The EDCTP Alumni Network

Dr
Nontobeko Mvubu

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Dr David Kateete

Lecturer

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Dr Sylvie Kwedi

Epidemiologist

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Dr Nelita du Plessis

Senior Scientist

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Profile EDCTP Fellowship 1

Project Title

Identification and characterization of the Mycobacterium tuberculosis complex lineage-specific epigenomes, transcriptome patterns and regulatory networks and pathways

EDCTP Project

TMA2020CDF-3167

EDCTP Program

EDCTP2

EDCTP Project Call

Career Development Fellowship (CDF)

Host Organisation

Department	Institution	Country
	University of KwaZulu-Natal (UKZN)	South Africa

Current Organisation

University of KwaZulu-Natal

Current Job Title

Lecturer and Researcher

Biography

Publications

Authors:

Mvubu, N. E., Pillay, B., McKinnon, L. R., and Pillay, M.

Journal:

Cytokine

Content:

Date:

2018-04-30

Authors:

Mvubu, N.E. Pillay, B. Gamieldien, J. Bishai, W. Pillay, M.

Journal:

Tuberculosis

Content:

Date:

2016-01-01

Authors:

Nontobeko Eunice Mvubu

Journal:

Pathogens and Disease

Content:

Many studies have identified host-derived lipids, characterised by the abundance of cholesterol, as a major source of carbon nutrition for Mycobacterium tuberculosis during infection. Members of the Mycobacterium tuberculosis complex are biologically different with regards to degree of disease, host range, pathogenicity and transmission. Therefore, the current study aimed at elucidating transcriptome changes during early infection of pulmonary epithelial cells and on an in vitro cholesterol-rich minimal media, in M. tuberculosis clinical strains F15/LAM4/KZN and Beijing, and the laboratory H37Rv strain. Infection of pulmonary epithelial cells elicited the upregulation of fadD28 and hsaC in both the F15/LAM4/KZN and Beijing strains and the downregulation of several other lipid-associated genes. Growth curve analysis revealed F15/LAM4/KZN and Beijing to be slow growers in 7H9 medium and cholesterol-supplemented media. RNA-seq analysis revealed strain-specific transcriptomic changes, thereby affecting different metabolic processes in an in vitro cholesterol model. The differential expression of these genes suggests that the genetically diverse M. tuberculosis clinical strains exhibit strain-specific behaviour that may influence their ability to metabolise lipids, specifically cholesterol, which may account for phenotypic differences observed during infection.

Date:

2022-12-12

Authors:

Mvubu NE, Pillay B, Gamieldien J, Bishai W, Pillay M.

Journal:

Tuberculosis

Content:

Date:

2016-03-31

Authors:

Mvubu, Nontobeko E. and Chiliza, Thamsanqa E.

Journal:

International Journal of Molecular Sciences

Content:

Date:

2021-08-31

Authors:

Wadzanai, Manjeese, Nontobeko E. Mvubu, Adrie J. C. Steyn, Thabisile Mpofana.

Journal:

International Journal of Environmental Research and Public Health

Content:

Date:

2021-04-23

Authors:

Journal:

Microbial Pathogenesis

Content:

Date:

2020-09-01

Authors:

Journal:

Gene

Content:

Date:

2020-08-01

Authors:

Mvubu NE, Pillay B, Gamieldien J, Bishai W, Pillay M.

Journal:

Developmental & Comparative Immunology

Content:

Date:

2016-12-30

Authors:

Nontobeko E. Mvubu Thamsanqa E. Chiliza

Journal:

International Journal of Molecular Sciences

Content:

Date:

2021-08-31

Authors:

Mvubu, N.E. Pillay, B. McKinnon, L.R. Pillay, M.

Journal:

Cytokine

Content:

Date:

2017-01-01

Authors:

Wadzanai Manjeese Nontobeko E. Mvubu Adrie J. C. Steyn Thabisile Mpofana

Journal:

International Journal of Environmental Research and Public Health

Content:

Date:

2021-04-23

Authors:

Wadzanai Manjeese Nontobeko.E. Mvubu Adrie.J.C. Steyn Thabisile Mpofana

Journal:

International Journal of Developmental Neuroscience

Content:

Date:

2021-05-01

Authors:

Mvubu, N.E. Pillay, B. Gamieldien, J. Bishai, W. Pillay, M.

Journal:

Developmental and Comparative Immunology

Content:

Date:

2016-01-01

Authors:

N.E. Mvubu, B. Pillay and M. Pillay

Journal:

Gene

Content:

Date:

2020-05-04

Authors:

Manjeese, Wadzanai, Mvubu, Nontobeko E, Steyn, Adrie JC, Mpofana, Thabisile.

Journal:

International Journal of Developmental Neuroscience

Content:

Date:

2021-05-01

Dr Nontobeko Mvubu

Related fellows

Dr David Kateete

Dr Sylvie Kwedi

Dr Nelita du Plessis

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Current Organisation

Current Job Title

Biography

Publications

Dr
Nontobeko Mvubu