Call | Senior Fellowship Plus (SFP) |
Programme | EDCTP2 |
Start Date | 2021-01-01 |
End Date | 2025-12-31 |
Project Code | TMA2019SFP2836 |
Status | Active |
The long-term consequences of pulmonary tuberculosis and respiratory viruses on lung health in young South African children
The overarching goal of the TB-lung FACT2 project is to improve our current understanding of the long-term impact of PTB and other LRTIs on lung health in children living in resource-limited settings.
Institution | Country |
---|---|
Stellenbosch University | South Africa |
Prospective observational cohort study
Mozambique, Manhica |
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
PhD | Michaile Anthony | Stellenbosch University, South Africa | 2021 | ||
MSc | Ingrid Courtney | Stellenbosch University, South Africa | 2021 | ||
MSc | Ruan Swanenpoel | Central University of Technology, South Africa | 2022 |
Call | Career Development Fellowship (CDF) |
Programme | EDCTP2 |
Start Date | 2017-07-01 |
End Date | 2020-12-31 |
Project Code | TMA2015CDF1012 |
Status | Completed |
The impact of pulmonary tuberculosis and other lower respiratory tract pathogens on lung function in young South African children
To investigate the effect of TB, TB/ HIV co-infection and other common respiratory pathogens on lung function in young children.
Institution | Country |
---|---|
Stellenbosch University (SU) | South Africa |
Prospective observational cohort study of children with suspected pulmonary TB including healthy controls
Desmond Tutu TB Center Stellenbosch University, South Africa |
Title | University | Start Date | End Date |
---|---|---|---|
the role of respiratory viruses in respiratory illnesses early in life | University of Utrecht, the Netherlands | 2005-08-01 | 2010-12-05 |
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
MSc | Bianca Hamman | University of Stellenbosch | 2017 | 2020 | |
BSc | Ruan Swanenpoel | Central University of Technology | 2018 | 2019 | |
PhD | Michaile Anthony | University of Stellenbosch | 01-01-2021 | 31-12-2024 | |
MSc | Ingrid Courtney | University of Stellenbosch | 01-07-2020 | 31-12-2021 |
In progress- data expected to come out July 2020
doi: 10.1016/S1473-3099(19)30564-X. |
doi: 10.5588/ijtld.19.0115. |
doi: 10.1097/INF.0000000000002240. |
doi: 10.1128/JCM.00781-18. |
doi: 10.1128/JCM.00056-18. |
doi: 10.1186/s13063-018-2608-5. |
doi: 10.1093/cid/cix834. |
DOI: 10.1093/cid/ciab018 |
DOI: 10.1186/s12879-020-05653-9 |
in press |
DOI: 10.1093/cid/ciaa1666 |
DOI: 10.1159/000512531 |
DOI: 10.1080/17476348.2021.1828069 |
doi: 10.1097/INF.0000000000002900 |
doi:10.1002/ppul.25015 |
DOI: 10.1136/bmjgh-2020-002844 |
DOI: 10.5588/ijtld.20.0067 |
doi: 10.2196/19154. |
DOI: 10.1093/cid/ciab142 |
Stellenbosch University, Desmond Tutu TB Centre
Paediatrician and Clinical researcher
2018 | South African MRC Researcher Initiated grant |
2019 | Subcontract of NIH award for Influenza study |
2020 | NIH R01: Multiplexed Antigen-Specific Antibody Fc Profiling on a Chip for Point-of-Care Diagnosis of TB in HIV-infected Children |
2020 | NIH K43 Emerging Global leader award |
2020 | Stellenbosch University SEED funding for COVID-kids South Africa |
2021 | NIH R21/ R33: Development and implementation of pediatric mobile phone reflectance pulse oximeters and a hypoxemia surveillance system in South Africa |
2021 | Horizon Europe- co-investigator on VERDI- project |
2022 | South African MRC Researcher Initiated grant: The long-term consequences of SARS-CoV-2 on lung health in young South African children |
2021 | Subcontract of NIH award for Influenza/ SARS-CoV-2 study |
2021 | Administrative supplement NIH-K43 for SARS-CoV-2 work |
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
Masters | Bianca Hamman | Stellenbosch University | 2017 | 2020 | |
Bachelor Technology | Ruan Swanenpoel | Central University of Technology | 2018 | 2019 | |
Masters | Ingrid Courtney | Stellenbosch University | 2020 | 2022 | |
PhD | Michaile Anthony | Stellenbosch University | 2020 | 2024 |
Role | Committee/board | Start Date | End Date |
---|---|---|---|
Paediatric advisor | National TB think tank, South Africa | 2019 | |
Member | Post TB working group, Union | 2019 | |
Member | Child and adolescent TB working group, WHO | 2018 |
Institution | Degree | Year |
---|---|---|
University of Utrecht, Netherlands | MD | 2005-08-01 |
University Of Utrecht, Netherlands | MSc epidemiology | 2009-10-01 |
University Of Utrecht, Netherlands | PhD | 2009-12-05 |
Tuberculosis (TB) Lower Respiratory Tract Infections (LRTIs)
Background People who survive tuberculosis face clinical and societal consequences after recovery, including increased risks of recurrent tuberculosis, premature death, reduced lung function, and ongoing stigma. To describe the size of this issue, we aimed to estimate the number of individuals who developed first-episode tuberculosis between 1980 and 2019, the number who survived to 2020, and the number who have been treated within the past 5 years or 2 years.
Methods In this modelling study, we estimated the number of people who survived treated tuberculosis using country-level WHO data on tuberculosis case notifications, excluding those who died during treatment. We estimated the number of individuals surviving untreated tuberculosis using the difference between WHO country-level incidence estimates and notifications, applying published age-stratified and HIV-stratified case fatality ratios. To estimate survival with time, post-tuberculosis life tables were developed for each country-year by use of UN World Population Prospects 2019 mortality rates and published post-tuberculosis mortality hazard ratios.
Findings Between 1980 and 2019, we estimate that 363 million people (95% uncertainty interval [UI] 287 million–438 million) developed tuberculosis, of whom 172 million (169 million–174 million) were treated. Individuals who developed tuberculosis between 1980 and 2019 had lived 3480 million life-years (95% UI 3040 million–3920 million) after tuberculosis by 2020, with survivors younger than 15 years at the time of tuberculosis development contributing 12% (95% UI 7–17) of these life-years. We estimate that 155 million tuberculosis survivors (95% UI 138 million–171 million) were alive in 2020, the largest proportion (47% [37–57]) of whom were in the WHO South-East Asia region. Of the tuberculosis survivors who were alive in 2020, we estimate that 18% (95% UI 16–20) were treated in the past 5 years and 8% (7–9) were treated in the past 2 years.
Interpretation The number of tuberculosis survivors alive in 2020 is more than ten times the estimated annual tuberculosis incidence. Interventions to alleviate respiratory morbidity, screen for and prevent recurrent tuberculosis, and reduce stigma should be immediately prioritised for recently treated tuberculosis survivors.