|Prof Alison Elliott
To investigate (1) the safety and tolerability and (2) the infectivity of male Schistosoma mansoni (Sm) cercariae in healthy adult Ugandan volunteers with (a) minimal prior exposure to Sm, and (b) intense prior exposure to Sm.
To investigate the kinetics of controlled infection with male Schistosoma mansoni cercariae in healthy adult Ugandan volunteers (a) with minimal prior exposure to Sm, and (b) with intense prior exposure to Sm.
To investigate immunological, metabolic and microbiome changes after infection with Schistosoma mansoni male cercariae.
To investigate volunteer and wider community understandings of CHI in the context of CHI-S
Two Ugandan communities, one with minimal and one with intense prior schistosome exposure
Open label intervention study