1. The overall objective is to assess a seasonal preventive strategy targeting school-aged children in Mali, using either Dihydroartemisinin and Piperaquine (DHA-PQ), SP-AQ or control.
A double blind randomized controlled clinical trial to assess the efficacy of Dihydroartemisinin-Piperaquine and Sulfadoxine-Pyrimethamine associated to Amodiaquine for Seasonal Malaria Chemoprevention in school children aged from 6-15 years in Mali, 3 treatments arms. Four SMC rounds were conducted
School aged children (6-15 years old at Bandiagara, Mali
Incidence of clinical malaria and prevalence of malaria infection by treatment arms; Incidence of adverse events reported following administration of study drugs by treatment arms; Prevalence of malaria parasitaemia (sexual and asexual forms) at monthly visits by treatment arms: Prevalence of anemia; Prevalence of resistance markers to artemisinin and Piperaquine in children carrying parasites at the end of malaria transmission seasons; Dynamics of children performance at schools during the study period; Parasite genetic diversity.
EDCTP Clinical Research & Development Fellowship