EDCTP Alumni Network

Title

Optimising linezolid use for drug-resistant tuberculosis in South Africa: the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance.

Objectives

1. Develop a population PK model of linezolid in South African patients with DR-TB. 2. Determine the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance in South African patients with MDR and XDR- or pre-XDR-TB. 3. Define the relationships between linezolid PK parameters, functional mitochondrial activity, and clinical toxicity, and explore the association of SNPs in mtDNA with the risk of linezolid toxicity in this population

Host Organisation

Institution	Country
University of Cape Town (UCT)	South Africa

Participants

Name	Institution	Country
Professor Graeme Meintjes	University of Cape Town (UCT)	South Africa
Professor Gary Maartens	University of Cape Town (UCT)	South Africa

Study Design

Prospective observational cohort study

Sites

Brooklyn Chest Hospital, Cape Town

King Dinuzulu Hospital, Durban

Jose Pearson Hospital, Port Elizabeth

Phd Study

Title	University	Start Date	End Date
Optimising linezolid for drug-resistant tuberculosis	University of Cape Town	2016-01-04

Publications

Wasserman S, Meintjes G, Maartens G. Linezolid in the treatment of drug-resistant tuberculosis: the challenge of its narrow therapeutic index. Expert review of anti-infective therapy. 2016;14(10):901-15. Epub 2016/08/18. doi: 10.1080/14787210.2016.1225498.