EDCTP Alumni Network

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All Profiles
Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2018-04-01
End Date 2023-03-31
Project Code TMA2016SF1514
Status Active

Title

Strengthening Malaria Epidemiological, Pathophysiological and Intervention Studies in Highly Endemic Eastern Uganda

Objectives

1. To conduct epidemiological studies on acute kidney injury in childhood severe malaria at Mbale Regional Referral Hospital to characterise the disease over a period of 48months. 2. To describe the pathophysiology of haemoglobinuric malaria at Mbale Regional Referral Hospital to understanding the disease process. a. To explore the dose and effect of paracetamol in treatment of renal impairment in children with haemoglobinuric malaria. b. To train two junior researchers in malaria research including clinical trials. 3. To study safety and early efficacy of paracetamol in ameliorating acute kidney injury in children with severe malaria.

Host Organisation

Institution Country
Mbale Regional Referral Hospital Uganda

Participants

Name Institution Country
Professor Kathryn Maitland KEMRI-Wellcome Trust Kenya

Study Design

Prospective cross sectional studies are being conducted for malaria epidemiological and pathophysiological studies. Phase I/II randomised clinical trial will be conducted for evaluation of feasibility, safety and early effectiveness of paracetamol for treatment of AKI

Sites

Mbale Regional Referral Hospital

Students Supervised

Type Name Title University Start Date End Date
Masters Cate Namayanja Dr Busitema University 2018 2021
Masters George Paasi Dr Busitema University 2018 2020

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