The EDCTP Alumni Network

Mr
Godfrey Opolot

Related fellows

Mr Ouanan Nicolas Tuo

Student

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Dr Damalie Nalwanga

Medical Officer

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Dr Edith Majonga

Research Fellow

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Profile EDCTP Fellowship 1

Project Title

Consortium for Development of Sustainable Research Based Fellowship Training on Infectious Disease Epidemiology and Biostatistics in Africa (IDEA)

EDCTP Project

CSA2020E-3126

EDCTP Program

EDCTP2

EDCTP Project Call

Disease Outbreak and Epidemic Response (EPI Fellows)

Host Organisation

Department	Institution	Country

Current Organisation

Amuria District Local Government

Current Job Title

Senior Environmental Health Officer

Biography

Publications

Authors:

opolot Godfrey

Journal:

PLOS ONE

Content:

Background

Over 34 countries in Africa have introduced rotavirus vaccine to their national immunization programs: monovalent (Rotarix®, RV1) and pentavalent (RotaTeq®, RV5) after South Africa introduced it in 2009. Since then several studies assessing the impact of the vaccine have been conducted. The principal aim of this study was to evaluate the impact of the rotavirus vaccine in sub-Saharan Africa.

Methods

A Literature search was performed using Mendeley, PubMed, ScienceDirect, grey literature and Web of Science databases of published studies from January 1, 2017, as years of recent publications on rotavirus vaccine impact in sub-Saharan Africa. A meta-analysis was conducted for rotavirus infection in children under 5 years using proportions of pre and post-vaccine introduction in these populations. Random-effect estimates were considered since the samples were from universal populations.

Results

Out of the 935 articles identified, 17 studies met the inclusion for systematic review and meta-analysis. The pooled proportion for pre-vaccination period was 42%, 95% (CI: 38–46%), and reduced to 21%, 95% (CI: 17–25%) during post-vaccination period. Rotavirus diarrhoea was significantly reduced in children < 12 months as compared to children 12–24 months old. Seasonal peaks of rotavirus diarrhoea were between June–September. However, data is limited to one year of post-vaccine introduction, and bias may present due to early vaccine impact.

Conclusion

We observed that the introduction of the rotavirus vaccine was partly responsible for the significant reduction in the burden of rotavirus-associated diarrhoea in sub-Saharan Africa.

Date:

2020-04-17

Mr Godfrey Opolot

Related fellows

Mr Ouanan Nicolas Tuo

Dr Damalie Nalwanga

Dr Edith Majonga

Project Title

EDCTP Project

EDCTP Program

EDCTP Project Call

Host Organisation

Current Organisation

Current Job Title

Biography

Publications

Mr
Godfrey Opolot