Call | Career Development Fellowship (CDF) |
Programme | EDCTP2 |
Start Date | 2021-06-01 |
End Date | 2023-12-01 |
Project Code | TMA2019CDF-2776 |
Status | Active |
Characterisation of cardiac disease in adolescents with perinatally-acquired HIV infection in the antiretroviral therapy era (CORD)
Institution | Country |
---|---|
Biomedical Research and Training Institute (BRTI) | Zimbabwe |
Call | EDCTP-AREF Preparatory Fellowships (PF) |
Programme | EDCTP2 |
Start Date | 2020-09-01 |
End Date | 2021-05-31 |
Project Code | TMA2018PF-2533 |
Status | Active |
Cardiovascular disease in adolescents with HIV in Sub-Saharan Africa (CVDA)
Institution | Country |
---|---|
Biomedical Research and Training Institute (BRTI) | Zimbabwe |
Biomedical Research and Training Institute (BRTI)
Research Fellow
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
BSc. Hons in Radiography | Memory Sibanda | ANTERO-POSTERIOR LUMBAR X-RAYS: IMPACT OF STRETCHER BEDS ON IMAGE QUALITY AND RADIATION DOSE | University of Zimbabwe | 2020 | 2021 |
BSc. Hons in Radiography | Edith Mazhinye | EMOTIONAL WELLBEING, STRESS AND COPING STRATEGIES AMONG RADIOGRAPHY STUDENTS IN HARARE | University of Zimbabwe | 2020 | 2021 |
Masters of Public Health | Lazarus Tombo | Barriers to provision of Optimal Radiology Services in Zimbabwe | Univeristy of Burmingham, UK | 2018 | 2019 |
BSc. Hons in Radiography | Sasha Matau | RADIATION PROTECTION AUDIT OF LEAD-RUBBER APRONS USED IN THE OPERATING THEATRES AT CENTRAL HOSPITALS IN HARARE. | University of Zimbabwe | 2019 | 2020 |
Kudzai Mukabeta | A COMPARATIVE ANALYSIS OF THE PRONE AND SUPINE X-RAY PROJECTIONS IN EVALUATION OF ABDOMEN. | University of Zimbabwe | 2019 | 2020 |
Role | Committee/board | Start Date | End Date |
---|
Institution | Degree | Year |
---|---|---|
University of Zimbabwe, Zimbabwe | BSc | 2007-10-09 |
National University of Science and Technology, Zimbabwe | MSc | 2013-11-01 |
London School of Hygiene and Tropical Medicine, United Kingdom | PhD | 2018-11-01 |
Human Immuno-deficiency Virus (HIV) cardiovascular disease echocardiography cardiac magnetic resonance carotid intima media thickness epidemiology
Perinatal HIV infection (PHIV) and prolonged use of antiretroviral therapy (ART) may increase the likelihood of developing subclinical vascular dysfunction at an early age. We conducted a systematic review to assess the effect of PHIV and ART on intima-media thickness (IMT), arterial stiffness and endothelial function in individuals aged 6–25 years.
Medline, Embase and Web of Science were searched, and studies screened by two independent reviewers. We performed a meta-analysis on selected studies reporting on IMT.
A total of 680 studies were retrieved from the databases, with 21 studies deemed eligible for qualitative analysis. There were few studies assessing IMT, arterial stiffness and endothelial function. More than half of the studies found either increased IMT, stiffer arteries or impaired endothelial function in PHIV compared to uninfected controls. A minority of the studies reported that the two groups had similar vascular parameters, a conflicting finding. There was a lack of standardisation for IMT assessment and reporting in numerous studies. In a meta-analysis of seven studies with matching methodologies, IMT was higher in PHIV compared to uninfected controls, (mean difference, 0.05 (0.01–0.09; p = 0.01) but heterogeneity between the studies was substantial (I2, 96.7%; p < 0.001).
PHIV may affect vascular structure and function. Existing studies are generally small, often contradictory, and predominantly cross-sectional in design. Further studies are required to understand vascular health in PHIV to identify cardiovascular disease risk and improve interventional strategies aimed at prevention and treatment of early vascular changes in this population.
Background and aims: Perinatal HIV infection (PHIV) and prolonged use of antiretroviral therapy (ART) may increase the likelihood of developing subclinical vascular dysfunction at an early age. We conducted a systematic review to assess the effect of PHIV and ART on intima-media thickness (IMT), arterial stiffness and endothelial function in individuals aged 6-25 years.
Methods: Medline, Embase and Web of Science were searched, and studies screened by two independent reviewers. We performed a meta-analysis on selected studies reporting on IMT.
Results: A total of 680 studies were retrieved from the databases, with 21 studies deemed eligible for qualitative analysis. There were few studies assessing IMT, arterial stiffness and endothelial function. More than half of the studies found either increased IMT, stiffer arteries or impaired endothelial function in PHIV compared to uninfected controls. A minority of the studies reported that the two groups had similar vascular parameters, a conflicting finding. There was a lack of standardisation for IMT assessment and reporting in numerous studies. In a meta-analysis of seven studies with matching methodologies, IMT was higher in PHIV compared to uninfected controls, (mean difference, 0.05 (0.01-0.09; p = 0.01) but heterogeneity between the studies was substantial (I2, 96.7%; p < 0.001).
Conclusions: PHIV may affect vascular structure and function. Existing studies are generally small, often contradictory, and predominantly cross-sectional in design. Further studies are required to understand vascular health in PHIV to identify cardiovascular disease risk and improve interventional strategies aimed at prevention and treatment of early vascular changes in this population.
Name | Country | Institution |
---|---|---|
Edith Majonga | Zimbabwe | Biomedical Research & Training Institute |