||University if Cape Town
(1) To compare the composition and diversity of the vaginal virome in pregnant women with HIV versus age- and parity-matched pregnant women withouth HIV, using shotgun metagenomic sequencing to evaluate the effect of HIV infection on the vaginal virome;
(2) To identify in vivo associations between vaginal viruses associated with HIV infection and bacteriome and validate key bacterial-viral interactions in vitro; and
(3) To compare vaginal virome diversity and composition of women with HIV experiencing preterm birth versus age-, parity- and antiretroviral regimen-matched women with HIV with normal birth outcomes
University if Cape Town, South Africa
Women with and without HIV
Understanding the interplay between vaginal viruses, bacteria and preterm birth is relevant for developing novel diagnostics and interventions for improving preterm birth among women with HIV, and to potentially decrease infant morbidity and mortality.
Vaginal virome of pregnant women living with HIV in sub-Saharan Africa