EDCTP Alumni Network

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All Profiles
Call Senior Fellowship (SF)
Programme EDCTP1
Start Date 2005-01-01
End Date 2009-02-08
Project Code TA.2004.40200.003
Status Completed

Title

Assessment of the Public Health Benefit of artemisinin based combination therapies for uncomplicated malaria treatment in Mali

Objectives

1. To test the hypothesis that repeated administration of artesunate+amodiaquine (AS+AQ (Arsucam)), artesunate plus sulphadoxine-pyrimethamine (AS/SP) and artemether-lumefantrine (AR-L (Coartem)) for treatment of consecutive episodes of uncomplicated malaria reduces the incidence of uncomplicated malaria 2. To measure the impact of repeated administration of the drugs on malarial immunity and malaria transmission

Host Organisation

Institution Country
Malaria Research & Training Center Mali

Participants

Name Institution Country
Demba Dembele Malaria Research & Training Center Mali
Bakary Fofana Malaria Research & Training Center Mali
Bakari Sidibe Malaria Research & Training Center Mali
Sekou Toure Malaria Research & Training Center Mali

Study Design

Phase IV Randomised Control Trial

Results & Outcomes

Study results showed that in this setting of perennial transmission with seasonal peaks, the incidence density of malaria in the AS + SP and Arsucam® arms were reduced as compared to the ARL arm. Using crude efficacy, ARL was also significantly less efficacious during the peak season of malaria while all arms had similar and above 98% efficacy after adjusting for re-infections by PCR. All ACTs maintained acceptable clinical and laboratory safety profiles despite their repetitive usage. Combined therapy of Arsucam or Arsumax reduced malaria incidence more than Coartem.

Publications

Kaddouri H, Djimdé AA, Dama S, Kodio A, Tekete M, Hubert V, Koné A, Maiga H, Yattara O, Fofana B, Sidibe B, Sangaré CPO, Doumbo OK, Le Bras J. Baseline in vitro efficacy of ACT component drugs on Plasmodium falciparum clinical isolates of Mali. International Journal of Parasitology 2008 Jun;38(7):791-8.
Djimdé AA, Fofana B, Sagara I, Sidibe B, Toure S, Dembele D, Dama S, Ouologuem D, Dicko A, Doumbo OK. Efficacy, Safety, and Selection of Molecular Markers of Drug Resistance by two ACTs in Mali. American Journal of Tropical Medicine and Hygiene 2008;78(3): 455–461
Tekete M, Djimde AA, Beavogui AH, Maiga H, Sagara I, Fofana B, Ouologuem D, Dama S, Kone A, Dembele D, Wele M, Dicko A, Doumbo OK. Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali. Malaria Journal 2009 Feb Project Porftolio Page 363 of 622 26;8:34
Barger B, Maiga H, Traore OB, Tekete M, Timbine A, Dara A, Traore ZI, Gantt S, Doumbo OK, Djimde AA. Intermittent preventive treatment using artemisinin-based combination therapy reduces malaria morbidity among school-aged children in Mali. Tropical Medicine and International Health. 2009 Jul;14(7):784-91. doi: 10.1111/j.1365-3156.2009.02294

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