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Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2019-09-01
End Date 2022-08-31
Project Code TMA2018CDF-2345 PrazOpt
Status Active

Title

Optimization of praziquantel therapy for Schistosoma mansoni infection in preschool-aged children in Ethiopia: PrazOpt

Objectives

Primary Objective: The primary objective of this study is to determine curative rate of praziquantel 40 mg/kg single dose in S. mansoni infection in preschool-aged children. Secondary objectives of this clinical research are to: - Determine egg reduction rate - Assess safety outcomes (adverse events) - Estimate pharmacokinetic parameters - Assess polymorphisms of gene for praziquantel metabolizing enzymes - Identify correlates of curative outcome.

Host Organisation

Institution Country
Addis Ababa University Ethiopia

Participants

Name Institution Country
Prof Eyasu Makonnen CDT-Africa Ethiopia
Prof Eleni Aklillu Karolinska Institute Sweden
Dr Birkineh Tilahun Hawassa University Ethiopia

Study Design

This study is a prospective observational study which assesses treatment outcome of S. mansoni infected preschool-aged children who got praziquantel treatment. So, the study doesn’t have any interventions except collection of biological specimen for safety and efficacy evaluations.

Sites

The study sites include health centers in districts of Sidama, where there is a high burden of schistosomiasis infection. These include Bushulo Health Center (Loke district), Wosha Health Center (Wosha district) and Chuko Health Center (Chuko district).

Students Supervised

Type Name Title University Start Date End Date
MSc Mahlet Abbay Prevalence and treatment outcome of schistosomiasis in preschool-aged children: A systematic review and meta-analysis Addis Ababa University 2019 2020
PhD Tafese Tadele Burden of schistosomiasis in preschool-aged children and the determinants of treatment outcome Hawassa University 2019 2022

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