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Professor
Eric Achidi

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Profile EDCTP Fellowship 1

Project Title

Malaria baseline studies towards characterising and establishing a clinical trial site at Mutengene, South West Region of Cameroon

EDCTP Project

TA.2009.40200.008

EDCTP Program

EDCTP1

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

The epidemiological study was designed to provide data on baseline malariometric parameters valuable for future intervention studies aimed at validating disease control tools. The specific objectives include conducting a population census of the study area, determining the malaria prevalence rates and density in cross sectional surveys, helminth and malaria co-infection rates and densities, number of episodes per year in cohort longitudinal studies, vectors transmitting parasites, their dynamics and inoculation rates, natural immune responses to malaria parasite exposure and prevalence of some genetic traits that protect against malaria.

Study Design

Epidemiological studies for clinical trials site development

Host Organisation

Department Institution Country
University of Buea Cameroon

Sites

Results & Outcomes

At the end of the project a total of 15,344 individuals were included and a series of baseline studies were conducted. These included studies on household mosquito net ownership, prevalence of fever, prevalence of malaria parasitaemia by season, prevalence of intestinal helminthes by season, prevalence of anaemia, the prevalence of the sickle cell trait (HbAS) in the study group and levels of Plasmodium falciparum specific IgE/IgG2 antibodies in study participants. The project is well integrated within the EDCTP-funded central African network of excellence, CANTAM, and also received additional funding from the European Virtual Institute for Malaria Research (EVIMalaR). Eight members of the study team received various short term trainings.