Call | Career Development Fellowship (CDF) |
Programme | EDCTP2 |
Start Date | 2019-01-01 |
End Date | 2021-12-31 |
Project Code | TMA2017CDF-1887 |
Status | Active |
Clinical evaluation of Novel Plasma Biomarkers for Stage Diagnosis and Treatment efficacy monitoring Among Sleeping Sickness Patients in Uganda
1. To identify plasma biomarkers associated with either early or late stage T. b. gambiense disease using proteomics methods and compare with those previously identified for T. b. rhodesiense. 2. To determine the potential of plasma biomarkers identified using proteomics methods in discriminating between early and late stage patients for both T. b. rhodesiense and T. b. gambiense sleeping sickness. 3. To initiate the setup of a biomarker research team and laboratory at Makerere University.
Institution | Country |
---|---|
Makerere University | Uganda |
Name | Institution | Country |
---|---|---|
Kato Charles Drago | Makerere University | Uganda |
Enock Matovu | Makerere University | Uganda |
In this study, we propose to carry out a clinical validation of these novel plasma biomarkers as stage diagnostic markers. We shall conduct a retrospective study using archived samples from the trypanosomiasis biobank at Makerere University to assess disease staging potential. We shall select patient samples that were recruited at Lwala hospital (north Eastern Uganda) to represent Trypanosoma brucei rhodesiense cases and Omugo (West Nile) to represent T. b. gambiense cases. We shall use proteomics methods to find out if markers identified for T. b. rhodesiense also apply to T. b. gambiense. Clinical validation of identified markers will involve analysis as a single biomarker and as a panel of 2 or more analytes to determine the best predictor of late stage disease. Successful biomarkers identified from this study will form a basis for translation into field based dipstick assays for disease staging and inform policy regarding disease staging. This will greatly improve on patient management through the abolition of the mandatory requirement of an invasive lumber puncture that is painful and a discomfort to the patients. Furthermore, successful execution of this project will build capacity at Makerere University by offering critical skills to junior researchers to establish as research leaders. This work will also aid the creation or strengthening of existing networks and foster teams leading into joint grant writing to combat neglected tropical diseases.
Kampala, Uganda |
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
PhD | Angella Musewa | Epidemiology and molecular characterization of Erysipelothrix rhusiopathiae infections in swine and humans in Uganda | Nairobi University | 2019 | 2022 |
MSc | Cissy Namuleme | Levels of Oxidative stress and Frequency of Cytokine gene polymorphisms among Sickle cell disease patients in Mulago hospital, Uganda | Makerere University | 2020 | 2021 |
MSc | Immaculate Assiimwe | IDENTIFICATION AND CLINICAL VALIDATION OF NOVEL STAGE DIAGNOSTIC BIOMARKERS FOR Trypanosoma brucei gambiense | Makerere University | 2019 | 2021 |
MSc | Kesiime Christine | THERAPEUTIC POTENTIAL OF INTERLEUKIN (IL10) AND IL6 IN THE MANAGEMENT OF LATE STAGE TRYPANOSOMA BRUCEI RHODESIAN HUMAN AFRICAN TRYPANOSOMIASIS | Makerere University | 2020 | 2021 |
Ongoing
Makerere University
Lecturer
2020 | Establishment of a Biomarker research facility to first track the development of COVID19 novel diagnostics and treatment alternatives in Uganda |
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
PhD | Musewa Angella | Epidemiology and Molecular Characterization of Erysipelothrix rhusiopathiae infections in pigs and humans in three selected districts, Uganda | University of Nairobi | 2019 | 2022 |
MSc | Julius Nsubuga | Plasma cytokines profiles associated with responses in Plasmodium falciparum and T brucei rhodesiense trypanosome co-infections in Uganda | Makerere University | 2018 | 2020 |
MSc | Cissy Namuleme | Levels of Oxidative stress and Frequency of Cytokine gene polymorphisms among Sickle cell disease patients in Mulago hospital, Uganda | Makerere University | 2019 | 2022 |
Role | Committee/board | Start Date | End Date |
---|---|---|---|
Editor | Special Journals Publisher | 2020 | 2025 |
Institution | Degree | Year |
---|---|---|
Makerere University, Uganda | PhD | 2016-01-14 |
Makerere University, Uganda | MSc | 2009-01-05 |
University of London, United Kingdom | 2011-08-05 |
Neglected Infectious Diseases (NID)
Name | Country | Institution |
---|---|---|
Kato Charles Drago | Uganda | Makerere University |
Enock Matovu | Uganda | Makerere University |