||Senior Fellowship (SF)
Clinical trials in HIV/AIDS in Africa: Should they routinely control for
mental health factors?
The study aimed to answer the following questions:
1. What is the prevalence of mental health problems associated
with major depressive disorders (MDD) and maladaptive
coping style (MACS) among HIV-infected patients in Uganda,
and what is the incidence of MDD in HIV/AIDS?
2. Do mental health problems associated with MDD and MACS
significantly impact on HIV disease progression in an Ugandian
socio-cultural environment including through non-adherence
3. What would be the potential impact of MDD and MACS
mental health covariates on HIV disease progression on the
DART trial results under a range of possible differential
treatment effects in the subgroups of patients with and
without psychological problems?
|Medical Research Council Programme on AIDS/Uganda Virus Research Institute (UVRI)
||Mwanza Intervention Trials Unit (MITU)
||Tanzania, United Republic of
||Medical Research Council Programme on AIDS/Uganda Virus Research Institute (UVRI)
||London School of Hygiene and Tropical Medicine (LSHTM)
Prevalence study of mental health among clinical trials participants in
Results & Outcomes
230 subjects (Entebbe: 140; Masaka: 90) were recruited.
|Kinyanda E, Hoskins S, Nakku J, Nawaz S, Patel V. Prevalence and risk factors of major depressive disorder in HIV/AIDS as seen in semi-urban Entebbe district, Uganda. BMC Psychiatry. 2011;11:205
|Kinyanda E, Weiss HA, Levin J, Nakasujja N, Birabwa H, Nakku J, Mpango R, Grosskurth H, Seedat S, Araya R, Patel V. Incidence and Persistence of Major Depressive Disorder Among People Living with HIV in Uganda. AIDS Behav. 2016 Oct 8. [Epub ahead of print] PubMed PMID: 27722834.
|Kinyanda E, Kuteesa M, Scholten F, Mugisha J, Baisley K, Seeley J. Risk of major depressive disorder among older persons living in HIVendemic central and southwestern Uganda. AIDS Care. 2016 Dec;28(12):1516-1521. PubMed PMID: 27263868.
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