EDCTP Alumni Network

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All Profiles
Call Senior Fellowship (SF)
Programme EDCTP1
Start Date 2007-05-14
End Date 2010-08-08
Project Code TA.2005.40200.004
Status Completed


A pilot study of the Implementation of Seasonal Intermittent Preventive Treatment with Community Participation in Senegal


The purpose of this trial was to compare the acceptability, efficacy and safety of three alternative drug regimens for use for seasonal Intermittent Preventive Treatment to prevent malaria in children. Children aged 2 months to 5 years were randomized to receive IPT with one of three regimens during the transmission season: sulfadoxinepyrimethamine (SP) plus amodiaquine, show to be highly effective for IPT in a recent trial; SP plus piperaquine, used for malaria prophylaxis in China for many years; or Duocotexcin (a combination of piperaquine with an artemisinin).

Host Organisation

Institution Country
University Cheikh Anta Diop Senegal


Name Institution Country
Pierre Gazin Institut de Recherche pour le Développement Senegal
Omar Gaye University of Dakar Senegal
Brian Greenwood London School of Hygiene and Tropical Medicine (LSHTM) United Kingdom
Paul Milligan London School of Hygiene and Tropical Medicine (LSHTM) United Kingdom
Pape Moussa Thior Ministry of Health and Medical Prevention Senegal
Jean-François Trape Institut de Recherche pour le Développement Senegal

Study Design

Phase III Clinical Trial

Results & Outcomes

This study provided evidence that seasonal IPTc with SP+PQ among children is highly effective and well tolerated. The combination of two long-acting drugs is optimal for malaria prevention and is most effective in the face of an emergence of resistant parasite genotypes. It was also demonstrated that amendments to age-based dosing of SPamodiaquine had the potential of increasing dosing accuracy and improve tolerability of the IPTc. The work has been an important reference for the WHO scientific advisory group. One junior physician, two nurses and 45 community volunteers were trained. The grantee also recruited an MSc student in parasitology and he was also a recipient of second Senior Fellowship grant from Malaria Capacity Development Consortium. Two more EDCTP-funded projects followed on from the ground work of this project. These were a Senior Fellowship to Jean Louis Ndiaye and the Malaria Vectored Vaccines Consortium (IP.2008.31100.001), both awarded in 2010.


Cisse B, Cairns M, Faye E, NDiaye O, Faye B, Cames C, Cheng Y, NDiaye M, Lô AC, Simondon K, Trape JF, Faye O, NDiaye JL, Gaye O, Greenwood B, Milligan P. Randomised Trial of Piperaquine with Sulfadoxine-Pyrimethamine or Dihydroartemisinin for Malaria Intermittent Preventive Treatment in Children. PloS ONE. 2009;4(9):e7164

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