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Dr Christina Thobakgale

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2020-02-01
End Date 2025-01-31
Project Code TMA2018SF-2447
Status Active

Title

Innate Immunological Mechanisms of Control and Factors Driving Inflammation in HIV Controllers from a high incidence setting in South Africa-Prospects for HIV Cure

Host Organisation

Institution Country
University of the Witwatersrand South Africa

Current Organisation

University of the Witwatersrand

Current Job Title

Senior Researcher

Students Supervised

Type Name Title University Start Date End Date

Memberships

Role Committee/board Start Date End Date

Education

Institution Degree Year
,

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV)

Grants

Publications

The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans
Authors:
Kewreshini K. Naidoo , author
Manish Sagar , editor
Zesuliwe B. Shangase , author
Tabassum Rashid , author
Ayanda Ngubane , author
Nasreen Ismail , author
Thumbi Ndung’u , author
Christina F. Thobakgale , author
Date:
2020-11-19
Journal:
PLOS ONE
Content:
Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.
Authors:
Thobakgale CF , author
Ramduth D , author
Reddy S , author
Mkhwanazi N , author
de Pierres C , author
Moodley E , author
Mphatswe W , author
Blanckenberg N , author
Cengimbo A , author
Prendergast A , author
Tudor-Williams G , author
Goulder PJ , author
Date:
2007-09-01
Journal:
Journal of virology
Content:
Neutrophil counts in persons of African origin.
Authors:
Thobakgale CF , author
Ndung'u T , author
Date:
2014-01-01
Journal:
Current opinion in hematology
Content:
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Authors:
Kiepiela P , author
Leslie AJ , author
Honeyborne I , author
Ramduth D , author
Thobakgale C , author
Chetty S , author
Rathnavalu P , author
Moore C , author
Pfafferott KJ , author
Hilton L , author
Zimbwa P , author
Moore S , author
Allen T , author
Goulder PJ , author
Date:
2004-12-01
Journal:
Nature
Content:
Interleukin 1-Beta (IL-1β) Production by Innate Cells Following TLR Stimulation Correlates With TB Recurrence in ART-Treated HIV-Infected Patients.
Authors:
Thobakgale C , author
Naidoo K , author
McKinnon LR , author
Werner L , author
Samsunder N , author
Karim SA , author
Ndungʼu T , author
Altfeld M , author
Naidoo K , author
Date:
2017-02-01
Journal:
Journal of acquired immune deficiency syndromes (1999)
Content:
Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.
Authors:
Brumme Z , author
Wang B , author
Nair K , author
Brumme C , author
de Pierres C , author
Reddy S , author
Julg B , author
Moodley E , author
Thobakgale C , author
Lu Z , author
van der Stok M , author
Bishop K , author
Mncube Z , author
Chonco F , author
Losina E , author
Date:
2009-09-01
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Authors:
Muenchhoff M , author
Adland E , author
Karimanzira O , author
Crowther C , author
Pace M , author
Csala A , author
Leitman E , author
Moonsamy A , author
McGregor C , author
Hurst J , author
Groll A , author
Mori M , author
Sinmyee S , author
Goulder P , author
Date:
2016-09-01
Journal:
Science translational medicine
Content:
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
Authors:
Leslie A , author
Kavanagh D , author
Honeyborne I , author
Pfafferott K , author
Edwards C , author
Pillay T , author
Hilton L , author
Thobakgale C , author
Ramduth D , author
Draenert R , author
Le Gall S , author
Luzzi G , author
Edwards A , author
Goulder P , author
Date:
2005-03-01
Journal:
The Journal of experimental medicine
Content:
High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.
Authors:
Mphatswe W , author
Blanckenberg N , author
Tudor-Williams G , author
Prendergast A , author
Thobakgale C , author
Mkhwanazi N , author
McCarthy N , author
Walker BD , author
Kiepiela P , author
Goulder P , author
Date:
2007-06-01
Journal:
AIDS (London, England)
Content:
KIR-HLA footprints and NK cell-mediated recognition of HIV-1.
Authors:
Thobakgale C , author
Carlson J , author
Wright J , author
van Teijlingen N , author
Jaggernath M , author
Goulder P , author
Walker B , author
Carrington M , author
Heckerman D , author
Altfeld M , author
Ndung'u T , author
Date:
2012-09-01
Journal:
Retrovirology
Content:
Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection.
Authors:
Thobakgale CF , author
Fadda L , author
Lane K , author
Toth I , author
Pereyra F , author
Bazner S , author
Ndung'u T , author
Walker BD , author
Rosenberg ES , author
Alter G , author
Carrington M , author
Allen TM , author
Altfeld M , author
Date:
2012-04-01
Journal:
Journal of virology
Content:
Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
Authors:
Ngumbela KC , author
Day CL , author
Mncube Z , author
Nair K , author
Ramduth D , author
Thobakgale C , author
Moodley E , author
Reddy S , author
de Pierres C , author
Mkhwanazi N , author
Bishop K , author
van der Stok M , author
Ismail N , author
Walker BD , author
Date:
2008-01-01
Journal:
AIDS research and human retroviruses
Content:
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Authors:
Thobakgale CF , author
Prendergast A , author
Crawford H , author
Mkhwanazi N , author
Ramduth D , author
Reddy S , author
Molina C , author
Mncube Z , author
Leslie A , author
Prado J , author
Chonco F , author
Mphatshwe W , author
Goulder PJ , author
Date:
2009-07-01
Journal:
Journal of virology
Content:
Greentree white paper: sexual violence, genitoanal injury, and HIV: priorities for research, policy, and practice.
Authors:
Klot JF , author
Auerbach JD , author
Veronese F , author
Brown G , author
Pei A , author
Wira CR , author
Hope TJ , author
M'boup S , author
Greentree Meeting on Sexual Violence and HIV , author
Date:
2012-11-01
Journal:
AIDS research and human retroviruses
Content:
Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants.
Authors:
Prendergast A , author
Mphatswe W , author
Tudor-Williams G , author
Rakgotho M , author
Pillay V , author
Thobakgale C , author
McCarthy N , author
Morris L , author
Walker BD , author
Goulder P , author
Date:
2008-07-01
Journal:
AIDS (London, England)
Content:
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
Authors:
Ramduth D , author
Day CL , author
Thobakgale CF , author
Mkhwanazi NP , author
de Pierres C , author
Reddy S , author
van der Stok M , author
Mncube Z , author
Nair K , author
Moodley ES , author
Kaufmann DE , author
Streeck H , author
Walker BD , author
Date:
2009-04-01
Journal:
PloS one
Content:
Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
Authors:
Hölzemer A , author
Thobakgale CF , author
Jimenez Cruz CA , author
Garcia-Beltran WF , author
Carlson JM , author
van Teijlingen NH , author
Mann JK , author
Jaggernath M , author
Kang SG , author
Körner C , author
Chung AW , author
Altfeld M , author
Date:
2015-11-01
Journal:
PLoS medicine
Content:
P07-07. Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+ specific T cell responses over time.
Authors:
Prado J , author
Prendergast A , author
Thobakgale C , author
Juarez C , author
Tudor-Williams A , author
Ndung'u T , author
Walker B , author
Goulder P , author
Date:
2009-10-01
Journal:
Retrovirology
Content:
Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate.
Authors:
Prado JG , author
Prendergast A , author
Thobakgale C , author
Molina C , author
Tudor-Williams G , author
Ndung'u T , author
Walker BD , author
Goulder P , author
Date:
2010-01-01
Journal:
Journal of virology
Content:
Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
Authors:
Ramduth D , author
Thobakgale CF , author
Mkhwanazi NP , author
De Pierres C , author
Reddy S , author
van der Stok M , author
Mncube Z , author
Mphatswe W , author
Blanckenberg N , author
Cengimbo A , author
Prendergast A , author
Walker BD , author
Date:
2008-02-01
Journal:
AIDS research and human retroviruses
Content:
Raising antibodies in chickens against primaquine, pyrimethamine, dapsone, tetracycline, and doxycycline.
Authors:
Goldring JP , author
Thobakgale C , author
Hiltunen T , author
Coetzer TH , author
Date:
2005-01-01
Journal:
Immunological investigations
Content:
Reduced Expression of Siglec-7, NKG2A, and CD57 on Terminally Differentiated CD56-CD16+ Natural Killer Cell Subset Is Associated with Natural Killer Cell Dysfunction in Chronic HIV-1 Clade C Infection.
Authors:
Zulu MZ , author
Naidoo KK , author
Mncube Z , author
Jaggernath M , author
Goulder PJR , author
Ndung'u T , author
Altfeld M , author
Thobakgale CF , author
Date:
2017-09-01
Journal:
AIDS research and human retroviruses
Content:
Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
Authors:
Mkhwanazi N , author
Thobakgale CF , author
van der Stok M , author
Reddy S , author
Mncube Z , author
Chonco F , author
Walker BD , author
Altfeld M , author
Goulder PJ , author
Ndung'u T , author
Date:
2010-07-01
Journal:
Virology
Content:
CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.
Authors:
Koofhethile CK , author
Ndhlovu ZM , author
Thobakgale-Tshabalala C , author
Prado JG , author
Ismail N , author
Mncube Z , author
Mkhize L , author
van der Stok M , author
Yende N , author
Walker BD , author
Goulder PJR , author
Ndung'u T , author
Date:
2016-07-01
Journal:
Journal of virology
Content:
Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape.
Authors:
Leitman EM , author
Thobakgale CF , author
Adland E , author
Ansari MA , author
Raghwani J , author
Prendergast AJ , author
Tudor-Williams G , author
Kiepiela P , author
Hemelaar J , author
Brener J , author
Tsai MH , author
Mori M , author
Goulder PJR , author
Date:
2017-10-01
Journal:
The Journal of experimental medicine
Content:
Frequent and strong antibody-mediated NK cell activation to HIV-1 Env in individuals with chronic HIV-1 infection.
Authors:
Thobakgale C , author
Fadda L , author
Lane K , author
Toth I , author
Pereyra F , author
Bazner S , author
Ndung'u T , author
Walker B , author
Rosenberg E , author
Alter G , author
Carrington M , author
Allen T , author
Altfeld M , author
Date:
2012-09-01
Journal:
Retrovirology
Content:
Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
Authors:
Thobakgale CF , author
Streeck H , author
Mkhwanazi N , author
Mncube Z , author
Maphumulo L , author
Chonco F , author
Prendergast A , author
Tudor-Williams G , author
Walker BD , author
Goulder PJ , author
Altfeld M , author
Ndung'u T , author
Date:
2011-03-01
Journal:
AIDS research and human retroviruses
Content:
Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.
Authors:
Naidoo VL , author
Mann JK , author
Noble C , author
Adland E , author
Carlson JM , author
Thomas J , author
Brumme CJ , author
Thobakgale-Tshabalala CF , author
Brumme ZL , author
Brockman MA , author
Goulder PJR , author
Ndung'u T , author
Date:
2017-08-01
Journal:
Journal of virology
Content:
Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.
Authors:
Adland E , author
Paioni P , author
Thobakgale C , author
Laker L , author
Mori L , author
Muenchhoff M , author
Csala A , author
Clapson M , author
Flynn J , author
Novelli V , author
Hurst J , author
Naidoo V , author
Shapiro R , author
Huang KH , author
Goulder PJ , author
Date:
2015-06-01
Journal:
PLoS pathogens
Content:
P07-02. Cytotoxic T lymphocyte-mediated immune responses in HIV-1 clade C infected mother-child pairs.
Authors:
Moodley E , author
Thobakgale C , author
Ramkalawon P , author
Vanderstok M , author
Mncube Z , author
Bishop K , author
Reddy S , author
Chonco F , author
Walker B , author
Goulder P , author
Ndung'u T , author
Date:
2009-10-01
Journal:
Retrovirology
Content:
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
Authors:
Martinez-Picado J , author
Prado JG , author
Fry EE , author
Pfafferott K , author
Leslie A , author
Chetty S , author
Thobakgale C , author
Honeyborne I , author
Crawford H , author
Matthews P , author
Pillay T , author
Rousseau C , author
Goulder P , author
Date:
2006-04-01
Journal:
Journal of virology
Content:
Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection.
Authors:
Thobakgale CF , author
Prendergast A , author
Crawford H , author
Mkhwanazi N , author
Ramduth D , author
Reddy S , author
Molina C , author
Mncube Z , author
Leslie A , author
Prado J , author
Chonco F , author
Mphatshwe W , author
Goulder PJ , author
Date:
2015-07-01
Journal:
Journal of virology
Content:
Oral abstracts of the 21st International AIDS Conference 18-22 July 2016, Durban, South Africa.
Authors:
Date:
2016-07-01
Journal:
Journal of the International AIDS Society
Content:
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Authors:
Kiepiela P , author
Ngumbela K , author
Thobakgale C , author
Ramduth D , author
Honeyborne I , author
Moodley E , author
Reddy S , author
de Pierres C , author
Mncube Z , author
Mkhwanazi N , author
Bishop K , author
van der Stok M , author
Goulder P , author
Date:
2006-12-01
Journal:
Nature medicine
Content:

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