EDCTP Alumni Network

Title

Clinical trials in HIV/AIDS in Africa: Should they routinely control for mental health factors?

Objectives

The study aimed to answer the following questions: 1. What is the prevalence of mental health problems associated with major depressive disorders (MDD) and maladaptive coping style (MACS) among HIV-infected patients in Uganda, and what is the incidence of MDD in HIV/AIDS? 2. Do mental health problems associated with MDD and MACS significantly impact on HIV disease progression in an Ugandian socio-cultural environment including through non-adherence to ART? 3. What would be the potential impact of MDD and MACS mental health covariates on HIV disease progression on the DART trial results under a range of possible differential treatment effects in the subgroups of patients with and without psychological problems?

Host Organisation

Institution	Country
Medical Research Council Programme on AIDS/Uganda Virus Research Institute (UVRI)	Uganda

Participants

Name	Institution	Country
Heiner Grosskurth	Mwanza Intervention Trials Unit (MITU)	Tanzania, United Republic of
Jonathan Levin	Medical Research Council Programme on AIDS/Uganda Virus Research Institute (UVRI)	Uganda
Vikram Patel	London School of Hygiene and Tropical Medicine (LSHTM)	United Kingdom

Study Design

Prevalence study of mental health among clinical trials participants in HIV/AIDS

Results & Outcomes

230 subjects (Entebbe: 140; Masaka: 90) were recruited.

Publications

Kinyanda E, Hoskins S, Nakku J, Nawaz S, Patel V. Prevalence and risk factors of major depressive disorder in HIV/AIDS as seen in semi-urban Entebbe district, Uganda. BMC Psychiatry. 2011;11:205

Kinyanda E, Weiss HA, Levin J, Nakasujja N, Birabwa H, Nakku J, Mpango R, Grosskurth H, Seedat S, Araya R, Patel V. Incidence and Persistence of Major Depressive Disorder Among People Living with HIV in Uganda. AIDS Behav. 2016 Oct 8. [Epub ahead of print] PubMed PMID: 27722834.

Kinyanda E, Kuteesa M, Scholten F, Mugisha J, Baisley K, Seeley J. Risk of major depressive disorder among older persons living in HIVendemic central and southwestern Uganda. AIDS Care. 2016 Dec;28(12):1516-1521. PubMed PMID: 27263868.