EDCTP Alumni Network

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All Profiles

Dr Dawit Wolday

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2018-07-01
End Date 2023-06-30
Project Code TMA2016SF1437
Status Active

Title

Evaluation of the LAMP & db-PCR-NALFIA for the Diagnosis and/or as Test-of-Cure in Patients with Visceral Leishmaniasis in Ethiopia

Host Organisation

Institution Country
Mekelle University Ethiopia

Participants

Name Institution Country
Prof. Henk Schallig Academic Medical Center, University of Amsterdam Netherlands
Dr Yazezew Kebede Mekelle University Ethiopia
Dr Mahmud Abdelkader Mekelle University Ethiopia

Sites

Mekelle University
Academic Medical Center - Amsterdam University
University of Bologna

Students Supervised

Type Name Title University Start Date End Date
PhD Dawit Gebreegzabher Mr. Amsterdam University/Mekelle University 01/08/2018 30/07/2022
MSc Etsay Negus Mr. Mekelle University 15/06/2019 30/03/2021
PhD Getahun Kahsay Mr. University of Bologna/Mekelle University 01/08/2020 01/08/2024
PhD Teklay Cherkos Mr. Mekelle University 15/07/2020 30/12/2023

Current Organisation

Mekelle University College of Health Sciences (MUCHS)

Current Job Title

Associate Prof of Medicine

Students Supervised

Type Name Title University Start Date End Date
PhD Dawit Gebreegzabheer Mr. MUCHS 2018 2022
MSc Etsay Nigus Mr MUCHS 2019 2020

Memberships

Role Committee/board Start Date End Date
Scientific and Strategic Advisory Board, Member Research Networks for Health Innovation in Sub-Saharan Africa”, German Federal Ministry of Education and Research (BMBF), Bonn, Germany 2018 2022
External Examiner PhD Students University of Pretoria 2017 2020
Reviewer Parasite Immunology 2019 2020
Reviewer Journal of Infectious Diseases 2019 2019
Reviewer Lancet Public Health 2017 2017
Grant Reviewer EDCTP 2014 2018

Education

Institution Degree Year
Karolinska Institute, Sweden PhD 2000-01-17
Addis Ababa University, Ethiopia MD 1987-08-01

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV) Tuberculosis (TB) Neglected Infectious Diseases (NID)

Grants

Rapid diagnostic profiling of SARS-CoV-2 in the context of persistent immune activation in Sub-Saharan Africa – Profile-Cov Project
Grant Code:
RIA2020EF-2905
Source of funding:
European and Developing Countries Clinical Trials Partnership (EDCTP)
Amount:
499579.75
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2021-01-01

Publications

Identification and characterization of HIV positive Ethiopian elite controllers.
Authors:
Kiros YK, Elinav H, Gebreyesus A, Gebremeskel H, Azar J, Chemtob D, Abreha H, Elbirt D, Shahar E, Chowers M, Turner D, Grossman Z, Haile A, Sutton RE, Maayan SL, Wolday D.
Date:
2018-10-04
Journal:
HIV Med 2019; 20: 33-37.
Content:
External Quality Assessment on CD4+ T-Cell Count Using in-House Proficiency Testing Panels for CD4 Count Laboratories in Addis Ababa, Ethiopia.
Authors:
Date:
2019-05-01
Journal:
Ethiop J Health Sci. 2019; 29: 309-320. doi:10.4314/ejhs.v2913.3
Content:
Global and regional molecular epidemiology of HIV-1, 1990-2015: a systematic review, global survey and trend analysis.
Authors:
1. Hemelaar J, Elangovan R, Yun J, et al: WHO-UNAIDS Network for HIV isolation and characterization.
Date:
2018-11-30
Journal:
Lancet Infect Dis 2019; 19: 143-155.
Content:
HPV genotype distribution among women with normal and abnormal cervical cytology presenting in a tertiary gynecology referral clinic in Ethiopia.
Authors:
Wolday D, Derese M, Gebressellassie S, Tsegaye B, Ergete W, Gebrehiwot Y, Caplan O, Wolf DG, Maayan S.
Date:
2018-08-06
Journal:
Infectious Agents and Cancer 2018; 13: 28-35. doi:10.1186/s13027-018-0201-x.
Content:
Role of CD4/CD8 ratio on the incidence of tuberculosis in HIV-infected patients on antiretroviral therapy followed up for more than a decade.
Authors:
1. Wolday D, Kebede Y, Legesse D, Siraj DS, McBride JA, Kirsch MJ, Striker R.
Date:
2020-02-05
Journal:
PLoS One. 2020; 15: e0233049. doi: 10.1371/journal.pone.0233049
Content:

Projects

Role of CD4/CD8 ratio on the incidence of tuberculosis in HIV-infected patients on ART
Fellow:
Dawit Wolday
Collaborators:
Name Country Institution
Prof. R. Striker United States Wisconsin University
Objectives:
To determine whether the CD4/CD8 ratio was associated with development of TB in a cohort of HIV infected individuals on ART followed up for more than a decade in the setting of sub-Saharan Africa.
Sites:
Addis Ababa
Study Design:
Retrospective cohort study
Subjects:
347
Outcomes:
- No. of incident TB cases developed after initiation of ART - CD4/CD8 ratio cut-off as risk biomarker for developing TB
Start Date:
2017-01-10
End Date:
2019-12-03
Application of deep learning for the diagnosis of cervical cancer in resource-poor settings
Fellow:
Dawit Wolday
Collaborators:
Name Country Institution
Prof. Shlomo Maayan Israel Barzilai Medical Center
Prof. Ofer Israel Barzilai Medical Center
Dr. Gellila United States Univ of Illinois, Chicago
Objectives:
To evaluate deep learning technology using gynescope for the diagnosis and classification of cervical abnormality status, including cervical cancer compared to molecular HPV diagnosis
Sites:
Mekelle
Study Design:
Prospective cohort study
Subjects:
100
Outcomes:
- No. of patients correctly diagnosed with cervical cancer as assessed by gynescope deep-learning
Start Date:
2020-02-04
End Date:
2020-12-30
Rapid diagnostic profiling of SARS-CoV-2 in the context of persistent immune activation
Fellow:
Dawit Wolday
Collaborators:
Name Country Institution
Prof. Tobias Rinke de Wit Netherlands Amsterdam Institute of Global Health
Prof. Henk Schallig Netherlands Amsterdam University
Dr. Brittta Urban United Kingdom Liverpool School of Tropical Medicine
Geremew Tasew Ethiopia Ethiopian Public Health Institute
Abraham Desta Ethiopia Tigray Health research Institute
Objectives:
To evaluate the profile of the immune response of Ethiopian population and examine its relationship with the noted low CD4+ T-cell count and underlying immune activation status among participants with COVID-19 and will compare results with those residing in Europe. In addition, this project will evaluate the performance of various rapid diagnostic tests (RDTs) for SARS-CoV-2, taking into account the above-determined immune system characteristics
Sites:
Addis Ababa
Study Design:
Prospective cohort study
Subjects:
120
Outcomes:
Primary Outcomes: (1) Proportion of patients identified as Covid-19 by and monitoring virus clearance with COVID-19 using algorithm of RDTs; (2) proportion of non-Covid-19 cases identified as negative by antibody assay. Other Outcome: The proportion of Ethiopian vs. European COVID-19 patients with predominant Th1 type immune responses.
Start Date:
2020-01-07
End Date:
2021-03-06
Evaluation of the Loop-mediated Amplification assay and direct-blood PCR Nucleic Acid Lateral-Flow I
Fellow:
Dawit Wolday
Collaborators:
Name Country Institution
Prof. Henk Schallig Netherlands Academic Medical Center, University of Amsterdam
Objectives:
o To assess the use of the loop-mediated amplification assay (LAMP) as a diagnostic and/or Test-of-cure (ToC) for visceral leishmaniasis (VL) in Ethiopia and to further develop the direct-blood PCR nucleic-acid lateral-flow immune-assay (db-PCR-NALFIA) platform for VL.
Sites:
Mekelle, Tigray Regional State, Ethiopia
Study Design:
Prospective cohort study
Subjects:
500
Outcomes:
1. Primary: - No. of participants correctly diagnosed with VL by LAMP assay - No. of participants treated for VL and identified as cured by LAMP 2. Secondary: - No. of patients co-infected with HIV correctly diagnosed with Vl by LAMP - No. of participants correctly diagnosed as VL by db-PCR-NALFIA
Start Date:
2018-07-01
End Date:
2018-06-30

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