Dr Marieke van der Zalm
| Call | Career Development Fellowship (CDF) |
| Programme | EDCTP2 |
| Start Date | 2017-07-01 |
| End Date | 2020-06-30 |
| Project Code | TMA2015CDF1012 |
| Status | Active |
Title
The impact of pulmonary tuberculosis and other lower respiratory tract pathogens on lung function in young South African children
Objectives
To investigate the effect of TB, TB/ HIV co-infection and other common respiratory pathogens on lung function in young children.
Host Organisation
| Institution | Country |
|---|---|
| Stellenbosch University (SU) | South Africa |
Study Design
Prospective observational cohort study of children with suspected pulmonary TB including healthy controls
Sites
| Desmond Tutu TB Center Stellenbosch University, South Africa |
Phd Study
| Title | University | Start Date | End Date |
|---|---|---|---|
| the role of respiratory viruses in respiratory illnesses early in life | University of Utrecht, the Netherlands | 2005-08-01 | 2010-12-05 |
Students Supervised
| Type | Name | Title | University | Start Date | End Date |
|---|---|---|---|---|---|
| MSc | Bianca Hamman | University of Stellenbosch | 2017 | 2020 | |
| BSc | Ruan Swanenpoel | Central University of Technology | 2018 | 2019 | |
| PhD | Michaile Anthony | University of Stellenbosch | 01-01-2021 | 31-12-2024 | |
| MSc | Ingrid Courtney | University of Stellenbosch | 01-07-2020 | 31-12-2021 |
Results & Outcomes
In progress- data expected to come out July 2020
Publications
| doi: 10.1016/S1473-3099(19)30564-X. |
| doi: 10.5588/ijtld.19.0115. |
| doi: 10.1097/INF.0000000000002240. |
| doi: 10.1128/JCM.00781-18. |
| doi: 10.1128/JCM.00056-18. |
| doi: 10.1186/s13063-018-2608-5. |
| doi: 10.1093/cid/cix834. |
| DOI: 10.1093/cid/ciab018 |
| DOI: 10.1186/s12879-020-05653-9 |
| in press |
| DOI: 10.1093/cid/ciaa1666 |
| DOI: 10.1159/000512531 |
| DOI: 10.1080/17476348.2021.1828069 |
| doi: 10.1097/INF.0000000000002900 |
| doi:10.1002/ppul.25015 |
| DOI: 10.1136/bmjgh-2020-002844 |
| DOI: 10.5588/ijtld.20.0067 |
| doi: 10.2196/19154. |
| DOI: 10.1093/cid/ciab142 |
Current Organisation
Stellenbosch University, Desmond Tutu TB Centre
Current Job Title
Clinical researcher
Awards
| 2018 | South African MRC Researcher Initiated grant |
| 2019 | Subcontract of NIH award for Influenza study |
| 2020 | NIH R01 |
| 2020 | NIH K43 |
| 2020 | Stellenbosch University SEED funding |
Students Supervised
| Type | Name | Title | University | Start Date | End Date |
|---|---|---|---|---|---|
| Masters | Bianca Hamman | Stellenbosch University | 2017 | 2020 | |
| Bachelor Technology | Ruan Swanenpoel | Central University of Technology | 2018 | 2019 | |
| Masters | Ingrid Courtney | Stellenbosch University | 2020 | 2021 | |
| PhD | Michaile Anthony | Stellenbosch University | 2020 | 2024 |
Memberships
| Role | Committee/board | Start Date | End Date |
|---|---|---|---|
| Paediatric advisor | National TB think tank, South Africa | 2019 | |
| Member | Post TB working group, Union | 2019 | |
| Member | Child and adolescent TB working group, WHO | 2018 |
Education
| Institution | Degree | Year |
|---|---|---|
| University of Utrecht, Netherlands | MD | 2005-08-01 |
| University Of Utrecht, Netherlands | MSc epidemiology | 2009-10-01 |
| University Of Utrecht, Netherlands | PhD | 2009-12-05 |
Areas Of Specialisation
Tuberculosis (TB) Lower Respiratory Tract Infections (LRTIs)
Grants
Grant Code:
OPP1212276
Source of funding:
Bill and Melinda Gates Foundation
Amount:
199948
Role:
Researcher
Start Date:
2019-01-01
End Date:
2020-01-01
Grant Code:
Subcontract to NIH (through University of the Western Cape)
Source of funding:
NIH
Amount:
100000
Role:
Principal Investigator
Start Date:
2019-01-01
End Date:
2021-01-01
Grant Code:
Subaward to 1R25TW011217-01
Source of funding:
NIH
Amount:
5000
Role:
Researcher
Start Date:
2020-01-01
End Date:
2021-01-01
Grant Code:
552767
Source of funding:
South African Medical Research Council
Amount:
38500
Role:
Principal Investigator
Start Date:
2018-01-01
End Date:
2021-01-01
Grant Code:
K43TW011028
Source of funding:
NIH
Amount:
550000
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2025-01-01
Grant Code:
None- Stellenbosch University SEED funding
Source of funding:
Stellenbosch University
Amount:
6000
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2021-01-01
Grant Code:
1R01AI152158-01
Source of funding:
NIH
Amount:
1400000
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2025-01-01
Publications
Authors:
Date:
2016-01-01
Journal:
Pediatric Infectious Disease Journal
Content:
Authors:
James A Seddon
Date:
2021-02-25
Journal:
Lancet Infectious Diseases
Content:
Background People who survive tuberculosis face clinical and societal consequences after recovery, including increased risks of recurrent tuberculosis, premature death, reduced lung function, and ongoing stigma. To describe the size of this issue, we aimed to estimate the number of individuals who developed first-episode tuberculosis between 1980 and 2019, the number who survived to 2020, and the number who have been treated within the past 5 years or 2 years.
Methods In this modelling study, we estimated the number of people who survived treated tuberculosis using country-level WHO data on tuberculosis case notifications, excluding those who died during treatment. We estimated the number of individuals surviving untreated tuberculosis using the difference between WHO country-level incidence estimates and notifications, applying published age-stratified and HIV-stratified case fatality ratios. To estimate survival with time, post-tuberculosis life tables were developed for each country-year by use of UN World Population Prospects 2019 mortality rates and published post-tuberculosis mortality hazard ratios.
Findings Between 1980 and 2019, we estimate that 363 million people (95% uncertainty interval [UI] 287 million–438 million) developed tuberculosis, of whom 172 million (169 million–174 million) were treated. Individuals who developed tuberculosis between 1980 and 2019 had lived 3480 million life-years (95% UI 3040 million–3920 million) after tuberculosis by 2020, with survivors younger than 15 years at the time of tuberculosis development contributing 12% (95% UI 7–17) of these life-years. We estimate that 155 million tuberculosis survivors (95% UI 138 million–171 million) were alive in 2020, the largest proportion (47% [37–57]) of whom were in the WHO South-East Asia region. Of the tuberculosis survivors who were alive in 2020, we estimate that 18% (95% UI 16–20) were treated in the past 5 years and 8% (7–9) were treated in the past 2 years.
Interpretation The number of tuberculosis survivors alive in 2020 is more than ten times the estimated annual tuberculosis incidence. Interventions to alleviate respiratory morbidity, screen for and prevent recurrent tuberculosis, and reduce stigma should be immediately prioritised for recently treated tuberculosis survivors.
Authors:
Date:
2018-01-01
Journal:
Journal of Clinical Microbiology
Content:
Authors:
Date:
2007-01-01
Journal:
Hypertension
Content:
Authors:
Date:
2008-01-01
Journal:
Emerging Infectious Diseases
Content:
Authors:
Date:
2009-01-01
Journal:
Journal of Pediatrics
Content:
Authors:
Date:
2021-01-05
Journal:
Respiration
Content:
Authors:
Date:
2021-01-15
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Authors:
Date:
2021-02-01
Journal:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Content:
Authors:
Date:
2021-03-01
Journal:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Content:
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Date:
2018-02-01
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
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Date:
2018-01-01
Journal:
Trials
Content:
Authors:
Date:
2021-02-01
Journal:
Expert Review of Respiratory Medicine
Content:
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Date:
2007-01-01
Journal:
Medical Care
Content:
Authors:
Date:
2020-09-07
Journal:
The Pediatric infectious disease journal
Content:
Authors:
Date:
2005-01-01
Journal:
Journal of Cystic Fibrosis
Content:
Authors:
Date:
2008-01-01
Journal:
Pediatrics
Content:
Authors:
Date:
2021-02-13
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Authors:
Date:
2013-01-01
Journal:
Pediatric Infectious Disease Journal
Content:
Authors:
Date:
2017-01-01
Journal:
Pediatric Infectious Disease Journal
Content:
Authors:
Date:
2018-01-01
Journal:
Journal of Clinical Microbiology
Content:
Authors:
Date:
2021-04-05
Journal:
Pediatric pulmonology
Content:
Authors:
Date:
2020-11-10
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Authors:
Date:
2021-03-10
Journal:
The Lancet. Global health
Content:
Authors:
Date:
2010-01-01
Journal:
Current Respiratory Medicine Reviews
Content:
Authors:
Date:
2019-01-01
Journal:
The Lancet Infectious Diseases
Content:
Authors:
Date:
2020-08-01
Journal:
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Content:
Authors:
Date:
2006-01-01
Journal:
Journal of Allergy and Clinical Immunology
Content:
Authors:
Date:
2011-01-01
Journal:
Journal of Clinical Virology
Content:
Authors:
Date:
2019-01-01
Journal:
Pediatric Infectious Disease Journal
Content:
Authors:
Date:
2017-01-01
Journal:
Journal of Clinical Microbiology
Content:
Authors:
Date:
2021-02-25
Journal:
The Lancet. Infectious diseases
Content:
Authors:
Date:
2020-12-04
Journal:
BMC infectious diseases
Content:
Authors:
Date:
2017-01-01
Journal:
Pediatric Infectious Disease Journal
Content:
Authors:
Date:
2020-11-11
Journal:
JMIR mHealth and uHealth
Content:
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Date:
2009-01-01
Journal:
Pharmacoepidemiology and Drug Safety
Content:
Authors:
Date:
2011-01-01
Journal:
American Journal of Respiratory and Critical Care Medicine
Content:
Authors:
Date:
2019-01-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content:
Authors:
Date:
2015-01-01
Journal:
Human Mutation
Content:
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Date:
2020-01-01
Journal:
BMJ Global Health
Content:
Authors:
Date:
2020-08-07
Journal:
Pediatric pulmonology
Content:
Authors:
Date:
2009-01-01
Journal:
Pediatric Infectious Disease Journal
Content:
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