EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

All Profiles

Professor Novel Chegou

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2019-11-01
End Date 2024-10-31
Project Code TMA2018SF-2470
Status Active

Title

Evaluation of new biomarker-based approaches for improving the diagnosis of childhood tuberculous meningitis (TBMBIOMARKERS)

Host Organisation

Institution Country
Stellenbosch University South Africa

Current Organisation

Stellenbosch University

Current Job Title

Professor

Awards

2022 2022 Royal Society Africa Prize, awarded by the United Kingdom’s National Science Academy (The Royal Society)

Students Supervised

Type Name Title University Start Date End Date
BSc. Honours Lani Thiart Ms Stellenbosch University 2010 2010
BSc. Honours Enock K Tshehla Mr Stellenbosch University 2014 2014
BSc. Honours Nonjabulo Makhoba Ms Stellenbosch University 2016 2017
BSc. Honours Monkoe Leqheka Mr Stellenbosch University 2017 2017
MSc. Angela M Menezes Ms Stellenbosch University 2010 2012
MSc. Khutso Phalane Ms Stellenbosch Unversity 2011 2013
MSc. Josefina Nakanyala Ms University of Namibia 2012 2014
MSc. Ruschca Jacobs Ms Stellenbosch University 2015 2016
MSc. Portia M. Manngo Ms Stellenbosch University 2017 2018
MSc. Masilo C. Manyelo Mr Stellenbosch University 2017 2018
MSc. Joseph Mendy Mr Stellenbosch University 2017 2019
MSc. Sedzani Ndou Ms Stellenbosch University 2019 2020
Ph.D Paulin Essone Ndong Mr Stellenbosch University 2011 2014
Ph.D Dolapo O Awoniyi Mr Stellenbosch University 2013 2017
Ph.D Hygon Mutavhatsindi Mr Stellenbosch University 2016 2019
Ph.D Masilo Charles Manyelo Mr Stellenbosch University 2019 2022
BSc. Hons. Stephanie Vickers Miss Stellenbosch University 2022 2022
BSc. Hons. Leandre van Rooyen Miss Stellenbosch University 2022 2022
BSc. Hons. Monique Von Molendorff Miss Stellenbosch University 2022 2022
Ph.D Bih Hycenta Chendi Dr University of Oslo 2018 2023
Ph.D Osagie Aiwerioghene Eribo Dr Stellenbosch University 2018 2023

Memberships

Role Committee/board Start Date End Date
Guest Associate Editor Frontiers in Immunology 2022
Guest Associate Editor Frontiers in Cellular and Infection Microbiology 2021 2021
Associate Editor PLOS ONE 2022

Education

Institution Degree Year
Stellenbosch University, South Africa Ph.D 2009-12-12
Stellenbosch University, South Africa Hons.BSc.MedSci 2005-12-14
Universith of Buea, Cameroon BMLS-Hons. 2002-12-18

Areas Of Specialisation

Tuberculosis (TB)

Grants

Development of an mRNA based point-of-care screening test for tuberculosis.
Grant Code:
MRC-RFA-SHIP 02-2018
Source of funding:
SAMRC
Amount:
518626
Role:
Principal Investigator
Start Date:
2019-01-01
End Date:
2023-01-01
Derivation of a unified diagnostic test for the diagnosis of active TB and for monitoring the clinical response to anti-microbial TB therapy.
Grant Code:
INV-045851
Source of funding:
Bill and Melinda Gates Foundation
Amount:
1354000
Role:
Principal Investigator
Start Date:
2022-01-01
End Date:
2024-01-01
Understanding ischemia in children with tuberculous meningitis (iThemba).
Grant Code:
R01HD107063
Source of funding:
NIH
Amount:
2695281
Role:
Co-Investigator
Start Date:
2022-01-01
End Date:
2027-01-01

Publications

Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring
Authors:
Essone, P.N.
Kalsdorf, B.
Chegou, N.N.
Loxton, A.G.
Kriel, M.
Preyer, R.
Ernst, M.
Walzl, G.
Lange, C.
Date:
2014-01-01
Journal:
Respiration
Content:
Identifiers:
DOI: 10.1159/000365816
EID: 2-s2.0-84906578875
Tuberculosis Immunodiagnostic Tests: A Potential Shift From Iterferon-Gamma (IFN-³) Release Assays To Tumor Necrosis Factor-Alpha (TNF-±) Release Assays With Newly Identified Mycobacterium Tuberculosis Antigens
Authors:
Paulin N. Essone , author
Tom H. Ottenhoff , author
Novel N. Chegou , author
Gerhard Walzl , author
Date:
2012-05-01
Journal:
D96. WHAT'S NEW IN TUBERCULOSIS DIAGNOSTICS
Content:
Identifiers:
DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6508
Identification of Potential Biomarkers in Peripheral Blood Supernatants of South African Patients with Syphilitic and Herpetic Uveitis
Authors:
Andreae, C.D.
Smit, D.P.
Makhoba, N.S.
Kidd, M.
Walzl, G.
Chegou, N.N.
Date:
2019-01-01
Journal:
Ocular Immunology and Inflammation
Content:
Identifiers:
DOI: 10.1080/09273948.2019.1674341
EID: 2-s2.0-85075030117
The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?
Authors:
Eribo, O.A.
du Plessis, N.
Ozturk, M.
Guler, R.
Walzl, G.
Chegou, N.N.
Date:
2019-01-01
Journal:
Cellular and Molecular Life Sciences
Content:
Identifiers:
DOI: 10.1007/s00018-019-03370-4
EID: 2-s2.0-85075259880
Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats
Authors:
Mediline Goboza , author
Yapo G. Aboua , author
Novel Chegou , author
Oluwafemi O. Oguntibeju , author
Date:
2019-04-01
Journal:
Biomedicine & Pharmacotherapy
Content:
Identifiers:
DOI: 10.1016/j.biopha.2019.108638
Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area
Authors:
Date:
2012-01-01
Journal:
Content:
Identifiers:
DOI: 10.1371/journal.pone.0038501
Part of ISSN: 1932-6203
Agreement between assays of cell-mediated immunity utilizing Mycobacterium bovis-specific antigens for the diagnosis of tuberculosis in African buffaloes (Syncerus caffer).
Authors:
Novel N Chegou , author
Date:
2014-03-27
Journal:
Veterinary Immunology and Immunopathology
Content:
Identifiers:
DOI: http://dx.doi.org/doi:10.1016/j.vetimm.2014.03.015
QuantiFERON-TB performance enhanced by novel Mycobacterium tuberculosis-specific antigens.
Authors:
Losi M , author
Knights AJ , author
Mariani F , author
Altieri AM , author
Paone G , author
Loxton AG , author
Chegou NN , author
Kenneth J , author
Alma MG , author
Colizzi V , author
Walzl G , author
Saltini C , author
Boyle J , author
Amicosante M , author
Date:
2016-02-01
Journal:
Content:
Identifiers:
PMID: 26585425
DOI: 10.1183/13993003.01015-2015
Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity
Authors:
Sutherland, J.S.
Loxton, A.G.
Haks, M.C.
Kassa, D.
Ambrose, L.
Lee, J.-S.
Ran, L.
van Baarle, D.
Maertzdorf, J.
Howe, R.
Mayanja-Kizza, H.
Boom, W.H.
Thiel, B.A.
Crampin, A.C.
Hanekom, W.
Ota, M.O.C.
Dockrell, H.
Walzl, G.
Kaufmann, S.H.E.
Ottenhoff, T.H.M.
Walzl, G.
Beyers, N.
van Helden, P.
Thompson, B.
Loxton, A.
Chegou, N.
Black, G.
Kriel, D.
Stanley, K.
Golakai, H.
Du Plessis, N.
van der Spuy, G.
Ota, M.
Sutherland, J.
Adetifa, I.
Togun, T.
Donkor, S.
Antonio, M.
Hill, P.
Adegbola, R.
Henry Boom, W.
Chervenak, K.
Thiel, B.
Heaphy, E.
Mayanja-Kizza, H.
Joloba, M.
Zalwango, S.
Nsereko, M.
Okwera Hussein Kisingo, B.
Baseke, J.
Buteme, H.
Nalukwango, S.
Crampin, M.
French, N.
Ngwira, B.
Ben Smith, A.
Watkins, K.
Ambrose, L.
Simukonda, F.
Mvula, H.
Chilongo, F.
Saul, J.
Branson, K.
Dockrell, H.
Lalor, M.
Smith, S.
Gorak-Stolinska, P.
Hur, Y.-G.
Blitz, R.
Ottenhoff, T.
Haks, M.
Franken, K.
Joosten, S.
Friggen, A.
van Meijgaarden, K.
Geluk, A.
Klein, M.
Howe, R.
Yamuah, L.
Mihret, A.
Asseffa, A.
Aytenew, M.
Assefa, Y.
Girma, S.
Iwnetu, R.
Tafesse, M.
Miedema, F.
Ran, L.
Jacobi, R.
van Baarle, D.
Kassa, D.
Abebe, A.
Gebremichael, G.
Mesele, T.
Tegbaru, B.
Alemayehu, Y.
Andersen, P.
Doherty, M.
Rosenkrands, I.
Weldingh, K.
Hanekom, W.
Scriba, T.
Hughes, J.
Mohamed, H.
Abel, B.
Bowmaker, M.
Kagina, B.
Kwong Chung, W.
Mulenga, H.
Keyser, A.
Erasmus, M.
Hussey, G.
Sadoff, J.
Sizemore, D.
Barker, L.
Brennan, M.
Weichold, F.
Malone, A.
Zhou, J.
Mueller, S.
Geiter, L.
Schoolnik, G.
Dolganov, G.
Van, T.
Kaufmann, S. H. E.
Golinski, R.
Parida, S.
Jacobsen, M.
Weiner, J.
Lauhkonen, R.
Maertzdorf, J.
Date:
2014-01-01
Journal:
Content:
Identifiers:
DOI: 10.1111/1469-0691.12383
EID: 2-s2.0-84895926841
Highly discordant T cell responses in individuals with recent exposure to household tuberculosis
Authors:
Date:
2009-01-01
Journal:
Content:
Identifiers:
Part of ISSN: 0040-6376
DOI: 10.1136/thx.2007.085340
Prospective evaluation of host biomarkers other than interferon gamma in QuantiFERON Plus supernatants as candidates for the diagnosis of tuberculosis in symptomatic individuals
Authors:
Manngo, P.M.
Gutschmidt, A.
Snyders, C.I.
Mutavhatsindi, H.
Manyelo, C.M.
Makhoba, N.S.
Ahlers, P.
Hiemstra, A.
Stanley, K.
McAnda, S.
Kidd, M.
Malherbe, S.T.
Walzl, G.
Chegou, N.N.
Date:
2019-01-01
Journal:
Journal of Infection
Content:
Identifiers:
DOI: 10.1016/j.jinf.2019.07.007
EID: 2-s2.0-85069166139
Abstracts of the Eighth EDCTP Forum, 6-9 November 2016.
Authors:
Date:
2017-02-01
Journal:
BMJ global health
Content:
Identifiers:
PMID: 28589036
PMC: PMC5418676
DOI: 10.1136/bmjgh-2016-000260
Effects of Anchomanes difformis on Inflammation, Apoptosis, and Organ Toxicity in STZ-Induced Diabetic Cardiomyopathy
Authors:
Toyin D. Alabi , author
Novel N. Chegou , author
Nicole L. Brooks , author
Oluwafemi O. Oguntibeju , author
Date:
2020-02-08
Journal:
Biomedicines
Content:
Identifiers:
DOI: 10.3390/biomedicines8020029
Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment response.
Authors:
Jacobs R , author
Malherbe S , author
Loxton AG , author
Stanley K , author
van der Spuy G , author
Walzl G , author
Chegou NN , author
Date:
2016-09-01
Journal:
Content:
Identifiers:
PMID: 27557501
PMC: PMC5295374
DOI: 10.18632/oncotarget.11420
Serum and cerebrospinal fluid host proteins indicate stroke in children with tuberculous meningitis
Authors:
Charles M. Manyelo , author
Katalin Andrea Wilkinson , editor
Novel N. Chegou , author
James A. Seddon , author
Candice I. Snyders , author
Hygon Mutavhatsindi , author
Portia M. Manngo , author
Gerhard Walzl , author
Kim Stanley , author
Regan S. Solomons , author
Date:
2021-04-30
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0250944
Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
Authors:
Jane Alexandra Shaw , author
Godfrey Musuka , editor
Maynard Meiring , author
Tracy Cummins , author
Novel N. Chegou , author
Conita Claassen , author
Nelita Du Plessis , author
Marika Flinn , author
Andriette Hiemstra , author
Léanie Kleynhans , author
Vinzeigh Leukes , author
Andre G. Loxton , author
Candice MacDonald , author
Nosipho Mtala , author
Helmuth Reuter , author
Donald Simon , author
Kim Stanley , author
Gerard Tromp , author
Wolfgang Preiser , author
Stephanus T. Malherbe , author
Gerhard Walzl , author
Date:
2021-02-25
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0247852
Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches
Authors:
Charles M. Manyelo , author
Regan S. Solomons , author
Gerhard Walzl , author
Novel N. Chegou , author
Colleen Suzanne Kraft , editor
Date:
2021-02-18
Journal:
Journal of Clinical Microbiology
Content:
Identifiers:
DOI: 10.1128/JCM.01771-20
Identification of novel tuberculosis diagnostic biomarkers in plasma and saliva
Authors:
Ruschca Jacobs , author
Gerhard Walzl , author
Novel Chegou , author
Date:
2016-09-01
Journal:
European Respiratory Journal
Content:
Identifiers:
DOI: 10.1183/13993003.congress-2016.pa2119
Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease.
Authors:
Awoniyi DO , author
Teuchert A , author
Sutherland JS , author
Mayanja-Kizza H , author
Howe R , author
Mihret A , author
Loxton AG , author
Sheehama J , author
Kassa D , author
Crampin AC , author
Dockrell HM , author
Kidd M , author
Rosenkrands I , author
Geluk A , author
Ottenhoff TH , author
Corstjens PL , author
Chegou NN , author
Walzl G , author
AE-TBC Consortium , author
Date:
2016-09-01
Journal:
Content:
Identifiers:
PMID: 27311746
DOI: 10.1016/j.jinf.2016.04.036
Distinct serum biosignatures are associated with different tuberculosis treatment outcomes
Authors:
Ronacher, K.
Chegou, N.N.
Kleynhans, L.
Djoba Siawaya, J.F.
du Plessis, N.
Loxton, A.G.
Maasdorp, E.
Tromp, G.
Kidd, M.
Stanley, K.
Kriel, M.
Menezes, A.
Gutschmidt, A.
van der Spuy, G.D.
Warren, R.M.
Dietze, R.
Okwera, A.
Thiel, B.
Belisle, J.T.
Cliff, J.M.
Boom, W.H.
Johnson, J.L.
van Helden, P.D.
Dockrell, H.M.
Walzl, G.
Date:
2019-01-01
Journal:
Tuberculosis
Content:
Identifiers:
DOI: 10.1016/j.tube.2019.101859
EID: 2-s2.0-85070613342
Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses.
Authors:
Ayepola OR , author
Chegou NN , author
Brooks NL , author
Oguntibeju OO , author
Date:
2013-01-01
Journal:
Content:
Identifiers:
DOI: 10.1186/1472-6882-13-363
PMID: 24359406
PMC: PMC3878222
Changes in Host Immune-Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes.
Authors:
Date:
2017-01-01
Journal:
Frontiers in immunology
Content:
Identifiers:
PMID: 28674532
PMC: PMC5475380
DOI: 10.3389/fimmu.2017.00690
Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa.
Authors:
Corstjens PL , author
Tjon Kon Fat EM , author
de Dood CJ , author
van der Ploeg-van Schip JJ , author
Franken KL , author
Chegou NN , author
Sutherland JS , author
Howe R , author
Mihret A , author
Kassa D , author
van der Vyver M , author
Sheehama J , author
Simukonda F , author
Mayanja-Kizza H , author
Ottenhoff TH , author
Walzl G , author
Geluk A , author
AE-TBC consortium , author
Date:
2016-01-01
Journal:
Content:
Identifiers:
PMID: 26285074
DOI: 10.1016/j.clinbiochem.2015.08.013
Using biomarkers to predict TB treatment duration (Predict TB): A prospective, randomized, noninferiority, treatment shortening clinical trial
Authors:
Chen, R.Y.
Via, L.E.
Dodd, L.E.
Walzl, G.
Malherbe, S.T.
Loxton, A.G.
Dawson, R.
Wilkinson, R.J.
Thienemann, F.
Tameris, M.
Hatherill, M.
Diacon, A.H.
Liu, X.
Xing, J.
Jin, X.
Ma, Z.
Pan, S.
Zhang, G.
Gao, Q.
Jiang, Q.
Zhu, H.
Liang, L.
Duan, H.
Song, T.
Alland, D.
Tartakovsky, M.
Rosenthal, A.
Whalen, C.
Duvenhage, M.
Cai, Y.
Goldfeder, L.C.
Arora, K.
Smith, B.
Winter, J.
Barry, C.E.
Lourens, M.
Patientia, R.
Mukasa, S.
Goliath, R.
Omar-Davies, N.
Swanepoel, L.
Morar, T.
Oelofse, R.
Geldenhuys, H.
Luabeya, A.
Shenje, J.
Swarts, A.
Ockhuis, R.
Khomba, G.
Mabwe, S.
Bilek, N.
Scriba, T.
Musvosvi, M.
Arendsen, D.
Botes, N.
Rossouw, S.
Ahlers, P.
Tlali, M.
Hiemstra, A.M.
Tromp, G.
Chegou, N.N.
Tonsing, S.
Beltran, C.G.G.
Stanley, K.
Narunsky, K.
Louw, G.
Sewgoolam, B.
Unzueta, A.R.
Gao, J.
Yang, X.
Ruan, X.
Wang, W.
Zheng, S.
Chen, Y.
Li, B.
Shi, H.
Gao, X.
Yang, R.
Zhao, Y.
Ma, L.
Li, H.
Wang, S.
Shi, J.
Duan, H.
Wei, X.
Zhang, G.
Qu, Y.
Wang, Y.
Chen, B.
Zhao, T.
Liu, Z.
Wang, D.
Yan, J.
Date:
2017-01-01
Journal:
Gates Open Research
Content:
Identifiers:
DOI: 10.12688/gatesopenres.12750.1
EID: 2-s2.0-85057752188
Host markers in Quantiferon supernatants differentiate active TB from latent TB infection: preliminary report
Authors:
Date:
2009-01-01
Journal:
Content:
Identifiers:
DOI: 10.1186/1471-2466-9-21
Part of ISSN: 1471-2466
Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats.
Authors:
Date:
2017-12-01
Journal:
Pharmaceutical biology
Content:
Identifiers:
PMID: 28447512
DOI: 10.1080/13880209.2017.1318293
The Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis.
Authors:
du Plessis WJ , author
Kleynhans L , author
du Plessis N , author
Stanley K , author
Malherbe ST , author
Maasdorp E , author
Ronacher K , author
Chegou NN , author
Walzl G , author
Loxton AG , author
Date:
2016-01-01
Journal:
Content:
Identifiers:
PMID: 27050308
PMC: PMC4822853
DOI: 10.1371/journal.pone.0152710
Differential expression of host biomarkers in saliva and serum samples from individuals with suspected pulmonary tuberculosis.
Authors:
Phalane KG , author
Kriel M , author
Loxton AG , author
Menezes A , author
Stanley K , author
van der Spuy GD , author
Walzl G , author
Chegou NN , author
Date:
2013-01-01
Journal:
Content:
Identifiers:
DOI: 10.1155/2013/981984
PMID: 24327799
PMC: PMC3845251
A serum circulating miRNA signature for short-term risk of progression to active tuberculosis among household contacts
Authors:
Duffy, F.J.
Thompson, E.
Downing, K.
Suliman, S.
Mayanja-Kizza, H.
Henry Boom, W.
Thiel, B.
Weiner, J.
Kaufmann, S.H.E.
Dover, D.
Tabb, D.L.
Dockrell, H.M.
Ottenhoff, T.H.M.
Tromp, G.
Scriba, T.J.
Zak, D.E.
Walzl, G.
Kaufmann, S.H.E.
Parida, S.K.
Golinski, R.
Maertzdorf, J.
Weiner, J.
Jacobson, M.
McEwen, G.
Walzl, G.
Black, G.
van der Spuy, G.
Stanley, K.
Kriel, M.
Du Plessis, N.
Nene, N.
Loxton, A.
Chegou, N.N.
Suliman, S.
Scriba, T.
Mahomed, H.
Erasmus, M.
Xasa, O.
Veldsman, A.
Hughes, J.
Downing, K.
Penn-Nicholson, A.
Mulenga, H.
Abel, B.
Bowmaker, M.
Kagina, B.
Kwong, W.C.
Hanekom, W.
Ottenhoff, T.H.M.
Klein, M.R.
Haks, M.C.
Franken, K.L.
Geluk, A.
van Meijgaarden, K.E.
Joosten, S.A.
van Baarle, D.
Miedema, F.
Boom, W.H.
Thiel, B.
Sadoff, J.
Sizemore, D.
Ramachandran, S.
Barker, L.
Brennan, M.
Weichold, F.
Muller, S.
Geiter, L.
Schoolnik, G.
Dolganov, G.
Van, T.
Mayanja-Kizza, H.
Joloba, M.
Zalwango, S.
Nsereko, M.
Okwera, B.
Kisingo, H.
Dockrell, H.
Smith, S.
Gorak-Stolinska, P.
Hur, Y.-G.
Lalor, M.
Lee, J.-S.
Crampin, A.C.
French, N.
Ngwira, B.
Smith, A.B.
Watkins, K.
Ambrose, L.
Simukonda, F.
Mvula, H.
Chilongo, F.
Saul, J.
Branson, K.
Kassa, D.
Abebe, A.
Mesele, T.
Tegbaru, B.
Howe, R.
Mihret, A.
Aseffa, A.
Bekele, Y.
Iwnetu, R.
Tafesse, M.
Yamuah, L.
Ota, M.
Sutherland, J.
Hill, P.
Adegbola, R.
Corrah, T.
Antonio, M.
Togun, T.
Adetifa, I.
Donkor, S.
Andersen, P.
Rosenkrands, I.
Doherty, M.
Weldingh, K.
Date:
2018-01-01
Journal:
Frontiers in Immunology
Content:
Identifiers:
DOI: 10.3389/fimmu.2018.00661
EID: 2-s2.0-85045324159
Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy
Authors:
Date:
2013-01-01
Journal:
Content:
Identifiers:
DOI: 10.1016/j.tube.2012.09.003
Part of ISSN: 1472-9792
Correction: Potential of Host Markers Produced by Infection Phase-DependentAntigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly EndemicArea.
Authors:
Chegou NN , author
Essone PN , author
Loxton AG , author
Stanley K , author
Black GF , author
van der Spuy GD , author
van Helden PD , author
Franken KL , author
Parida SK , author
Klein MR , author
Kaufmann SHE , author
Ottenhoff THM , author
Walzl G , author
Date:
2012-01-01
Journal:
Content:
Identifiers:
PMC: PMC3442423
Chronic obstructive pulmonary disease (COPD): Neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD
Authors:
Guiedem, E.
Ikomey, G.M.
Nkenfou, C.
Walter, P.-Y.E.
Mesembe, M.
Chegou, N.N.
Jacobs, G.B.
Okomo Assoumou, M.C.
Date:
2018-01-01
Journal:
BMC Research Notes
Content:
Identifiers:
DOI: 10.1186/s13104-018-3309-6
EID: 2-s2.0-85045224275
Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: Preliminary report
Authors:
Chegou, N.
Date:
2010-01-01
Journal:
Content:
Identifiers:
EID: 2-s2.0-78649335962
Differenzierung zwischen latenter Infektion mit M. tuberculosis und aktiver Tuberkulose
Authors:
Date:
2012-01-01
Journal:
Content:
Identifiers:
Part of ISSN: 0934-8387
DOI: 10.1055/s-0032-1302531
POLICY-DRIVEN INTERVENTIONS: TUBERCULOSIS
Authors:
Gerhard Walzl , author
Novel Chegou , author
Stephanus Malherbe , author
Mark Hatherill , author
Thomas J. Scriba , author
Daniel E. Zak , author
Clifton E. Barry , author
Stefan H.E. Kaufmann , author
Date:
2017-02-01
Journal:
BMJ Global Health
Content:
Identifiers:
DOI: 10.1136/bmjgh-2016-000260.5
Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment
Authors:
Ruschca Jacobs , author
Enock Tshehla , author
Stephanus Malherbe , author
Magdalena Kriel , author
Andre G. Loxton , author
Kim Stanley , author
Gian van der Spuy , author
Gerhard Walzl , author
Novel N. Chegou , author
Date:
2016-05-01
Journal:
Cytokine
Content:
Identifiers:
DOI: 10.1016/j.cyto.2016.02.004
Tuberculosis research in South Africa over the past 30 years: From bench to bedside
Authors:
Warren, R.M.
Ismail, N.
Chegou, N.N.
Teron, G.
Walzl, G.
Malherbe, S.T.
Kinnear, C.J.
Van Der Spuy, G.D.
Goosen, W.
Miller, M.A.
Diacon, A.H.
Van Helden, P.D.
Date:
2019-01-01
Journal:
South African Medical Journal
Content:
Identifiers:
DOI: 10.7196/SAMJ.2019.v109i11b.14249
EID: 2-s2.0-85077808854
Potential of host serum protein biomarkers in the diagnosis of tuberculous meningitis in children
Authors:
Manyelo, C.M.
Solomons, R.S.
Snyders, C.I.
Mutavhatsindi, H.
Manngo, P.M.
Stanley, K.
Walzl, G.
Chegou, N.N.
Date:
2019-01-01
Journal:
Frontiers in Pediatrics
Content:
Identifiers:
DOI: 10.3389/fped.2019.00376
EID: 2-s2.0-85072918762
Distinct host-immune response toward species related intracellular mycobacterial killing: A transcriptomic study
Authors:
Madhvi, A.
Mishra, H.
Chegou, N.N.
Tromp, G.
Van Heerden, C.J.
Pietersen, R.D.
Leisching, G.
Baker, B.
Date:
2020-01-01
Journal:
Virulence
Content:
Identifiers:
DOI: 10.1080/21505594.2020.1726561
EID: 2-s2.0-85079338488
Hepatoprotective, Antihyperlipidemic, and Anti-inflammatory Activity of Moringa oleifera in Diabetic-induced Damage in Male Wistar Rats.
Authors:
Date:
2017-01-01
Journal:
Pharmacognosy research
Content:
Identifiers:
PMID: 28539743
PMC: PMC5424560
DOI: 10.4103/0974-8490.204651
A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Authors:
Zak DE , author
Penn-Nicholson A , author
Scriba TJ , author
Thompson E , author
Suliman S , author
Amon LM , author
Mahomed H , author
Erasmus M , author
Whatney W , author
Hussey GD , author
Abrahams D , author
Kafaar F , author
Hawkridge T , author
Verver S , author
Hughes EJ , author
Ota M , author
Sutherland J , author
Howe R , author
Dockrell HM , author
Boom WH , author
Date:
2016-06-01
Journal:
Content:
Identifiers:
PMID: 27017310
DOI: 10.1016/s0140-6736(15)01316-1
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Authors:
Walzl, G.
McNerney, R.
du Plessis, N.
Bates, M.
McHugh, T.D.
Chegou, N.N.
Zumla, A.
Date:
2018-01-01
Journal:
The Lancet Infectious Diseases
Content:
Identifiers:
DOI: 10.1016/S1473-3099(18)30111-7
EID: 2-s2.0-85044277892
Four-gene pan-African blood signature predicts progression to tuberculosis
Authors:
Suliman, S.
Thompson, E.G.
Sutherland, J.
Weiner, J.
Ota, M.O.C.
Shankar, S.
Penn-Nicholson, A.
Thiel, B.
Erasmus, M.
Maertzdorf, J.
Duffy, F.J.
Hill, P.C.
Jane Hughes, E.
Stanley, K.
Downing, K.
Fisher, M.L.
Valvo, J.
Parida, S.K.
Van Der Spuy, G.
Tromp, G.
Adetifa, I.M.O.
Donkor, S.
Howe, R.
Mayanja-Kizza, H.
Henry Boom, W.
Dockrell, H.M.
Ottenhoff, T.H.M.
Hatherill, M.
Aderem, A.
Hanekom, W.A.
Scriba, T.J.
Kaufmann, S.H.E.
Zak, D.E.
Walzl, G.
Black, G.F.
Kriel, M.
Du Plessis, N.
Nene, N.
Roberts, T.
Kleynhans, L.
Gutschmidt, A.
Smith, B.
Loxton, A.G.
Chegou, N.N.
Tabb, D.
Klein, M.R.
Haks, M.C.
Franken, K.L.M.C.
Geluk, A.
Van Meijgaarden, K.E.
Joosten, S.A.
Joloba, M.
Zalwango, S.
Nsereko, M.
Okwera, B.
Kisingo, H.
Golinski, R.
Jacobson, M.
Lalor, M.
Smith, S.
Gorak-Stolinska, P.
Hur, Y.-G.
Lee, J.-S.
Crampin, A.C.
French, N.
Ngwira, B.
Ben-Smith, A.
Watkins, K.
Ambrose, L.
Simukonda, F.
Mvula, H.
Chilongo, F.
Saul, J.
Branson, K.
Mahomed, H.
Bilek, N.
Xasa, O.
Veldsman, A.
Mulenga, H.
Abel, B.
Bowmaker, M.
Kagina, B.
Kwong Chung, W.
Sadoff, J.
Sizemore, D.
Ramachandran, S.
Barker, L.
Brennan, M.
Weichold, F.
Muller, S.
Geiter, L.
Kassa, D.
Abebe, A.
Mesele, T.
Tegbaru, B.
Van Baarle, D.
Miedema, F.
Mihret, A.
Aseffa, A.
Bekele, Y.
Iwnetu, R.
Tafesse, M.
Yamuah, L.
Adegbola, R.
Corrah, T.
Antonio, M.
Togun, T.
Andersen, P.
Rosenkrands, I.
Doherty, M.
Weldingh, K.
Schoolnik, G.
Dolganov, G.
Van, T.
Kafaar, F.
Workman, L.
Cloete, Y.
Abrahams, D.
Moyo, S.
Gelderbloem, S.
Tameris, M.
Geldenhuys, H.
Hussey, G.
Ehrlich, R.
Verver, S.
Verver, S.
Date:
2018-01-01
Journal:
American Journal of Respiratory and Critical Care Medicine
Content:
Identifiers:
DOI: 10.1164/rccm.201711-2340OC
EID: 2-s2.0-85046554525
Biomarkers to predict FDG PET/CT activity after the standard duration of treatment for spinal tuberculosis: An exploratory study
Authors:
Theresa N. Mann , author
James Warwick , author
Novel N. Chegou , author
Johan H. Davis , author
Caroline G.G. Beltran , author
Stephanie Griffith-Richards , author
Martin Kidd , author
Jacques du Toit , author
Robert P. Lamberts , author
Gerhard Walzl , author
Date:
2021-07-01
Journal:
Tuberculosis
Content:
Identifiers:
DOI: 10.1016/j.tube.2021.102107
Rapid diagnosis of tuberculosis using ex vivo host biomarkers in sputum
Authors:
Ota, M.O.C.
Mendy, J.F.
Donkor, S.
Togun, T.
Daramy, M.
Gomez, M.P.
Chegou, N.N.
Sillah, A.K.
Owolabi, O.
Kampmann, B.
Walzl, G.
Sutherland, J.S.
Date:
2014-01-01
Journal:
Content:
Identifiers:
DOI: 10.1183/09031936.00209913
EID: 2-s2.0-84903841974
Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis
Authors:
Date:
2009-01-01
Journal:
Content:
Identifiers:
DOI: 10.1016/j.cyto.2009.05.016
Part of ISSN: 1043-4666
Evaluation of Adapted Whole-Blood Interferon-γ Release Assays for the Diagnosis of Pleural Tuberculosis
Authors:
Date:
2008-01-01
Journal:
Content:
Identifiers:
DOI: 10.1159/000128575
Part of ISSN: 1423-0356
Modulation of inflammatory cytokines and islet morphology as therapeutic mechanisms of Basella alba in streptozotocin-induced diabetic rats
Authors:
Arokoyo, D.S.
Oyeyipo, I.P.
Du Plessis, S.S.
Chegou, N.N.
Aboua, Y.G.
Date:
2018-01-01
Journal:
Toxicological Research
Content:
Identifiers:
DOI: 10.5487/TR.2018.34.4.325
EID: 2-s2.0-85057146999
Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome
Authors:
Duffy, F.J.
Weiner, J.
Hansen, S.
Tabb, D.L.
Suliman, S.
Thompson, E.
Maertzdorf, J.
Shankar, S.
Tromp, G.
Parida, S.
Dover, D.
Axthelm, M.K.
Sutherland, J.S.
Dockrell, H.M.
Ottenhoff, T.H.M.
Scriba, T.J.
Picker, L.J.
Walzl, G.
Kaufmann, S.H.E.
Zak, D.E.
Golinski, R.
Jacobson, M.
McEwen, G.
Walzl, G.
Black, G.F.
Van Der Spuy, G.
Stanley, K.
Kriel, M.
DuPlessis, N.
Nene, N.
Loxton, A.G.
Chegou, N.N.
Fisher, M.
Mahomed, H.
Hughes, J.
Downing, K.
Penn-Nicholson, A.
Mulenga, H.
Abel, B.
Bowmaker, M.
Kagina, B.
Kwong, W.
Hanekom, C.W.
Klein, M.R.
Haks, M.C.
F ranken, K.L.
Geluk, A.
Van Meijgaarden, K.E.
Joosten, S.A.
Van Baarle, D.
Miedema, F.
Boom, W.H.
Thiel, B.
Sadoff, J.
Sizemore, D.
Ramachandran, S.
Barker, L.
Brennan, M.
Weichold, F.
Muller, S.
Geiter, L.
Schoolnik, G.
Dolganov, G.
Van, T.
Mayanja-Kizza, H.
Joloba, M.
Zalwango, S.
Nsereko, M.
Okwera, B.
Kisingo, H.
Dockrell, H.M.
Smith, S.
Gorak-Stolinska, P.
Hur, Y.-G.
Lalor, M.
Lee, J.-S.
Crampin, A.C.
French, N.
Ngwira, B.
Smith, A.B.
Watkins, K.
Ambrose, L.
Simukonda, F.
Mvula, H.
Chilongo, F.
Saul, J.
Branson, K.
Kassa, D.
Abebe, A.
Mesele, T.
Tegbaru, B.
Howe, R.
Mihret, A.
Aseffa, A.
Bekele, Y.
Iwnetu, R.
Tafesse, M.
Yamuah, L.
Ota, M.
Sutherland, J.
Hill, P.
Adegbola, R.
Corrah, T.
Antonio, M.
Togun, T.
Adetifa, I.
Donkor, S.
Andersen, P.
Rosenkrands, I.
Doherty, M.
Weldingh, K.
Date:
2019-01-01
Journal:
Frontiers in Immunology
Content:
Identifiers:
DOI: 10.3389/fimmu.2019.00527
EID: 2-s2.0-85064722750
Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.
Authors:
Chegou NN , author
Sutherland JS , author
Malherbe S , author
Crampin AC , author
Corstjens PL , author
Geluk A , author
Mayanja-Kizza H , author
Loxton AG , author
van der Spuy G , author
Stanley K , author
Kotzé LA , author
van der Vyver M , author
Rosenkrands I , author
Kidd M , author
van Helden PD , author
Dockrell HM , author
Ottenhoff TH , author
Kaufmann SH , author
Walzl G , author
AE-TBC consortium , author
Date:
2016-09-01
Journal:
Content:
Identifiers:
PMID: 27146200
DOI: 10.1136/thoraxjnl-2015-207999
Diagnostic Potential of Novel Salivary Host Biomarkers as Candidates for the Immunological Diagnosis of Tuberculosis Disease and Monitoring of Tuberculosis Treatment Response
Authors:
Ruschca Jacobs , author
Madhukar Pai , editor
Elizna Maasdorp , author
Stephanus Malherbe , author
Andre G. Loxton , author
Kim Stanley , author
Gian van der Spuy , author
Gerhard Walzl , author
Novel N. Chegou , author
Date:
2016-08-03
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0160546
Host urine immunological biomarkers as potential candidates for the diagnosis of tuberculosis
Authors:
Osagie A. Eribo , author
Monkoe S. Leqheka , author
Stephanus T. Malherbe , author
Shirley McAnda , author
Kim Stanley , author
Gian D. van der Spuy , author
Gerhard Walzl , author
Novel N. Chegou , author
Date:
2020-08-01
Journal:
International Journal of Infectious Diseases
Content:
Identifiers:
DOI: 10.1016/j.ijid.2020.08.019
Host blood RNA signatures predict the outcome of tuberculosis treatment
Authors:
Thompson, E.G.
Du, Y.
Malherbe, S.T.
Shankar, S.
Braun, J.
Valvo, J.
Ronacher, K.
Tromp, G.
Tabb, D.L.
Alland, D.
Shenai, S.
Via, L.E.
Warwick, J.
Aderem, A.
Scriba, T.J.
Winter, J.
Walzl, G.
Zak, D.E.
Du Plessis, N.
Loxton, A.G.
Chegou, N.N.
Lee, M.
Date:
2017-01-01
Journal:
Tuberculosis
Content:
Identifiers:
DOI: 10.1016/j.tube.2017.08.004
EID: 2-s2.0-85027493960
Reproductive parameters in streptozotocin-induced diabetic male wistar rats: Beneficial role of basella alba aqueous leave extract
Authors:
Arokoyo, D.S.
Oyeyipo, I.P.
Du Plessis, S.S.
Chegou, N.N.
Aboua, Y.G.
Date:
2017-01-01
Journal:
Journal of Kerman University of Medical Sciences
Content:
Identifiers:
EID: 2-s2.0-85047270572
Evaluation of Potential Antigen-specific Host Biomarkers in QuantiFERON Supernatants as Candidates for the Diagnosis of Ocular Tuberculosis
Authors:
Nonjabulo S. Makhoba , author
Derrick P. Smit , author
Gerhard Walzl , author
Novel N. Chegou , author
Date:
2021-11-17
Journal:
Ocular Immunology and Inflammation
Content:
Identifiers:
DOI: 10.1080/09273948.2020.1763404
Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa.
Authors:
Sutherland JS , author
Lalor MK , author
Black GF , author
Ambrose LR , author
Loxton AG , author
Chegou NN , author
Kassa D , author
Mihret A , author
Howe R , author
Mayanja-Kizza H , author
Gomez MP , author
Donkor S , author
Franken K , author
Hanekom W , author
Klein MR , author
Parida SK , author
Boom WH , author
Thiel BA , author
Crampin AC , author
Ota M , author
Walzl G , author
Ottenhoff TH , author
Dockrell HM , author
Kaufmann SH , author
GCGH Biomarkers for TB consortium , author
Date:
2013-01-01
Journal:
Content:
Identifiers:
DOI: 10.1371/journal.pone.0074080
PMID: 24040170
PMC: PMC3769366
Application of Cerebrospinal Fluid Host Protein Biosignatures in the Diagnosis of Tuberculous Meningitis in Children from a High Burden Setting
Authors:
Charles M. Manyelo , author
Regan S. Solomons , author
Candice I. Snyders , author
Portia M. Manngo , author
Hygon Mutavhatsindi , author
Belinda Kriel , author
Kim Stanley , author
Gerhard Walzl , author
Novel N. Chegou , author
Date:
2019-04-16
Journal:
Mediators of Inflammation
Content:
Identifiers:
DOI: 10.1155/2019/7582948
Metabolite changes in blood predict the onset of tuberculosis
Authors:
Weiner, J.
Maertzdorf, J.
Sutherland, J.S.
Duffy, F.J.
Thompson, E.
Suliman, S.
McEwen, G.
Thiel, B.
Parida, S.K.
Zyla, J.
Hanekom, W.A.
Mohney, R.P.
Boom, W.H.
Mayanja-Kizza, H.
Howe, R.
Dockrell, H.M.
Ottenhoff, T.H.M.
Scriba, T.J.
Zak, D.E.
Walzl, G.
Kaufmann, S.H.E.
Abebe, A.
Abel, B.
Adegbola, R.
Adetifa, I.
Ambrose, L.
Andersen, P.
Antonio, M.
Aseffa, A.
van Baarle, D.
Barker, L.
Bekele, Y.
Bilek, N.
Black, G.F.
Bowmaker, M.
Branson, K.
Brennan, M.
Chegou, N.N.
Chilongo, F.
Chung, W.K.
Corrah, T.
Crampin, A.C.
Doherty, M.
Dolganov, G.
Donkor, S.
Downing, K.
Fisher, M.
Franken, K.L.M.C.
French, N.
Geiter, L.
Geluk, A.
Golinski, R.
Gorak-Stolinska, P.
Haks, M.C.
Hill, P.
Hughes, J.
Hur, Y.-G.
Iwnetu, R.
Jacobson, M.
Joloba, M.
Joosten, S.A.
Kagina, B.
Kassa, D.
Kisingo, H.
Klein, M.R.
Kriel, M.
Lalor, M.
Lee, J.-S.
Loxton, A.G.
Mahomed, H.
van Meijgaarden, K.E.
Mesele, T.
Miedema, F.
Mihret, A.
Mulenga, H.
Muller, S.
Mvula, H.
Nene, N.
Ngwira, B.
Nsereko, M.
Okwera, B.
Ota, M.
Penn-Nicholson, A.
Du Plessis, N.
Ramachandran, S.
Rosenkrands, I.
Sadoff, J.
Saul, J.
Schoolnik, G.
Simukonda, F.
Sizemore, D.
Smith, S.
Ben Smith, A.
van der Spuy, G.
Stanley, K.
Tabb, D.
Tafesse, M.
Tegbaru, B.
Togun, T.
Tromp, G.
Van, T.
Watkins, K.
Weichold, F.
Weldingh, K.
Yamuah, L.
Zalwango, S.
Date:
2018-01-01
Journal:
Nature Communications
Content:
Identifiers:
DOI: 10.1038/s41467-018-07635-7
EID: 2-s2.0-85058031697
Identification of novel salivary candidate protein biomarkers for tuberculosis diagnosis: A preliminary biomarker discovery study
Authors:
Hygon Mutavhatsindi , author
Bridget Calder , author
Shirley McAnda , author
Stephanus T. Malherbe , author
Kim Stanley , author
Martin Kidd , author
Gerhard Walzl , author
Novel N. Chegou , author
Date:
2021-09-01
Journal:
Tuberculosis
Content:
Identifiers:
DOI: 10.1016/j.tube.2021.102118
High level of discordant IGRA results in HIV-infected adults and children.
Authors:
Mandalakas AM , author
Hesseling AC , author
Chegou NN , author
Kirchner HL , author
Zhu X , author
Marais BJ , author
Black GF , author
Beyers N