Call | Career Development Fellowship (CDF) |
Programme | EDCTP2 |
Start Date | 2021-05-01 |
End Date | 2023-10-31 |
Project Code | TMA2019CDF-2730 |
Status | Active |
Pre-treatment of hypermicrofilaremic loiasis for eligibility to Community Directed Ivermectin Intervention for Onchocerciasis control in co-endemic settings of Gabon
Main Objective The objective of this study is to determine an albendazole optimal and safe regimen for the treatment of Loa loa hypermicrofilaraemia in patients living in a loiasis-onchocerchiasis coendemic for their eligibility to the CDTI. Secondary objectives: • To evaluate the clinical and parasiticidal activity of 400 and 800 mg albendazole regimens on the Day (D) 30 and the adequate clinical and parasitological response (ACPR) of hypermicrofilaraemic loiasis treatment; • To evaluate the dose-response of albendazole on selected secondary endpoints [time to microfilariae clearance, observed microfilaraemia rate reduction (MRR) below 8,000 mf/mL at different estimated time points, microfilaraemia clearance rate and microfilaraemia recrudescence at 6 months, D180; • To evaluate the safety and tolerability of the different dosages of albendazole for the treatment of patients with Loa loa hypermicrofilaraemia; • To characterize the pharmacokinetics (PK) of albendazole and its metabolite in plasma of patients with different levels of L. loa microfilareamia according to the treatment regimens; • To evaluate the relationship between ACPR and concentration of albendazole and its metabolites Tertiary objectives • To compare the frequency of STH infection between the pre-treated individuals and those who will directly benefit from IVM MDA after the interventions. • To determine the dose regimen suitable for recommendation of an albendazole curative treatment regimen of loiasis.
Institution | Country |
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Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Name | Institution | Country |
---|---|---|
Ndong Akomezogho Luccheri | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Ogoula Stéphane | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Hombo Ndomana Lys Anna | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Adekpedjou Oulfath Abebi | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Ndama-Ndama Ivane-Guy-Tiburce | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
MIhindou Coella Joyce | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Ndong Ngomo Jacques Mari | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Moutombi Ditombi Bridy Chesly | Faculté de Médecine | Gabon |
Obali Ndjena Andress | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Chabi Espédiee | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
MIMBILA MINKO Melly Chancelle | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
MOUDOUMBI-MOUANDZA Junior Dimitri | Faculté de Médecine, Université des Sciences de la Santé Libreville | Gabon |
Clinical trial of phase IIb
BITAM-MINVOUL |
Type | Name | Title | University | Start Date | End Date |
---|---|---|---|---|---|
Bachelor in Science | Nyalendo Taylor Josué | Epidémiologie des parasitoses intestinales et relation avec l’anémie et l’indice de masse corporelle dans 4 villages du Nord du Gabon | ISMS-Elite Center | 2022 | 10/2022 |
Bachelor in Science | Mengue M'asse Tanguy | Epidémiologie de la coinfection paludisme-loaose dans 4 villages du Nord du Gabon : aspect hématologique et biochimique. | ISMS-Elite Center | 01/2022 | 10/2022 |
Department of Fundamental Sciences of the Faculty of Medicine of the Université des Sciences de la Santé
Lecturer-Researcher