EDCTP Alumni Network

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All Profiles
Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-02-01
End Date 2020-01-31
Project Code TMA2015CDF1018
Status Active

Title

Optimising linezolid use for drug-resistant tuberculosis in South Africa: the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance.

Objectives

1. Develop a population PK model of linezolid in South African patients with DR-TB. 2. Determine the effects of linezolid exposure on toxicity, treatment response, and linezolid resistance in South African patients with MDR and XDR- or pre-XDR-TB. 3. Define the relationships between linezolid PK parameters, functional mitochondrial activity, and clinical toxicity, and explore the association of SNPs in mtDNA with the risk of linezolid toxicity in this population

Host Organisation

Institution Country
University of Cape Town (UCT) South Africa

Participants

Name Institution Country
Professor Graeme Meintjes University of Cape Town (UCT) South Africa
Professor Gary Maartens University of Cape Town (UCT) South Africa

Study Design

Prospective observational cohort study

Sites

Brooklyn Chest Hospital, Cape Town
King Dinuzulu Hospital, Durban
Jose Pearson Hospital, Port Elizabeth

Phd Study

Title University Start Date End Date
Optimising linezolid for drug-resistant tuberculosis University of Cape Town 2016-01-04

Publications

Wasserman S, Meintjes G, Maartens G. Linezolid in the treatment of drug-resistant tuberculosis: the challenge of its narrow therapeutic index. Expert review of anti-infective therapy. 2016;14(10):901-15. Epub 2016/08/18. doi: 10.1080/14787210.2016.1225498.

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