EDCTP Alumni Network

Title

Evaluating pharmacokinetic interactions between artemisinin-based therapies and rifampicin-based tuberculosis treatment in African patients

Objectives

To investigate drug interactions between antimalarial and anti TB drugs with the overall goal of developing co-treatment strategies for malaria and TB co-infection

Host Organisation

Institution	Country
Makerere University	Uganda

Participants

Name	Institution	Country
Abdulrazaq Habib	Bayero University	Nigeria
Saye Khoo	University of Liverpool	United Kingdom
Concepta Merry	University of Dublin	Ireland
Pauline Byakika-Kibwika	Makerere University	Uganda
Robert Balikuddembe	Makerere University	Uganda
Andrew Kambugu	Makerere University	Uganda
Lydia Nakiyingi	Makerere University	Uganda
Alphonse Okwera	Makerere University	Uganda
Joel Tarning	Mahidol University	Thailand

Study Design

Pharmacokinetic study

Sites

Mulago National Teaching and Referral Hospital, Kampala (Uganda)

Bayero University Kano (Nigeria)

Publications

Seden K, Khoo S, Back D, Prevatt N, Lamorde M, Byakika-Kibwika P, Mayito J,Ryan M, Merry C. Drug-drug interactions between antiretrovirals and drugs used in the management of neglected tropical diseases: important considerations in the WHO 2020 Roadmap and London Declaration on Neglected Tropical Project Porftolio Page 357 of 622 Diseases. AIDS. 2013 Mar 13;27(5):675-86.

Lamorde M, Byakika-Kibwika P, Mayito J, Nabukeera L, Ryan M, Hanpithakpong W, Lefèvre G, Back DJ, Khoo SH, Merry C. Lower artemether, dihydroartemisinin and lumefantrine concentrations during rifampicin-based tuberculosis treatment. AIDS. 2013 Mar 27;27(6):961-5.

Lamorde M, Walimbwa S, Byakika-Kibwika P, Katwere M, Mukisa L, Sempa JB, Else L, Back DJ, Khoo SH, Merry C (2015) Steady-state pharmacokinetics of rilpivirine under different meal conditions in HIV-1-infected Ugandan adults. Antimicrobial Chemotherapy; 70: 1482-1486