EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

All Profiles

Dr Innocent Ali

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2021-07-01
End Date 2024-06-30
Project Code TMA2020CDF-3171
Status Active

Title

Plasmodium vivax burden, range and transmission among Duffy-negative inhabitants in Cameroon (VIBRANT)

Host Organisation

Institution Country
University of Dschang Cameroon

Current Organisation

University of Dschang

Current Job Title

Senior Lecturer- Researcher

Students Supervised

Type Name Title University Start Date End Date
Msc Keming Eva Mai Ms University of Dschang 2019 2021
Msc Nguene Darlin Bean Mr University of Dschang 2019 2021

Memberships

Role Committee/board Start Date End Date

Education

Institution Degree Year
,

Areas Of Specialisation

Malaria Neglected Infectious Diseases (NID)

Grants

Publications

Effectiveness and safety of artesunate–amodiaquine versus artemether–lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6–120 months in Yaoundé, Cameroon: a randomized trial
Authors:
Date:
2022-12-01
Journal:
BMC Infectious Diseases
Content:
Abstract Background Many studies have reported high efficacy and safety of artesunate-amodiaquine (AS-AQ) and artemether-lumefantrine (AL) when administered under direct observation in Cameroon. There is paucity of data to support their continuous use in home-based treatment of uncomplicated Plasmodium falciparum malaria in Cameroon. Hence, this study aimed to assess the effectiveness and safety of AS-AQ versus AL for home-based treatment of uncomplicated P. falciparum malaria among children 6–120 months in Yaoundé, Cameroon. Methods A two-arm, open-label, randomized, controlled trial comparing the equivalence of AS-AQ (experimental group) and AL (control group) was carried out from May 2019 to April 2020 at two secondary hospitals in Yaoundé. Participants were randomized to receive either AS-AQ or AL. After the first dose, antimalarial drugs were given at home, rather than under direct observation by a study staff. The conventional on-treatment and post-treatment laboratory and clinical evaluations were not done until day 3 of the full antimalarial treatment course. The evaluation of effectiveness was mainly based on per protocol polymerase chain reaction adjusted adequate clinical and parasitological response (PP PCR adjusted ACPR) on day 28 post-treatment. Safety was based on assessment of adverse events (AEs) and severe adverse events (SAEs) from day 1 to day 28. Results A total of 242 children were randomized to receive AS-AQ (n = 114) and AL (n = 128). The PP PCR adjusted day 28 cure rates were [AS-AQ = 96.9% (95% CI, 91.2–99.4) versus AL = 95.5% (95% CI, 89.9–98.5), P = 0.797]. Expected mild to moderate adverse events were reported in both arms [AS-AQ = 83 (84.7%) versus AL = 99 (86.1%), P = 0.774]. The most common adverse events included: transient changes of hematologic indices and fever. Conclusions This study demonstrated that AS-AQ and AL are effective and safe for home management of malaria in Yaoundé. The evidence from this study supports the parallel use of the two drugs in routine practice. However, the findings from this study do not describe the likely duration of antimalarial effectiveness in holoendemic areas where multiple courses of treatment might be required. Trial registration: This study is a randomized controlled trial and it was retrospectively registered on 23/09/2020 at ClinicalTrials.gov with registration number NCT04565184.
Single nucleotide polymorphisms in the cyp2C8 and nat2 genes and treatment outcomes in patients suffering from uncomplicated malaria in Garoua, Northern Region of Cameroon
Authors:
Date:
2019-07-02
Journal:
Pharmacy & Pharmacology International Journal
Content:
Allelic frequencies of mutants of the Plasmodium falciparum, quinoline and folate metabolizing genes in the west region of Cameroon
Authors:
Date:
2023-02-27
Journal:
Heliyon, Volume 8, Issue 11, November 2022, e11861
Content:
Amodiaquine-artesunate versus artemether-lumefantrine against uncomplicated malaria in children less than 14 years in Ngaoundere, North Cameroon: Efficacy, safety, and baseline drug resistant mutations in pfcrt, pfmdr1, and pfdhfr genes
Authors:
Ali, I.M.
Netongo, P.M.
Atogho-Tiedeu, B.
Ngongang, E.-O.
Ajua, A.
Achidi, E.A.
Mbacham, W.F.
Date:
2013-01-01
Journal:
Malaria Research and Treatment
Content:
Prevalence of potato viruses on cultivated potato (Solanum tuberosum L.) in the Western highlands of Cameroon
Authors:
Date:
2021-08-01
Journal:
Journal of Agriculture and Food Research
Content:
Mutations within folate metabolising genes of Plasmodium falciparum in Cameroon
Authors:
Mbacham, W.F.
Evehe, M.-S.B.
Netongo, P.M.
Ali, I.M.
Nfor, E.N.
Akaragwe, A.I.
Mimche, P.N.
Nji, A.
Djoko, C.F.
Tawe, B.
Gawa, B.
Asongna, T.
Toh, G.B.
Atogho-Tieudeu, B.
Nge, N.
Ebeng, R.
Mokube, J.A.
Kuaban, C.
Bickii, J.
Penlap, V.
Titanji, V.P.
Njikam, N.
Date:
2009-01-01
Journal:
African Journal of Biotechnology
Content:
High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly-diagnosed antiretroviral treatment naive children in sub-Saharan Africa.
Authors:
Date:
2020-05-20
Journal:
AIDS (London, England)
Content:
: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.
Arboviruses as an unappreciated cause of non-malarial acute febrile illness in the Dschang Health District of western Cameroon
Authors:
Date:
2022-11-12
Journal:
PLos Neglected Tropical Diseases
Content:
Current status of 4-aminoquinoline resistance markers 18 years after cessation of chloroquine use for the treatment of uncomplicated falciparum malaria in the littoral coastline region of Cameroon
Authors:
Marcel Nyuylam Moyeh , author
Sandra Noukimi Fankem , author
Innocent Mbulli Ali , author
Denis Sofeu , author
Sorelle Mekachie Sandie , author
Dieudonne Lemuh Njimoh , author
Stephen Mbigha Ghogomu , author
Helen Kuokuo Kimbi , author
Wilfred Fon Mbacham , author
Date:
2022-03-31
Journal:
Pathogens and Global Health
Content:
Current status of 4-aminoquinoline resistance markers 18 years after cessation of chloroquine use for the treatment of uncomplicated falciparum malaria in the littoral coastline region of Cameroon
Authors:
Date:
2023-02-27
Journal:
Pathogens and Global Health Volume 116, 2022 - Issue 8
Content:
Diagnosis of malaria in pregnancy: accuracy of CareStart™ malaria Pf/PAN against light microscopy among symptomatic pregnant women at the Central Hospital in Yaoundé, Cameroon
Authors:
Date:
2022-03-09
Journal:
Malaria Journal
Content:
The Influence of Health Insurance on the Utilization of Maternal Health Care Services in Kumba Health District: A Community-based Assessment
Authors:
Date:
Journal:
Content:
Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon
Authors:
Akindeh M. Nji , author
Innocent Mbulli Ali , author
Peter Thelma Ngwa Niba , author
Evehe Marie-Solange , author
Christian Heumann , author
Guenter Froeschl , author
Wilfred F. Mbacham , author
Date:
2021-08-01
Journal:
Pathogens
Content:
Study to evaluate the performance of a point-of-care whole blood HIV viral load test (SAMBA II HIV-1 Semi-Q Whole Blood).
Authors:
Date:
2020-12-21
Journal:
Journal of Clinical Microbiology
Content:
Remote areas of many low and middle income (LMI) countries have poor access to HIV viral load (HIV VL) testing. The SAMBA-II (Simple Amplification-based Assay) Semi-Q Whole Blood Test (Diagnostics for the Real World (DRW), Cambridge, UK) is a point of care assay which uses leucodepletion technology to allow whole blood testing in remote settings. 1540 consecutive HIV-positive clinic patients in Cameroon (250), UK (633), Ukraine (412) and Zimbabwe (245) donated venous blood (all countries) and finger-prick blood (all except UK) for testing on SAMBA-II. SAMBA II results were compared with simultaneous plasma results on the Abbott RealTime HIV-1 (Abbott Molecular, Des Plaines, IL) viral load assay and interpreted as either <1000 RNA copies/ml or ≥1000 RNA copies/ml. For 1528 venous whole-blood samples tested on SAMBA II, overall percent agreement with the reference test at a cut-off of HIV VL ≥1000 cps/ml was 96.9% (1480/1528 95% CI 95.9-97.7), negative percent agreement 97.7% (1259/1289 95% CI 96.7-98.4), positive percent agreement 92.5% (221/239 95% CI 88.4-95.5). For 854 finger-prick samples there was 95.0% (811/854 95% CI 93.3-96.3) overall percent agreement; negative percent agreement 98.0% (625/638, 95% CI 96.5-98.9); positive percent agreement 86.1% (186/216 95% CI 80.8-90.4). These rose to 93.5% (82.1, 98.6), 97.6% (95.6, 98.8) and 95.6% (93.3, 97.3) after exclusion of aberrant results from the Ukraine centre. These results show a high level of agreement between SAMBA-II and a laboratory-based assay. SAMBA-II has a performance that is suitable to use as a VL point of care assay in remote settings
Detection of Cucumber mosaic virus on Solanum lycopersicum L. and Capsicum annuum L. in Western region of Cameroon
Authors:
Date:
2022-03-01
Journal:
Journal of Agriculture and Food Research
Content:
Effects of Drug Policy Changes on Evolution of Molecular Markers of Plasmodium falciparum Resistance to Chloroquine, Amodiaquine, and Sulphadoxine-Pyrimethamine in the South West Region of Cameroon
Authors:
Marcel N. Moyeh , author
Dieudonne L. Njimoh , author
Marie Solange Evehe , author
Innocent M. Ali , author
Akindeh M. Nji , author
Dominique N. Nkafu , author
Palmer N. Masumbe , author
Atogho-Tiedeu Barbara , author
Valentine N. Ndikum , author
Wilfred F. Mbacham , author
Date:
2018-05-02
Journal:
Malaria Research and Treatment
Content:
Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon.
Authors:
Ali IM , author
Evehe MS , author
Netongo PM , author
Atogho-Tiedeu B , author
Akindeh-Nji M , author
Ngora H , author
Domkam IK , author
Diakite M , author
Baldip K , author
Ranford-Cartwright L , author
Mimche PN , author
Lamb T , author
Mbacham WF , author
Date:
2014-10-01
Journal:
Pathogens and global health
Content:
Ionised and total hypocalcaemia in pregnancy: An analysis of prevalence and risk factors in a resource-limited setting, Cameroon
Authors:
Atem Bethel Ajong , author
Frank T. Spradley , editor
Bruno Kenfack , author
Innocent Mbulli Ali , author
Martin Ndinakie Yakum , author
Ukaogo Prince Onydinma , author
Fulbert Nkwele Mangala , author
Loai Aljerf , author
Phelix Bruno Telefo , author
Date:
2022-05-18
Journal:
PLOS ONE
Content:
The Effect of HBV/HCV in Response to HAART in HIV Patients after 12 Months in Kumba Health District in the South West Region of Cameroon
Authors:
Adamu Ndongho Ndifontiayong , author
Innocent Mbulli Ali , author
Jean Baptiste Sokoudjou , author
Jerimiah Mbogwe Ndimumeh , author
Christopher Bonglavnyuy Tume , author
Date:
2021-08-10
Journal:
Tropical Medicine and Infectious Disease
Content:
Predominance of N-acetyl transferase 2 slow acetylator alleles in children less than ten years experiencing adverse treatment events following artemisinin-based combination therapy in North and South West Regions of Cameroon
Authors:
Date:
2016-06-22
Journal:
African Journal of Biotechnology
Content:
Aetiology and risk factors of bacterial gastroenteritis among febrile outpatients at the Dschang District Hospital, West Region of Cameroon: a cross-sectional study
Authors:
Karimo Ousenu , author
Leonard Fonkeng Sama , author
Innocent Mbulli Ali , author
Jude Leinyuy Fonbah , author
Ongbayokolak Sylvie Nadine , author
Solange Dabou , author
Christopher Tume , author
Date:
2021-09-01
Journal:
BMJ Open
Content:
Seroprevalence of Toxoplasma gondii IgG and IgM antibodies and associated risk factors in women of child-bearing age in Njinikom, NW Cameroon.
Authors:
Wam EC , author
Sama LF , author
Ali IM , author
Ebile WA , author
Aghangu LA , author
Tume CB , author
Date:
2016-08-01
Journal:
BMC research notes
Content:
Comparison of the Accuracy of Four Malaria Diagnostic Methods in a High Transmission Setting in Coastal Cameroon
Authors:
Marcel N. Moyeh , author
Innocent M. Ali , author
Dieudonné L. Njimoh , author
Akindeh M. Nji , author
Palmer M. Netongo , author
Marie S. Evehe , author
Barbara Atogho-Tiedeu , author
Stephen M. Ghogomu , author
Wilfred F. Mbacham , author
Date:
2019-03-10
Journal:
Journal of Parasitology Research
Content:
Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
Authors:
Atem Bethel Ajong , author
Bruno Kenfack , author
Innocent Mbulli Ali , author
Martin Ndinakie Yakum , author
Phelix Bruno Telefo , author
Frank T. Spradley , editor
Date:
2019-11-07
Journal:
PLOS ONE
Content:
Allelic Frequencies of Mutants of the Plasmodium falciparum, Quinoline and Folate Metabolizing genes in the West Region of Cameroon
Authors:
Date:
2022-11-23
Journal:
Heliyon
Content:
Field evaluation of the 22 rapid diagnostic tests for community management of malaria with artemisinin combination therapy in Cameroon.
Authors:
Ali IM , author
Bigoga JD , author
Forsah DA , author
Cho-Ngwa F , author
Tchinda V , author
Moor VA , author
Fogako J , author
Nyongalema P , author
Nkoa T , author
Same-Ekobo A , author
Mbede J , author
Fondjo E , author
Mbacham WF , author
Leke RG , author
Date:
2016-01-01
Journal:
Malaria journal
Content:
Randomized non-inferiority and safety trial of dihydroartemisin-piperaquine and artesunate-amodiaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroonian children.
Authors:
Nji AM , author
Ali IM , author
Moyeh MN , author
Ngongang EO , author
Ekollo AM , author
Chedjou JP , author
Ndikum VN , author
Evehe MS , author
Froeschl G , author
Heumann C , author
Mansmann U , author
Ogundahunsi O , author
Mbacham WF , author
Date:
2015-01-01
Journal:
Malaria journal
Content:
Adverse Events Clustering with NAT2 Slow Metabolisers following Deparasitization in Children in Bangolan, NWR Cameroon
Authors:
Date:
Journal:
Content:
Delayed entry into HIV care after diagnosis in two specialized care and treatment centres in Cameroon: the influence of CD4 count and WHO staging.
Authors:
Takah NF , author
Awungafac G , author
Aminde LN , author
Ali I , author
Ndasi J , author
Njukeng P , author
Date:
2016-07-01
Journal:
BMC public health
Content:
Assessing Asymptomatic Malaria Carriage of Plasmodium falciparum and Non-falciparum Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
Authors:
Date:
2021-10-24
Journal:
Children
Content:
Malaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis is considered to be an important strategy in the control of the disease especially in children, who are the most vulnerable group. This study assessed the prevalence of asymptomatic malaria in children at the Nkolbisson health area in Yaoundé, Cameroon. A cross-sectional study design and a convenience sampling plan were used. A total of 127 participants were recruited after informed and signed consent from parents and/or guardians. Blood samples were collected by finger-pricking and venipuncture from children aged 6 months to 10 years and then screened for asymptomatic parasitemia by a rapid diagnostic test (RDT), light microscopy (LM) staining with Giemsa and 18S rRNA polymerase chain reaction (PCR) for speciation. The data were analyzed using SPSS version 20 software. The study identified 85 children who were positive from the PCR, 95 positive from the RDT and 71 from the LM, revealing a malaria prevalence of 66.9%, 74.8% and 55.9%, respectively. The prevalence was not observed to be dependent on the sex and age group of the participants. Plasmodium falciparum was the predominant species followed by Plasmodium malariae and then Plasmodium ovale. The RDT and LM had the same sensitivity (90.6%) with a slight difference in their specificity (RDT: 57.1%; LM: 54.8%). The RDT also demonstrated higher positive and negative predictive values compared with those of the LM.
Prevalence, Predictors and Treatment Outcome of Type 2 Diabetes among Newly Diagnosed Sputum Positive Pulmonary Tuberculosis Patients in Western Cameroon
Authors:
Date:
2017-06-30
Journal:
Journal of Infectious Diseases and Epidemiology
Content:
Diagnostic Accuracy of CareStart™ Malaria HRP2 and SD Bioline Pf/PAN for Malaria in Febrile Outpatients in Varying Malaria Transmission Settings in Cameroon
Authors:
Date:
2021-08-27
Journal:
Diagnostics
Content:
Background: There was an increase in the number of malaria cases in Cameroon in 2018 that could reflect changes in provider practice, despite effective interventions. In this study, we assessed the diagnostic performance of two malaria rapid diagnostic tests (mRDTs) for diagnostic confirmation of suspected cases of malaria in public and private health facilities in two malaria transmission settings in Cameroon. Methods: We evaluated the diagnostic performance of CareStart pf and SD Bioline Pf/PAN mRDT and compared these parameters by RDT type and transmission setting. Nested PCR and blood film microscopy were used as references. The chi square test was used for independent sample comparisons, while the McNemar’s test was used to test for the dependence of categorical data in paired sample testing. A p < 0.05 was considered significant in all comparisons. The R (v.4.0.2) software was used for analyses. Results: A total of 1126 participants consented for the study in the four sites. The diagnostic accuracy of the CareStart Pf mRDT was 0.93.6% (0.911–0.961) in Yaoundé, 0.930% (0.90–0.960) in Ngounso, 0.84% (0.794–0.891) in St Vincent Catholic Hospital Dschang and 0.407 (0.345–0.468) in Dschang district hospital. For SD Bioline Pf/PAN the accuracy was 0.759 (0.738–0.846) for St Vincent Catholic Hospital Dschang and 0.426 (0.372–0.496) for the Dschang district hospital. The accuracy was slightly lower in each case but not statistically different when PCR was considered as the reference. The likelihood ratios of the positive and negative tests were high in the high transmission settings of Yaoundé (10.99 (6.24–19.35)) and Ngounso (14.40 (7.89–26.28)) compared to the low transmission settings of Dschang (0.71 (0.37–1.37)) and St Vincent Catholic hospital (7.37 (4.32−12.59)). There was a high degree of agreement between the tests in Yaoundé (Cohen’s Kappa: 0.85 ± 0.05 (0.7–0.95)) and Ngounso (Cohen’s Kappa: 0.86 ± 0.05 (0.74, 0.97)) and moderate agreement in St Vincent hospital Dschang (k: 0.58 ± 0.06 (0.44–0.71)) and poor agreement in the District Hospital Dschang (Cohen’s Kappa: −0.11 ± 0.05 (−0.21–0.01)). The diagnostic indicators of the SD Bioline Pf/PAN were slightly better than for CareStart Pf mRDT in St Vincent Catholic hospital Dschang, irrespective of the reference test. Conclusions: Publicly procured malaria rapid diagnostic tests in Cameroon have maintained high accuracy (91–94%) in the clinical diagnosis of malaria in high malaria transmission regions of Cameroon, although they failed to reach WHO standards. We observed an exception in the low transmission region of Dschang, West region, where the accuracy tended to be lower and variable between facilities located in this town. These results underscore the importance of the routine monitoring of the quality and performance of malaria RDTs in diverse settings in malaria endemic areas.
Diagnosis of malaria in pregnancy: accuracy of CareStart™ malaria Pf/PAN against light microscopy among symptomatic pregnant women at the Central Hospital in Yaoundé, Cameroon
Authors:
Cliford Ebontane Ebong , author
Innocent Mbulli Ali , author
Hortence Jeanne Fouedjio , author
Estelle Essangui , author
Dorothy Fosah Achu , author
Ayong Lawrence , author
Dohbit Sama , author
Date:
2022-12-01
Journal:
Malaria Journal
Content:
Predominance of Plasmodium malariae-falciparum Co-Infection by Molecular Speciation in Bangolan, North West Region of Cameroon
Authors:
Date:
2013-06-28
Journal:
Journal of Life Sciences
Content:
A Cross-Sectional Comparative Study of the Performance of the Widal Test and the Typhidot Immunoassay for Typhoid Fever Diagnosis in the West Region of Cameroon
Authors:
Karimo Ousenu , author
Innocent Mbulli Ali , author
Leonard Fonkeng Sama , author
Marcel Nsangou Ndam , author
Thibau Florant Tchouangueu , author
Christopher Bonglavnyuy Tume , author
Maria De Francesco , editor
Date:
2021-08-07
Journal:
Canadian Journal of Infectious Diseases and Medical Microbiology
Content:
Hypocalcaemia and calcium intake in pregnancy: A research protocol for critical analysis of risk factors, maternofoetal outcomes and evaluation of diagnostic methods in a third-category health facility, Cameroon
Authors:
Atem Bethel Ajong , author
Frank T. Spradley , editor
Bruno Kenfack , author
Innocent Mbulli Ali , author
Martin Ndinakie Yakum , author
Loai Aljerf , author
Phelix Bruno Telefo , author
Date:
2020-11-05
Journal:
PLOS ONE
Content:
Sero-prevalence of Hepatitis B and C virus and High Risk of Hepatotoxicity among TB/HIV Positive and HIV Negative Population in Western Cameroon
Authors:
Date:
2017-05-13
Journal:
Global Journal of Infectious Diseases and Clinical Research
Content:

Projects

Send a Message