EDCTP Alumni Network

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All Profiles
Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2018-07-01
End Date 2021-06-30
Project Code TMA2016CDF1571
Status Active

Title

Identification of host regulators of tissue fibroproliferative pathology in schistosomiasis-diseased children in Africa

Objectives

The overall aim of the present study is to unequivocally establish a gene expression profile that trigger / promote tissue fibrosis during schistosomiasis and in so doing generate a comprehensive database of druggable fibrosis-regulating factors and build a solid capacity in clinical genomics in the applicant. The present project proposes to address the differential gene expression profile of blood cells from schistosomiasis-diseased patients presenting with a differential grade of liver fibrosis. The overall goal of the study is to define in the most informed manner possible cohorts of schistosomiasis-diseased children that present a differential fibrotic profile following an infection with S. mansoni and evaluate thereafter changes in their blood gene expression profiles that might associate with the observed differential fibroproliferative responses.

Host Organisation

Institution Country
University of Cape Town (UCT) South Africa

Participants

Name Institution Country
Justin Komguep Nono University of Cape Town South Africa

Study Design

Cross-sectional, observational, case-control study.

Sites

Bokito, Cameroon

Phd Study

Title University Start Date End Date
Immunomodulation through Excretory/Secretory Products of the parasitic Helminth Echinococcus multilocularis University of Wuerzburg, Germany 2009-01-15 2013-07-17

Students Supervised

Type Name Title University Start Date End Date
PhD Severin Donald Kamdem Mr University of Cape Town 2018 2020
MSc Erve Kuekom Mr Catholic University of Central Africa 2018 2020
MSc Josephine Ntankheuh Ms Catholic University of Central Africa 2018 2020
MSc Francis Konhawa Mr Catholic University of Central Africa 2018 2020
PhD Fungai Musaigwa Mr University of Cape Town 2019 2021
PhD Thabo Mpotje Mr University of Cape Town 2018 2021
MSc Elvis Leonel Kamguia Meyo Mr Protestant University of Central Africa 2020 2021

Publications

Sci Rep. 2020 Feb 17;10(1):2773. doi: 10.1038/s41598-020-59613-z
Front Immunol. 2019 Dec 3;10:2827.
Front Immunol. 2018 Nov 28;9:2781.
Front Immunol. 2018 Oct 9;9:2295.

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