EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-07-01
End Date 2019-12-31
Project Code TMA2015CDF1027
Status Active

Title

Evaluation of Treatment Response, Drug Resistance and HIV-1 Variability among Adolescents on First- and Second-Line Antiretroviral Therapy in Cameroon: The READY-Study

Objectives

General Objectives: Among Cameroonian adolescents (10-19 years old) receiving ART, we shall monitor the therapeutic response to first- and second-line regimens, drug resistance profiling and HIV-1 genetic variability during one-year follow-up. Specific objectives: In this population of adolescents receiving ART in Cameroon, we shall: 1) Evaluate the rate of immunovirologic failure in the entire population at enrolment, month-6 and month-12 follow-up points; 2) Evaluate acquired DRMs and HIV-1 subtype distribution among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 3) Evaluate the genetic variability in circulating (plasma) versus archived (cellular) viral strains among those experiencing VF at enrolment, month-6 and month-12 follow-up points; 4) Evaluate HIVDR early warning indicators (EWIs), including survival analysis, in the entire study population through out the one-year monitoring period.

Host Organisation

Institution Country
International Reference Centre Chantal Biya (CIRCB) Cameroon

Participants

Name Institution Country
Prof. Alexis Ndjolo CIRCB Cameroon
Prof. Vittorio Colizzi CIRCB Cameroon
Prof. Carlo-Federico Perno University of Rome Tor Vergata Cameroon

Study Design

Prospective, open, observational study

Sites

Prospective, open, observational study

Students Supervised

Type Name Title University Start Date End Date
MD Thesis Armanda Nangmo Assessment of immuno-virological response and hiv-1 drug resistance among adolescents on antiretroviral therapy in two reference pediatric centers in Yaoundé Faculty of Health Sciences, University of Bamenda 02/01/2018 30/09/2018
MD Thesis Carlson Wandum Evaluation of treatment response, HIV drug resistance and genetic diversity in rural settings of the Centre region of Cameroon Faculty of Health Sciences, University of Bamenda 02/01/2018 30/09/2018
MD Thesis Anubodem Felix Pretreatment HIV drug resistance in the Southwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
MD Thesis Chenwi Collins Determinants of HIV-1 drug resistance Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
Dentistry Thesis Buolikeze Geh Determinants of periodontitis among HIV-infected patients in Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2017 30/07/2018
Pharmacy Thesis Odine Padimel Pretreatment HIV drug resistance in the urban setting of the Northwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017
MD Thesis Suh Emile Pretreatment HIV drug resistance in the rural setting of the Northwest region of Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017
MD Thesis Le Koungou Catherine Feasibility study of Human identification by DNA technology Faculty of Medicine and Biomedical Sciences, University of Yaounde I 15/11/2016 30/07/2017

Current Organisation

CIRCB: Chantal BIYA International Reference Centre for research on HIV/AIDS prevention and management

Current Job Title

Head of Virology Laboratory (Chief or Service)

Publications

Authors:
Ketchaji A, Assah F, Fokam J, Asangbeng TE, Monebenimp F, Ngowe NM
Date:
2019-10-12
Journal:
American Journal of Public Health Research, 2019, Vol. 7, No. 4, 126-136. DOI:10.12691/ajphr-7-4-1.
Content:
Identifiers:
Authors:
Dambaya B, Nkenfou CN, Ambada G, Ikomey GM, Mouafo LM, Ngoufack N, Ndzi EN, Této G, Nanfack A, Sonela N, Fokam J, Flobert N, Colizzi V, Ndjolo A
Date:
2019-09-18
Journal:
Pan Afr Med J. 2019 Sep 18;34:39. doi: 10.11604/pamj.2019.34.39.15038. eCollection 2019. PMID: 31762906
Content:
Identifiers:
Authors:
Fokam J, Sosso SM, Yagai B, Billong SC, Djubgang Mbadie RE, Kamgaing Simo R, Edimo SV, Nka AD, Tiga Ayissi A, Yimga JF, Takou D, Moudourou S, Ngo Nemb M, Nfetam Elat JB, Santoro MM, Perno CF, Colizzi V, Ndjolo A.
Date:
2019-11-19
Journal:
AIDS Res Ther. 2019 Nov 19;16(1):36. doi: 10.1186/s12981-019-0252-0.
Content:
Identifiers:
Authors:
Takou D, Fokam J, Teto G, Santoro MM, Ceccherini-Silberstein F, Nanfack AJ, Sosso SM, Dambaya B, Salpini R, Billong SC, Gori C, Fokunang CN, Cappelli G, Colizzi V, Perno CF, Ndjolo A.
Date:
2019-02-15
Journal:
BMC Infect Dis. (2019) 19:246 https://doi.org/10.1186/s12879-019-3871-0.
Content:
Identifiers:
Authors:
Anoubissi JD, Gabriel EL, Kengne Nde C, Fokam J, Tseuko DG, Messeh A, Moussa Y, Nkenfou CN, Bonono L, Billong SC, Nfetam JE.
Date:
2019-04-15
Journal:
PLoS One. 2019 Apr 12;14(4):e0208963. doi: 10.1371/journal.pone.0208963. eCollection 2019
Content:
Identifiers:
Authors:
Njom Nlend AE, Guessong CO, Nga Motaze AC, Soffo C, Koki Ndombo PO, Tsambang L, Fokam J
Date:
2019-03-15
Journal:
PLoS One. 2019 Mar 18;14(3):e0213900. doi: 10.1371/journal.pone.0213900. eCollection 2019.
Content:
Identifiers:
Authors:
Nka AD, Sosso SM, Fokam J, Bouba Y, Teto G, Simo Rachel R, Tiga A, Yimga J, Nukenine EN, Nanfack AJ, Takou D, Aroga Z, Colizzi V, Ndjolo A
Date:
2019-09-26
Journal:
BMC Res Notes. 2019 Sep 26;12(1):632. doi: 10.1186/s13104-019-4664-7.
Content:
Identifiers:
Authors:
Kamga RW, Taheu C, Tchatchouang S, Fokam J
Date:
2020-02-15
Journal:
Biomed J Sci & Tech Res 25 (4) 2020. BJSTR. MS.ID.004248
Content:
Identifiers:
Authors:
Dambaya B, Fokam J, Ngoufack ES, Takou D, Santoro MM, Teto G, Beloumou GA, Mouafo LCM, Kamgaing N, Sosso SM, Billong SC, Njom Nlend AE, Sobze MS, Nkenfou C, Koki PN, Njiokou F, Colizzi V, Perno CF, Ndjolo A.
Date:
2020-02-01
Journal:
Explor Res Hypothesis Med 10.14218/ERHM.2019.00031
Content:
Identifiers:
Authors:
Billong SC, Nguefack-Tsague G, Fokam J, Emmanuel F, Isac S, Fodjo RAT, Ngoufack MN, Kwedi S, Moukam LV, Tchetmi T, Tapka VK, Ndjolo A, Shubber Z, Cheikh N, Blanchard J, Elat JN, Mziray EN
Date:
2019-02-15
Journal:
PLoS One. 2019 Feb 26;14(2):e0212315. doi: 10.1371/journal.pone.0212315. eCollection 2019.
Content:
Identifiers:
Authors:
Efeutmecheh Sangong R, Tiotsia Tsapi A, Djeunang Dongho GB, Fokam J, Azeufack Ngueko Y, Bell Pallawo I, Zogning Makemjio E, Jagni Semengue EN, Bouting Mayaka G, Azetsop J, Ercoli L, Colizzi V, Panà A, Russo G, Sanou Sobze M
Date:
2018-07-02
Journal:
Ig Sanita Pubbl. 2018 Jul-Aug;74(4):337-347.
Content:
Identifiers:
Authors:
Billong SC, Messeh A, Penda CI, Anoubissi JDD, Fokam J, Owona N, Moutapam RP, Evouna A, Bohimbo RC, Billong EJ, Takpa V, Bonono L, Zoung-Kanyi Bissek AC, Essi MJ
Date:
2020-01-02
Journal:
Health Sci. Dis: Vol 21 (1) January 2020
Content:
Identifiers:
Authors:
Fokam J, Santoro MM, Chimbiri I, Chindiura J, Deula R, Rombe A, Massari R, Lungu A, Perno CF
Date:
2019-05-15
Journal:
Health Sci. Dis: Vol 20 (3) May - June 2019.
Content:
Identifiers:
Authors:
Geretti AM, Abdullahi A, Mafotsing FO, Bonnett L, Fokom DV, Moudourou S, Fokam J, Kouanfack C, Torimiro J
Date:
2019-09-15
Journal:
J Antimicrob Chemother 2019. doi:10.1093/jac/dkz264.
Content:
Identifiers:
Authors:
Chatté Adawaye, Erick Ntambwe Kamangu, Joseph Fokam, Fabrice Susin, Ali Mahamat Moussa, Tchombou Hig-Zounet Bertin, Joseph MadToingué, Dolores Vaira and Michel Moutschen
Date:
2018-02-15
Journal:
J Infect Dis Ther 2018, 6:5 DOI: 10.4172/2332-0877.1000382
Content:

 

 

 

 

 

 

 

 

 

 

Identifiers:
Authors:
Billong SC, Zeh A, Penda CI, Diallo I, Tiemtore OW, Bongwong B, Diallo H, Clary B, Zhao J, Fokam J, Je Guiard-Schmid JB, Elat JBN, Nguefack-Tsague G
Date:
2019-01-02
Journal:
Health Sci. Dis: Vol 20 (1) January – February 2019
Content:
Identifiers:
Authors:
Fokam J, Kamga WR, Serges T, Nguwoh PS, Taheu CN, Carlos TTM, Samuel F, Njom-Nlend AE, Colizzi V, Nkenfou NC
Date:
2019-10-22
Journal:
BMC Pediatr. 2019 Oct 22;19(1):366. doi: 10.1186/s12887-019-1750-x.
Content:
Identifiers:
Authors:
Fokam J, Santoro MM, Takou D, Njom-Nlend AE, Koki PN, Kamgaing N, Kamta C, Essiane A, Sosso SM, Ndjolo A, Colizzi V, Perno CF
Date:
2019-07-15
Journal:
BMC Pediatrics (2019) 19:226 https://doi.org/10.1186/s12887-019-1599-z.
Content:
Identifiers:

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