The EDCTP Alumni Network

Professor
Wendy Burgers

South Africa

Related fellows

Dr Bugwesa Zablon Katale

Director of Research

View

Dr Willy Ssengooba

Scientific Director of the Mycobacteriology (BSL-3) Facility

View

Dr Sarah Nyangu

Research Manager - TB REACH Wave 10 (STOPTBPartnership funded project)

View

Profile EDCTP Fellowship 1 EDCTP Fellowship 2

Current Organisation

University of Cape Town

Current Job Title

Associate Professor

Biography

Publications

Authors:

Bere, A. Denny, L. Hanekom, W. Burgers, W.A. Passmore, J.-A.S.

Journal:

Content:

Date:

2010-01-01

Authors:

Moosa Y Tanko RF Ramsuran V Singh R Madzivhandila M Yende-Zuma N Abrahams MR Selhorst P Gounder K Moore PL Williamson C Abdool Karim SS Burgers WA

Journal:

BMC infectious diseases

Content:

Date:

2018-01-01

Authors:

Burgers, W.A. Shephard, E. Monroe, J.E. Greenhalgh, T. Binder, A. Hurter, E. Van Harmelen, J.H. Williamson, C. Williamson, A.-L.

Journal:

Content:

Date:

2008-01-01

Authors:

Nemes E Burgers WA Riou C Andersen-Nissen E Ferrari G Gray CM Scriba T

Journal:

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Content:

Date:

2016-11-01

Authors:

Zembe, L. Burgers, W.A. Jaspan, H.B. Bekker, L.-G. Bredell, H. Stevens, G. Gilmour, J. Cox, J.H. Fast, P. Hayes, P. Vardas, E. Williamson, C. Gray, C.M.

Journal:

Content:

Date:

2011-01-01

Authors:

Bunjun R Riou C Soares AP Thawer N Müller TL Kiravu A Ginbot Z Oni T Goliath R Kalsdorf B von Groote-Bidlingmaier F Hanekom W Walzl G Burgers WA

Journal:

The Journal of infectious diseases

Content:

Date:

2017-12-01

Authors:

Olivier, A.J. Masson, L. Ronacher, K. Walzl, G. Coetzee, D. Lewis, D.A. Williamson, A.-L. Passmore, J.-A.S. Burgers, W.A.

Journal:

Content:

Date:

2014-01-01

Authors:

Burgers, W.A. Williamson, C.

Journal:

Content:

Date:

2005-01-01

Authors:

Riou C Berkowitz N Goliath R Burgers WA Wilkinson RJ

Journal:

Frontiers in immunology

Content:

Date:

2017-08-01

Authors:

Soares A Müller TL Chege GK Williamson AL Burgers WA

Journal:

Vaccine

Content:

Date:

2015-06-01

Authors:

Moyo-Gwete T Madzivhandila M Makhado Z Ayres F Mhlanga D Oosthuysen B Lambson BE Kgagudi P Tegally H Iranzadeh A Doolabh D Tyers L Moore PL

Journal:

The New England journal of medicine

Content:

Date:

2021-04-01

Authors:

Fuks, F. Burgers, W.A. Brehm, A. Hughes-Davies, L. Kouzarides, T.

Journal:

Content:

Date:

2000-01-01

Authors:

Burgers, W.A. van Harmelen, J.H. Shephard, E. Adams, C. Mgwebi, T. Bourn, W. Hanke, T. Williamson, A.-L. Williamson, C.

Journal:

Content:

Date:

2006-01-01

Authors:

Burgers, W.A. Blanchon, L. Pradhan, S. De Launoit, Y. Kouzarides, T. Fuks, F.

Journal:

Content:

Date:

2007-01-01

Authors:

Jacob, R.A. Abrahams, F. Tongo, M. Schomaker, M. Roux, P. Ngole, E.M. Burgers, W.A. Dorfman, J.R.

Journal:

Content:

Date:

2012-01-01

Authors:

Bunjun R

Journal:

Tuberculosis (Edinb)

Content:

Date:

2016-01-01

Authors:

Burgers, W.A. Chege, G.K. Müller, T.L. van Harmelen, J.H. Khoury, G. Shephard, E.G. Gray, C.M. Williamson, C. Williamson, A.-L.

Journal:

Content:

Date:

2009-01-01

Authors:

Hoving JC Brown GD Gómez BL Govender NP Limper AH May RC Meya DB Abassi M Acen GR Adenis A Ahimbisibwe C Ahmadu A Ahmed N Ajose O Andrianopoulos A Ballou E Bangdiwala A Bhana Z Bohjanen P Borain R Bosch C Botha A Boulware D Boyer Chammard T Brink A Brown G Burgers W Cerrone M Chakrabarti A Chawinga C Chisale M Clay O Comins K Conroy J Cresswell F Cuomo C Cushion M DeSanto D Dunaiski CM Duvenage L Enock K Garvy B Gomez B Govender N Greene G Harrison T Hlungulu S Hlupeni A Hoft M Huppler Hullsiek K Itabangi H Izco Esteban S Jarvis J Jolly A,Jordan A Kamudumuli P Kgotle E Kolls J Kronstad J Krysan D Kurzai O Lahiri S Lawrence D Le T Lechiile K Madu L Makaha E Maphanga TG Masina N Matlapeng P Mbewe A Meintjes G Meya D Mohamed Z Molloy S Morar T Mosepele M Mthembu N Mtshizana T Mzinganjira H Nielsen K Ntoi M Odo M Ogundeji A,Okurut S Okwir M,Oladele R Otieno-Odhiambo P Pappas P Pastick K Perfect J Pilenyane N Porotloane BF Prentice E Rajasingham R Rhein J Rutakingirwa M Salie S Samie A Samie S Schwartz I Shandu R Shey M Shroufi A Singh A Skipper C Spies R St. Louis I Stone N Stott K Toplis B Trivino Duran L Tugume L Valashiya N Vreulink JM Wake R Wasserman S Wedel P Wilkinson RJ Williams D Wills N

Journal:

Trends in Microbiology

Content:

Date:

Authors:

Rubina Bunjun Fidilia M. A. Omondi Mohau S. Makatsa Roanne Keeton Jerome M. Wendoh Tracey L. Müller Caryn S. L. Prentice Robert J. Wilkinson Catherine Riou Wendy A. Burgers

Journal:

The Journal of Immunology

Content:

Date:

2021-09-01

Authors:

Fuks F Burgers WA Brehm A Hughes-Davies L Kouzarides T

Journal:

Nature Genetics

Content:

Date:

Authors:

Shephard, E. Burgers, W.A. Van Harmelen, J.H. Monroe, J.E. Greenhalgh, T. Williamson, C. Williamson, A.-L.

Journal:

Content:

Date:

2008-01-01

Authors:

Makatsa MS Omondi FMA Bunjun R Wilkinson RJ Riou C Burgers WA

Journal:

Content:

Date:

2020-10-01

Authors:

Riou C Keeton R Moyo-Gwete T Hermanus T Kgagudi P Baguma R Tegally H Doolabh D Iranzadeh A Tyers L Mutavhatsindi H Tincho MB Benede N SA-CIN

Journal:

Content:

Date:

2021-06-01

Authors:

Riou C Tanko RF Soares AP Masson L Werner L Garrett NJ Samsunder N Karim QA Karim SSA Burgers WA

Journal:

Journal of immunology (Baltimore, Md. : 1950)

Content:

Date:

2015-07-01

Authors:

Chege, G.K. Burgers, W.A. Stutz, H. Meyers, A.E. Chapman, R. Kiravu, A. Bunjun, R. Shephard, E.G. Jacobs Jr., W.R. Rybicki, E.P. Williamson, A.-L.

Journal:

Content:

Date:

2013-01-01

Authors:

Bunjun R Riou C Soares AP Thawer N Müller TL Kiravu A Ginbot Z Oni T Goliath R Kalsdorf B Von Groote-Bidlingmaier F Hanekom W Walzl G Wilkinson RJ Burgers WA

Journal:

JID

Content:

Date:

2017-01-01

Authors:

Riou, C., Strickland, N., Soares, A. P., Corleis, B., Kwon, D., Wherry, E. J., … Burgers, W. A.

Journal:

Journal of Immunology

Content:

Date:

2016-01-28

Authors:

Tongo, M. Martin, D.P. Zembe, L. Mpoudi-Ngole, E. Williamson, C. Burgers, W.A.

Journal:

Content:

Date:

2013-01-01

Authors:

Keeton R Richardson SI Moyo-Gwete T Hermanus T Tincho MB Benede N Manamela NP Baguma R Makhado Z Ngomti A Motlou T Mennen M Chinhoyi L Burgers WA

Journal:

Content:

Date:

2021-07-01

Authors:

Fuks, F. Burgers, W.A. Godin, N. Kasai, M. Kouzarides, T.

Journal:

Content:

Date:

2001-01-01

Authors:

Burgers, W.A. Riou, C. Mlotshwa, M. Maenetje, P. Rosa, D.D.A. Brenchley, J. Mlisana, K. Douek, D.C. Koup, R. Roederer, M. De Bruyn, G. Karim, S.A. Williamson, C. Gray, C.M.

Journal:

Content:

Date:

2009-01-01

Authors:

Riou C Bunjun R Müller TL Kiravu A Ginbot Z Oni T Goliath R Wilkinson RJ Burgers WA

Journal:

Tuberculosis (Edinburgh, Scotland)

Content:

Date:

2016-08-01

Authors:

Burgers, W.A. Manrique, A. Masopust, D. McKinnon, L.R. Reynolds, M.R. Rolland, M. Blish, C. Chege, G.K. Curran, R. Fischer, W. Herrera, C. Sather, D.N.

Journal:

Content:

Date:

2012-01-01

Authors:

Burgers, W.A. Ginbot, Z. Shen, Y.-J. Chege, G.K. Soares, A.P. Müller, T.L. Bunjun, R. Kiravu, A. Munyanduki, H. Douglass, N. Williamson, A.-L. Williamson, A.-L.

Journal:

Content:

Date:

2014-01-01

Authors:

Chege GK Burgers WA Müller TL Gray CM Shephard EG Barnett SW Ferrari G Montefiori D Williamson C Williamson AL

Journal:

Vaccine

Content:

Date:

2017-01-01

Authors:

Jurette S. Grove Elizabeth S. Mayne Wendy A. Burgers Jonathan Blackburn Sarika Jugwanth Wendy Stevens Lesley Scott Anura David Maemu Gededzha Ian M. Sanne Mpho R. Maphayi Taryn Pillay Jaya A. George

Journal:

Southern African Journal of Infectious Diseases

Content:

Date:

2021-07-26

Authors:

Rametse CL Adefuye AO Olivier AJ Curry L Gamieldien H Burgers WA Lewis DA Williamson AL Katz AA Passmore JS

Journal:

Frontiers in immunology

Content:

Date:

2018-12-01

Authors:

Tongo M Essomba RG Nindo F Abrahams F Nanfack AJ Fokam J Takou D Torimiro JN Mpoudi-Ngole E Burgers WA Martin DP Dorfman JR

Journal:

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Content:

Date:

2015-07-01

Authors:

Chege, G.K. Warren, R.M. Van Pittius, N.C.G. Burgers, W.A. Wilkinson, R.J. Shephard, E.G. Williamson, A.-L.

Journal:

Content:

Date:

2008-01-01

Authors:

Riou C Bunjun R Müller TL Kiravu A Ginbot Z Oni T Goliath R Wilkinson RJ Burgers WA.

Journal:

Content:

Date:

2016-01-01

Authors:

Schiff AE Linder AH Luhembo SN Banning S Deymier MJ Diefenbach TJ Dickey AK Tsibris AM Balazs AB Cho JL Medoff BD Walzl G Wilkinson RJ Burgers W Corleis B Kwon DS

Journal:

Scientific Reports

Content:

Date:

Authors:

Deplus R Brenner C Burgers WA Putmans P Kouzarides T de Launoit Y Fuks F

Journal:

Content:

Date:

2002-09-01

Authors:

Jaspan, H.B. Liebenberg, L. Hanekom, W. Burgers, W. Coetzee, D. Williamson, A.-L. Little, F. Myer, L. Coombs, R.W. Sodora, D. Passmore, J.-A.

Journal:

Content:

Date:

2011-01-01

Authors:

Bunjun R Soares AP Thawer N Müller TL Kiravu A Ginbot Z Corleis B Murugan BD Kwon DS von Groote-Bidlingmaier F Riou C Wilkinson RJ Burgers WA

Journal:

Frontiers in immunology

Content:

Date:

2021-06-01

Authors:

Gumbi, P.P. Nkwanyana, N.N. Bere, A. Burgers, W.A. Gray, C.M. Williamson, A.-L. Hoffman, M. Coetzee, D. Denny, L. Passmore, J.-A.S.

Journal:

Content:

Date:

2008-01-01

Authors:

Makatsa MS Tincho MB Wendoh JM Ismail SD Nesamari R Pera F de Beer S David A Jugwanth S Gededzha MP Mampeule N Sanne I Stevens W Burgers WA

Journal:

Frontiers in plant science

Content:

Date:

2021-03-01

Authors:

Olivier, A.J. Liebenberg, L.J. Coetzee, D. Williamson, A.-L. Passmore, J.A.S. Burgers, W.A.

Journal:

Content:

Date:

2012-01-01

Authors:

Riou, C. Treurnicht, F. Abrahams, M.-R. Mlisana, K. Liu, M.K.P. Goonetilleke, N. Koup, R. Roederer, M. Karim, S.A. De Bruyn, G. Williamson, C. Gray, C.M. Burgers, W.A.

Journal:

Content:

Date:

2012-01-01

Authors:

Natalie Strickland Tracey L. Müller Natacha Berkowitz Rene Goliath Mary N. Carrington Robert J. Wilkinson Wendy A. Burgers Catherine Riou

Journal:

The Journal of Immunology

Content:

Date:

2017-10-01

Authors:

Kløverpris HN Kazer SW Mjösberg J Mabuka JM Wellmann A Ndhlovu Z Yadon MC Nhamoyebonde S Muenchhoff M Simoni Y Andersson F Kuhn W Leslie A

Journal:

Immunity

Content:

Date:

2016-02-01

Authors:

Keeton R Richardson SI Moyo-Gwete T Hermanus T Tincho M Benede N Manamela NP Baguma R Makhado Z Ngomti A Motlou T Mennen M Chinhoyi RL Skelem S Maboreke H Doolabh D Iranzadeh A Otter AD Brooks T Noursadeghi M Moon JC Grifoni A Weiskopf D Sette A Blackburn J Hsiao N Williamson C Riou C Goga A Garrett N Bekker L Gray G Ntusi N Moore PL Burgers W

Journal:

Cell Host and Microbe

Content:

Date:

Authors:

Ramla F. Tanko Andreia P. Soares Lindi Masson Nigel J. Garrett Natasha Samsunder Quarraisha Abdool Karim Salim S. Abdool Karim Catherine Riou Wendy A. Burgers

Journal:

Clinical Immunology

Content:

Date:

2018-10-01

Authors:

Smith M Abdesselem HB Mullins M Tan TM Nel AJM Al-Nesf MAY Bensmail I Majbour NK Vaikath NN Naik A Ouararhni K Mohamed-Ali V Blackburn JM

Journal:

Viruses

Content:

Date:

2021-04-01

Authors:

Bere, A. Denny, L. Naicker, P. Burgers, W.A. Passmore, J.-A.S.

Journal:

Content:

Date:

2013-01-01

Authors:

Gumbi, P.P. Jaumdally, S.Z. Salkinder, A.L. Burgers, W.A. Mkhize, N.N. Hanekom, W. Coetzee, D. Williamson, A. Passmore, J.S.

Journal:

Content:

Date:

2011-01-01

Authors:

Riou, C. Burgers, W.A. Mlisana, K. Koup, R.A. Roederer, M. Abdool Karim, S.S. Williamson, C. Gray, C.M.

Journal:

Content:

Date:

2014-01-01

Authors:

Tongo M Dorfman JR Abrahams MR Mpoudi-Ngole E Burgers WA Martin DP

Journal:

Evolution, medicine, and public health

Content:

Date:

2015-09-01

Authors:

Gededzha MP Mampeule N Jugwanth S Zwane N David A Burgers WA Blackburn JM Grove JS George JA Sanne I Scott L Stevens W Mayne ES

Journal:

PloS one

Content:

Date:

2021-06-01

Authors:

Williams TC Burgers WA

Journal:

The Lancet. Respiratory medicine

Content:

Date:

2021-01-01

Authors:

Riou C. Strickland N. Soares A. P. Corleis B. Kwon D. Wherry E. J. … Burgers W. A.

Journal:

Content:

Date:

2016-01-01

Authors:

Ramla F. Tanko Andreia P. Soares Tracey L. Müller Nigel J. Garrett Natasha Samsunder Quarraisha Abdool Karim Salim S. Abdool Karim Catherine Riou Wendy A. Burgers

Journal:

The Journal of Immunology

Content:

Date:

2017-02-01

Authors:

Roberts, L. Passmore, J.-A.S. Williamson, C. Little, F. Bebell, L.M. Mlisana, K. Burgers, W.A. Van Loggerenberg, F. Walzl, G. Djoba Siawaya, J.F. Abdool Karim, Q. Abdool Karim, S.S.

Journal:

Content:

Date:

2010-01-01

Authors:

Bere, A. Denny, L. Burgers, W.A. Passmore, J.-A.S.

Journal:

Content:

Date:

2010-01-01

Authors:

Riou C Strickland N Soares AP Corleis B Kwon DS Wherry EJ Wilkinson RJ Burgers WA

Journal:

Journal of immunology (Baltimore, Md. : 1950)

Content:

Date:

2016-02-01

Authors:

Nkwanyana, N.N. Gumbi, P.P. Roberts, L. Denny, L. Hanekom, W. Soares, A. Allan, B. Williamson, A.-L. Coetzee, D. Olivier, A.J. Burgers, W.A. Passmore, J.-A.

Journal:

Content:

Date:

2009-01-01

Authors:

Day CL Abrahams DA Bunjun R Stone L de Kock M Walzl G Wilkinson RJ Burgers WA Hanekom WA

Journal:

Frontiers in immunology

Content:

Date:

2018-08-01

Authors:

Tongo M Riou C Crunchant E Müller TL Strickland N Mpoudi-Ngole E Burgers WA

Journal:

Content:

Date:

2015-03-01

Authors:

Tongo, M. Burgers, W.A.

Journal:

Content:

Date:

2014-01-01

Authors:

Burgers, W.A. Fuks, F. Kouzarides, T.

Journal:

Content:

Date:

2002-01-01

Authors:

Rubina Bunjun Fidilia M.A. Omondi Mohau S. Makatsa Tracey L. Müller Caryn S.L. Prentice Robert J. Wilkinson Catherine Riou Wendy A. Burgers

Journal:

Content:

Date:

2019-08-13

Authors:

Margolin E Burgers WA Sturrock ED Mendelson M Chapman R Douglass N Williamson AL Rybicki EP

Journal:

Nature Reviews Microbiology

Content:

Date:

Authors:

Ismail SD Riou C Joseph SB Archin NM Margolis DM Perelson AS Cassidy T Abrahams MR Moeser M Council OD McKinnon LR Osman F Burgers WA

Journal:

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Content:

Date:

2021-06-01

Authors:

Tongo, M. Zembe, L. Ebong, E. Roux, S. Bekker, L.-G. Williamson, C. Mpoudi-Ngole, E. Burgers, W.A.

Journal:

Content:

Date:

2014-01-01

Project Title

Characterizing the spectrum of TB and Co-infection with HIV - the role of Th22 cells (CaTCH-22)

EDCTP Project

TMA2016SF-1535

EDCTP Program

EDCTP2

EDCTP Project Call

Senior Fellowship (SF)

Host Organisation

Department	Institution	Country
Pathology	University of Cape Town (UCT)	ZA

Project Objectives

1: To determine the evolution of Mtb-specific Th22 CD4+ cells during TB disease and treatment. 2: To define the dynamics of Mtb Th22 responses in LTBI and HIV co-infection after antiretroviral (ART). 3: To examine Mtb-specific Th22 cells along the spectrum of TB infection and disease.

Study Design

Observational study

Project Summary

Tuberculosis (TB) remains a leading cause of death from an infectious disease. 10.6 million people developed TB in 2022, including over 1.3 million children, and 1.3 million people died of TB. The need for new and improved ways to prevent the spread of TB is greater than ever. An effective vaccine and biomarkers to identify those at greatest risk of disease will be key to reducing TB. The challenge with developing these interventions is that we lack an understanding of why some people who become infected with Mycobacterium tuberculosis (M.tb), the bacterium causing TB, do not develop disease, while others do. In this project, we are investigating a range of CD4 T helper cell subsets that form part of the adaptive response to M.tb. In the fifth year of the project, we have continued to study CD4 helper subsets in TB immunity, focusing on those who are highly exposed to TB due to occupational exposure, and yet appear to resist infection. http://www.idm.uct.ac.za/Wendy_Burgers

Results & Outcomes

We found that a majority of those classified as resisting TB infection by virtue of being negative on the usual diagnostic assays (TST test and IGRA) in fact have evidence of TB sensitisation when additional immunodominant M.tb antigens are included to measure the M.tb response (EspC, EspF and Rv2348), when additional cytokines are measured and not just IFN- (IL-2, TNF-, IL-17 and IL-22), and when using an assay with higher sensitivity to detect low frequency responses to M.tb (intracellular cytokine staining and flow cytometry rather than soluble cytokine detection). These studies have important implications for diagnosis of M.tb in settings where the bacterium is not endemic and these tests are used to identify those requiring interventions. These studies have been performed by a team of young African scientists, who are being trained and are performing cutting-edge immunology research on TB, to understand more about how the immune system controls M.tb. Our findings provide important and novel insights into M.tb-specific T cell immunity that may ultimately contribute to more effective diagnostics or the development of an effective TB vaccine.

Professor Wendy Burgers

Related fellows

Dr Bugwesa Zablon Katale

Dr Willy Ssengooba

Dr Sarah Nyangu

Current Organisation

Current Job Title

Biography

Publications

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Project Objectives

Study Design

Project Summary

Results & Outcomes

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Project Objectives

Study Design

Professor
Wendy Burgers