EDCTP Alumni Network

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Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2017-06-01
End Date 2020-05-31
Project Code TMA2015CDF1032
Status Active

Title

The epidemiology of HPV infection and related disease among HIV infected men in South Africa (TEHSA)

Objectives

Aim: generate further evidence regarding the epidemiology and burden of disease associated with HPV infection in HIV positive men, in order to inform future prevention policies in South Africa (SA). Specific Objectives: 1) Describe and report the epidemiology of anogenital and oropharyngeal cancer patterns and trends in men including incidence and mortality rates and differences by ethnicity in SA between 1994 and 2010. Furthermore, the influence of HIV status on epidemiology of these cancers will be explored. 2) Determine the prevalence of anogenital and oropharyngeal HPV infection, genotype distribution, and associations with anogenital disease, according to HIV-related factors (e.g. plasma viral load, CD4+ counts) and exposure to antiretroviral treatment (ART). a) Within this, compare the performance of oral swabs to oral rinses in detecting oral HPV infection in an urban cohort of HIV positive men in SA. 3) Determine the incidence, persistence, and clearance of type-specific anogenital and oropharyngeal HPV infection and anal cytological lesions over 18 months and the effects of HIV-related factors and ART on these outcomes. a) Within this, determine the clinical relevance of HPV viral load to predict persistence of infection and cytological abnormalities at follow-up and effects of HIV-related factors on these outcomes.

Host Organisation

Institution Country
Wits Reproductive and HIV Research Institute, University of the Witwatersrand South Africa

Study Design

Multi-design: (i) Review of the pathology based cancer reports from the South Africa National Cancer Registry (NCR) and mortality statistics from Statistics South Africa from 1994 to 2013 (ii) A 18 months observational cohort of 304 HIV-infected men from Johannesburg.

Current Organisation

Wits Reproductive and HIV Research Institute, University of the Witwatersrand

Current Job Title

Senior Research Clinician

Students Supervised

Type Name Title University Start Date End Date

Memberships

Role Committee/board Start Date End Date

Education

Institution Degree Year
,

Grants

Grant Code:
Source of funding:
FRC
Amount:
8600
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2020-01-01
Grant Code:
NA
Source of funding:
CANADIAN INSTITUTES OF HEALTH RESEARCH
Amount:
500000
Role:
Researcher
Start Date:
2021-01-01
End Date:
2021-01-01
Grant Code:
NA
Source of funding:
Bill and Melinda Gates Foundation
Amount:
4300000
Role:
Researcher
Start Date:
2019-01-01
End Date:
2023-01-01
Grant Code:
NA
Source of funding:
Amount:
10000
Role:
Start Date:
2018-01-01
End Date:
2018-01-01

Publications

Authors:
Segondy, M., Kelly, H., Magooa, M., Djigma, F., Ngou, J., Gilham, C., Omar, T., Goumbri Lompo, O., Michelow, P., Doutre, S., Clavero, O., Chikandiwa, A., Sawadogo, B., Marie-Noelle Didelot, M-N., Costes, V., Meda, N., Delany-Moretlwe, S and Mayaud, P
Date:
2016-07-01
Journal:
British Journal of Cancer
Content:
Authors:
Kolia-Diafouka P, Foulongne V, Boulle N, Ngou J, Kelly H, Sawadogo B, Delany-Moretlwe S, Mayaud P, Segondy M; HARP Study Group
Date:
2016-03-01
Journal:
Sexually Transmitted Infection
Content:
Authors:
Delany-Moretlwe, S., Kelley, K., James, S., Scorgie, F., Subedar, H., Pillay, Y., Nicolette Naidoo, N., Chikandiwa, A Helen Rees
Date:
2018-10-01
Journal:
Global Health: Science and Practice
Content:
Authors:
Kelly, H, Chikandiwa, A, Sawadogo, B, Gilham, C, Michelow, P, Lompo, O, Omar, T, Zan, S, Magooa, P, Segondy, M, Nagot, N, Meda, N Delany-Moretlwe, S and Mayaud, P, for the HARP study group
Date:
2020-10-22
Journal:
Plos One
Content:
Authors:
Doutre, S., Omar, T., Lompo, O., Kelly, H., Clavero, O., Zan, S., Chikandiwa, A., Sawadogo, B., Delany-Moretlwe, S., Costes, V., Mayaud, P and Segondy, M on behalf of the HARP Study Group.(
Date:
2017-05-31
Journal:
Journal of Clinical Pathology
Content:
Authors:
Kelly, H., Faust, H., Chikandiwa, A., Ngou, J., Weiss, H., Segondy, M., Dillner, J., Delany-Moretlwe, S and Mayaud, P.
Date:
2018-10-01
Journal:
Journal of Infectious Diseases
Content:
Authors:
Ngou, J., Gilham, C., Goumbri-Lompo, O., Sylviane Doutre, S., Michelow, P., Kelly, H., Didelot, M,N., Chikandiwa, A., Sawadogo, B., Delany-Moretlwe, S., Meda, N., Costes, V., Mayaud, P. and Segondy, M (2015
Date:
2015-05-01
Journal:
JAIDS
Content:
Authors:
Chikandiwa, A.,Pisa P.T., Singh E., Delany-Moretlwe S, and Sengayi, M
Date:
2019-10-01
Journal:
Cancer Epidemiology
Content:
Authors:
Khoza, N., Stadler, J., MacPhail, C., Chikandiwa, A.,Brahmbatt, H. and Delany-Moretlwe, S
Date:
2018-01-13
Journal:
BMC Public Health
Content:
Authors:
Kelly, H., Chikandiwa, A., Warman, R., Segondy, M., Sawadogo, B., Vasiljevic, N., Didelot, M-N., Meda, Weiss, H.A., Delany-Moretlwe, S., Mayaud, P and Lorincz, A
Date:
2018-10-01
Journal:
AIDS
Content:
Authors:
Chikandiwa, A., Chimoyi, L., Burgess, E and Otwombe, K.
Date:
2018-10-01
Journal:
BMC Women's Health
Content:
Authors:
Kelly, H., Ngou, J., Chikandiwa, A., Sawadogo, B., Omar, T., Lompo, O., Clare G., Doutre, S., Meda, N., Weiss, H., Delany-Moretlwe, S., Segondy, M and Mayaud, P for the HARP Study Group* (
Date:
2017-01-01
Journal:
PloS One
Content:
Authors:
van de Wijgert JHHM, Gill AC, Darby A, Kelly H, Chikandiwa A, Delany-Moretlwe S, Verwijs MC, Francis S, Mayaud P
Date:
2019-10-01
Journal:
Sex Transm Dis
Content:
Authors:
Chikandiwa, A, Pisa, P.T, Tamalet, C, Muller E,F., Michelow, P, Chersich, M.F, Mayaud, P and Sinead Delany-Moretlwe, S
Date:
2019-12-01
Journal:
PloS One
Content:
Authors:
Chikandiwa, A., Pisa, P.T., Chersich, M.F., Muller, E.E., Michelow, P., Mayaud, P and Delany-Moretlwe, S.
Date:
2018-08-01
Journal:
International Journal of STD & AIDS
Content:
Authors:
Ong J.J,Magooa M.M, Chikandiwa A, Kelly H, Didelot. M-N, Muller, E.E, Maseko V, Segondy, M, Delany-Moretlwe S, Kularatne, R, Mayaud, M
Date:
2019-05-01
Journal:
Sex Transm Dis
Content:
Authors:
Chikandiwa, A., Chimoyi, L., Pisa, P.T., Chersich, M.F., Muller, E.E., Michelow, P., Mayaud, P and Delany-Moretlwe, S.
Date:
2017-01-01
Journal:
BMC Public Health
Content:
Authors:
Chikandiwa, A., Faust, H., Mayaud, P., Dillner, J and Delany-Moretlwe S
Date:
2020-02-01
Journal:
JAIDS
Content:
Authors:
3. Pisa, PT, Pisa N, Chikandiwa, P, and Chikandiwa, A
Date:
2020-03-10
Journal:
SAMJ
Content:
Authors:
2. Maringa, D.V, Mbodi, L, Chikandiwa, A, Kelly, H, Mayaud, P, Delany-Moretlwe, S and Adam, Y.
Date:
2020-10-18
Journal:
International Journal of Gynecology
Content:
Authors:
Ong, J.J., Magooa, M.P., Chikandiwa, A., Kelly, H., Didelot, M.N., Muller, E.E., Segondy, M., Delany-Moretlwe, S., Kularatne, R and Mayaud, P
Date:
2018-05-01
Journal:
Clinical Infectious Diseases
Content:
Authors:
Chikandiwa, A and van Wyk, B. (2013Delany-Moretlwe, S., Chikandiwa, A. and Gibbs, J
Date:
2013-05-01
Journal:
South African Journal of Epidemiology and Infection
Content:
Authors:
Kelly, H., Sawadogo, B., Chikandiwa, A., Segondy, M., Gilham, C., Goumbri-Lompo, O., Omar, T., Didelot, M-N., Nagot, N., Meda, N., Weiss, H.A., Magooa, M., Djigma, F., Ngou, J., Gilham, C., Delany-Moretlwe, S and Mayaud, P
Date:
2017-10-01
Journal:
AIDS
Content:
Authors:
Olorunfemi, G., Ndlovu, N., Masukume, G., Chikandiwa, A., Pisa, P.T and Singh, E. (2018).
Date:
2018-10-02
Journal:
International Journal of Cancer
Content:
Authors:
Delany-Moretlwe, S., Chikandiwa, A. and Gibbs, J
Date:
2013-09-06
Journal:
South African Journal of HIV Medicine
Content:

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