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All Profiles
Call Senior Fellowship (SF)
Programme EDCTP1
Start Date 2012-12-01
End Date 2015-05-30
Project Code TA.2011.40200.053
Status Completed

Title

Functional characteristics of effector and memory NK cellular responses and their comparison with adaptive T cell responses in HIV-vaccinated subjects and risk populations

Objectives

1. To determine if NK cell recall responses are elicited in HIV uninfected infants and infected adults who received HIV vaccine candidates 2. To determine if NK cell recall responses are present in HIVexposed but uninfected adults and in HIV sero-discordant couples. If present, we will characterise these responses (both the effector recall NK responses) 3. To determine the relationship between NK cell responses and the frequency and quality of CD4+ and CD8+ T cell responses in at-risk populations

Host Organisation

Institution Country
Medical Research Council (MRC) Laboratories Gambia

Participants

Name Institution Country
Anders Fomsgaard Statens Serum Institut, (SSI) Denmark
Assan Jaye Medical Research Council (MRC) Laboratories Gambia
Souleymane Mboup University Cheikh Anta DIOP de Dakar (UCAD) Senegal
Eleanor Mary Riley London School of Hygiene and Tropical Medicine (LSHTM) United Kingdom

Sites

The Gambia, Guinea Bissau and Dakar

Results & Outcomes

A preliminary analysis or a pilot study has been performed on some of the samples from the discordant couples cohort in Senegal. This data shows that HIV peptides can activate NK functional responses in HIV-positive individuals; and that HIV exposed but uninfected subjects elicit higher NK functional responses (as measured by higher degranulation and higher interferon –gamma production); and less NK activation (lower CD25) as compared to those who are HIV-infected. These results have been presented nationally, regionally and internationally. In a recent international scientific meeting, the 17th Annual meeting of the International Conference on AIDS and STIs in Africa (ICASA), in Cape town, South Africa, the abstract on results from this preliminary study won one of the five best abstract awards; the “Best Young Investigators award for basic science.

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