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All Profiles

Dr Admire Chikandiwa

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-06-01
End Date 2020-05-31
Project Code TMA2015CDF1032
Status Active

Title

The epidemiology of HPV infection and related disease among HIV infected men in South Africa (TEHSA)

Objectives

Aim: generate further evidence regarding the epidemiology and burden of disease associated with HPV infection in HIV positive men, in order to inform future prevention policies in South Africa (SA). Specific Objectives: 1) Describe and report the epidemiology of anogenital and oropharyngeal cancer patterns and trends in men including incidence and mortality rates and differences by ethnicity in SA between 1994 and 2010. Furthermore, the influence of HIV status on epidemiology of these cancers will be explored. 2) Determine the prevalence of anogenital and oropharyngeal HPV infection, genotype distribution, and associations with anogenital disease, according to HIV-related factors (e.g. plasma viral load, CD4+ counts) and exposure to antiretroviral treatment (ART). a) Within this, compare the performance of oral swabs to oral rinses in detecting oral HPV infection in an urban cohort of HIV positive men in SA. 3) Determine the incidence, persistence, and clearance of type-specific anogenital and oropharyngeal HPV infection and anal cytological lesions over 18 months and the effects of HIV-related factors and ART on these outcomes. a) Within this, determine the clinical relevance of HPV viral load to predict persistence of infection and cytological abnormalities at follow-up and effects of HIV-related factors on these outcomes.

Host Organisation

Institution Country
Wits Reproductive and HIV Research Institute, University of the Witwatersrand South Africa

Study Design

Multi-design: (i) Review of the pathology based cancer reports from the South Africa National Cancer Registry (NCR) and mortality statistics from Statistics South Africa from 1994 to 2013 (ii) A 18 months observational cohort of 304 HIV-infected men from Johannesburg.

Current Organisation

Wits Reproductive and HIV Research Institute, University of the Witwatersrand

Current Job Title

Senior Research Clinician

Grants

University of the Witwatersrand Faculty of Research Small Grant Application
Grant Code:
Source of funding:
FRC
Amount:
8600
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2020-01-01
Dynamic modeling study to estimate the impact (i.e. population-level effectiveness and cost-effectiveness) of various HPV vaccination strategies whilst accounting for the HPV and HIV interactions
Grant Code:
NA
Source of funding:
CANADIAN INSTITUTES OF HEALTH RESEARCH
Amount:
500000
Role:
Researcher
Start Date:
2021-01-01
End Date:
2021-01-01
Impact of 2-dose and 1-dose vaccination schedules on community level HPV prevalence among sexually active adolescents in South Africa
Grant Code:
NA
Source of funding:
Bill and Melinda Gates Foundation
Amount:
4300000
Role:
Researcher
Start Date:
2019-01-01
End Date:
2023-01-01
Impact of HPV infection on vaginal microbiome
Grant Code:
NA
Source of funding:
Amount:
10000
Role:
Start Date:
2018-01-01
End Date:
2018-01-01

Publications

Performance of the careHPV Test for Cervical Cancer Screening among Women Living with HIV-1 in Burkina Faso and South Africa: HARP Study
Authors:
Segondy, M., Kelly, H., Magooa, M., Djigma, F., Ngou, J., Gilham, C., Omar, T., Goumbri Lompo, O., Michelow, P., Doutre, S., Clavero, O., Chikandiwa, A., Sawadogo, B., Marie-Noelle Didelot, M-N., Costes, V., Meda, N., Delany-Moretlwe, S and Mayaud, P
Date:
2016-07-01
Journal:
British Journal of Cancer
Content:
Identifiers:
Detection of four human polyomaviruses (MCPyV, HPyV6, HPyV7 and TSPyV) in cervical specimens from HIV-infected and HIV-uninfected women.
Authors:
Kolia-Diafouka P, Foulongne V, Boulle N, Ngou J, Kelly H, Sawadogo B, Delany-Moretlwe S, Mayaud P, Segondy M; HARP Study Group
Date:
2016-03-01
Journal:
Sexually Transmitted Infection
Content:
Identifiers:
HPV vaccine introduction in South Africa: implementation lessons from an evaluation of the national school-based vaccination campaign (2018)
Authors:
Delany-Moretlwe, S., Kelley, K., James, S., Scorgie, F., Subedar, H., Pillay, Y., Nicolette Naidoo, N., Chikandiwa, A Helen Rees
Date:
2018-10-01
Journal:
Global Health: Science and Practice
Content:
Identifiers:
Prospective evaluation of cervical cancer screening and screening-triage strategies among women living with HIV-1 in Africa – a diagnostic accuracy study.
Authors:
Kelly, H, Chikandiwa, A, Sawadogo, B, Gilham, C, Michelow, P, Lompo, O, Omar, T, Zan, S, Magooa, P, Segondy, M, Nagot, N, Meda, N Delany-Moretlwe, S and Mayaud, P, for the HARP study group
Date:
2020-10-22
Journal:
Plos One
Content:
Identifiers:
Cervical intraepithelial neoplasia in African women living with human immunodeficiency virus (HIV): Role and effect of rigorous histopathological review by a panel of pathologists in the HARP study endpoint determination.
Authors:
Doutre, S., Omar, T., Lompo, O., Kelly, H., Clavero, O., Zan, S., Chikandiwa, A., Sawadogo, B., Delany-Moretlwe, S., Costes, V., Mayaud, P and Segondy, M on behalf of the HARP Study Group.(
Date:
2017-05-31
Journal:
Journal of Clinical Pathology
Content:
Identifiers:
Type-specific serologic responses to human papillomaviruses among women living with HIV-1 in South Africa: seroprevalence, seroconversion and risk of re-infection
Authors:
Kelly, H., Faust, H., Chikandiwa, A., Ngou, J., Weiss, H., Segondy, M., Dillner, J., Delany-Moretlwe, S and Mayaud, P.
Date:
2018-10-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
The effect of antiretroviral therapy on anal high-risk human papillomavirus, intraepithelial neoplasia and cancer among people living with HIV: a systematic review and meta-analysis
Authors:
Kelly, H, Chikandiwa, A, De Sanjose, S, Palefsky, J, and Mayaud P
Date:
2020-10-12
Journal:
Lancet HIV
Content:
Identifiers:
Comparison of the Digene HC2 HPV DNA Assay with the INNO-LiPA HPV Genotyping Assay for Cervical Cancer Screening in African Women Infected with HIV-1-HARP study
Authors:
Ngou, J., Gilham, C., Goumbri-Lompo, O., Sylviane Doutre, S., Michelow, P., Kelly, H., Didelot, M,N., Chikandiwa, A., Sawadogo, B., Delany-Moretlwe, S., Meda, N., Costes, V., Mayaud, P. and Segondy, M (2015
Date:
2015-05-01
Journal:
JAIDS
Content:
Identifiers:
HPV-related cancers other than cervical in South Africa: patterns and trends from 1994 to 2013.
Authors:
Chikandiwa, A.,Pisa P.T., Singh E., Delany-Moretlwe S, and Sengayi, M
Date:
2019-10-01
Journal:
Cancer Epidemiology
Content:
Identifiers:
Cash transfer interventions for sexual health: meanings and experiences of adolescent males and females in inner-city Johannesburg
Authors:
Khoza, N., Stadler, J., MacPhail, C., Chikandiwa, A.,Brahmbatt, H. and Delany-Moretlwe, S
Date:
2018-01-13
Journal:
BMC Public Health
Content:
Identifiers:
Associations of human gene EPB41L3 DNA methylation and cervical intraepithelial neoplasia (CIN) in women living with HIV-1 in Burkina Faso and South Africa.
Authors:
Kelly, H., Chikandiwa, A., Warman, R., Segondy, M., Sawadogo, B., Vasiljevic, N., Didelot, M-N., Meda, Weiss, H.A., Delany-Moretlwe, S., Mayaud, P and Lorincz, A
Date:
2018-10-01
Journal:
AIDS
Content:
Identifiers:
Use of contraceptives, high risk births and under-five mortality in Sub Saharan Africa : Evidence from Kenyan (2014) and Zimbabwean (2011) Demographic Health Surveys (2018).
Authors:
Chikandiwa, A., Chimoyi, L., Burgess, E and Otwombe, K.
Date:
2018-10-01
Journal:
BMC Women's Health
Content:
Identifiers:
Associations of human papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa
Authors:
Kelly, H., Ngou, J., Chikandiwa, A., Sawadogo, B., Omar, T., Lompo, O., Clare G., Doutre, S., Meda, N., Weiss, H., Delany-Moretlwe, S., Segondy, M and Mayaud, P for the HARP Study Group* (
Date:
2017-01-01
Journal:
PloS One
Content:
Identifiers:
Human Papillomavirus Infection and Cervical Dysplasia in HIV-positive Women: Potential Role of the Vaginal Microbiota
Authors:
van de Wijgert JHHM, Gill AC, Darby A, Kelly H, Chikandiwa A, Delany-Moretlwe S, Verwijs MC, Francis S, Mayaud P
Date:
2019-10-01
Journal:
Sex Transm Dis
Content:
Identifiers:
Prevalent, persistent anal HPV infection and squamous intraepithelial lesions: Findings from a cohort of men living with HIV/AIDS in South Africa
Authors:
Chikandiwa, A, Pisa, P.T, Tamalet, C, Muller E,F., Michelow, P, Chersich, M.F, Mayaud, P and Sinead Delany-Moretlwe, S
Date:
2019-12-01
Journal:
PloS One
Content:
Identifiers:
Oropharyngeal HPV infection: prevalence and sampling methods among HIV-infected men in South Africa
Authors:
Chikandiwa, A., Pisa, P.T., Chersich, M.F., Muller, E.E., Michelow, P., Mayaud, P and Delany-Moretlwe, S.
Date:
2018-08-01
Journal:
International Journal of STD & AIDS
Content:
Identifiers:
Clinical Characteristics of Mycoplasma Genitalium and the Usefulness of Syndromic Management Among Women Living With HIV
Authors:
Ong J.J,Magooa M.M, Chikandiwa A, Kelly H, Didelot. M-N, Muller, E.E, Maseko V, Segondy, M, Delany-Moretlwe S, Kularatne, R, Mayaud, M
Date:
2019-05-01
Journal:
Sex Transm Dis
Content:
Identifiers:
Prevalence of anogenital HPV infection, related disease and risk factors among HIV-infected men in inner-city Johannesburg, South Africa: Baseline findings from a cohort study
Authors:
Chikandiwa, A., Chimoyi, L., Pisa, P.T., Chersich, M.F., Muller, E.E., Michelow, P., Mayaud, P and Delany-Moretlwe, S.
Date:
2017-01-01
Journal:
BMC Public Health
Content:
Identifiers:
HPV seroprevalence and seroconversion among HIV-positive men: Cohort study in South Africa
Authors:
Chikandiwa, A., Faust, H., Mayaud, P., Dillner, J and Delany-Moretlwe S
Date:
2020-02-01
Journal:
JAIDS
Content:
Identifiers:
Economic growth as an underlying probable systemic driverfor childhood obesity in South Africa: a joinpoint regression analysis.
Authors:
3. Pisa, PT, Pisa N, Chikandiwa, P, and Chikandiwa, A
Date:
2020-03-10
Journal:
SAMJ
Content:
Identifiers:
The Performance Swede Score in Predicting CIN in Women Living with HIV-1 in South Africa
Authors:
2. Maringa, D.V, Mbodi, L, Chikandiwa, A, Kelly, H, Mayaud, P, Delany-Moretlwe, S and Adam, Y.
Date:
2020-10-18
Journal:
International Journal of Gynecology
Content:
Identifiers:
Prevalence and antimicrobial resistance of Mycoplasma Genitalium infection among women living with HIV in South Africa.
Authors:
Ong, J.J., Magooa, M.P., Chikandiwa, A., Kelly, H., Didelot, M.N., Muller, E.E., Segondy, M., Delany-Moretlwe, S., Kularatne, R and Mayaud, P
Date:
2018-05-01
Journal:
Clinical Infectious Diseases
Content:
Identifiers:
Knowledge and awareness about HPV and intention to take up HPV vaccine among female tertiary students in the Eastern Cape Province
Authors:
Chikandiwa, A and van Wyk, B. (2013Delany-Moretlwe, S., Chikandiwa, A. and Gibbs, J
Date:
2013-05-01
Journal:
South African Journal of Epidemiology and Infection
Content:
Identifiers:
Natural history of high risk HPV and cervical lesions in women living with HIV: impact of HIV related factors
Authors:
Kelly, H., Sawadogo, B., Chikandiwa, A., Segondy, M., Gilham, C., Goumbri-Lompo, O., Omar, T., Didelot, M-N., Nagot, N., Meda, N., Weiss, H.A., Magooa, M., Djigma, F., Ngou, J., Gilham, C., Delany-Moretlwe, S and Mayaud, P
Date:
2017-10-01
Journal:
AIDS
Content:
Identifiers:
Temporal trends in the epidemiology of cervical cancer in South Africa (1994-2012)
Authors:
Olorunfemi, G., Ndlovu, N., Masukume, G., Chikandiwa, A., Pisa, P.T and Singh, E. (2018).
Date:
2018-10-02
Journal:
International Journal of Cancer
Content:
Identifiers:
The Epidemiology of HPV infection in men in South Africa: The impact of HIV.
Authors:
Delany-Moretlwe, S., Chikandiwa, A. and Gibbs, J
Date:
2013-09-06
Journal:
South African Journal of HIV Medicine
Content:
Identifiers:

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