EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Senior Fellowship (SF)
Programme EDCTP1
Start Date 2012-12-01
End Date 2015-05-30
Project Code TA.2011.40200.053
Status Completed

Title

Functional characteristics of effector and memory NK cellular responses and their comparison with adaptive T cell responses in HIV-vaccinated subjects and risk populations

Objectives

1. To determine if NK cell recall responses are elicited in HIV uninfected infants and infected adults who received HIV vaccine candidates 2. To determine if NK cell recall responses are present in HIVexposed but uninfected adults and in HIV sero-discordant couples. If present, we will characterise these responses (both the effector recall NK responses) 3. To determine the relationship between NK cell responses and the frequency and quality of CD4+ and CD8+ T cell responses in at-risk populations

Host Organisation

Institution Country
Medical Research Council (MRC) Laboratories Gambia

Participants

Name Institution Country
Anders Fomsgaard Statens Serum Institut, (SSI) Denmark
Assan Jaye Medical Research Council (MRC) Laboratories Gambia
Souleymane Mboup University Cheikh Anta DIOP de Dakar (UCAD) Senegal
Eleanor Mary Riley London School of Hygiene and Tropical Medicine (LSHTM) United Kingdom

Sites

The Gambia, Guinea Bissau and Dakar

Results & Outcomes

A preliminary analysis or a pilot study has been performed on some of the samples from the discordant couples cohort in Senegal. This data shows that HIV peptides can activate NK functional responses in HIV-positive individuals; and that HIV exposed but uninfected subjects elicit higher NK functional responses (as measured by higher degranulation and higher interferon –gamma production); and less NK activation (lower CD25) as compared to those who are HIV-infected. These results have been presented nationally, regionally and internationally. In a recent international scientific meeting, the 17th Annual meeting of the International Conference on AIDS and STIs in Africa (ICASA), in Cape town, South Africa, the abstract on results from this preliminary study won one of the five best abstract awards; the “Best Young Investigators award for basic science.

Current Organisation

National Institute of Communicable Diseases (NICD)

Current Job Title

Medical Scientist

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV) Public Health Vaccine-preventable diseases

Publications

Authors:
Sabelle Jallow
Date:
2019-05-14
Journal:
Clin Infect Dis. 2019 May 14. pii: ciz361. doi: 10.1093/cid/ciz361. [Epub ahead of print]
Content:

Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate and that the child was perinatally exposed to HIV.

Identifiers:
Authors:
Sabelle Jallow
Date:
2018-06-18
Journal:
Clin Infect Dis. 2019 Jun 18;69(1):151-154. doi: 10.1093/cid/ciy1071.
Content:

Human immunodeficiency virus (HIV)-exposed, uninfected infants have higher risks of respiratory syncytial virus-associated hospitalization than HIV-unexposed infants. Despite similar neutralizing antibody titers between HIV-infected and -uninfected women, maternal HIV infection and hypergammaglobulinemia were independently associated with lower titers in newborns. Maternal hypergammaglobulinemia was associated with lower cord-to-maternal antibody ratio.

Identifiers:
Authors:
Sabelle Jallow, Clare L. Cutland, Alexis K. Masbou, Peter Adrian, Shabir A. Madhi , Maternal HIV infection associated with reduced transplacental transfer of measles antibodies and increased susceptibility to disease. Sabelle Jallow, Clare L. Cutland, Alexis K. Masbou, Peter Adrian, Shabir A. Madhi. Journal of Clinical Virology, 2017; 94 p50–56.
Date:
2017-01-01
Journal:
Journal of Clinical Virology
Content:
Identifiers:
Authors:
Sabelle Jallow, Shabir A. Madhia, Metsekae Richard Madimabe, Nadia van Niekerk, Kiran Parbhoo, Fatima Moosa, Kebashni Thandrayen, Nosisa Sipambo, Avy Violari, Udai Kala, Karen Petersen, Sanushka Naidoo, Charl Verwey, David Paul Moore and Marta C. Nunes , Immunogenicity of 13-valent pneumococcal conjugate vaccine among children with underlying medical conditions. Sabelle Jallow, Shabir A. Madhia, Metsekae Richard Madimabe, Nadia van Niekerk, Kiran Parbhoo, Fatima Moosa, Kebashni Thandrayen, Nosisa Sipambo, Avy Violari, Udai Kala, Karen Petersen, Sanushka Naidoo, Charl Verwey, David Paul Moore and Marta C. Nunes. Vaccines. 2017 Aug 3;35(34):4321-4329
Date:
2017-08-01
Journal:
Vaccines
Content:
Identifiers:
Authors:
Jallow S, Madhi SA , Pneumococcal conjugate vaccine in HIV-infected and HIV-exposed, uninfected children. Expert Rev Vaccines 2017
Date:
2017-05-01
Journal:
Expert Rev Vaccines
Content:
Identifiers:

Send a Message