The EDCTP Alumni Network

Christian Happi

Related fellows

Project Title

Validation of New Biomarkers for Monitoring Plasmodium falciparum Reduced susceptibility/Tolerance or Resistance to Artemisinin Derivatives and Partner Drugs in Nigeria

EDCTP Project

TA.2007.40200.016

EDCTP Program

EDCTP1

EDCTP Project Call

Senior Fellowship (SF)

Project Objectives

1. Evaluate clinical treatment response parameters, in vitro and in vivo efficacy and drug blood levels of artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ) combinations in patients’ infected with P. falciparum in Ibadan, Southwest Nigeria 2. Use the PCR, DNA sequencing approaches to identify new biomarkers/ molecular determinants of P. falciparum response to ARTs and Partner drugs in vitro and in vivo 3. Validate the role of new biomarkers/molecular determinants of P. falciparum response to ARTs and partner drugs by collating SNPs/SNPs patterns in parasite genes with clinical treatment response parameters, patients’ treatment outcome, blood drug levels and in vitro quantitative responses (phenotypes).

Study Design

In vitro and in vivo bio-markers studies

Host Organisation

Department	Institution	Country
	University of Ibadan	Nigeria

Results & Outcomes

Five major sub-studies were completed. The capacity building programme at the grantee’s laboratory at the College of Medicine, University of Ibadan, in Nigeria has been improved and has been used to train several students.

Current Organisation

Current Job Title

Biography

Publications

Authors:

Gbotosho GO Happi C Folarin O Keyamo O Sowunmi A Oduola AMJ

Journal:

Content:

Date:

2010-01-01

Authors:

Van Tyne D Park DJ Schaffner SF Neafsey DE Angelino E Cortese JF Barnes KG Rosen DM Lukens AK Daniels RF Milner Jr DA Johnson Shlyakhter I Grossman SR Becker JS Yamins D Karlsson EK Ndiaye D Sarr O Mboup S Happi C Furlotte NA Eskin E Kang HM Hartl DL Birren BW Wiegand RC Lander ES Wirth DF Volkman SK Sabeti PC

Journal:

Content:

Date:

2011-01-01

Authors:

. Sowunmi A Adewoye EO Gbotosho GO Happi CT Sijuade A Folarin OA Okuboyejo TM Michael OS

Journal:

Content:

Date:

2010-01-01

Authors:

Michael OS Gbotosho GO Folarin OA Okuboyejo T Sowunmi A Oduola AMJ Happi CT

Journal:

Content:

Date:

2010-01-01

Christian Happi

Related fellows

Phindile Ximba

Elodie Ekoka

Nichole Thomas

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Project Objectives

Study Design

Host Organisation

Results & Outcomes

Current Organisation

Current Job Title

Biography

Publications