Call |
Career Development Fellowship (CDF) |
Programme |
EDCTP2
|
Start Date |
2017-02-01
|
End Date |
2020-01-31
|
Project Code |
TMA2015CDF1018 |
Status |
Active
|
Title
Optimising linezolid use for drug-resistant tuberculosis in South Africa: the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance.
Objectives
1. Develop a population PK model of linezolid in South African patients with DR-TB.
2. Determine the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance in South African patients with MDR and XDR- or pre-XDR-TB.
3. Define the relationships between linezolid PK parameters, functional mitochondrial activity, and clinical toxicity, and explore the association of SNPs in mtDNA with the risk of linezolid toxicity in this population
Host Organisation
Institution |
Country |
University of Cape Town (UCT) |
South Africa |
Participants
Name |
Institution |
Country |
Professor Graeme Meintjes |
University of Cape Town (UCT) |
South Africa |
Professor Gary Maartens |
University of Cape Town (UCT) |
South Africa |
Study Design
Prospective observational cohort study
Sites
Brooklyn Chest Hospital, Cape Town |
King Dinuzulu Hospital, Durban |
Jose Pearson Hospital, Port Elizabeth |
|
Phd Study
Title |
University |
Start Date |
End Date |
Optimising linezolid for drug-resistant tuberculosis |
University of Cape Town |
2016-01-04 |
|
Publications
Wasserman S, Meintjes G, Maartens G. Linezolid in the treatment of drug-resistant tuberculosis: the challenge of its narrow therapeutic index. Expert review of anti-infective therapy. 2016;14(10):901-15. Epub 2016/08/18. doi: 10.1080/14787210.2016.1225498. |
Current Organisation
University of Cape Town (UCT)
Current Job Title
Senior Lecturer
Awards
2016 |
International Society for Infectious Diseases (ISID) Research Grant |
Students Supervised
Type |
Name |
Title |
University |
Start Date |
End Date |
Memberships
Role |
Committee/board |
Start Date |
End Date |
Member |
Western Cape Provincial Clinical Advisory Committee for drug-resistant tuberculosis |
|
|
Education
Institution |
Degree |
Year |
University of Cape Town, South Africa |
MBChB |
2004 |
University of Cape Town, South Africa |
MMed |
2012 |
Colleges of Medicine of South Africa, South Africa |
FCP (SA) |
2012 |
Colleges of Medicine of South Africa, South Africa |
Cert ID(Phys) SA |
2014 |
Grants
Publications
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