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Dr Noé Patrick M'Bondoukwé

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2021-05-01
End Date 2023-10-31
Project Code TMA2019CDF-2730
Status Active

Title

Pre-treatment of hypermicrofilaremic loiasis for eligibility to Community Directed Ivermectin Intervention for Onchocerciasis control in co-endemic settings of Gabon

Objectives

Main Objective The objective of this study is to determine an albendazole optimal and safe regimen for the treatment of Loa loa hypermicrofilaraemia in patients living in a loiasis-onchocerchiasis coendemic for their eligibility to the CDTI. Secondary objectives: • To evaluate the clinical and parasiticidal activity of 400 and 800 mg albendazole regimens on the Day (D) 30 and the adequate clinical and parasitological response (ACPR) of hypermicrofilaraemic loiasis treatment; • To evaluate the dose-response of albendazole on selected secondary endpoints [time to microfilariae clearance, observed microfilaraemia rate reduction (MRR) below 8,000 mf/mL at different estimated time points, microfilaraemia clearance rate and microfilaraemia recrudescence at 6 months, D180; • To evaluate the safety and tolerability of the different dosages of albendazole for the treatment of patients with Loa loa hypermicrofilaraemia; • To characterize the pharmacokinetics (PK) of albendazole and its metabolite in plasma of patients with different levels of L. loa microfilareamia according to the treatment regimens; • To evaluate the relationship between ACPR and concentration of albendazole and its metabolites Tertiary objectives • To compare the frequency of STH infection between the pre-treated individuals and those who will directly benefit from IVM MDA after the interventions. • To determine the dose regimen suitable for recommendation of an albendazole curative treatment regimen of loiasis.

Host Organisation

Institution Country
Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon

Participants

Name Institution Country
Ndong Akomezogho Luccheri Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
Ogoula Stéphane Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
Hombo Ndomana Lys Anna Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
Adekpedjou Oulfath Abebi Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
Ndama-Ndama Ivane-Guy-Tiburce Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
MIhindou Coella Joyce Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
Ndong Ngomo Jacques Mari Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
Moutombi Ditombi Bridy Chesly Faculté de Médecine Gabon
Obali Ndjena Andress Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
Chabi Espédiee Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
MIMBILA MINKO Melly Chancelle Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon
MOUDOUMBI-MOUANDZA Junior Dimitri Faculté de Médecine, Université des Sciences de la Santé Libreville Gabon

Study Design

Clinical trial of phase IIb

Sites

BITAM-MINVOUL

Students Supervised

Type Name Title University Start Date End Date
Bachelor in Science Nyalendo Taylor Josué Epidémiologie des parasitoses intestinales et relation avec l’anémie et l’indice de masse corporelle dans 4 villages du Nord du Gabon ISMS-Elite Center 2022 10/2022
Bachelor in Science Mengue M'asse Tanguy Epidémiologie de la coinfection paludisme-loaose dans 4 villages du Nord du Gabon : aspect hématologique et biochimique. ISMS-Elite Center 01/2022 10/2022

Current Organisation

Department of Fundamental Sciences of the Faculty of Medicine of the Université des Sciences de la Santé

Current Job Title

Lecturer-Researcher

Publications

Circulating Cytokine Profiles of Polyparasitized Individuals in Gabon.
Authors:
Noé Patrick M'Bondoukwé , author
Reinne Moutongo , author
Komi Gbédandé , author
Jacques Mari Ndong Ngomo , author
Tatiana Hountohotegbe , author
Rafiou Adamou , author
Jeanne Vanessa Koumba Lengongo , author
Kowir Pambo Bello , author
Denise Patricia Mawili-Mboumba , author
Adrian John Frederick Luty , author
Marielle Karine Bouyou-Akotet , author
Date:
2020-09-10
Journal:
Content:
Identifiers:
DOI: 10.21203/rs.3.rs-24917/v2
Circulating Cytokine Profiles of Polyparasitized Individuals in Gabon.
Authors:
Noé Patrick M'Bondoukwé , author
Reinne Moutongo , author
Komi Gbédandé , author
Jacques Mari Ndong Ngomo , author
Tatiana Hountohotegbe , author
Rafiou Adamou , author
Jeanne Vanessa Koumba Lengongo , author
Kowir Pambou , author
Denise Patricia Mawili-Mboumba , author
Adrian John Frederick Luty , author
Marielle Karine Bouyou-Akotet , author
Date:
2020-04-30
Journal:
Content:
Identifiers:
DOI: 10.21203/rs.3.rs-24917/v1
Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profiles of polyparasitized individuals in rural and urban areas of gabon
Authors:
Noé Patrick M’Bondoukwé , author
De’Broski R. Herbert , editor
Reinne Moutongo , author
Komi Gbédandé , author
Jacques Mari Ndong Ngomo , author
Tatiana Hountohotegbé , author
Rafiou Adamou , author
Jeanne Vanessa Koumba Lengongo , author
Kowir Pambou Bello , author
Denise Patricia Mawili-Mboumba , author
Adrian John Frederick Luty , author
Marielle Karine Bouyou-Akotet , author
Date:
2022-04-14
Journal:
PLOS Neglected Tropical Diseases
Content:
Identifiers:
DOI: 10.1371/journal.pntd.0010308

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