EDCTP Alumni Network

Title

Immune reconstitution inflammatory syndrome (IRIS) in schistosomiasis patients undergoing HAART

Objectives

To study the Immunopathogenesls, clinical aspects and management of manifestation of IRIS in HIV-schistosome co-infection patients undergoing HAART In western Kenya. Schistosome infections are common in the same areas where HIV prevalence is also high.

Host Organisation

Institution	Country
Kenya Medical Research Institute (KEMRI)	Kenya

Participants

Name	Institution	Country
Robert Colebunders	Prince Leopold Institute of Tropical Medicine (ITM)	Belgium
Diana Karanja	Kenya Medical Research Institute (KEMRI)	Kenya
Luc Kestens	Prince Leopold Institute of Tropical Medicine (ITM)	Belgium
Erick Muok	Kenya Medical Research Institute (KEMRI)	Kenya
Katja Polman	Prince Leopold Institute of Tropical Medicine (ITM)	Kenya

Study Design

Prevalence study on IRIS in schistomiasis on HAART

Results & Outcomes

622 HIV-positive patients were followed. In the first year of follow up 12 patients expressed signs and symptoms of IRIS of whom two met the case definition of IRIS. As a requirement for all staff participants on this project, GCP/GCLP training was provided online from the EDCTPsponsored AMANET online courses.

Publications

Ogola GO, Ouma C, Jura WG, Muok EO, Colebunders R, Mwinzi PN. A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory Syndrome in a Kenyan population. BMC Infect Dis. 2014 Jun 10;14(1):316. doi:10.1186/1471-2334-14-316.