Call | Senior Fellowship (SF) |
Programme | EDCTP2 |
Start Date | 2020-04-01 |
End Date | 2025-03-31 |
Project Code | TMA2018SF-2471 |
Status | Active |
Research Capacity Building by DHA-PQ SMC Clinical Trial in school aged children in Mali
- Assess the impact of SMC on the incidence of clinical malaria and infection in school-aged children; - Evaluate the effect of SMC with DHA-PQ on malaria transmission, measured by the reduction in the prevalence of gametocytes in DHA-PQ treatment group; - Assess the impact of SMC on the genetic diversity of malaria parasites, measured by studying the dynamics of molecular markers associated with resistance to drugs used in SMC. - Evaluate the clinical tolerance of DHA-PQ compared to SP-AQ and control
Institution | Country |
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USTTB | Mali |
Name | Institution | Country |
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Karim Traore | USTTB | Mali |
Interventional study, Phase IV randomized trial with 3 treatment arms: DHA-PQ vs. SP-AQ vs. Albendazole. The trial was randomized double-blinded controlled. Efficacy and tolerability of Dihydroartemisinin-Piperaquine compared to Sulfadoxine-Pyrimethamine associated to Amodiaquine in Seasonal Malaria Chemoprevention in school aged children from 6-15 years were assessed. Participants were followed for 12 months, 4 SMC rounds and 2 cross-sectional surveys were conducted.
MRTC- Bandiagara Malaria Project clinical center |
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
MD candidate | Mohamed Cisse | USTTB | 2019 | 2021 | |
MD candidate | Kindie Kouriba | USTTB | 2020 | 2022 | |
MD candidate | Souleymane Traore | USTTB | 2020 | 2022 | |
MD candidate | Youssouf Traore | USTTB | 2020 | 2022 | |
Master student | Bourema Guindo | USTTB | 2021 | ||
Master student | Mohamed Cisse | USTTB | 2022 |
We screened a total of 385 volunteers of which 345 were successfully enrolled. Thus, 116 were randomized to SP-AQ arm, 114 to treatment DHA-PQ arm and 115 to control arm. All randomized patients successfully completed the first two rounds of SMC. Two patients in SP-AQ arm and one patient in control arm missed the third round. In the fourth round, as in the cross-sectional visit, 113 volunteers from SP-AQ arm, 114 from DHA-PQ arm and 114 from control arm were seen. At the last cross-sectional survey, 105 volunteers from SP-AQ arm, 109 from DHA-PQ arm and 112 from control arm were seen. The total rates of lost to follow-up were 1.15% at the 4th SMC rounds, and 5.5% at the end of the study (last cross-sectional survey).
Malaria Research and Training Center
Senior Researcher
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
Master student | Boureima Guindo | Dr | University of sciences, Technics and Technologies | 2020 | |
MD candidate | Kinde Kouriba | Mr | University of sciences, Technics and Technologies | 2020 | 2022 |
MD candidate | Souleymane Traore | Mr | University of sciences, Technics and Technologies | 2020 | 2022 |
MD Candidate | Youssouf Traore | Mr | University of sciences, Technics and Technologies | 2021 | 2022 |
MD candidate | Mohamed Cisse | Mr | University of sciences, Technics and Technologies | 2019 | 2021 |
Master student | Mohamed Cisse | Dr | University of sciences, Technics and Technologies | 2021 |
Role | Committee/board | Start Date | End Date |
---|---|---|---|
Editorial Team | Revue Malienne d’Infectiologie et de Microbiologie | 2021 |
Institution | Degree | Year |
---|---|---|
Faculty of Medicine, Mali | MD | 2002-05-22 |
Faculty of Medicine and pharmacy, Senegal | CES | 2008-07-03 |
Faculty of Medicine and pharmacy, Senegal | DES | 2011-06-29 |
Faculty of Medicine and pharmacy, Senegal | MSc | 2012-02-02 |
University of Lyon, France | PhD | 2018-02-06 |
, |
Malaria Neglected Infectious Diseases (NID)
The role of some nutrient-derived metabolites on the innate and adaptive immune responses is now established. Global research approach investigating the interplay between environment, lifestyle and the host's immune responses is crucial in the understanding of malaria susceptibility. Advanced Glycation end products (AGE), which are food-derived metabolites result from the link between reducing sugar and amino group of proteins, lipids or nucleic acids. The level of exposure to AGEs varies depending on the type of diet. The dysfunction of the immune system induced by AGE and the cellular receptors for AGEs (RAGE) in susceptibility to bacterial infection has been described. But no study has yet explored their role in susceptibility to malaria. Therefore, we aimed to evaluate systemic AGE and RAGE gene polymorphism in two sympatric populations with previously described difference of susceptibility to malaria. We measured by ELISA the plasma levels of AGEs, and their soluble receptors (sRAGE) from 170 volunteers (68 Fulani and 102 Dogon). We also determined by real-time quantitative PCR the expression of RAGE, and the -374 T/A, -429 T/C polymorphisms and 63 bp deletion by fragment length restriction polymorphism. The prevalence rate of Plasmodium in Fulani and Dogon were respectively 42.64% and 51.30% for P. falciparum, 5.88% and 6.5% for P. malariae, 0% and 2.6% for P. ovale. The average AGE was 12.65 μg/ml, and 496.48pg/ml for sRAGE. Highest levels of sRAGE were observed in Fulani (563,07pg/ml, 95% CI [547.81-580.13] vs 465.68pg/ml, 95% CI [331.19-467.51]) for Dogon, p = 0.00001. Fulani had the lowest mean of AGE (10.21μg/ml, 95% CI [8.02-10.92]) compared to Dogon (16.88μg/ml, 95% CI [13.92-17.96]; p = 0.00001. RAGE was more expressed in Dogon than Fulani (0.08 vs 0.04), P = 0.08. The -374A polymorphism vas more frequent in Fulani (32%) compared to Dogon (20%). The chronic exposure to dietary AGE could lead to immune responses impairment and polymorphism with implications in malaria susceptibility. More studies are necessary to better investigate this hypothesis.
Name | Country | Institution |
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Karim Traore | Mali | USTTB |
Name | Country | Institution |
---|---|---|
Dr Karim Traore | Mali | MRTC |
Pr Abraham Kwabena Anang | Ghana | NMIMR |
Dr Abdoul Habib Beavogui | Guinea | CNFR |
Pr Emmanuele Gormally | France | Lyon Catholic University |
Name | Country | Institution |
---|---|---|
Karim Traore | Mali | MRTC |