EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2017-04-01
End Date 2022-03-31
Project Code TMA2015SF1041
Status Active

Title

What is the feasibility, accuracy, and optimal manner in which next-generation tests for tuberculosis can be used in high-burden setting? (The OPTIMAL DIAGNOSIS study)

Objectives

To evaluate the point-of-care feasibility, accuracy and effectiveness of highly sensitive, next-generation diagnostics for the diagnosis of pulmonary TB, extra-pulmonary TB, and drug-resistant TB, whilst assembling a comprehensive, well-characterised biobank for the future research, training, and capacity development.

Host Organisation

Institution Country
Stellenbosch University (SU) South Africa

Study Design

Diagnostic evaluation

Students Supervised

Type Name Title University Start Date End Date
Post-doctoral fellow Byron Reeve Dr SU 2016 2021
PhD Stephanie Minnies Ms SU 2018 2021
PhD Samantha Pillay Ms SU 2016 2021
Post-doctoral fellow Charissa Naidoo Dr SU 2016 2021
PhD Georgina Nyawo Ms SU 2017 2021
PhD Gcobisa Nglangalavu Ms SU 2019 2021
PhD Yonas Ghebrekristos Mr SU 2020 2023
MSc Loren Rockman Ms SU 2019 2021

Publications

https://doi.org/10.1093/cid/ciaa873
https://doi.org/10.1016/S2214-109X(20)30227-8
https://doi.org/10.1016/ S2213-2600(19)30370-4
https://doi.org/10.1038/s41591-020-0940-2
https://www.nature.com/articles/s41598-020-59164-3

Current Organisation

Stellenbosch University

Awards

2019 Gertrud Meisner Award (European Society of Mycobacteriology)

Students Supervised

Type Name Title University Start Date End Date
Grant Theron

Publications

Authors:
Teresa DeAtley , author
Lesley Workman , author
Grant Theron , author
Sabine Bélard , author
Margaretha Prins , author
Lindy Bateman , author
Martin P. Grobusch , author
Keertan Dheda , author
Mark P. Nicol , author
Katherine Sorsdahl , author
Caroline Kuo , author
Dan J. Stein , author
Heather J. Zar , author
Date:
2021-07-25
Journal:
Pediatric Pulmonology
Content:
Identifiers:
Authors:
Byron William Patrick Reeve , author
Rosella Centis , author
Grant Theron , author
Date:
2019-09-01
Journal:
European Respiratory Journal
Content:
Identifiers:
Authors:
Murugesan, K.
Hogan, C.A.
Palmer, Z.
Reeve, B.
Theron, G.
Andama, A.
Somoskovi, A.
Steadman, A.
Madan, D.
Andrews, J.
Croda, J.
Sahoo, M.K.
Cattamanchi, A.
Pinsky, B.A.
Banaei, N.
Date:
2019-01-01
Journal:
Journal of Clinical Microbiology
Content:
Identifiers:
Authors:
Date:
2014-01-01
Journal:
The Lancet Global Health
Content:
Identifiers:
Authors:
Date:
2016-01-01
Journal:
Molecular Microbiology
Content:
Identifiers:
Authors:
Sulaiman, I.
Wu, B.G.
Li, Y.
Scott, A.S.
Malecha, P.
Scaglione, B.
Wang, J.
Basavaraj, A.
Chung, S.
Bantis, K.
Carpenito, J.
Clemente, J.C.
Shen, N.
Bessich, J.
Rafeq, S.
Michaud, G.
Donington, J.
Naidoo, C.
Theron, G.
Schattner, G.
Garofano, S.
Condos, R.
Kamelhar, D.
Addrizzo-Harris, D.
Segal, L.N.
Date:
2018-01-01
Journal:
European Respiratory Journal
Content:
Authors:
Date:
2015-01-01
Journal:
European Respiratory Journal
Content:
Authors:
Date:
2014-01-01
Journal:
American journal of respiratory and critical care medicine
Content:
Identifiers:
Authors:
Date:
2017-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Identifiers:
Authors:
Schumacher, S.G.
Wells, W.A.
Nicol, M.P.
Steingart, K.R.
Theron, G.
Dorman, S.E.
Pai, M.
Churchyard, G.
Scott, L.
Stevens, W.
Nabeta, P.
Alland, D.
Weyer, K.
Denkinger, C.M.
Gilpin, C.
Date:
2019-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Date:
2015-01-01
Journal:
BMC infectious diseases
Content:
Identifiers:
Authors:
Marx, F.M.
Cohen, T.
Menzies, N.A.
Salomon, J.A.
Theron, G.
Yaesoubi, R.
Date:
2020-01-01
Journal:
The Lancet Global Health
Content:
Identifiers:
Authors:
Date:
2015-01-01
Journal:
IEEE Transactions on Medical Imaging
Content:
Identifiers:
Authors:
Date:
2015-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Authors:
J.B. te Riele , author
V. Buser , author
G. Calligaro , author
A. Esmail , author
G. Theron , author
M. Lesosky , author
K. Dheda , author
Date:
2019-02-01
Journal:
International Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Date:
2011-01-01
Journal:
The Lancet
Content:
Authors:
Reeve, B.W.P.
McFall, S.M.
Song, R.
Warren, R.
Steingart, K.R.
Theron, G.
Date:
2018-01-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content:
Identifiers:
Authors:
Date:
2015-01-01
Journal:
The Lancet
Content:
Identifiers:
Authors:
Pooran, A.
Theron, G.
Zijenah, L.
Chanda, D.
Clowes, P.
Mwenge, L.
Mutenherwa, F.
Lecesse, P.
Metcalfe, J.
Sohn, H.
Hoelscher, M.
Pym, A.
Peter, J.
Dowdy, D.
Dheda, K.
Date:
2019-01-01
Journal:
The Lancet Global Health
Content:
Identifiers:
Authors:
Date:
2012-01-01
Journal:
Clinical infectious diseases
Content:
Identifiers:
Authors:
Date:
2011-01-01
Journal:
American journal of respiratory and critical care medicine
Content:
Identifiers:
Authors:
Date:
2012-01-01
Journal:
The International Journal of Tuberculosis and Lung Disease
Content:
Identifiers:
Authors:
Loveday, M.
Ramjee, A.
Osburn, G.
Master, I.
Kabera, G.
Brust, J.C.M.
Padayatchi, N.
Warren, R.
Theron, G.
Date:
2017-01-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content:
Identifiers:
Authors:
Date:
2012-01-01
Journal:
European Respiratory Monograph Tuberculosis
Content:
Identifiers:
Authors:
Date:
2012-01-01
Journal:
The Lancet Infectious Diseases
Content:
Authors:
Venter, R.
Derendinger, B.
De Vos, M.
Pillay, S.
Dolby, T.
Simpson, J.
Kitchin, N.
Ruiters, A.
Van Helden, P.D.
Warren, R.M.
Theron, G.
Date:
2017-01-01
Journal:
Scientific Reports
Content:
Identifiers:
Authors:
Tomasicchio, M.
Davids, M.
Pooran, A.
Theron, G.
Smith, L.
Semple, L.
Meldau, R.
Hapgood, J.P.
Dheda, K.
Date:
2019-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Date:
2016-01-01
Journal:
Clinical Infectious Diseases
Content:
Identifiers:
Authors:
Naidoo, C.C.
Nyawo, G.R.
Wu, B.G.
Walzl, G.
Warren, R.M.
Segal, L.N.
Theron, G.
Date:
2019-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Authors:
Botha, G.H.R.
Theron, G.
Warren, R.M.
Klopper, M.
Dheda, K.
Van Helden, P.D.
Niesler, T.R.
Date:
2018-01-01
Journal:
Physiological Measurement
Content:
Identifiers:
Authors:
Date:
2015-01-01
Journal:
South African Respiratory Journal
Content:
Identifiers:
Authors:
Date:
2011-01-01
Journal:
American Journal of Respiratory and Critical Care Medicine
Content:
Authors:
Metcalfe, J.Z.
Streicher, E.
Theron, G.
Colman, R.E.
Penaloza, R.
Allender, C.
Lemmer, D.
Warren, R.M.
Engelthaler, D.M.
Date:
2017-01-01
Journal:
Antimicrobial Agents and Chemotherapy
Content:
Identifiers:
Authors:
Tomasicchio, M.
Limberis, J.
van der Merwe, R.
Jacobson, R.
Meldau, R.
Theron, G.
Nicol, M.
Warren, R.
Dheda, K.
Date:
2020-01-01
Journal:
International Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Date:
2011-01-01
Journal:
Continuing Medical Education
Content:
Identifiers:
Authors:
Naidoo, P.
Theron, G.
Rangaka, M.X.
Chihota, V.N.
Vaughan, L.
Brey, Z.O.
Pillay, Y.
Date:
2017-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Mambuque, E.T.
Abascal, E.
Venter, R.
Bulo, H.
Bouza, E.
Theron, G.
García-Basteiro, A.L.
García-de-Viedma, D.
Date:
2018-01-01
Journal:
Tuberculosis
Content:
Identifiers:
Authors:
Date:
2014-01-01
Journal:
Journal of clinical microbiology
Content:
Identifiers:
Authors:
Turner, C.T.
Gupta, R.K.
Tsaliki, E.
Roe, J.K.
Mondal, P.
Nyawo, G.R.
Palmer, Z.
Miller, R.F.
Reeve, B.W.
Theron, G.
Noursadeghi, M.
Date:
2020-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Authors:
De Vos, M.
Derendinger, B.
Dolby, T.
Simpson, J.
Van Helden, P.D.
Rice, J.E.
Wangh, L.J.
Theron, G.
Warren, R.M.
Date:
2018-01-01
Journal:
Journal of Clinical Microbiology
Content:
Identifiers:
Authors:
De Vos, M.
Ley, S.D.
Wiggins, K.B.
Derendinger, B.
Dippenaar, A.
Grobbelaar, M.
Reuter, A.
Dolby, T.
Burns, S.
Schito, M.
Engelthaler, D.M.
Metcalfe, J.
Theron, G.
Van Rie, A.
Posey, J.
Warren, R.
Cox, H.
Date:
2019-01-01
Journal:
New England Journal of Medicine
Content:
Identifiers:
Authors:
García-Basteiro, A.L.
DiNardo, A.
Saavedra, B.
Silva, D.R.
Palmero, D.
Gegia, M.
Migliori, G.B.
Duarte, R.
Mambuque, E.
Centis, R.
Cuevas, L.E.
Izco, S.
Theron, G.
Date:
2018-01-01
Journal:
Revista Portuguesa de Pneumologia (English Edition)
Content:
Identifiers:
Authors:
Date:
2013-01-01
Journal:
Respirology
Content:
Identifiers:
Authors:
Date:
2016-01-01
Journal:
The Cochrane Library
Content:
Identifiers:
Authors:
Date:
2017-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Authors:
Date:
2011-01-01
Journal:
Biotechnology and Applied Biochemistry
Content:
Identifiers:
Authors:
Rouxjeane Venter , author
Stephanie Minnies , author
Brigitta Derendinger , author
Happy Tshivhula , author
Margaretha de Vos , author
Tania Dolby , author
Ashley Ruiters , author
Robin M. Warren , author
Grant Theron , author
Date:
2020-12-01
Journal:
Scientific Reports
Content:
Identifiers:
Authors:
Grant Theron , author
Rouxjeane Venter , author
Liezel Smith , author
Aliasgar Esmail , author
Philippa Randall , author
Vishesh Sood , author
Suzette Oelfese , author
Greg Calligaro , author
Robin Warren , author
Keertan Dheda , author
Geoffrey A. Land , editor
Date:
2018-03-05
Journal:
Journal of Clinical Microbiology
Content:
Identifiers:
Authors:
David M. Engelthaler , author
Elizabeth M. Streicher , author
Erin J. Kelley , author
Christopher J. Allender , author
Kristin Wiggins , author
Dulce Jimenez , author
Darrin Lemmer , author
Eric Vittinghoff , author
Grant Theron , author
Frederick A. Sirgel , author
Robin M. Warren , author
John Z. Metcalfe , author
Date:
2019-12-01
Journal:
American Journal of Respiratory Cell and Molecular Biology
Content:
Identifiers:
Authors:
Bulabula, A.N.H.
Nelson, J.A.
Musafiri, E.M.
MacHekano, R.
Sam-Agudu, N.A.
Diacon, A.H.
Shah, M.
Creswell, J.
Theron, G.
Warren, R.M.
Jacobson, K.R.
Chirambiza, J.-P.
Kalumuna, D.
Bisimwa, B.C.
Katoto, P.D.M.C.
Kaswa, M.K.
Birembano, F.M.
Kitete, L.
Grobusch, M.P.
Kashongwe, Z.M.
Nachega, J.B.
Date:
2019-01-01
Journal:
Clinical Infectious Diseases
Content:
Identifiers:
Authors:
Date:
2015-01-01
Journal:
The Lancet
Content:
Authors:
Date:
2014-01-01
Journal:
The lancet Respiratory medicine
Content:
Identifiers:
Authors:
Date:
2016-01-01
Journal:
Cochrane Database of Systematic Reviews
Content:
Identifiers:
Authors:
Date:
2009-01-01
Journal:
Content:
Identifiers:
Authors:
Dheda, K.
Gumbo, T.
Maartens, G.
Dooley, K.E.
Murray, M.
Furin, J.
Nardell, E.A.
Warren, R.M.
Esmail, A.
Nardell, E.
London, L.
Lessem, E.
Limberis, J.
Theron, G.
McNerney, R.
Niemann, S.
Dowdy, D.
Van Rie, A.
Pasipanodya, J.G.
Rodrigues, C.
Clark, T.G.
Sirgel, F.A.
Schaaf, H.S.
Chang, K.C.
Lange, C.
Nahid, P.
Fourie, B.
Ndjeka, N.
Nunn, A.
Migliori, G.B.
Udwadia, Z.F.
Horsburgh, C.R.
Churchyard, G.J.
Menzies, D.
Hesseling, A.C.
Seddon, J.A.
Low, M.
Keshavjee, S.
Nuermberger, E.
McIlleron, H.
Fennelly, K.P.
Jindani, A.
Jaramillo, E.
Padayatchi, N.
Barry, C.E.
Date:
2019-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Authors:
Date:
2011-01-01
Journal:
European Respiratory Journal
Content:
Identifiers:
Authors:
Date:
2012-01-01
Journal:
International journal of tuberculosis and lung disease
Content:
Identifiers:
Authors:
Grant Theron , author
Jason Limberis , author
Rouxjeane Venter , author
Liezel Smith , author
Elize Pietersen , author
Aliasgar Esmail , author
Greg Calligaro , author
Julian te Riele , author
Marianna de Kock , author
Paul van Helden , author
Tawanda Gumbo , author
Taane G. Clark , author
Kevin Fennelly , author
Robin Warren , author
Keertan Dheda , author
Date:
2020-09-29
Journal:
Nature Medicine
Content:
Identifiers:
Authors:
Brown, P.
Zhou, Y.
Tan, A.-C.
El-Esawi, M.A.
Liehr, T.
Blanck, O.
Gladue, D.P.
Almeida, G.M.F.
Cernava, T.
Sorzano, C.O.
Yeung, A.W.K.
Engel, M.S.
Chandrasekaran, A.R.
Muth, T.
Staege, M.S.
Daulatabad, S.V.
Widera, D.
Zhang, J.
Meule, A.
Honjo, K.
Pourret, O.
Yin, C.-C.
Zhang, Z.
Cascella, M.
Flegel, W.A.
Goodyear, C.S.
van Raaij, M.J.
Bukowy-Bieryllo, Z.
Campana, L.G.
Kurniawan, N.A.
Lalaouna, D.
Hüttner, F.J.
Ammerman, B.A.
Ehret, F.
Cobine, P.A.
Tan, E.-C.
Han, H.
Xia, W.
McCrum, C.
Dings, R.P.M.
Marinello, F.
Nilsson, H.
Nixon, B.
Voskarides, K.
Yang, L.
Costa, V.D.
Bengtsson-Palme, J.
Bradshaw, W.
Grimm, D.G.
Kumar, N.
Martis, E.
Prieto, D.
Sabnis, S.C.
Amer, S.E.D.R.
Liew, A.W.C.
Perco, P.
Rahimi, F.
Riva, G.
Zhang, C.
Devkota, H.P.
Ogami, K.
Basharat, Z.
Fierz, W.
Siebers, R.
Tan, K.H.
Boehme, K.A.
Brenneisen, P.
Brown, J.A.L.
Dalrymple, B.P.
Harvey, D.J.
Ng, G.
Werten, S.
Bleackley, M.
Dai, Z.
Dhariwal, R.
Gelfer, Y.
Hartmann, M.D.
Miotla, P.
Tamaian, R.
Govender, P.
Gurney-Champion, O.J.
Kauppila, J.H.
Zhang, X.
Echeverría, N.
Subhash, S.
Sallmon, H.
Tofani, M.
Bae, T.
Bosch, O.
Cuív, P.O.
Danchin, A.
Diouf, B.
Eerola, T.
Evangelou, E.
Filipp, F.
Klump, H.
Kurgan, L.
Smith, S.S.
Terrier, O.
Tuttle, N.
Ascher, D.B.
Janga, S.C.
Schulte, L.N.
Becker, D.
Browngardt, C.
Bush, S.J.
Gaullier, G.
Ide, K.
Meseko, C.
Werner, G.D.A.
Zaucha, J.
Al-Farha, A.A.
Greenwald, N.F.
Popoola, S.I.
Rahman, S.
Xu, J.
Yang, S.Y.
Hiroi, N.
Alper, O.M.
Baker, C.I.
Bitzer, M.
Chacko, G.
Debrabant, B.
Dixon, R.
Forano, E.
Gilliham, M.
Kelly, S.
Klempnauer, K.-H.
Lidbury, B.A.
Lin, M.Z.
Lynch, I.
Ma, W.
Maibach, E.W.
Mather, D.E.
Nandakumar, K.S.
Ohgami, R.S.
Parchi, P.
Tressoldi, P.
Xue, Y.
Armitage, C.
Barraud, P.
Chatzitheochari, S.
Coelho, L.P.
Diao, J.
Doxey, A.C.
Gobet, A.
Hu, P.
Kaiser, S.
Mitchell, K.M.
Salama, M.F.
Shabalin, I.G.
Song, H.
Stevanovic, D.
Yadollahpour, A.
Zeng, E.
Zinke, K.
Alimba, C.G.
Beyene, T.J.
Cao, Z.
Chan, S.S.
Gatchell, M.
Kleppe, A.
Piotrowski, M.
Torga, G.
Woldesemayat, A.A.
Cosacak, M.I.
Haston, S.
Ross, S.A.
Williams, R.
Wong, A.
Abramowitz, M.K.
Effiong, A.
Lee, S.
Abid, M.B.
Agarabi, C.
Alaux, C.
Albrecht, D.R.
Atkins, G.J.
Beck, C.R.
Bonvin, A.M.J.J.
Bourke, E.
Brand, T.
Braun, R.J.
Bull, J.A.
Cardoso, P.
Carter, D.
Delahay, R.M.
Ducommun, B.
Duijf, P.H.G.
Epp, T.
Eskelinen, E.-L.
Fallah, M.
Farber, D.B.
Fernandez-Triana, J.
Feyerabend, F.
Florio, T.
Friebe, M.
Furuta, S.
Gabrielsen, M.
Gruber, J.
Grybos, M.
Han, Q.
Heinrich, M.
Helanterä, H.
Huber, M.
Jeltsch, A.
Jiang, F.
Josse, C.
Jurman, G.
Kamiya, H.
de Keersmaecker, K.
Kristiansson, E.
de Leeuw, F.-E.
Li, J.
Liang, S.
Lopez-Escamez, J.A.
Lopez-Ruiz, F.J.
Marchbank, K.J.
Marschalek, R.
Martín, C.S.
Miele, A.E.
Montagutelli, X.
Morcillo, E.
Nicoletti, R.
Niehof, M.
O'Toole, R.
Ohtomo, T.
Oster, H.
Palma, J.-A.
Paterson, R.
Peifer, M.
Portilla, M.
Portillo, M.C.
Pritchard, A.L.
Pusch, S.
Raghava, G.P.S.
Roberts, N.J.
Ross, K.
Schuele, B.
Sergeant, K.
Shen, J.
Stella, A.
Sukocheva, O.
Uversky, V.N.
Vanneste, S.
Villet, M.H.
Viveiros, M.
Vorholt, J.A.
Weinstock, C.
Yamato, M.
Zabetakis, I.
Zhao, X.
Ziegler, A.
Aizat, W.M.
Atlas, L.
Bridges, K.M.
Chakraborty, S.
Deschodt, M.
Domingues, H.S.
Esfahlani, S.S.
Falk, S.
Guisado, J.L.
Kane, N.C.
Kueberuwa, G.
Lau, C.L.
Liang, D.
Liu, E.
Luu, A.M.
Ma, C.
Ma, L.
Moyer, R.
Norris, A.D.
Panthee, S.
Parsons, J.R.
Peng, Y.
Pinto, I.M.
Reschke, C.R.
Sillanpää, E.
Stewart, C.J.
Uhle, F.
Yang, H.
Zhou, K.
Zhu, S.
Ashry, M.
Bergsland, N.
Berthold, M.
Chen, C.-E.
Colella, V.
Cuypers, M.
Eskew, E.A.
Fan, X.
Gajda, M.
Gonzálezlez-Prendes, R.
Goodin, A.
Graham, E.B.
Groen, E.J.N.
Gutiérrez-Sacristán, A.
Habes, M.
Heffler, E.
Higginbottom, D.B.
Janzen, T.
Jayaraman, J.
Jibb, L.A.
Jongen, S.
Kinyanjui, T.
Koleva-Kolarova, R.G.
Li, Z.
Liu, Y.-P.
Lund, B.A.
Lussier, A.A.
Ma, L.
Mier, P.
Moore, M.D.
Nagler, K.
Orme, M.W.
Pearson, J.A.
Prajapati, A.S.
Saito, Y.
Tröder, S.E.
Uchendu, F.
Verloh, N.
Voutchkova, D.D.
Abu-Zaid, A.
Bakkach, J.
Baumert, P.
Dono, M.
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Kulkarni, A.
Kumar, N.
Liu, S.
Loft, N.D.
Reddan, T.
Senghore, T.
Vindin, H.
Xu, H.
Bannon, R.
Chen, B.
Cheung, J.T.K.
Cooper, J.
Esnakula, A.K.
Feghali, K.A.
Ghelardi, E.
Gnasso, A.
Horbar, J.
Lai, H.M.
Li, J.
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Ma, R.
Pan, Z.
Peres, M.A.
Pranata, R.
Seow, E.
Sydes, M.
Testoni, I.
Westermair, A.L.
Yang, Y.
Afnan, M.
Albiol, J.
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Amiya, E.
Amorim, R.M.
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Andersen, S.U.
Aplin, J.D.
Argyropoulos, C.
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Atanasov, A.G.
Atchison, D.A.
Avery, S.V.
Avillach, P.
Baade, P.D.
Backman, L.
Badie, C.
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