EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

All Profiles
Call Senior Fellowship (SF)
Programme EDCTP1
Start Date 2011-04-11
End Date 2014-04-10
Project Code TA.2010.40200.0019
Status Completed

Title

Short- and long-term clinical and immunological outcomes of patients with HIV/TB coinfections on ART

Objectives

To study short-term effects of TB and ART treatment (the incidence, predictors and clinical characteristics of TB-IRIS, side effects of the therapy, causes of early mortality) and long term effects of ART after completing TB treatment (clinical events such as infections, late-onset IRIS, adverse effects of therapy or immunological and virological events such as changes in CD4 counts, CD4 %; viral load, viral resistance). Also to study possible factors influencing these outcomes such as adherence and factors affecting them, TB relapse and mycobacteriological factors, immunological defects and social factors that are associated with a recurrent TB episode and causes of mortality

Host Organisation

Institution Country
Makerere University Uganda

Participants

Name Institution Country
Robert Colebunders University of Antwerp Belgium
Yukari Manabe Makerere University Uganda

Study Design

A cohort study to compare the effectiveness of early versus delayed antiretroviral therapy on prevention of mortality HIV-TB co-infected patients in a programmatic setting

Sites

The HIV-TB Clinic of the Infectious Disease Institute, Kampala, Uganda

Phd Study

Title University Start Date End Date
The Challenges of TB-HIV in Resource-limited settings University of Antwerp, Belgium 2006-08-25 2012-01-12

Students Supervised

Type Name Title University Start Date End Date
Masters of Medicine Dr. Christian Roy Thomas Dr Makerere University 2013 2014

Results & Outcomes

Targeted recruitment: 189 out of 280 patients were enrolled for the study. Capacity Building: 1) Dr Jabo Christian who enrolled for a Masters of Medicine in Radiology at Makerere University successfully defended his thesis in May 2014. 2) Ms Justine Nakiwala, the PhD student at the Institute of Tropical Medicine, Antwerp who was studying the role of neutrophils in the pathogenesis of TB-IRIS completed the initial stage of her data collection at this site and continued with her PhD work in South Africa.

Publications

Worodria W, Ssempijja V, Hanrahan C, Ssegonja R, Muhofwa A, Mazapkwe D, Mayanja-Kizza H, Reynolds SJ, Colebunders R, Manabe YC. Opportunistic diseases diminish the clinical benefit of immediate antiretroviral therapy in HIV-tuberculosis co-infected adults with low CD4+ cell counts. AIDS. 2018 Sep 24;32(15):2141-2149. doi: 10.1097/QAD.0000000000001941. PMID: 30005014
Nakiwala JK, Walker NF, Diedrich CR, Worodria W, Meintjes G, Wilkinson RJ, Mayanja-Kizza H, Colebunders R, Kestens L, Wilkinson KA, Lowe DM. Neutrophil activation and enhanced release of granule products in HIV-TB immune reconstitution inflammatory syndrome. J Acquir Immune Defic Syndr. 2018 Feb 1;77(2):221-229. doi: 10.1097/QAI.0000000000001582.

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