EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

All Profiles
Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-07-01
End Date 2020-06-30
Project Code TMA2015CDF1027
Status Active

Title

Evaluation of Treatment Response, Drug Resistance and HIV-1 Variability among Adolescents on First- and Second-Line Antiretroviral Therapy in Cameroon: The READY-Study

Objectives

General Objectives: Among Cameroonian adolescents (10-19 years old) receiving ART, we shall monitor the therapeutic response to first- and second-line regimens, drug resistance profiling and HIV-1 genetic variability during one-year follow-up. Specific objectives: In this population of adolescents receiving ART in Cameroon, we shall: 1) Evaluate the rate of immunovirologic failure in the entire population at enrolment, month-6 and month-12 follow-up points; 2) Evaluate acquired DRMs and HIV-1 subtype distribution among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 3) Evaluate the genetic variability in circulating (plasma) versus archived (cellular) viral strains among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 4) Evaluate HIVDR early warning indicators (EWIs), including survival analysis, in the entire study population through out the one-year monitoring period.

Host Organisation

Institution Country
International Reference Centre Chantal Biya (CIRCB) Cameroon

Participants

Name Institution Country
Prof. Alexis Ndjolo CIRCB Cameroon
Prof. Vittorio Colizzi CIRCB Cameroon
Prof. Carlo-Federico Perno University of Rome Tor Vergata Cameroon

Study Design

Prospective, open, observational study

Sites

Prospective, open, observational study

Phd Study

Title University Start Date End Date
MOLECULAR CHARACTERISATION OF HIV ANTIRETROVIRAL DRUG RESISTANT STRAINS IN NAÏVE AND TREATED SUBJECTS IN CAMEROON USING GENOTYPING AND BIOINFORMATICS Faculty of Medicine and Biomedical Sciences, University of Yaounde I 2009-10-06 2014-01-17

Students Supervised

Type Name Title University Start Date End Date
MD Thesis Armanda Nangmo Assessment of immuno-virological response and hiv-1 drug resistance among adolescents on antiretroviral therapy in two reference pediatric centers in Yaoundé Faculty of Health Sciences, University of Bamenda 02/01/2018 30/09/2018
MD Thesis Carlson Wandum Evaluation of treatment response, HIV drug resistance and genetic diversity in rural settings of the Centre region of Cameroon Faculty of Health Sciences, University of Bamenda 02/01/2018 30/09/2018
MD Thesis Anubodem Felix Pretreatment HIV drug resistance in the Southwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
MD Thesis Chenwi Collins Determinants of HIV-1 drug resistance Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
Dentistry Thesis Buolikeze Geh Determinants of periodontitis among HIV-infected patients in Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
Pharmacy Thesis Odine Padimel Pretreatment HIV drug resistance in the urban setting of the Northwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017
MD Thesis Suh Emile Pretreatment HIV drug resistance in the rural setting of the Northwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017
MD Thesis Le Koungou Catherine Feasibility study of Human identification by DNA technology Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017

Publications

BMC Pediatrics. 18:259 https://doi.org/10.1186/s12887-018-1235-3
BMC Pedaitrics
Medicine (Baltimore)
Pan Afr Med J
J Infect Dis Ther 2018
Viruses. 8(7). pii: E196. doi: 10.3390/v8070196
AIDS Res Hum Retroviruses. 32(4):329-33. doi: 10.1089/AID.2015.0065. PMID: 26602836.
Int. J Mycobact. Epub 2016 Mar 08. doi:10.1016/j.ijmyco.2016.02.005
Afr J. Bitotec. Vol. 15(50), pp. 2744-2750. DOI: 10.5897/AJB2016.15554
PLoS One. 10(12):e0145772. doi: 10.1371/journal.pone.0145772. eCollection 2015. PMID: 26717411
International Journal of Immunology; Volume 3, Issue 6. Pages: 72-77. DOI: 10.11648/j.iji.20150306.12
Curr HIV Res. PMID: 26419862
Infect Genet Evol. 35:9-18. doi: 10.1016/j.meegid.2015.07.017. PMID: 26190450
Pan Afr Med J. 21:256. doi: 10.11604/pamj.2015.21.256.7556. eCollection 2015. PMID: 26523191
PLoS One. 10(6):e0129210. doi: 10.1371/journal.pone.0129210. eCollection 2015.
Curr HIV Res. 13(4):286-91.
International Journal of Health Sciences & Research ISSN: 2249-9571. Vol.5; Issue: 2
Pan Afr Med J. 20:79. doi: 10.11604/pamj.2015.20.79.4216. eCollection 2015
Ig Sanita Pubbl. 70 (4): 381-92.
PAMJ. 18.91.2794.
British Microbiology Research Journal. ISSN: 2231-0886, Vol.: 4, Issue: 12
PLoS One. 8(8): e72680.
Ig Sanita Pubbl. 69(2): 183-94.
J Infect Dis. 207 Suppl 2:S70-7.
BMC Public Health. 13: 308
Health Sci. Dis. Vol 14, No 2; 1-9
Health Sci. Dis. Vol 13, No 1.
PLoS One. 7(5): e36777
J Med Virol. 84(5): 721-7
Revue de Médecine et de Pharmacie. Vol 2, No 2. 185-196.
Pediatr Infect Dis J. 30(12): 1062-8
Arch Virol. 156(7): 1235-43
J Health Med Informat. 2: 104. Doi: 10.4172/2157-7420.1000104

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