EDCTP Alumni Network

Swaib A. Lule , author
Harriet Mpairwe , author
Margaret Nampijja , author
Florence Akello , author
Joyce Kabagenyi , author
Benigna Namara , author
Gyaviira Nkurunungi , author
Dennison Kizito , author
Joseph Kahwa , author
Lawrence Muhangi , author
Stephen Nash , author
Moses Muwanga , author
Emily L. Webb , author
Alison M. Elliott , author

2017-03-01

Pediatric Allergy and Immunology

DOI: 10.1111/pai.12719

Gyaviira Nkurunungi , author
Jimreeves E. Lutangira , author
Swaib A. Lule , author
Hellen Akurut , author
Robert Kizindo , author
Joseph R. Fitchett , author
Dennison Kizito , author
Ismail Sebina , author
Lawrence Muhangi , author
Emily L. Webb , author
Stephen Cose , author
Alison M. Elliott , author
Madhukar Pai , editor

2012-10-01

PLoS ONE

DOI: 10.1371/journal.pone.0047340

Patrice Akusa Mawa , author
Emily L. Webb , author
Abdelali Filali-Mouhim , author
Gyaviira Nkurunungi , author
Rafick-Pierre Sekaly , author
Swaib Abubaker Lule , author
Sarah Prentice , author
Stephen Nash , author
Hazel M. Dockrell , author
Alison M. Elliott , author
Stephen Cose , author

2017-01-01

Vaccine

DOI: 10.1016/j.vaccine.2016.11.079

Jan Pieter Koopman , author
Moses Egesa , author
Anne Wajja , author
Moses Adriko , author
Jacent Nassuuna , author
Gyaviira Nkurunungi , author
Emmanuella Driciru , author
Gijsbert van Willigen , author
Stephen Cose , author
Maria Yazdanbakhsh , author
Pontiano Kaleebu , author
Narcis Kabatereine , author
Edridah Tukahebwa , author
Meta Roestenberg , author
Alison M. Elliott , author

2019-08-01

AAS Open Research

DOI: 10.12688/aasopenres.12972.2
Part of ISSN: 2515-9321

Nampijja, M.
Webb, E.L.
Kaweesa, J.
Kizindo, R.
Namutebi, M.
Nakazibwe, E.
Oduru, G.
Kabuubi, P.
Kabagenyi, J.
Kizito, D.
Muhangi, L.
Akello, M.
Verweij, J.J.
Nerima, B.
Tukahebwa, E.
Elliott, A.M.
Sanya, R.
Mirembe, B.
Okello, J.
Levin, J.
Zziwa, C.
Tumusiime, J.
Sewankambo, M.
Nsubuga, D.
Niwagaba, E.
Kabwami, G.
Abayo, E.
Nkurunungi, G.
Muwonge, F.
Abiriga, D.
Nannozi, V.

2015-01-01

Trials

DOI: 10.1186/s13063-015-0702-5
EID: 2-s2.0-84928567190

Gyaviira Nkurunungi , author
Ludoviko Zirimenya , author
Jacent Nassuuna , author
Agnes Natukunda , author
Prossy N Kabuubi , author
Emmanuel Niwagaba , author
Gloria Oduru , author
Grace Kabami , author
Rebecca Amongin , author
Alex Mutebe , author
Milly Namutebi , author
Christopher Zziwa , author
Susan Amongi , author
Caroline Ninsiima , author
Caroline Onen , author
Florence Akello , author
Moses Sewankambo , author
Samuel Kiwanuka , author
Robert Kizindo , author
James Kaweesa , author
Stephen Cose , author
Emily Webb , author
Alison M Elliott , author

2021-02-01

BMJ Open

DOI: 10.1136/bmjopen-2020-040426

Richard E. Sanya , author
Gyaviira Nkurunungi , author
Irene Andia Biraro , author
Harriet Mpairwe , author
Alison M. Elliott , author

2017-03-01

Transactions of The Royal Society of Tropical Medicine and Hygiene

DOI: 10.1093/trstmh/trx010

Gyaviira Nkurunungi , author
Lawrence Lubyayi , author
Serge A Versteeg , author
Richard E Sanya , author
Jacent Nassuuna , author
Joyce Kabagenyi , author
Prossy N Kabuubi , author
Josephine Tumusiime , author
Christopher Zziwa , author
Robert Kizindo , author
Emmanuel Niwagaba , author
Carol Nanyunja , author
Margaret Nampijja , author
Harriet Mpairwe , author
Maria Yazdanbakhsh , author
Ronald van Ree , author
Emily L Webb , author
Alison M Elliott , author

2019-01-11

Clinical & Experimental Allergy

DOI: 10.1111/cea.13335
Part of ISSN: 0954-7894

Gyaviira Nkurunungi , author
Joyce Kabagenyi , author
Margaret Nampijja , author
Richard E Sanya , author
Bridgious Walusimbi , author
Jacent Nassuuna , author
Emily L Webb , author
Alison M Elliott , author
The LaVIISWA study team , author

2017-11-01

Parasite Immunology

DOI: 10.1111/pim.12506
Part of ISSN: 0141-9838

Benigna Namara , author
Stephen Nash , author
Swaib A Lule , author
Hellen Akurut , author
Harriet Mpairwe , author
Florence Akello , author
Josephine Tumusiime , author
Moses Kizza , author
Joyce Kabagenyi , author
Gyaviira Nkurunungi , author
Lawrence Muhangi , author
Emily L. Webb , author
Moses Muwanga , author
Alison M. Elliott , author

2017-09-11

Pediatric Allergy and Immunology

DOI: 10.1111/pai.12804

Gyaviira Nkurunungi , author
Angela van Diepen , author
Jacent Nassuuna , author
Richard E. Sanya , author
Margaret Nampijja , author
Irene Nambuya , author
Joyce Kabagenyi , author
Sonia Serna , author
Niels-Christian Reichardt , author
Ronald van Ree , author
Emily L. Webb , author
Alison M. Elliott , author
Maria Yazdanbakhsh , author
Cornelis H. Hokke , author

2019-12-01

Scientific Reports

DOI: 10.1038/s41598-019-40009-7

Jan Pieter Koopman , author
Moses Egesa , author
Anne Wajja , author
Moses Adriko , author
Jacent Nassuuna , author
Gyaviira Nkurunungi , author
Emmanuella Driciru , author
Gijsbert van Willigen , author
Stephen Cose , author
Maria Yazdanbakhsh , author
Pontiano Kaleebu , author
Narcis Kabatereine , author
Edridah Tukahebwa , author
Meta Roestenberg , author
Alison M. Elliott , author

2019-06-03

AAS Open Research

DOI: 10.12688/aasopenres.12972.1

Sanya, R.E.
Muhangi, L.
Nampijja, M.
Nannozi, V.
Nakawungu, P.K.
Abayo, E.
Webb, E.L.
Elliott, A.M.
Sanya, R.
Nerima, B.
Webb, E.
Muhangi, L.
Mirembe, B.
Okello, J.
Levin, J.
Namutebi, M.
Zziwa, C.
Nakazibwe, E.
Tumusiime, J.
Ninsiima, C.
Kamukama, G.
Amongin, S.
Akello, M.
Kizindo, R.
Sewankambo, M.
Nsubuga, D.
Nakawungu, P.K.
Niwagaba, E.
Oduru, G.
Kabami, G.
Abayo, E.
Kabagenyi, J.
Nkurunungi, G.
Muwonge, F.
Kizito, D.
Cose, S.
Abiriga, D.
Nannozi, V.
Mbaraga, B.
Musoke, R.
George, W.
Kaweesa, J.
Tukahebwa, E.
Elliott, A.

2015-01-01

Tropical Medicine and International Health

DOI: 10.1111/tmi.12545
EID: 2-s2.0-84937641887

Harriet Mpairwe , author
Gyaviira Nkurunungi , author
Pius Tumwesige , author
Hellen Akurut , author
Milly Namutebi , author
Irene Nambuya , author
Marble Nnaluwooza , author
Barbara Apule , author
Caroline Onen , author
Tonny Katongole , author
Emmanuel Niwagaba , author
Mike Mukasa , author
Emily L. Webb , author
Alison M. Elliott , author
Neil Pearce , author

2021-01-08

Clinical & Experimental Allergy

DOI: 10.1111/cea.13769

Gyaviira Nkurunungi , author
Harriet Mpairwe , author
Serge A. Versteeg , author
Angela Diepen , author
Jacent Nassuuna , author
Joyce Kabagenyi , author
Irene Nambuya , author
Richard E. Sanya , author
Margaret Nampijja , author
Sonia Serna , author
Niels‐Christian Reichardt , author
Cornelis H. Hokke , author
Emily L. Webb , author
Ronald Ree , author
Maria Yazdanbakhsh , author
Alison M. Elliott , author

2021-01-08

Allergy

DOI: 10.1111/all.14469

Joyce Kabagenyi , author
Agnes Natukunda , author
Jacent Nassuuna , author
Richard E. Sanya , author
Margaret Nampijja , author
Emily L. Webb , author
Alison M. Elliott , author
Gyaviira Nkurunungi , author

2020-05-01

Parasitology International

DOI: 10.1016/j.parint.2020.102132
Part of ISSN: 1383-5769

2021-02-16

BMJ open

Introduction

Vaccine-specific immune responses vary between populations and are often impaired in low income, rural settings. Drivers of these differences are not fully elucidated, hampering identification of strategies for optimising vaccine effectiveness. We hypothesise that urban-rural (and regional and international) differences in vaccine responses are mediated to an important extent by differential exposure to chronic infections, particularly parasitic infections.

Methods and analysis

Three related trials sharing core elements of study design and procedures (allowing comparison of outcomes across the trials) will test the effects of (1) individually randomised intervention against schistosomiasis (trial A) and malaria (trial B), and (2) Bacillus Calmette-Guérin (BCG) revaccination (trial C), on a common set of vaccine responses. We will enrol adolescents from Ugandan schools in rural high-schistosomiasis (trial A) and rural high-malaria (trial B) settings and from an established urban birth cohort (trial C). All participants will receive BCG on day '0'; yellow fever, oral typhoid and human papilloma virus (HPV) vaccines at week 4; and HPV and tetanus/diphtheria booster vaccine at week 28. Primary outcomes are BCG-specific IFN-γ responses (8 weeks after BCG) and for other vaccines, antibody responses to key vaccine antigens at 4 weeks after immunisation. Secondary analyses will determine effects of interventions on correlates of protective immunity, vaccine response waning, priming versus boosting immunisations, and parasite infection status and intensity. Overarching analyses will compare outcomes between the three trial settings. Sample archives will offer opportunities for exploratory evaluation of the role of immunological and 'trans-kingdom' mediators in parasite modulation of vaccine-specific responses.

Ethics and dissemination

Ethics approval has been obtained from relevant Ugandan and UK ethics committees. Results will be shared with Uganda Ministry of Health, relevant district councils, community leaders and study participants. Further dissemination will be done through conference proceedings and publications.

Trial registration numbers

ISRCTN60517191, ISRCTN62041885, ISRCTN10482904.

PMID: 33593767
DOI: 10.1136/bmjopen-2020-040425

Swaib Abubaker Lule , author
Patrice A. Mawa , author
Gyaviira Nkurunungi , author
Margaret Nampijja , author
Dennison Kizito , author
Florence Akello , author
Lawrence Muhangi , author
Alison M. Elliott , author
Emily L. Webb , author

2015-02-01

Vaccine

DOI: 10.1016/j.vaccine.2014.12.015

Richard E Sanya , author
Gyaviira Nkurunungi , author
Remy Hoek Spaans , author
Margaret Nampijja , author
Geraldine O’Hara , author
Robert Kizindo , author
Gloria Oduru , author
Prossy Kabuubi Nakawungu , author
Emmanuel Niwagaba , author
Elson Abayo , author
Joyce Kabagenyi , author
Christopher Zziwa , author
Esther Nakazibwe , author
Josephine Tumusiime , author
James Kaweesa , author
Fred Muwonge Kakooza , author
Mirriam Akello , author
Lawrence Lubyayi , author
Jaco Verweij , author
Stephen Nash , author
Ronald van Ree , author
Harriet Mpairwe , author
Edridah Tukahebwa , author
Emily L Webb , author
Alison M Elliott , author
LaVIISWA trial team , author

2018-09-08

Clinical Infectious Diseases

DOI: 10.1093/cid/ciy761
Part of ISSN: 1058-4838

Agnes Natukunda , author
Gyaviira Nkurunungi , author
Ludoviko Zirimenya , author
Jacent Nassuuna , author
Gloria Oduru , author
Rebecca Amongin , author
Prossy N Kabuubi , author
Alex Mutebe , author
Caroline Onen , author
Susan Amongi , author
Esther Nakazibwe , author
Florence Akello , author
Samuel Kiwanuka , author
Fred Kiwudhu , author
Moses Sewankambo , author
Denis Nsubuga , author
Robert Kizindo , author
Sarah G Staedke , author
Stephen Cose , author
Emily Webb , author
Alison M Elliott , author

2020-12-01

BMJ Open

DOI: 10.1136/bmjopen-2020-040427

Emily L. Webb , author
Margaret Nampijja , author
James Kaweesa , author
Robert Kizindo , author
Milly Namutebi , author
Esther Nakazibwe , author
Gloria Oduru , author
Proscovia Kabubi , author
Joyce Kabagenyi , author
Gyaviira Nkurunungi , author
Dennison Kizito , author
Lawrence Muhangi , author
Mirriam Akello , author
Jaco J. Verweij , author
Barbara Nerima , author
Edridah Tukahebwa , author
Alison M. Elliott , author
The LaVIISWA trial team , author

2016-02-01

Allergy

DOI: 10.1111/all.12867

Gyaviira Nkurunungi , author
Jacent Nassuuna , author
Harriet Mpairwe , author
Joyce Kabagenyi , author
Margaret Nampijja , author
Richard E. Sanya , author
Emily L. Webb , author
Alison M. Elliott , author

2021-05-05

Clinical & Experimental Allergy

DOI: 10.1111/cea.13834

Harriet Mpairwe , author
Milly Namutebi , author
Gyaviira Nkurunungi , author
Pius Tumwesige , author
Irene Nambuya , author
Mike Mukasa , author
Caroline Onen , author
Marble Nnaluwooza , author
Barbara Apule , author
Tonny Katongole , author
Gloria Oduru , author
Joseph Kahwa , author
Emily L Webb , author
Lawrence Lubyayi , author
Neil Pearce , author
Alison M Elliott , author

2019-11-15

eLife

DOI: 10.7554/eLife.49496

Lawrence Lubyayi , author
Harriet Mpairwe , author
Gyaviira Nkurunungi , author
Swaib A Lule , author
Angela Nalwoga , author
Emily L Webb , author
Jonathan Levin , author
Alison M Elliott , author

2021-09-22

eLife

DOI: 10.7554/eLife.66022

Angela Nalwoga , author
David Joseph Diemert , editor
Emily L. Webb , author
Belinda Chihota , author
Wendell Miley , author
Bridgious Walusimbi , author
Jacent Nassuuna , author
Richard E. Sanya , author
Gyaviira Nkurunungi , author
Nazzarena Labo , author
Alison M. Elliott , author
Stephen Cose , author
Denise Whitby , author
Robert Newton , author

2019-10-16

PLOS Neglected Tropical Diseases

DOI: 10.1371/journal.pntd.0007776

P. A. Mawa , author
G. Nkurunungi , author
M. Egesa , author
E. L. Webb , author
S. G. Smith , author
R. Kizindo , author
M. Akello , author
S. A. Lule , author
M. Muwanga , author
H. M. Dockrell , author
S. Cose , author
A. M. Elliott , author

2015-05-11

Philosophical Transactions of the Royal Society B: Biological Sciences

DOI: 10.1098/rstb.2014.0137

2021-02-16

BMJ open

Introduction

There is evidence that BCG immunisation may protect against unrelated infectious illnesses. This has led to the postulation that administering BCG before unrelated vaccines may enhance responses to these vaccines. This might also model effects of BCG on unrelated infections.

Methods and analysis

To test this hypothesis, we have designed a randomised controlled trial of BCG versus no BCG immunisation to determine the effect of BCG on subsequent unrelated vaccines, among 300 adolescents (aged 13-17 years) from a Ugandan birth cohort. Our schedule will comprise three main immunisation days (week 0, week 4 and week 28): BCG (or no BCG) revaccination at week 0; yellow fever (YF-17D), oral typhoid (Ty21a) and human papillomavirus (HPV) prime at week 4; and HPV boost and tetanus/diphtheria (Td) boost at week 28. Primary outcomes are anti-YF-17D neutralising antibody titres, Salmonella typhi lipopolysaccharide-specific IgG concentration, IgG specific for L1-proteins of HPV-16/HPV-18 and tetanus and diphtheria toxoid-specific IgG concentration, all assessed at 4 weeks after immunisation with YF, Ty21a, HPV and Td, respectively. Secondary analyses will determine effects on correlates of protective immunity (where recognised correlates exist), on vaccine response waning and on whether there are differential effects on priming versus boosting immunisations. We will also conduct exploratory immunology assays among subsets of participants to further characterise effects of BCG revaccination on vaccine responses. Further analyses will assess which life course exposures influence vaccine responses in adolescence.

Ethics and dissemination

Ethics approval has been obtained from relevant Ugandan and UK ethics committees. Results will be shared with Uganda Ministry of Health, relevant district councils, community leaders and study participants. Further dissemination will be done through conference proceedings and publications.

Trial registration number

ISRCTN10482904.

PMID: 33593770
DOI: 10.1136/bmjopen-2020-040430