1.10–4.79), p = 0.026]. Given the clear association between several factors and

unsuppressed VL, prevention should involve the implementation of innovative strategies targeting

at-risk patient groups. Strengthening the monitoring of these factors among active patients at each

appointment is recommended to achieve this goal.

Date:

2024-09-18

Dr Michel Luhembwe

Related fellows

Dr Justin Nono Komguep

Associate Professor Richard Phillips

Dr ADOUAKA Gaetan Robert

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Project Objectives

Study Design

Host Organisation

Current Organisation

Current Job Title

Biography

Publications

Dr
Michel Luhembwe