EDCTP Alumni Network

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All Profiles

Dr Joseph Fokam

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-07-01
End Date 2019-12-31
Project Code TMA2015CDF1027
Status Active

Title

Evaluation of Treatment Response, Drug Resistance and HIV-1 Variability among Adolescents on First- and Second-Line Antiretroviral Therapy in Cameroon: The READY-Study

Objectives

General Objectives: Among Cameroonian adolescents (10-19 years old) receiving ART, we shall monitor the therapeutic response to first- and second-line regimens, drug resistance profiling and HIV-1 genetic variability during one-year follow-up. Specific objectives: In this population of adolescents receiving ART in Cameroon, we shall: 1) Evaluate the rate of immunovirologic failure in the entire population at enrolment, month-6 and month-12 follow-up points; 2) Evaluate acquired DRMs and HIV-1 subtype distribution among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 3) Evaluate the genetic variability in circulating (plasma) versus archived (cellular) viral strains among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 4) Evaluate HIVDR early warning indicators (EWIs), including survival analysis, in the entire study population through out the one-year monitoring period.

Host Organisation

Institution Country
International Reference Centre Chantal Biya (CIRCB) Cameroon

Participants

Name Institution Country
Prof. Alexis Ndjolo CIRCB Cameroon
Prof. Vittorio Colizzi CIRCB Cameroon
Prof. Carlo-Federico Perno University of Rome Tor Vergata Cameroon

Study Design

Prospective, open, observational study

Sites

Prospective, open, observational study

Students Supervised

Type Name Title University Start Date End Date
MD Thesis Armanda Nangmo Assessment of immuno-virological response and hiv-1 drug resistance among adolescents on antiretroviral therapy in two reference pediatric centers in Yaoundé Faculty of Health Sciences, University of Bamenda 02/01/2018 30/09/2018
MD Thesis Carlson Wandum Evaluation of treatment response, HIV drug resistance and genetic diversity in rural settings of the Centre region of Cameroon Faculty of Health Sciences, University of Bamenda 02/01/2018 30/09/2018
MD Thesis Anubodem Felix Pretreatment HIV drug resistance in the Southwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
MD Thesis Chenwi Collins Determinants of HIV-1 drug resistance Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
Dentistry Thesis Buolikeze Geh Determinants of periodontitis among HIV-infected patients in Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
Pharmacy Thesis Odine Padimel Pretreatment HIV drug resistance in the urban setting of the Northwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017
MD Thesis Suh Emile Pretreatment HIV drug resistance in the rural setting of the Northwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017
MD Thesis Le Koungou Catherine Feasibility study of Human identification by DNA technology Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017

Current Organisation

CIRCB: Chantal BIYA International Reference Centre for research on HIV/AIDS prevention and management

Current Job Title

Head of Virology Laboratory (Chief or Service)

Publications

Predictors of Non-Adherence to Antiretroviral Therapy among Adolescents Living with HIV in the Centre Region of Cameroon.
Authors:
Ketchaji A, Assah F, Fokam J, Asangbeng TE, Monebenimp F, Ngowe NM
Date:
2019-10-12
Journal:
American Journal of Public Health Research, 2019, Vol. 7, No. 4, 126-136. DOI:10.12691/ajphr-7-4-1.
Content:
Identifiers:
Differential expression of Fas receptors (CD95) and Fas ligands (CD95L) in HIV infected and exposed uninfected children in Cameroon versus unexposed children
Authors:
Dambaya B, Nkenfou CN, Ambada G, Ikomey GM, Mouafo LM, Ngoufack N, Ndzi EN, Této G, Nanfack A, Sonela N, Fokam J, Flobert N, Colizzi V, Ndjolo A
Date:
2019-09-18
Journal:
Pan Afr Med J. 2019 Sep 18;34:39. doi: 10.11604/pamj.2019.34.39.15038. eCollection 2019. PMID: 31762906
Content:
Identifiers:
Viral suppression in adults, adolescents and children receiving antiretroviral therapy in Cameroon: adolescents at high risk of virological failure in the era of "test and treat"
Authors:
Fokam J, Sosso SM, Yagai B, Billong SC, Djubgang Mbadie RE, Kamgaing Simo R, Edimo SV, Nka AD, Tiga Ayissi A, Yimga JF, Takou D, Moudourou S, Ngo Nemb M, Nfetam Elat JB, Santoro MM, Perno CF, Colizzi V, Ndjolo A.
Date:
2019-11-19
Journal:
AIDS Res Ther. 2019 Nov 19;16(1):36. doi: 10.1186/s12981-019-0252-0.
Content:
Identifiers:
HIV-1 Drug Resistance Testing is Essential for Heavily-Treated Patients Switching from First- to Second-Line Regimens in Resource-Limited Settings: Evidence from Routine Clinical Practice in Cameroon
Authors:
Takou D, Fokam J, Teto G, Santoro MM, Ceccherini-Silberstein F, Nanfack AJ, Sosso SM, Dambaya B, Salpini R, Billong SC, Gori C, Fokunang CN, Cappelli G, Colizzi V, Perno CF, Ndjolo A.
Date:
2019-02-15
Journal:
BMC Infect Dis. (2019) 19:246 https://doi.org/10.1186/s12879-019-3871-0.
Content:
Identifiers:
Factors associated with risk of HIV-infection among pregnant women in Cameroon: Evidence from the 2016 national sentinel surveillance survey of HIV and syphilis.
Authors:
Anoubissi JD, Gabriel EL, Kengne Nde C, Fokam J, Tseuko DG, Messeh A, Moussa Y, Nkenfou CN, Bonono L, Billong SC, Nfetam JE.
Date:
2019-04-15
Journal:
PLoS One. 2019 Apr 12;14(4):e0208963. doi: 10.1371/journal.pone.0208963. eCollection 2019
Content:
Identifiers:
Outcomes of protease inhibitor-based antiretroviral therapy amongst children and associated-factors in Yaoundé, Cameroon
Authors:
Njom Nlend AE, Guessong CO, Nga Motaze AC, Soffo C, Koki Ndombo PO, Tsambang L, Fokam J
Date:
2019-03-15
Journal:
PLoS One. 2019 Mar 18;14(3):e0213900. doi: 10.1371/journal.pone.0213900. eCollection 2019.
Content:
Identifiers:
Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé
Authors:
Nka AD, Sosso SM, Fokam J, Bouba Y, Teto G, Simo Rachel R, Tiga A, Yimga J, Nukenine EN, Nanfack AJ, Takou D, Aroga Z, Colizzi V, Ndjolo A
Date:
2019-09-26
Journal:
BMC Res Notes. 2019 Sep 26;12(1):632. doi: 10.1186/s13104-019-4664-7.
Content:
Identifiers:
Evaluation of Nephrotoxicity Among First-Line Antiretroviral Therapy-Experienced Patients at Yaounde Central Hospital
Authors:
Kamga RW, Taheu C, Tchatchouang S, Fokam J
Date:
2020-02-15
Journal:
Biomed J Sci & Tech Res 25 (4) 2020. BJSTR. MS.ID.004248
Content:
Identifiers:
HIV-1 Drug Resistance and Genetic Diversity among Vertically Infected Cameroonian Children.
Authors:
Dambaya B, Fokam J, Ngoufack ES, Takou D, Santoro MM, Teto G, Beloumou GA, Mouafo LCM, Kamgaing N, Sosso SM, Billong SC, Njom Nlend AE, Sobze MS, Nkenfou C, Koki PN, Njiokou F, Colizzi V, Perno CF, Ndjolo A.
Date:
2020-02-01
Journal:
Explor Res Hypothesis Med 10.14218/ERHM.2019.00031
Content:
Identifiers:
Mapping and size estimates of female sex workers in Cameroon: Toward informed policy for design and implementation in the national HIV program.
Authors:
Billong SC, Nguefack-Tsague G, Fokam J, Emmanuel F, Isac S, Fodjo RAT, Ngoufack MN, Kwedi S, Moukam LV, Tchetmi T, Tapka VK, Ndjolo A, Shubber Z, Cheikh N, Blanchard J, Elat JN, Mziray EN
Date:
2019-02-15
Journal:
PLoS One. 2019 Feb 26;14(2):e0212315. doi: 10.1371/journal.pone.0212315. eCollection 2019.
Content:
Identifiers:
The problem of lost to follow-up of mother-child pairs enrolled in the PMTCT program in Dschang District Hospital-Cameroon
Authors:
Efeutmecheh Sangong R, Tiotsia Tsapi A, Djeunang Dongho GB, Fokam J, Azeufack Ngueko Y, Bell Pallawo I, Zogning Makemjio E, Jagni Semengue EN, Bouting Mayaka G, Azetsop J, Ercoli L, Colizzi V, Panà A, Russo G, Sanou Sobze M
Date:
2018-07-02
Journal:
Ig Sanita Pubbl. 2018 Jul-Aug;74(4):337-347.
Content:
Identifiers:
Financial flows in the fight against AIDS in Cameroon, 2016, 2017: Inadequacy between Resources, Orientation of Expenditures and Epidemiological Trends
Authors:
Billong SC, Messeh A, Penda CI, Anoubissi JDD, Fokam J, Owona N, Moutapam RP, Evouna A, Bohimbo RC, Billong EJ, Takpa V, Bonono L, Zoung-Kanyi Bissek AC, Essi MJ
Date:
2020-01-02
Journal:
Health Sci. Dis: Vol 21 (1) January 2020
Content:
Identifiers:
Programmatic Challenges in Implementing PMTCT Option B+ and Pediatric HIV Care: Baseline Assessment from “Save the Families for Africa” in Malawi
Authors:
Fokam J, Santoro MM, Chimbiri I, Chindiura J, Deula R, Rombe A, Massari R, Lungu A, Perno CF
Date:
2019-05-15
Journal:
Health Sci. Dis: Vol 20 (3) May - June 2019.
Content:
Identifiers:
An apparent paradox: resistance mutations in HIV-1 DNA predict improved virological responses to antiretroviral therapy.
Authors:
Geretti AM, Abdullahi A, Mafotsing FO, Bonnett L, Fokom DV, Moudourou S, Fokam J, Kouanfack C, Torimiro J
Date:
2019-09-15
Journal:
J Antimicrob Chemother 2019. doi:10.1093/jac/dkz264.
Content:
Identifiers:
Comparison of 3 Tests for Plasma HIV-1 RNA Quantitation of Non-B Subtypes in Patients Infected with HIV-1 in N’Djamena-Chad: Cobas AmpliPrep/Cobas TaqMan HIV-1 Test Version 2.0, Abbott m2000 RealTime and Generic HIV Viral Load®.
Authors:
Chatté Adawaye, Erick Ntambwe Kamangu, Joseph Fokam, Fabrice Susin, Ali Mahamat Moussa, Tchombou Hig-Zounet Bertin, Joseph MadToingué, Dolores Vaira and Michel Moutschen
Date:
2018-02-15
Journal:
J Infect Dis Ther 2018, 6:5 DOI: 10.4172/2332-0877.1000382
Content:

 

 

 

 

 

 

 

 

 

 

Identifiers:
Évaluation de la Cascade Nationale des Soins VIH et Sida du Cameroun
.
Authors:
Billong SC, Zeh A, Penda CI, Diallo I, Tiemtore OW, Bongwong B, Diallo H, Clary B, Zhao J, Fokam J, Je Guiard-Schmid JB, Elat JBN, Nguefack-Tsague G
Date:
2019-01-02
Journal:
Health Sci. Dis: Vol 20 (1) January – February 2019
Content:
Identifiers:
Hepatitis B infection and risk factors among children living with HIV in Yaounde, Cameroon: an integrated management
Authors:
Fokam J, Kamga WR, Serges T, Nguwoh PS, Taheu CN, Carlos TTM, Samuel F, Njom-Nlend AE, Colizzi V, Nkenfou NC
Date:
2019-10-22
Journal:
BMC Pediatr. 2019 Oct 22;19(1):366. doi: 10.1186/s12887-019-1750-x.
Content:
Identifiers:
Evaluation of treatment response, drug resistance and HIV-1 variability among adolescents on first- and second-line antiretroviral therapy: a study protocol for a prospective observational study in the centre region of Cameroon (EDCTP READY-study)
Authors:
Fokam J, Santoro MM, Takou D, Njom-Nlend AE, Koki PN, Kamgaing N, Kamta C, Essiane A, Sosso SM, Ndjolo A, Colizzi V, Perno CF
Date:
2019-07-15
Journal:
BMC Pediatrics (2019) 19:226 https://doi.org/10.1186/s12887-019-1599-z.
Content:
Identifiers:

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