EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2019-04-01
End Date 2024-04-30
Project Code TMA2016SF1513
Status Active

Title

Determining Correlates of Naturally Acquired Pre-Erythrocytic Immunity to Plasmodium falciparum Malaria in an Experimental Human Challenge Model (CoNAIPS)

Host Organisation

Institution Country
Kenya

Current Organisation

KEMRI - Wellcome Trust Research Prgramme

Current Job Title

Group Leader

Students Supervised

Type Name Title University Start Date End Date
Masters Robert Mugo Mr Pwani University (Kenya) 2019 2021
PhD Diana Nyabundi Ms Open University (UK) 2018 2021
Master Christine Kalekye Ms Pwani University (Kenya) 2020 2021

Memberships

Role Committee/board Start Date End Date
Member ASTMH Travel Grants 2019 2022

Education

Institution Degree Year
Open University, United Kingdom PhD 2005-05-01
Kenyatta University, Kenya Masters 1999-09-01
,

Areas Of Specialisation

Malaria Covid-19 Immunology Immunization

Grants

Grant Code:
RIA2020EF-3042
Source of funding:
European and Developing Countries Clinical Trials Partnership (EDCTP)
Amount:
497300.00
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2022-01-01
Grant Code:
107499/Z/15/Z
Source of funding:
Wellcome Trust
Amount:
4900000
Role:
Researcher
Start Date:
2015-01-01
End Date:
2021-01-01
Grant Code:
grant.MR/P020321/1
Source of funding:
MRC/DFID
Amount:
759000
Role:
Principal Investigator
Start Date:
2017-01-01
End Date:
2022-01-01
Grant Code:
MR/M003906/1
Source of funding:
MRC
Amount:
2300000
Role:
Researcher
Start Date:
2014-01-01
End Date:
2020-01-01

Publications

Authors:
Muema, D.K.M.
Ndungu, F.M.
Kinyanjui, S.M.
Berkley, J.A.
Date:
2011-01-01
Journal:
Malaria Journal
Content:
Authors:
Urban, B.C.
Ndungu, F.M.
Date:
2008-01-01
Journal:
Handbook of Dendritic Cells
Content:
Authors:
Huttner A , author
Agnandji ST , author
Combescure C , author
Fernandes JF , author
Bache EB , author
Kabwende L , author
Ndungu FM , author
Brosnahan J , author
Monath TP , author
Lemaître B , author
Grillet S , author
Botto M , author
VSV-EBOPLUS Consortia , author
Date:
2018-04-01
Journal:
The Lancet. Infectious diseases
Content:
Identifiers:
Authors:
Langhorne, J.
Ndungu, F.M.
Sponaas, A.-M.
Marsh, K.
Date:
2008-01-01
Journal:
Nature Immunology
Content:
Identifiers:
Authors:
John Joseph Valletta , author
John W.G. Addy , author
Adam J. Reid , author
Francis M. Ndungu , author
Yaw Bediako , author
Jedida Mwacharo , author
Khadija Said , author
Jennifer Musyoki , author
Joyce Mwongeli Ngoi , author
Joshua Wambua , author
Edward Otieno , author
Matt Berriman , author
Philip Bejon , author
Kevin Marsh , author
Jean Langhorne , author
Chris I. Newbold , author
Mario Recker , author
Date:
2021-09-13
Journal:
Content:
Identifiers:
Authors:
Ndungu, F.M.
Mwacharo, J.
Kimani, D.
Kai, O.
Moris, P.
Jongert, E.
Vekemans, J.
Olotu, A.
Bejon, P.
Date:
2012-01-01
Journal:
PLoS ONE
Content:
Authors:
Ndungu, F.M.
Sanni, L.
Urban, B.
Stephens, R.
Newbold, C.I.
Marsh, K.
Langhorne, J.
Date:
2006-01-01
Journal:
Journal of Immunology
Content:
Authors:
John Muthii Muriuki , author
Alexander J. Mentzer , author
Ruth Mitchell , author
Emily L. Webb , author
Anthony O. Etyang , author
Catherine Kyobutungi , author
Alireza Morovat , author
Wandia Kimita , author
Francis M. Ndungu , author
Alex W. Macharia , author
Caroline J. Ngetsa , author
Johnstone Makale , author
Swaib A. Lule , author
Solomon K. Musani , author
Laura M. Raffield , author
Clare L. Cutland , author
Sodiomon B. Sirima , author
Amidou Diarra , author
Alfred B. Tiono , author
Michal Fried , author
Moses Gwamaka , author
Seth Adu-Afarwuah , author
James P. Wirth , author
Rita Wegmüller , author
Shabir A. Madhi , author
Robert W. Snow , author
Adrian V. S. Hill , author
Kirk A. Rockett , author
Manjinder S. Sandhu , author
Dominic P. Kwiatkowski , author
Andrew M. Prentice , author
Kendra A. Byrd , author
Alex Ndjebayi , author
Christine P. Stewart , author
Reina Engle-Stone , author
Tim J. Green , author
Crystal D. Karakochuk , author
Parminder S. Suchdev , author
Philip Bejon , author
Patrick E. Duffy , author
George Davey Smith , author
Alison M. Elliott , author
Thomas N. Williams , author
Sarah H. Atkinson , author
Date:
2021-04-22
Journal:
Nature Medicine
Content:
Identifiers:
Authors:
Lamb, T.J.
Ndung'u, F.M.
Date:
2012-01-01
Journal:
Immunity to Parasitic Infection
Content:
Authors:
Ndungu, F.M.
Lundblom, K.
Rono, J.
Illingworth, J.
Eriksson, S.
Färnert, A.
Date:
2013-01-01
Journal:
European Journal of Immunology
Content:
Identifiers:
Authors:
John W.G. Addy , author
Yaw Bediako , author
Francis M. Ndungu , author
John Joseph Valetta , author
Adam J. Reid , author
Jedida Mwacharo , author
Joyce Mwongeli Ngoi , author
Joshua Wambua , author
Edward Otieno , author
Jennifer Musyoki , author
Khadija Said , author
Matthew Berriman , author
Kevin Marsh , author
Philip Bejon , author
Mario Recker , author
Jean Langhorne , author
Date:
2021-04-09
Journal:
Content:
Identifiers:
Authors:
Bryan D , author
Silva N , author
Rigsby P , author
Dougall T , author
Corran P , author
Bowyer PW , author
Ho MM , author
Collaborative study group , author
Date:
2017-08-01
Journal:
Malaria journal
Content:
Identifiers:
Authors:
Weiss, G.E.
Ndungu, F.M.
McKittrick, N.
Li, S.
Kimani, D.
Crompton, P.D.
Marsh, K.
Pierce, S.K.
Date:
2012-01-01
Journal:
Journal of Immunological Methods
Content:
Authors:
Osii RS , author
Otto TD , author
Garside P , author
Ndungu FM , author
Brewer JM , author
Date:
2020-07-01
Journal:
Frontiers in immunology
Content:
Identifiers:
Authors:
Bull, P.C.
Pain, A.
Ndungu, F.M.
Kinyanjui, S.M.
Roberts, D.J.
Newbold, C.J.
Marsh, K.
Date:
2005-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Illingworth, J.
Butler, N.S.
Roetynck, S.
Mwacharo, J.
Pierce, S.K.
Bejon, P.
Crompton, P.D.
Marsh, K.
Ndungu, F.M.
Date:
2013-01-01
Journal:
Journal of Immunology
Content:
Authors:
Tan, J.
Pieper, K.
Piccoli, L.
Abdi, A.
Foglierini, M.
Geiger, R.
Maria Tully, C.
Jarrossay, D.
Maina Ndungu, F.
Wambua, J.
Bejon, P.
Silacci Fregni, C.
Fernandez-Rodriguez, B.
Barbieri, S.
Bianchi, S.
Marsh, K.
Thathy, V.
Corti, D.
Sallusto, F.
Bull, P.
Lanzavecchia, A.
Date:
2016-01-01
Journal:
Nature
Content:
Identifiers:
Authors:
Ndungu, F.M.
Olotu, A.
Mwacharo, J.
Nyonda, M.
Apfeld, J.
Mramba, L.K.
Fegan, G.W.
Bejon, P.
Marsh, K.
Date:
2012-01-01
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Content:
Authors:
Date:
2019-09-04
Journal:
Science advances
Content:
Iron acquisition is critical for life. Ferroportin (FPN) exports iron from mature erythrocytes, and deletion of the Fpn gene results in hemolytic anemia and increased fatality in malaria-infected mice. The FPN Q248H mutation (glutamine to histidine at position 248) renders FPN partially resistant to hepcidin-induced degradation and was associated with protection from malaria in human studies of limited size. Using data from cohorts including over 18,000 African children, we show that the Q248H mutation is associated with modest protection against anemia, hemolysis, and iron deficiency, but we found little evidence of protection against severe malaria or bacteremia. We additionally observed no excess Plasmodium growth in Q248H erythrocytes ex vivo, nor evidence of selection driven by malaria exposure, suggesting that the Q248H mutation does not protect from malaria and is unlikely to deprive malaria parasites of iron essential for their growth.
Identifiers:
Authors:
Beeson, J.G.
Ndungu, F.
Persson, K.E.M.
Chesson, J.M.
Kelly, G.L.
Uyoga, S.
Hallamore, S.L.
Williams, T.N.
Reeder, J.C.
Brown, G.V.
Marsh, K.
Date:
2007-01-01
Journal:
American Journal of Tropical Medicine and Hygiene
Content:
Identifiers:
Authors:
Ndungu, F.M.
Urban, B.C.
Marsh, K.
Langhorne, J.
Date:
2005-01-01
Journal:
Parasite Immunology
Content:
Authors:
Cadman, E.T.
Abdallah, A.Y.
Voisine, C.
Sponaas, A.-M.
Corran, P.
Lamb, T.
Brown, D.
Ndungu, F.
Langhorne, J.
Date:
2008-01-01
Journal:
Infection and Immunity
Content:
Identifiers:
Authors:
Bull, P.C.
Kortok, M.
Kai, O.
Ndungu, F.
Ross, A.
Lowe, B.S.
Newbold, C.I.
Marsh, K.
Date:
2000-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Bediako, Y.
Ngoi, J.M.
Nyangweso, G.
Wambua, J.
Opiyo, M.
Nduati, E.W.
Bejon, P.
Marsh, K.
Ndungu, F.M.
Date:
2016-01-01
Journal:
BMC Medicine
Content:
Authors:
Ibison, F.
Olotu, A.
Muema, D.M.
Mwacharo, J.
Ohuma, E.
Kimani, D.
Marsh, K.
Bejon, P.
Ndungu, F.M.
Date:
2012-01-01
Journal:
PLoS ONE
Content:
Authors:
Nduati, E.W.
Ng, D.H.L.
Ndungu, F.M.
Gardner, P.
Urban, B.C.
Langhorne, J.
Date:
2010-01-01
Journal:
PLoS ONE
Content:
Authors:
Sutton HJ , author
Aye R , author
Idris AH , author
Vistein R , author
Nduati E , author
Kai O , author
Mwacharo J , author
Li X , author
Gao X , author
Andrews TD , author
Koutsakos M , author
Nguyen THO , author
Nekrasov M , author
Milburn P , author
Cockburn IA , author
Date:
2021-02-01
Journal:
Cell reports
Content:
Identifiers:
Authors:
Muriuki JM , author
Mentzer AJ , author
Kimita W , author
Ndungu FM , author
Macharia AW , author
Webb EL , author
Lule SA , author
Morovat A , author
Hill AVS , author
Bejon P , author
Elliott AM , author
Williams TN , author
Atkinson SH , author
Date:
2018-09-01
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Identifiers:
Authors:
Mandal RK , author
Crane RJ , author
Berkley JA , author
Gumbi W , author
Wambua J , author
Ngoi JM , author
Ndungu FM , author
Schmidt NW , author
Date:
2018-12-01
Journal:
The Journal of infectious diseases
Content:
Identifiers:
Authors:
Pejoski D , author
de Rham C , author
Martinez-Murillo P , author
Santoro F , author
Auderset F , author
Medaglini D , author
Pozzi G , author
Vono M , author
Lambert PH , author
Huttner A , author
Haks MC , author
Ottenhoff THM , author
VSV-EBOPLUS Consortium , author
Date:
2020-10-01
Journal:
NPJ vaccines
Content:
Identifiers:
Authors:
John Joseph Valletta , author
John W.G. Addy , author
Adam J. Reid , author
Francis M. Ndungu , author
Yaw Bediako , author
Jedida Mwacharo , author
Khadija Said , author
Jennifer Musyoki , author
Joyce Mwongeli Ngoi , author
Joshua Wambua , author
Edward Otieno , author
Matt Berriman , author
Philip Bejon , author
Kevin Marsh , author
Jean Langhorne , author
Chris I. Newbold , author
Mario Recker , author
Date:
2021-02-02
Journal:
Wellcome Open Research
Content:
Authors:
Griffiths, M.J.
Ndungu, F.
Baird, K.L.
Muller, D.P.R.
Marsh, K.
Newton, C.R.J.C.
Date:
2001-01-01
Journal:
British Journal of Haematology
Content:
Authors:
Olotu, A.
Clement, F.
Jongert, E.
Vekemans, J.
Njuguna, P.
Ndungu, F.M.
Marsh, K.
Leroux-Roels, G.
Bejon, P.
Date:
2014-01-01
Journal:
PLoS ONE
Content:
Authors:
Shaban J. Mwangi , author
Agnes Gwela , author
Kioko Mwikali , author
Joel L. Bargul , author
Eunice W. Nduati , author
Francis M. Ndungu , author
Philip Bejon , author
Julian C. Rayner , author
Abdirahman I. Abdi , author
Date:
2021-04-13
Journal:
Content:
Identifiers:
Authors:
Francis M. Ndungu , author
Jedida Mwacharo , author
Juliana Wambua , author
Patricia Njuguna , author
Kevin Marsh , author
Chris Drakeley , author
Philip Bejon , author
Date:
2019-03-05
Journal:
Content:
Identifiers:
Authors:
Allsopp, C.E.M.
Sanni, L.A.
Reubsaet, L.
Ndungu, F.
Newbold, C.
Mwangi, T.
Marsh, K.
Langhorne, J.
Date:
2002-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Date:
2019-02-23
Journal:
The Journal of Infectious Diseases
Content:
Identifiers:
DOI: 10.1093/infdis/jiy591
Part of ISSN: 0022-1899
Part of ISSN: 1537-6613
Authors:
Dorfman, J.R.
Bejon, P.
Ndungu, F.M.
Langhorne, J.
Kortok, M.M.
Lowe, B.S.
Mwangi, T.W.
Williams, T.N.
Marsh, K.
Date:
2005-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Emma Nelima Khaemba , author
Caroline Ogwang , author
Sam Kinyanjui , author
John Mutiso Muindi , author
Joseph Kipsigei Koske , author
Domtila Kimani , author
Joyce Ngoi , author
Jedidah Mwacharo , author
Jimmy Shangala , author
Patricia Njuguna , author
Dennis Mutinda , author
Emily Nyatichi , author
Judy Peshu , author
Brian Mutinda , author
Francis Ndungu , author
Anna Farnert , author
Mahfudh M. Bashraheil , author
Philip Bejon , author
Melissa C. Kapulu , author
Date:
2020-02-20
Journal:
Content:
Identifiers:
Authors:
Shaban J. Mwangi , author
Agnes Gwela , author
Kioko Mwikali , author
Joel L. Bargul , author
Eunice W. Nduati , author
Francis M. Ndungu , author
Philip Bejon , author
Julian C. Rayner , author
Abdirahman I. Abdi , author
Date:
2020-08-21
Journal:
Wellcome Open Research
Content:
Authors:
Beeson JG , author
Ndungu F , author
Persson KE , author
Chesson JM , author
Kelly GL , author
Uyoga S , author
Hallamore SL , author
Williams TN , author
Reeder JC , author
Brown GV , author
Marsh K , author
Date:
2007-07-01
Journal:
The American journal of tropical medicine and hygiene
Content:
Identifiers:
Authors:
John Joseph Valletta , author
John W.G. Addy , author
Adam J. Reid , author
Francis M. Ndungu , author
Yaw Bediako , author
Jedida Mwacharo , author
Khadija Said , author
Jennifer Musyoki , author
Joyce Mwongeli Ngoi , author
Joshua Wambua , author
Edward Otieno , author
Matt Berriman , author
Philip Bejon , author
Kevin Marsh , author
Jean Langhorne , author
Chris I. Newbold , author
Mario Recker , author
Date:
2021-09-13
Journal:
Wellcome Open Research
Content:
Authors:
Ndungu, F.M.
Cadman, E.T.
Coulcher, J.
Nduati, E.
Couper, E.
MacDonald, D.W.
Ng, D.
Langhorne, J.
Date:
2009-01-01
Journal:
PLoS Pathogens
Content:
Authors:
Ndungu, F.M.
Marsh, K.
Fegan, G.
Wambua, J.
Nyangweso, G.
Ogada, E.
Mwangi, T.
Nyundo, C.
Macharia, A.
Uyoga, S.
Williams, T.N.
Bejon, P.
Date:
2015-01-01
Journal:
BMC Medicine
Content:
Authors:
Poetsch JH , author
Dahlke C , author
Zinser ME , author
Kasonta R , author
Lunemann S , author
Rechtien A , author
Ly ML , author
Stubbe HC , author
Krähling V , author
Biedenkopf N , author
Eickmann M , author
Fehling SK , author
Olearo F , author
Addo MM , author
Date:
2019-01-01
Journal:
The Journal of infectious diseases
Content:
Identifiers:
Authors:
Bundi CK , author
Nalwoga A , author
Lubyayi L , author
Muriuki JM , author
Mogire RM , author
Opi H , author
Mentzer AJ , author
Mugyenyi CK , author
Mwacharo J , author
Webb EL , author
Bejon P , author
Williams TN , author
Gikunju JK , author
Atkinson SH , author
Date:
2020-06-01
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Identifiers:
Authors:
Stephens, R.
Ndungu, F.M.
Langhorne, J.
Date:
2009-01-01
Journal:
Parasite Immunology
Content:
Authors:
Date:
2020-12-01
Journal:
BMC Medicine
Content:
Identifiers:
Authors:
Date:
2019-11-16
Journal:
Immunological reviews
Content:
B-cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are critical for control of parasitemia and associated immunopathology. Antibodies also provide protection to reinfection. Long-lasting B-cell memory has been shown to occur in response to Plasmodium spp. in experimental model infections, and in human malaria. However, there are reports that antibody responses to several malaria antigens in young children living with malaria are not similarly long-lived, suggesting a dysfunction in the maintenance of circulating antibodies. Some studies attribute this to the expansion of atypical memory B cells (AMB), which express multiple inhibitory receptors and activation markers, and are hyporesponsive to B-cell receptor (BCR) restimulation in vitro. AMB are also expanded in other chronic infections such as tuberculosis, hepatitis B and C, and HIV, as well as in autoimmunity and old age, highlighting the importance of understanding their role in immunity. Whether AMB are dysfunctional remains controversial, as there are also studies in other infections showing that AMB can produce isotype-switched antibodies and in mouse can contribute to protection against infection. In light of these controversies, we review the most recent literature on either side of the debate and challenge some of the currently held views regarding B-cell responses to Plasmodium infections.
Identifiers:
Authors:
Pieper, K.
Tan, J.
Piccoli, L.
Foglierini, M.
Barbieri, S.
Chen, Y.
Silacci-Fregni, C.
Wolf, T.
Jarrossay, D.
Anderle, M.
Abdi, A.
Ndungu, F.M.
Doumbo, O.K.
Traore, B.
Tran, T.M.
Jongo, S.
Zenklusen, I.
Crompton, P.D.
Daubenberger, C.
Bull, P.C.
Sallusto, F.
Lanzavecchia, A.
Date:
2017-01-01
Journal:
Nature
Content:
Identifiers:
Authors:
Sutton HJ , author
Aye R , author
Idris AH , author
Vistein R , author
Nduati E , author
Kai O , author
Mwacharo J , author
Li X , author
Gao X , author
Andrews TD , author
Koutsakos M , author
Nguyen THO , author
Nekrasov M , author
Milburn P , author
Cockburn IA , author
Date:
2020-05-01
Journal:
Content:
Identifiers:
Authors:
Bediako Y , author
Adams R , author
Reid AJ , author
Valletta JJ , author
Ndungu FM , author
Sodenkamp J , author
Mwacharo J , author
Ngoi JM , author
Kimani D , author
Kai O , author
Wambua J , author
Nyangweso G , author
de Villiers EP , author
Langhorne J , author
Date:
2019-03-01
Journal:
BMC medicine
Content:
Identifiers:
Authors:
Bull, P.C.
Lowe, B.S.
Kaleli, N.
Njuga, F.
Kortok, M.
Ross, A.
Ndungu, F.
Snow, R.W.
Marsh, K.
Date:
2002-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
Authors:
Illingworth J , author
Butler NS , author
Roetynck S , author
Mwacharo J , author
Pierce SK , author
Bejon P , author
Crompton PD , author
Marsh K , author
Ndungu FM , author
Date:
2012-12-01
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Content:
Identifiers:
Authors:
Medaglini, D.
Harandi, A.M.
Ottenhof, T.H.M.
Siegrist, C.-A.
Agnandji, S.T.
Ahmed, R.
Anderson, J.
Auderset, F.
Borgianni, L.
Brosnahan, J.
Ciabattini, A.
Engler, O.
Haks, M.C.
Heppner, G.
Gerlini, A.
Kremsner, P.G.
Leib, S.
Monath, T.
Ndungu, F.
Njuguna, P.
Page, M.
Pozzi, G.
Rappuoli, R.
Santoro, F.
Strasser, M.
Date:
2015-01-01
Journal:
Science Translational Medicine
Content:
Authors:
Ndungu, F.M.
Bull, P.C.
Ross, A.
Lowe, B.S.
Kabiru, E.
Marsh, K.
Date:
2002-01-01
Journal:
Parasite Immunology
Content:
Authors:
Date:
2020-05-04
Journal:
European Journal of Immunology
Content:
Identifiers:
DOI: 10.1002/eji.201948473
Part of ISSN: 0014-2980
Part of ISSN: 1521-4141

Projects

Fellow:
Francis Ndungu
Collaborators:
Name Country Institution
Francis Ndungu Kenya KEMRI/Wellcome Trust
Objectives:
1) To characterize in detail Pf-pre-erythrocytic stage specific T cell responses prior to initiation of CHMI of CIA and non-CIA adults with intravenous injection of live sporozoites. 2) To comprehensively screen for Pf pre-erythrocytic stage antigen specific antibodies prior to initiation of CHMI in CIA and non-CIA adults with intravenous injection of live sporozoites. 3) To determine levels of inhibition of liver stage Pf development, in vitro, by serum antibodies taken prior to the initiation of CHMI in CIA and non-CIA adults with intravenous injection of live sporozoites (in vitro). 4) To compare the baseline levels and qualities of responses measured in 1), 2), and 3) between CIA and non-CIA adults.
Sites:
Kemri/wellcome Trust, Kilifi, Kenya
Study Design:
Longitudinal
Subjects:
Adult participants in human malaria experimental infections
Outcomes:
Ongoing
Linked Grant:
Determining Cellular Correlates of Immunity to Malaria in an Experimental Human Challenge Model of Exposed Adults
Start Date:
2019-04-01
End Date:
2024-04-01
Fellow:
Francis Ndungu
Collaborators:
Name Country Institution
Francis Ndungu Kenya KEMRI/Wellcome
Shaheen Sayed Kenya Aga Khan University
Mariele Haks Netherlands Academisch Ziekenhuis Leiden (LUMC)
Anna Farnert Sweden Karolinska Institutet
Bartek Makower Sweden Mabtech AB
Objectives:
1. Validate and adopt serological and cellular assays for complementing PCR in diagnosis of SARS-CoV-2 as well as for estimating the numbers of exposed people in population studies. 2. Determine the kinetics of antibody and cellular responses to SARS-CoV-2 and evaluate their relation to viral shedding, clinical symptoms and immunity. 3. Isolate monoclonal antibodies from survivors to inform vaccine immunogen target design, and to use these SARS-CoV-2-specific antibodies as potential therapeutics in the future.
Sites:
kemri/Wellcome Trust, Kilifi, Kenya Aga Khan University, Nairobi, Kenya
Study Design:
Longitudinal
Subjects:
Covid-19 patients and asymptomatic infections
Outcomes:
Recruitment ongoing
Linked Grant:
Host immune responses to SARS-CoV-2: correlating kinetics with the natural history of infection
Start Date:
2020-07-01
End Date:
2022-07-31

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